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HUS1500064I1 - HPV58 L1 optimalizált expressziója élesztõben - Google Patents

HPV58 L1 optimalizált expressziója élesztõben

Info

Publication number
HUS1500064I1
HUS1500064I1 HUS1500064C HUS1500064C HUS1500064I1 HU S1500064 I1 HUS1500064 I1 HU S1500064I1 HU S1500064 C HUS1500064 C HU S1500064C HU S1500064 C HUS1500064 C HU S1500064C HU S1500064 I1 HUS1500064 I1 HU S1500064I1
Authority
HU
Hungary
Prior art keywords
hpv
yeast
optimized expression
optimized
expression
Prior art date
Application number
HUS1500064C
Other languages
English (en)
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of HUS1500064I1 publication Critical patent/HUS1500064I1/hu

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01DNA viruses
    • C07K14/025Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5256Virus expressing foreign proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5258Virus-like particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/20011Papillomaviridae
    • C12N2710/20022New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/20011Papillomaviridae
    • C12N2710/20023Virus like particles [VLP]
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/20011Papillomaviridae
    • C12N2710/20034Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2800/00Nucleic acids vectors
    • C12N2800/22Vectors comprising a coding region that has been codon optimised for expression in a respective host

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
HUS1500064C 2003-11-12 2015-12-02 HPV58 L1 optimalizált expressziója élesztõben HUS1500064I1 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51921103P 2003-11-12 2003-11-12
EP04810619A EP1687329B8 (en) 2003-11-12 2004-11-10 Optimized expression of hpv 58 l1 in yeast

Publications (1)

Publication Number Publication Date
HUS1500064I1 true HUS1500064I1 (hu) 2016-02-29

Family

ID=34590374

Family Applications (1)

Application Number Title Priority Date Filing Date
HUS1500064C HUS1500064I1 (hu) 2003-11-12 2015-12-02 HPV58 L1 optimalizált expressziója élesztõben

Country Status (32)

Country Link
US (2) US7498036B2 (hu)
EP (1) EP1687329B8 (hu)
JP (2) JP4912885B2 (hu)
KR (1) KR101170654B1 (hu)
CN (1) CN1942583B (hu)
AR (1) AR046835A1 (hu)
AT (1) ATE452977T1 (hu)
AU (1) AU2004290032B2 (hu)
BE (1) BE2015C070I2 (hu)
BR (1) BRPI0416393B1 (hu)
CA (1) CA2543928C (hu)
CY (2) CY1113875T1 (hu)
DE (1) DE602004024821D1 (hu)
DK (1) DK1687329T3 (hu)
ES (1) ES2340287T3 (hu)
FR (1) FR15C0081I2 (hu)
HU (1) HUS1500064I1 (hu)
IL (1) IL175353A (hu)
IS (1) IS2741B (hu)
LT (1) LTC1687329I2 (hu)
LU (1) LU92901I2 (hu)
MY (1) MY139500A (hu)
NL (1) NL300775I1 (hu)
NO (3) NO340633B1 (hu)
NZ (1) NZ546697A (hu)
PL (1) PL1687329T3 (hu)
PT (1) PT1687329E (hu)
RU (1) RU2370538C2 (hu)
SI (1) SI1687329T1 (hu)
TW (1) TWI332988B (hu)
WO (1) WO2005047315A2 (hu)
ZA (1) ZA200603106B (hu)

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DK2154149T3 (da) * 2007-05-29 2019-10-14 Univ Xiamen En trunkeret l1-protein af human papillomavirus 6
CN101113417B (zh) * 2007-06-22 2011-04-27 山东大学 Hpv基因酵母体外翻译系统的建立
CN101200696B (zh) * 2007-11-14 2011-07-20 山东大学 人乳头瘤病毒的酵母增殖模型及建立方法与应用
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CN102336822B (zh) * 2010-07-16 2015-10-14 厦门大学 截短的人乳头瘤病毒58型l1蛋白
CN102154325B (zh) * 2011-01-01 2013-08-21 上海生物制品研究所有限责任公司 针对人乳头瘤状病毒的疫苗及其制法和用途
WO2012173390A2 (ko) * 2011-06-15 2012-12-20 중앙대학교 산학협력단 인유두종바이러스 l1 단백질의 생산 수율을 향상시키는 방법
CN108624614A (zh) * 2012-03-28 2018-10-09 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv11 l1蛋白的方法
EP2858680B1 (en) * 2012-06-07 2018-10-31 The Children's Hospital of Philadelphia Controlled gene expression methods
CN103992395B (zh) * 2013-02-18 2018-07-27 北京康乐卫士生物技术股份有限公司 重组hpv-58型l1的vlp疫苗及其制备方法
CN110423774A (zh) * 2013-04-26 2019-11-08 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv58 l1蛋白的方法
CN110592133A (zh) * 2013-05-17 2019-12-20 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv31 l1蛋白的方法
CN104164373B (zh) * 2013-05-17 2019-04-02 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv68l1蛋白的方法
WO2015057541A1 (en) 2013-10-16 2015-04-23 Merck Sharp & Dohme Corp. Method of obtaining thermostable dried vaccine formulations
WO2016038625A2 (en) * 2014-09-11 2016-03-17 Cadila Healthcare Limited Superior human papilloma virus antigens with superior immunological properties and vaccine containing it
CN106148359A (zh) * 2015-03-30 2016-11-23 上海泽润生物科技有限公司 重组人乳头瘤病毒33亚型蛋白表达
CN104878022A (zh) * 2015-04-27 2015-09-02 段青姣 编码hpv58l1、hpv52l1蛋白的核苷酸序列及其应用
KR102351259B1 (ko) * 2015-12-04 2022-01-14 시아먼 유니버시티 58형 인유두종 바이러스 엘1 단백질의 돌연변이체
AU2021219652A1 (en) 2020-02-14 2022-08-18 Merck Sharp & Dohme Llc HPV vaccine
CN113073105B (zh) * 2021-03-23 2023-06-13 重庆博唯佰泰生物制药有限公司 一种表达hpv 56l1的多核苷酸序列及其表达载体、宿主细胞和应用
CN113549634B (zh) * 2021-06-07 2023-03-31 郑州大学 编码可溶性hpv58 l1蛋白的基因及其重组质粒的构建与应用
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Also Published As

Publication number Publication date
TW200519203A (en) 2005-06-16
WO2005047315A2 (en) 2005-05-26
KR101170654B1 (ko) 2012-08-03
DE602004024821D1 (de) 2010-02-04
NO20062674L (no) 2006-06-09
IL175353A (en) 2010-11-30
EP1687329A2 (en) 2006-08-09
BRPI0416393A (pt) 2007-04-03
PT1687329E (pt) 2010-02-26
NZ546697A (en) 2009-05-31
NL300775I2 (hu) 2015-12-29
US7976848B2 (en) 2011-07-12
CN1942583A (zh) 2007-04-04
JP2012095652A (ja) 2012-05-24
EP1687329B1 (en) 2009-12-23
NO2017058I1 (no) 2017-11-10
RU2370538C2 (ru) 2009-10-20
FR15C0081I2 (fr) 2016-11-25
LTC1687329I2 (lt) 2017-05-10
PL1687329T3 (pl) 2010-06-30
JP5616879B2 (ja) 2014-10-29
CA2543928A1 (en) 2005-05-26
TWI332988B (en) 2010-11-11
ES2340287T3 (es) 2010-06-01
RU2006120402A (ru) 2007-12-27
FR15C0081I1 (fr) 2016-08-01
IL175353A0 (en) 2006-09-05
NL300775I1 (hu) 2015-12-29
LU92901I2 (fr) 2016-03-08
IS2741B (is) 2011-06-15
KR20060122852A (ko) 2006-11-30
IS8425A (is) 2006-04-21
JP4912885B2 (ja) 2012-04-11
CN1942583B (zh) 2010-10-27
CY2015051I1 (el) 2016-06-22
MY139500A (en) 2009-10-30
SI1687329T1 (sl) 2010-03-31
US20100272749A1 (en) 2010-10-28
BE2015C070I2 (hu) 2023-12-18
DK1687329T3 (da) 2010-04-12
CY1113875T1 (el) 2016-06-22
ZA200603106B (en) 2007-09-26
ATE452977T1 (de) 2010-01-15
CY2015051I2 (el) 2016-06-22
US7498036B2 (en) 2009-03-03
EP1687329B8 (en) 2010-03-17
US20070036824A1 (en) 2007-02-15
AU2004290032A1 (en) 2005-05-26
NO340633B1 (no) 2017-05-15
AU2004290032B2 (en) 2009-02-05
CA2543928C (en) 2011-04-05
WO2005047315A3 (en) 2006-09-28
JP2008500019A (ja) 2008-01-10
NO2022052I1 (no) 2022-11-30
AR046835A1 (es) 2005-12-28
BRPI0416393B1 (pt) 2021-06-29

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