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HUP0400823A2 - Heterociklusos vegyületek, előállításuk, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk öregedéssel kapcsolatos és diabeticus vascularis komplikációk kezelésére - Google Patents

Heterociklusos vegyületek, előállításuk, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk öregedéssel kapcsolatos és diabeticus vascularis komplikációk kezelésére

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Publication number
HUP0400823A2
HUP0400823A2 HU0400823A HUP0400823A HUP0400823A2 HU P0400823 A2 HUP0400823 A2 HU P0400823A2 HU 0400823 A HU0400823 A HU 0400823A HU P0400823 A HUP0400823 A HU P0400823A HU P0400823 A2 HUP0400823 A2 HU P0400823A2
Authority
HU
Hungary
Prior art keywords
ion
alkyl
same
compound
aryl
Prior art date
Application number
HU0400823A
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English (en)
Inventor
Alangudi Sankaranarayanan
Original Assignee
Torrent Pharmaceuticals Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Torrent Pharmaceuticals Ltd. filed Critical Torrent Pharmaceuticals Ltd.
Publication of HUP0400823A2 publication Critical patent/HUP0400823A2/hu
Publication of HUP0400823A3 publication Critical patent/HUP0400823A3/hu

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A61P17/00—Drugs for dermatological disorders
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    • A61P17/16—Emollients or protectives, e.g. against radiation
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    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Virology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Toxicology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)

Abstract

A találmány (I) általános képletű vegyületekre - amelyek képletében R1alkil- vagy arilcsoport; Y kén-, oxigén-, nitrogénatom vagyalkilcsoport; A és B heteroaromás gyűrűrendszert alkotó nitrogén-,kén-, oxigén- vagy szénatom; R2, R3 és R4 fluor-, klór-, bróm-,jódatom, -OR7, nitro-, alkil-, aril-, heteroaril-, formil-, acil-, -C(O)NR6R7, -C(O)OR6, -NR6R7, -N=C(R6)(R7), -SR6, szulfamoil-, alkil-szulfonil- vagy aril-szulfonil-csoport; vagy adott esetben R2, R3 ésR4 egymással kapcsolódva egy gyűrűrendszert képezhet; R5 - ha avegyület kvaternerizált - alkil- vagy arilcsoport; vagy ha a vegyületnem kvaternerizált, akkor R5 és X nincs értelmezve; R6 hidrogénatom,alkil-, aril-, heteroaril-, biztosítva azt, hogy ugyanazon vegyületbenRl, R2 és R3 jelentésében R6 jelentése azonos vagy egymástól eltérőlehet; R7 hidrogénatom, alkil-, aril-, heteroarilcsoport, valamintvalamennyi esetben az R6 szubsztituens jelentésével azonos vagy attóleltérő lehet, biztosítva azt, hogy ugyanazon vegyületben R1, R2 és R3jelentésében R7 jelentése azonos vagy egymástól eltérő lehet; X - ha avegyület kvaternerizált - halogenidion, acetátion, perklorátion,szulfonátion, oxalátion, citrátion, tozilátion, maleátion, mezilátion,karbonátion, szulfition, hidrogén-foszfát-ion, foszfonátion,foszfátion,[tetrafluoro-borát(III)]-ion (BF4-) vagy[hexafluoro-foszfát(V)]-ion (PF6-): biztosítva azt, hogy ha ugyanazon a szén- vagynitrogénatomon két alkilcsoport van jelen, a két alkilcsoport adottesetben egymással kapcsolódva egy ciklikus szerkezetet képezhet - és avegyületek gyógyszerészetileg elfogadható sóira vonatkozik. Ó
HU0400823A 2001-04-05 2002-04-02 Heterocyclic compounds for treating aging-related and diabetic vascular complications, their preparation and pharmaceutical compositions containing them HUP0400823A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28138001P 2001-04-05 2001-04-05
PCT/IB2002/001137 WO2002085897A1 (en) 2001-04-05 2002-04-02 Heterocyclic compounds for aging-related and diabetic vascular complications

Publications (2)

Publication Number Publication Date
HUP0400823A2 true HUP0400823A2 (hu) 2004-07-28
HUP0400823A3 HUP0400823A3 (en) 2010-06-28

Family

ID=23077044

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0400823A HUP0400823A3 (en) 2001-04-05 2002-04-02 Heterocyclic compounds for treating aging-related and diabetic vascular complications, their preparation and pharmaceutical compositions containing them

Country Status (22)

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US (2) US7223777B2 (hu)
EP (1) EP1373263B1 (hu)
JP (2) JP4485744B2 (hu)
KR (1) KR100785109B1 (hu)
CN (1) CN1259316C (hu)
AT (1) ATE280766T1 (hu)
AU (1) AU2002253432B2 (hu)
BR (1) BR0208561A (hu)
CA (1) CA2439593C (hu)
CZ (1) CZ20032013A3 (hu)
DE (1) DE60201740T2 (hu)
DK (1) DK1373263T3 (hu)
ES (1) ES2231685T3 (hu)
HK (1) HK1061234A1 (hu)
HU (1) HUP0400823A3 (hu)
MX (1) MXPA03008089A (hu)
PL (1) PL365441A1 (hu)
PT (1) PT1373263E (hu)
RU (1) RU2291154C2 (hu)
SI (1) SI1373263T1 (hu)
WO (1) WO2002085897A1 (hu)
ZA (1) ZA200306370B (hu)

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US7223777B2 (en) 2007-05-29
KR20030086340A (ko) 2003-11-07
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WO2002085897A9 (en) 2004-04-01
EP1373263B1 (en) 2004-10-27
DE60201740T2 (de) 2005-11-03
HUP0400823A3 (en) 2010-06-28
PT1373263E (pt) 2005-03-31
WO2002085897A1 (en) 2002-10-31
CN1259316C (zh) 2006-06-14
CA2439593C (en) 2010-02-09
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CN1498217A (zh) 2004-05-19
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US20070167493A1 (en) 2007-07-19
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CA2439593A1 (en) 2002-10-31
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