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HUP0400261A2 - Szubsztituált acetofenon sztereoszelektív redukciója - Google Patents

Szubsztituált acetofenon sztereoszelektív redukciója

Info

Publication number
HUP0400261A2
HUP0400261A2 HU0400261A HUP0400261A HUP0400261A2 HU P0400261 A2 HUP0400261 A2 HU P0400261A2 HU 0400261 A HU0400261 A HU 0400261A HU P0400261 A HUP0400261 A HU P0400261A HU P0400261 A2 HUP0400261 A2 HU P0400261A2
Authority
HU
Hungary
Prior art keywords
enzyme
microorganisms
ketoreductase
heterologous
recombinant
Prior art date
Application number
HU0400261A
Other languages
English (en)
Inventor
Ramesh Patel
Animesh Goswami
Linda Chu
Venkata Nanduri
Steven Goldberg
Robert Johnston
Mary Jo Donovan
K. David Mirfakhrae
Original Assignee
Bristol-Myers Squibb Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Co. filed Critical Bristol-Myers Squibb Co.
Publication of HUP0400261A2 publication Critical patent/HUP0400261A2/hu
Publication of HUP0400261A3 publication Critical patent/HUP0400261A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/938—Pichia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

A találmány tárgyát (S)-1-aril-etanol előállítására szolgáló újsztereoszelektív eljárás képezi, amelyben a ketocsoportot tartalmazómegfelelő vegyületeket oxidoreduktáz enzimmel rendelkezőmikroorganizmusok vagy ilyen mikroorganizmusokból izoláltoxidoreduktáz enzim segítségével redukálják. Az (S)-1-aril-etanolokintermedierként használhatók az Alzheimer-kór kezelésére alkalmas g-szekretáz inhibitor vegyületek szintézisében. A találmány szerintimikroorganizmus lehet vad típus vagy rekombináns szervezet és ennekmegfelelően az enzim - amely egy ketoreduktáz - lehet természetbenelőforduló vagy heterológ fehérje. A találmány szerinti ketoreduktázenzimet szolgáltató mikroorganizmus előnyösen Pichia species, aheterológ enzimfehérjét rekombináns E. coli-val termeltetik. Ó
HU0400261A 2001-03-22 2002-03-06 Stereoselective reduction of substituted acetophenone HUP0400261A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27802501P 2001-03-22 2001-03-22
PCT/US2002/006783 WO2002077258A1 (en) 2001-03-22 2002-03-06 Stereoselective reduction of substituted acetophenone

Publications (2)

Publication Number Publication Date
HUP0400261A2 true HUP0400261A2 (hu) 2004-09-28
HUP0400261A3 HUP0400261A3 (en) 2005-11-28

Family

ID=23063377

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0400261A HUP0400261A3 (en) 2001-03-22 2002-03-06 Stereoselective reduction of substituted acetophenone

Country Status (13)

Country Link
US (1) US6800477B2 (hu)
EP (1) EP1370677A1 (hu)
JP (1) JP2004532017A (hu)
KR (1) KR20030085012A (hu)
CN (1) CN1498273A (hu)
BR (1) BR0208265A (hu)
CA (1) CA2441267A1 (hu)
CZ (1) CZ20032496A3 (hu)
HU (1) HUP0400261A3 (hu)
IL (1) IL157386A0 (hu)
MX (1) MXPA03008437A (hu)
PL (1) PL364577A1 (hu)
WO (1) WO2002077258A1 (hu)

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Publication number Priority date Publication date Assignee Title
EP1453516A2 (de) * 2001-10-17 2004-09-08 Boehringer Ingelheim Pharma GmbH & Co.KG 5-substituierte 4-amino-2-phenylamino-pyrimdinderivate und ihre verwendung als beta-amyloid modulatoren
RU2007106863A (ru) * 2004-08-26 2008-08-27 Пфайзер Инк. (US) Энантиоселективное биопреобразование для получения промежуточных соединений ингибитора белка тирозинкиназы
WO2007084625A2 (en) * 2006-01-19 2007-07-26 Mount Sinai School Of Medicine Novel compounds and methods for inhibiting p53 activity
EP2066788B1 (en) * 2006-10-02 2014-07-23 Codexis, Inc. Compositions and methods for producing stereoisomerically pure statins and synthetic intermediates therefor
JP2010517574A (ja) * 2007-02-08 2010-05-27 コデクシス， インコーポレイテッド ケトレダクターゼおよびその使用
WO2009029554A2 (en) 2007-08-24 2009-03-05 Codexis, Inc. Improved ketoreductase polypeptides for the stereoselective production of (r)-3-hydroxythiolane
CN101855342B (zh) 2007-09-13 2013-07-10 科德克希思公司 用于还原苯乙酮的酮还原酶多肽
CN101889081B (zh) 2007-09-28 2014-06-18 科德克希思公司 酮还原酶多肽及其用途
EP2205727B1 (en) * 2007-10-01 2015-06-24 Codexis, Inc. Ketoreductase polypeptides for the production of azetidinone
EP2329013B1 (en) * 2008-08-27 2015-10-28 Codexis, Inc. Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
US8288131B2 (en) * 2008-08-27 2012-10-16 Codexis, Inc. Ketoreductase polypeptides and uses thereof
US8288141B2 (en) 2008-08-27 2012-10-16 Codexis, Inc. Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
WO2010025085A2 (en) 2008-08-29 2010-03-04 Codexis, Inc. Ketoreductase polypeptides for the stereoselective production of (4s)-3[(5s)-5(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one
US8501436B2 (en) * 2009-06-22 2013-08-06 Sk Biopharmaceuticals Co. Ltd. Method for preparation of carbamic acid (R)-1-aryl-2-tetrazolyl-ethyl ester
EP2446025B1 (en) 2009-06-22 2018-08-08 Codexis, Inc. Ketoreductase-mediated stereoselective route to alpha chloroalcohols
EP2467473B1 (en) 2009-08-19 2016-03-23 Codexis, Inc. Ketoreductase polypeptides for the preparation of phenylephrine
US8404461B2 (en) 2009-10-15 2013-03-26 SK Biopharmaceutical Co. Ltd. Method for preparation of carbamic acid (R)-1-aryl-2-tetrazolyl-ethyl ester
US9080192B2 (en) 2010-02-10 2015-07-14 Codexis, Inc. Processes using amino acid dehydrogenases and ketoreductase-based cofactor regenerating system
WO2011140219A1 (en) 2010-05-04 2011-11-10 Codexis, Inc. Biocatalysts for ezetimibe synthesis
CN103228658A (zh) * 2010-10-08 2013-07-31 卡迪拉保健有限公司 用于通过酶促转化制备西他列汀的中间体的方法
US9139819B2 (en) 2011-11-18 2015-09-22 Codexis, Inc. Biocatalysts for the preparation of hydroxy substituted carbamates
DE102012017026A1 (de) 2012-08-28 2014-03-06 Forschungszentrum Jülich GmbH Sensor für NADP(H) und Entwicklung von Alkoholdehydrogenasen
WO2016130412A1 (en) 2015-02-10 2016-08-18 Codexis, Inc. Ketoreductase polypeptides for the synthesis of chiral compounds
US11021729B2 (en) 2017-04-27 2021-06-01 Codexis, Inc. Ketoreductase polypeptides and polynucleotides
CN107686447A (zh) * 2017-08-25 2018-02-13 许昌恒生制药有限公司 一种替格瑞洛中间体的制备方法
EP3587393B1 (en) 2018-06-21 2024-01-17 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Enzymatic process for the preparation of droxidopa
CN117098762A (zh) 2021-04-02 2023-11-21 基因泰克公司 用于制备双环酮化合物的方法
WO2024150146A1 (en) 2023-01-12 2024-07-18 Novartis Ag Engineered ketoreductase polypeptides

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0538693A3 (en) * 1991-10-23 1994-08-17 Squibb & Sons Inc Stereoselective preparation of halophenyl alcohols
DE59306681D1 (de) 1992-03-13 1997-07-10 Forschungszentrum Juelich Gmbh Neue ketoester-reduktase, deren herstellung und verwendung für enzymatische redoxreaktionen
CA2103932A1 (en) 1992-11-05 1994-05-06 Ramesh N. Patel Stereoselective reduction of ketones
WO1999023242A1 (en) * 1997-11-04 1999-05-14 Eli Lilly And Company Ketoreductase gene and protein from yeast

Also Published As

Publication number Publication date
BR0208265A (pt) 2004-03-02
KR20030085012A (ko) 2003-11-01
MXPA03008437A (es) 2004-01-29
CZ20032496A3 (cs) 2003-12-17
IL157386A0 (en) 2004-02-19
WO2002077258A1 (en) 2002-10-03
EP1370677A1 (en) 2003-12-17
HUP0400261A3 (en) 2005-11-28
PL364577A1 (en) 2004-12-13
CA2441267A1 (en) 2002-10-03
JP2004532017A (ja) 2004-10-21
US6800477B2 (en) 2004-10-05
CN1498273A (zh) 2004-05-19
US20030068811A1 (en) 2003-04-10

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