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HUP0302633A2 - Eljárás Trp aminosavat tartalmazó peptid szintézisére - Google Patents

Eljárás Trp aminosavat tartalmazó peptid szintézisére

Info

Publication number
HUP0302633A2
HUP0302633A2 HU0302633A HUP0302633A HUP0302633A2 HU P0302633 A2 HUP0302633 A2 HU P0302633A2 HU 0302633 A HU0302633 A HU 0302633A HU P0302633 A HUP0302633 A HU P0302633A HU P0302633 A2 HUP0302633 A2 HU P0302633A2
Authority
HU
Hungary
Prior art keywords
synthesis
peptide
tryptophan
trp residue
lhrh
Prior art date
Application number
HU0302633A
Other languages
English (en)
Inventor
Steven Allen Jackson
Original Assignee
Kinerton Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kinerton Limited filed Critical Kinerton Limited
Publication of HUP0302633A2 publication Critical patent/HUP0302633A2/hu
Publication of HUP0302633A3 publication Critical patent/HUP0302633A3/hu
Publication of HU229701B1 publication Critical patent/HU229701B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/068—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for heterocyclic side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A találmány tárgyát Trp aminosavat tartalmazó peptidek szintéziséreszolgáló, szilárd fázisú eljárás képezi. A találmány szerinti eljárássorán - a technika állása szerinti jelenlegi irányzattal ellentétben -a szintézis során a triptofán aminosavak oldalláncai ideiglenesenvédve vannak, ami a triptofántartalmú LHRH-analógok (például a[D-Trp6]-LHRH) esetén javítja a kitermelést. Ó
HU0302633A 2000-12-22 2001-12-19 Process for the synthesis of a peptide having a trp residue HU229701B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IE20001079 2000-12-22
PCT/IE2001/000159 WO2002051861A2 (en) 2000-12-22 2001-12-19 Process for the synthesis of a peptide having a tryptophan residue

Publications (3)

Publication Number Publication Date
HUP0302633A2 true HUP0302633A2 (hu) 2003-12-29
HUP0302633A3 HUP0302633A3 (en) 2008-04-28
HU229701B1 HU229701B1 (en) 2014-05-28

Family

ID=11042704

Family Applications (2)

Application Number Title Priority Date Filing Date
HU1400157A HU230601B1 (hu) 2000-12-22 2001-12-19 Eljárás Trp aminosavat tartalmazó peptid szintézisére
HU0302633A HU229701B1 (en) 2000-12-22 2001-12-19 Process for the synthesis of a peptide having a trp residue

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HU1400157A HU230601B1 (hu) 2000-12-22 2001-12-19 Eljárás Trp aminosavat tartalmazó peptid szintézisére

Country Status (25)

Country Link
US (1) US7122628B2 (hu)
EP (1) EP1343808B1 (hu)
JP (1) JP4064817B2 (hu)
KR (1) KR100591832B1 (hu)
CN (2) CN1481389A (hu)
AT (1) ATE339442T1 (hu)
AU (1) AU2002222439C1 (hu)
BR (1) BR0116447B1 (hu)
CA (1) CA2432708C (hu)
CZ (1) CZ299141B6 (hu)
DE (1) DE60123115T2 (hu)
DK (1) DK1343808T3 (hu)
ES (1) ES2266104T3 (hu)
HK (1) HK1055749A1 (hu)
HU (2) HU230601B1 (hu)
IE (1) IES20011090A2 (hu)
IL (2) IL156258A0 (hu)
MX (1) MXPA03005678A (hu)
NO (1) NO325038B1 (hu)
NZ (1) NZ526990A (hu)
PL (1) PL205949B1 (hu)
PT (1) PT1343808E (hu)
RU (1) RU2276156C2 (hu)
WO (1) WO2002051861A2 (hu)
ZA (1) ZA200304809B (hu)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7091311B2 (en) 1996-06-07 2006-08-15 Smithkline Beecham Corporation Peptides and compounds that bind to a receptor
EP1542714B1 (en) 2002-09-18 2014-04-02 Ortho-McNeil Pharmaceutical, Inc. Methods of increasing platelet and hematopoietic stem cell production
US7576056B2 (en) * 2003-08-28 2009-08-18 Ortho-Mcneil Pharmaceutical, Inc. Peptides and compounds that bind to a receptor
WO2007077112A1 (en) * 2005-12-30 2007-07-12 F. Hoffmann-La Roche Ag Methods for the synthesis of arginine-containing peptides
CN103517915B (zh) * 2012-09-27 2015-11-25 深圳翰宇药业股份有限公司 一种制备布舍瑞林的方法
US10308677B2 (en) 2014-12-19 2019-06-04 Cem Corporation Coupling method for peptide synthesis at elevated temperatures
US9969769B2 (en) 2014-12-19 2018-05-15 Cem Corporation Coupling method for peptide synthesis at elevated temperatures

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4211693A (en) * 1977-09-20 1980-07-08 The Salk Institute For Biological Studies Peptides with para-substituted phenylalanine
US4569927A (en) * 1984-02-23 1986-02-11 The Salk Institute For Biological Studies GnRH Antagonists IV
IL74827A (en) 1984-05-21 1989-06-30 Salk Inst For Biological Studi Peptides active as gnrh antagonists and pharmaceutical compositions containing them
IT1203600B (it) * 1985-12-06 1989-02-15 Phidea Srl Metodo per preparare il (d-trp6)-lhrh
US5175254A (en) * 1988-09-24 1992-12-29 Societe D'expansion Scientifque Expansia Solid phase peptide synthesis using a polyacrylic support in aqueous solution
GB8822502D0 (en) * 1988-09-24 1988-10-26 Expansia Sa New peptide synthesis method
JPH05331188A (ja) 1992-05-28 1993-12-14 Nippon Chemiphar Co Ltd トリペプチド、その製造方法及びエンドセリン拮抗剤

Also Published As

Publication number Publication date
RU2003122779A (ru) 2005-02-20
IL156258A0 (en) 2004-01-04
NO325038B1 (no) 2008-01-21
IES20011090A2 (en) 2002-12-30
HU229701B1 (en) 2014-05-28
DK1343808T3 (da) 2006-12-11
DE60123115T2 (de) 2007-03-29
EP1343808A2 (en) 2003-09-17
CZ20031634A3 (cs) 2003-09-17
RU2276156C2 (ru) 2006-05-10
MXPA03005678A (es) 2003-10-06
AU2002222439B2 (en) 2005-04-07
JP2004516330A (ja) 2004-06-03
BR0116447A (pt) 2003-10-07
CN1481389A (zh) 2004-03-10
CZ299141B6 (cs) 2008-04-30
WO2002051861A3 (en) 2002-10-10
ZA200304809B (en) 2004-04-20
HU230601B1 (hu) 2017-02-28
NO20032852D0 (no) 2003-06-20
US20040077827A1 (en) 2004-04-22
JP4064817B2 (ja) 2008-03-19
BR0116447B1 (pt) 2014-04-29
CN101003563A (zh) 2007-07-25
HUP0302633A3 (en) 2008-04-28
AU2002222439C1 (en) 2005-10-27
CA2432708A1 (en) 2002-07-04
CA2432708C (en) 2011-07-12
EP1343808B1 (en) 2006-09-13
KR100591832B1 (ko) 2006-06-20
NO20032852L (no) 2003-08-22
PL361993A1 (en) 2004-10-18
PT1343808E (pt) 2007-01-31
PL205949B1 (pl) 2010-06-30
WO2002051861A2 (en) 2002-07-04
HK1055749A1 (en) 2004-01-21
DE60123115D1 (de) 2006-10-26
KR20030081355A (ko) 2003-10-17
HUP1400157A2 (en) 2003-12-29
US7122628B2 (en) 2006-10-17
IL156258A (en) 2008-06-05
ATE339442T1 (de) 2006-10-15
NZ526990A (en) 2005-04-29
ES2266104T3 (es) 2007-03-01

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