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HUP0301201A2 - Kinazolinonok és kinazolinonokat tartalmazó készítmények - Google Patents

Kinazolinonok és kinazolinonokat tartalmazó készítmények

Info

Publication number
HUP0301201A2
HUP0301201A2 HU0301201A HUP0301201A HUP0301201A2 HU P0301201 A2 HUP0301201 A2 HU P0301201A2 HU 0301201 A HU0301201 A HU 0301201A HU P0301201 A HUP0301201 A HU P0301201A HU P0301201 A2 HUP0301201 A2 HU P0301201A2
Authority
HU
Hungary
Prior art keywords
substituted
alkyl
heteroaryl
aryl
alkylheteroaryl
Prior art date
Application number
HU0301201A
Other languages
English (en)
Inventor
Gustav Bergnes
John C. Chabala
Bainian Feng
Jeffrey T. Finer
David J. Morgans
Whitney W. Smith
Original Assignee
Cytokinetics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytokinetics, Inc. filed Critical Cytokinetics, Inc.
Publication of HUP0301201A2 publication Critical patent/HUP0301201A2/hu
Publication of HUP0301201A3 publication Critical patent/HUP0301201A3/hu
Publication of HU229078B1 publication Critical patent/HU229078B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Paints Or Removers (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Fats And Perfumes (AREA)

Abstract

A jelen találmány tárgyát az (Ia), az (Ib), az (Ic) és az (Id)általános képletű kinazolinonok képezik. Ezek a vegyületek alkalmasaka sejtproliferációs betégségek, és a KSP nevű kinezin aktivitásávalkapcsolatos rendellenességek kezelésére. A találmány kiterjed avegyületeket tartalmazó gyógyszerkészítményekre is. A képletben az R1jelentése hidrogénatom, alkil-, aril-, alkil-aril-, heteroaril-,alkil-heteroaril-, szubsztituált alkil-, szubsztituált aril-,szubsztituált alkil-aril-, szubsztituált heteroaril- vagyszubsztituált alkil-heteroarilcsoport; az R2 és az R2' jelentéseegymástól függetlenül hidrogénatom, alkil-, oxa-alkil-, aril-, alkil-aril-, heteroaril-, alkil-heteroaril-, szubsztituált alkil-,szubsztituált aril-, szubsztituált alkil-aril-, szubsztituáltheteroaril- vagy szubsztituált alkil-heteroaril-csoport; vagy az R2 ésaz R2' együtt egy 3-7 tagú gyűrűt alkot; az R3 jelentése hidrogénatom,alkil-, aril-, alkil-aril-, heteroaril-, alkil-heteroaril-,szubsztituált alkil-, szubsztituált aril-, szubsztituált alkil-aril-;szubsztituált heteroaril-, szubsztituált alkil-heteroaril-, oxa-alkil-, oxa-alkil-aril-, szubsztituált oxa-alkil-aril-, oxa-alkil-heteroaril- vagy szubsztituált oxa-alkil-heteroaril-csoport, illetveaz R15-O- vagy az R15-NH- általános képletű csoport; az R4 jelentésehidrogénatom, a1kil-, aril-, alkil-aril-, heteroaril-, alkil-heteroaril-, szubsztituált alkil-, szubsztituált aril-, szubsztituáltalkil-aril-, szubsztituált heteroaril- vagy szubsztituált alkil-heteroarilcsoport, illetve az R16-alkilén- általános képletű csoport;az R5, az R6, az R7 és az R8 jelentése egymástól függetlenül hidrogén-vagy halogénatom, alkil-, alkoxi-, fluor-alkil-, nitro-, ciano-,dialkil-amino-, alkil-szulfonil-, alkil-szulfonamido-, szulfonamido-alkil-, szulfonamido-aril-, alkil-tio-, karboxi-alkil-, karboxamido-,amino-karbonil-, aril- vagy heteroarilcsoport; az R15 jelentésealkil-, aril-, alkil-aril-, heteroaril-, alkil-heteroaril-,szubsztituált alkil-, szubsztituált aril-, szubsztituált alkil-aril-,szubsztituált heteroaril- vagy szubsztituált alkilheteroaril-csoport;az R16 jelentése pedig alkoxi-, amino-, alkil-amino- vagy dialkil-amino-csoport, valamint egy nitrogéntartalmú heterociklusos csoportvagy egy szubsztituált, nitrogéntartalmú heterociklusos csoport. Ó
HU0301201A 2000-06-21 2001-04-27 Quinazolinones and pharmaceutical compositions containing them HU229078B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21310400P 2000-06-21 2000-06-21
US09/699,047 US6545004B1 (en) 1999-10-27 2000-10-24 Methods and compositions utilizing quinazolinones
PCT/US2001/013901 WO2001098278A1 (en) 2000-06-21 2001-04-27 Methods and compositions utilizing quinazolinones

Publications (3)

Publication Number Publication Date
HUP0301201A2 true HUP0301201A2 (hu) 2003-12-29
HUP0301201A3 HUP0301201A3 (en) 2004-03-29
HU229078B1 HU229078B1 (en) 2013-07-29

Family

ID=26907773

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0301201A HU229078B1 (en) 2000-06-21 2001-04-27 Quinazolinones and pharmaceutical compositions containing them

Country Status (24)

Country Link
US (7) US6545004B1 (hu)
EP (2) EP1707563A3 (hu)
JP (1) JP4854906B2 (hu)
KR (1) KR100847788B1 (hu)
CN (1) CN1229353C (hu)
AT (1) ATE323684T1 (hu)
AU (3) AU5927001A (hu)
BR (1) BR0111898A (hu)
CA (1) CA2413426C (hu)
CY (1) CY1105070T1 (hu)
CZ (1) CZ303007B6 (hu)
DE (1) DE60118921T2 (hu)
DK (1) DK1296959T3 (hu)
ES (1) ES2262649T3 (hu)
HK (1) HK1053837A1 (hu)
HU (1) HU229078B1 (hu)
IL (1) IL153554A (hu)
MX (1) MXPA02012627A (hu)
NO (1) NO324440B1 (hu)
NZ (1) NZ523233A (hu)
PL (1) PL204525B1 (hu)
PT (1) PT1296959E (hu)
SI (1) SI1296959T1 (hu)
WO (1) WO2001098278A1 (hu)

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AU2006236024A1 (en) 2006-12-07
KR100847788B1 (ko) 2008-07-23
US6562831B1 (en) 2003-05-13
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CZ20024178A3 (cs) 2003-05-14
CZ303007B6 (cs) 2012-02-22
DE60118921D1 (de) 2006-05-24
WO2001098278A1 (en) 2001-12-27
CA2413426A1 (en) 2001-12-27
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US6545004B1 (en) 2003-04-08
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