HUP0105048A2 - Biodegradálható polimerbe kapszulázott szerotonin receptor antagonista és eljárás előállítására - Google Patents
Biodegradálható polimerbe kapszulázott szerotonin receptor antagonista és eljárás előállításáraInfo
- Publication number
- HUP0105048A2 HUP0105048A2 HU0105048A HUP0105048A HUP0105048A2 HU P0105048 A2 HUP0105048 A2 HU P0105048A2 HU 0105048 A HU0105048 A HU 0105048A HU P0105048 A HUP0105048 A HU P0105048A HU P0105048 A2 HUP0105048 A2 HU P0105048A2
- Authority
- HU
- Hungary
- Prior art keywords
- polymer
- biodegradable polymer
- microparticles
- pharmaceutical ingredient
- receptor antagonist
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Anesthesiology (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Biological Depolymerization Polymers (AREA)
Abstract
A találmány tárgya eljárás gyógyszerkészítmények előállítására olymódon, hogy a) megfelelő mennyiségű szerotonin receptor antagonistahatású gyógyszer-hatóanyagot elkevernek megfelelő mennyiségűbiodegradálható polimerrel, megfelelő ideig és alkalmas hőmérsékletenés nyomáson, hogy az említett gyógyszerhatóanyag és polimer szárazkeverékét nyerjék, az említett biodegradálható polimer üvegátmenetihőmérséklete (Tg) kisebb, mint kb. 60°C; b) az előző lépésnél kapottszáraz keveréket megfelelő nyíróhatású keverőben alkalmashőmérsékleten és nyomáson elegendő ideig keverik, hogy a polimermeglágyuljon és fluidizált közeget képezzen és hogy agyógyszerhatóanyag megfelelően oldódjon és szilárd oldatot alkosson,amelyben a gyógyszerészeti hatóanyag és a polimer homogénen vandiszpergálva, majd a kapott homogén keveréket szállá alakítják; c) akapott szálat pelletizálják; és d) a pelleteket porítják, így abiodegradálható polimerből és gyógyszerhatóanyagból álló keverékmikrorészecskéit nyerik, amely mikrorészecskék méreteloszlása 10-200mm közötti érték és a mikrorészecske alkalmas injekciókészítményelőállítására. A találmány szerinti gyógyszerkészítmények alkalmasakkülönböző pszichotikus betegségek kezelésére. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21298698A | 1998-12-16 | 1998-12-16 | |
| PCT/US1999/027705 WO2000035423A1 (en) | 1998-12-16 | 1999-11-22 | Biodegradable polymer encapsulated serotonin receptor antagonist and method for preparing the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP0105048A2 true HUP0105048A2 (hu) | 2002-05-29 |
| HUP0105048A3 HUP0105048A3 (en) | 2002-09-30 |
| HU226586B1 HU226586B1 (en) | 2009-04-28 |
Family
ID=22793267
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0105048A HU226586B1 (en) | 1998-12-16 | 1999-11-22 | Biodegradable polymer encapsulated serotonin receptor antagonist and method for preparing the same |
Country Status (35)
| Country | Link |
|---|---|
| EP (1) | EP1140026B1 (hu) |
| JP (1) | JP4759141B2 (hu) |
| KR (1) | KR100707710B1 (hu) |
| CN (1) | CN1195497C (hu) |
| AP (1) | AP1769A (hu) |
| AR (1) | AR021652A1 (hu) |
| AT (1) | ATE303795T1 (hu) |
| AU (1) | AU770673B2 (hu) |
| BG (1) | BG65500B1 (hu) |
| BR (1) | BR9916276A (hu) |
| CA (1) | CA2355077C (hu) |
| CR (1) | CR6424A (hu) |
| CZ (1) | CZ301947B6 (hu) |
| DE (1) | DE69927177T2 (hu) |
| DK (1) | DK1140026T3 (hu) |
| EA (1) | EA004502B1 (hu) |
| EE (1) | EE200100314A (hu) |
| ES (1) | ES2245128T3 (hu) |
| HK (1) | HK1041645B (hu) |
| HR (1) | HRP20010446A2 (hu) |
| HU (1) | HU226586B1 (hu) |
| ID (1) | ID28909A (hu) |
| IL (2) | IL143761A0 (hu) |
| ME (2) | ME00066B (hu) |
| NO (1) | NO20012981L (hu) |
| NZ (1) | NZ511962A (hu) |
| OA (1) | OA11728A (hu) |
| PL (1) | PL196822B1 (hu) |
| RS (1) | RS50123B (hu) |
| SK (1) | SK285812B6 (hu) |
| TR (1) | TR200101759T2 (hu) |
| TW (1) | TWI221418B (hu) |
| UA (1) | UA73101C2 (hu) |
| WO (1) | WO2000035423A1 (hu) |
| ZA (1) | ZA200104899B (hu) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10061932A1 (de) * | 2000-12-13 | 2002-10-24 | Pharmatech Gmbh | Wirkstoffhaltige Mikropartikel und Verfahren zur Herstellung der Mikropartikel durch Abrasion |
| AU2002256694A1 (en) * | 2001-03-20 | 2002-10-03 | Euroscreen S.A. | Screening, diagnostic and/or dosage method and device of an agonist and/or antagonist for a calcium-coupled receptor |
| BR0209914A (pt) | 2001-05-23 | 2004-04-06 | Hexal Ag | Produto homogeneizado para implantes e micropartìculas |
| US20050215561A1 (en) * | 2004-03-19 | 2005-09-29 | Krishnendu Ghosh | Pharmaceutical dosage forms and compositions |
| EP1797871B1 (en) * | 2004-09-21 | 2015-02-25 | Shandong Luye Pharmaceutical Co., Ltd. | Long acting sustained-release formulation containing dopamine receptor agonist and the preparation method thereof |
| EP2262484B1 (en) | 2008-03-11 | 2013-01-23 | Depomed, Inc. | Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic |
| US8372432B2 (en) | 2008-03-11 | 2013-02-12 | Depomed, Inc. | Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic |
| BRPI0913724B8 (pt) * | 2008-09-18 | 2021-05-25 | Purdue Pharma Lp | formas farmacêuticas de liberação prolongada compreendendo naltrexona e poli (e-caprolactona) e seu preparo |
| US20100291214A1 (en) * | 2008-12-23 | 2010-11-18 | Armark Authentication Technologies, Llc | Three-dimensional microfiber extrudate structure and process for forming three-dimensional microfiber extrudate structure |
| WO2010151746A2 (en) * | 2009-06-26 | 2010-12-29 | Armark Authentication Technologies, Llc | Three-dimensional microfiber extrudate structure and process for forming three-dimensional microfiber extrudate structure |
| US8597681B2 (en) | 2009-12-22 | 2013-12-03 | Mallinckrodt Llc | Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans |
| US9198861B2 (en) | 2009-12-22 | 2015-12-01 | Mallinckrodt Llc | Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans |
| US8741885B1 (en) | 2011-05-17 | 2014-06-03 | Mallinckrodt Llc | Gastric retentive extended release pharmaceutical compositions |
| US8858963B1 (en) | 2011-05-17 | 2014-10-14 | Mallinckrodt Llc | Tamper resistant composition comprising hydrocodone and acetaminophen for rapid onset and extended duration of analgesia |
| US8658631B1 (en) | 2011-05-17 | 2014-02-25 | Mallinckrodt Llc | Combination composition comprising oxycodone and acetaminophen for rapid onset and extended duration of analgesia |
| US20160193151A1 (en) * | 2015-01-06 | 2016-07-07 | Maria Del Pilar Noriega Escobar | Dosage form incorporating an amorphous drug solid solution |
| BR112022012260A2 (pt) * | 2019-12-31 | 2022-08-30 | Wanka Tanka Ltd | Formulação plástica de liberação estendida |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4389330A (en) * | 1980-10-06 | 1983-06-21 | Stolle Research And Development Corporation | Microencapsulation process |
| DE3612212A1 (de) * | 1986-04-11 | 1987-10-15 | Basf Ag | Verfahren zur herstellung von festen pharmazeutischen formen |
| CH679207A5 (hu) * | 1989-07-28 | 1992-01-15 | Debiopharm Sa | |
| US5439688A (en) * | 1989-07-28 | 1995-08-08 | Debio Recherche Pharmaceutique S.A. | Process for preparing a pharmaceutical composition |
| EP0528978B1 (en) * | 1990-05-16 | 2002-10-16 | Southern Research Institute | Mikrocaspules for controlled release and their use to stimulate nerve fiber growth |
| DK0531410T3 (da) * | 1990-06-01 | 1995-01-30 | Merrell Dow Pharma | (+)-alfa-(2,3-Demethoxyphenyl)-1-(2-(4-fluorphenyl)ethyl)-4-piperidinmethanol |
| GB9016885D0 (en) * | 1990-08-01 | 1990-09-12 | Scras | Sustained release pharmaceutical compositions |
| KR0182801B1 (ko) * | 1991-04-16 | 1999-05-01 | 아만 히데아키 | 고체 분산체의 제조방법 |
| US5505963A (en) * | 1993-04-07 | 1996-04-09 | Schwartz Pharma Ag | Slow release pharmaceutical preparation |
| US5456917A (en) * | 1993-04-12 | 1995-10-10 | Cambridge Scientific, Inc. | Method for making a bioerodible material for the sustained release of a medicament and the material made from the method |
| AU4467396A (en) * | 1994-12-12 | 1996-07-10 | Omeros Medical Systems, Inc. | Irrigation solution and method for inhibition of pain, inflammation and spasm |
-
1999
- 1999-11-22 JP JP2000587744A patent/JP4759141B2/ja not_active Expired - Fee Related
- 1999-11-22 SK SK828-2001A patent/SK285812B6/sk not_active IP Right Cessation
- 1999-11-22 ES ES99960556T patent/ES2245128T3/es not_active Expired - Lifetime
- 1999-11-22 DE DE69927177T patent/DE69927177T2/de not_active Expired - Lifetime
- 1999-11-22 AT AT99960556T patent/ATE303795T1/de active
- 1999-11-22 ID IDW00200101296A patent/ID28909A/id unknown
- 1999-11-22 CN CNB998145831A patent/CN1195497C/zh not_active Expired - Fee Related
- 1999-11-22 WO PCT/US1999/027705 patent/WO2000035423A1/en active IP Right Grant
- 1999-11-22 CA CA002355077A patent/CA2355077C/en not_active Expired - Fee Related
- 1999-11-22 AU AU17425/00A patent/AU770673B2/en not_active Ceased
- 1999-11-22 OA OA1200100150A patent/OA11728A/en unknown
- 1999-11-22 PL PL348233A patent/PL196822B1/pl not_active IP Right Cessation
- 1999-11-22 HU HU0105048A patent/HU226586B1/hu not_active IP Right Cessation
- 1999-11-22 UA UA2001064165A patent/UA73101C2/uk unknown
- 1999-11-22 EE EEP200100314A patent/EE200100314A/xx unknown
- 1999-11-22 DK DK99960556T patent/DK1140026T3/da active
- 1999-11-22 CZ CZ20012157A patent/CZ301947B6/cs not_active IP Right Cessation
- 1999-11-22 NZ NZ511962A patent/NZ511962A/xx not_active IP Right Cessation
- 1999-11-22 EA EA200100551A patent/EA004502B1/ru not_active IP Right Cessation
- 1999-11-22 RS YUP-414/01A patent/RS50123B/sr unknown
- 1999-11-22 KR KR1020017007561A patent/KR100707710B1/ko not_active IP Right Cessation
- 1999-11-22 TR TR2001/01759T patent/TR200101759T2/xx unknown
- 1999-11-22 EP EP99960556A patent/EP1140026B1/en not_active Expired - Lifetime
- 1999-11-22 AP APAP/P/2001/002198A patent/AP1769A/en active
- 1999-11-22 ME MEP-2008-194A patent/ME00066B/me unknown
- 1999-11-22 BR BR9916276-8A patent/BR9916276A/pt not_active Application Discontinuation
- 1999-11-22 IL IL14376199A patent/IL143761A0/xx active IP Right Grant
- 1999-11-22 ME MEP-194/08A patent/MEP19408A/xx unknown
- 1999-12-10 TW TW088121702A patent/TWI221418B/zh not_active IP Right Cessation
- 1999-12-14 AR ARP990106345A patent/AR021652A1/es unknown
-
2001
- 2001-06-12 BG BG105591A patent/BG65500B1/bg unknown
- 2001-06-14 HR HR20010446A patent/HRP20010446A2/hr not_active Application Discontinuation
- 2001-06-14 IL IL143761A patent/IL143761A/en not_active IP Right Cessation
- 2001-06-14 ZA ZA200104899A patent/ZA200104899B/en unknown
- 2001-06-15 NO NO20012981A patent/NO20012981L/no not_active Application Discontinuation
- 2001-07-16 CR CR6424A patent/CR6424A/es not_active Application Discontinuation
-
2002
- 2002-05-04 HK HK02103401.5A patent/HK1041645B/zh not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUP0105048A2 (hu) | Biodegradálható polimerbe kapszulázott szerotonin receptor antagonista és eljárás előállítására | |
| JP3233929B2 (ja) | 活性物質徐放性を有する溶剤フリーの経口投与すべき医薬製剤およびその製造方法 | |
| Maniruzzaman et al. | A review of hot‐melt extrusion: process technology to pharmaceutical products | |
| FI91482B (fi) | Menetelmä hitaasti vapauttavan kiinteän annostusmuodon valmistamiseksi | |
| JP4040084B2 (ja) | 微粒子医薬調合物の調製プロセス | |
| Sprockel et al. | A melt-extrusion process for manufacturing matrix drug delivery systems | |
| CA1041905A (en) | Integral solid gel-lattice dosage form of high moisture content | |
| KR890001526A (ko) | 경구용 서방성 아세트 아미노펜 제형 및 이의 제조방법 | |
| PT89823B (pt) | Processo para a preparacao de um granulado farmaceutico com propriedades de fluidez melhoradas | |
| KR930016091A (ko) | 거의 수불용성인 약제의 고체 분산액을 제조하는 방법 | |
| JP2005535622A (ja) | 迅速溶解性組成物およびそれを基にした錠剤 | |
| JPH07508280A (ja) | 荷電樹脂を用いる球体形成法 | |
| KR970706801A (ko) | 용융성(fusible) 담체를 함유하는 약제학적 조성물 및 그 제조방법(PHARMACEUTICAL COMPOSITIONS AND METHOD OF PRODUCING THE SAME) | |
| NO20001670L (no) | Fremgangsmate for fremstilling av en smaksmaskert farmasoytisk blanding og smaksmaskert farmasoytisk blanding fremstilt ifolge denne fremgangsmaten, samt smaksmaskerte tyggbare tabletter | |
| DE69920686D1 (de) | Verbesserungen bezüglich der verkapselung bioaktiver wirkstoffe | |
| CN107397720A (zh) | 剂型 | |
| HUP0000141A2 (hu) | Eljárás legfeljebb 90 tömeg% gyógyhatású anyagot tartalmazó pelletek előállítására | |
| US20020160050A1 (en) | Melt granulated composition and modified release dosage form prepared from said composition | |
| PT1331001E (pt) | Nova formula galenica dispersivel e soluvel de paracetamol metodo para a sua preparacao e suas aplicacoes | |
| CN105232486A (zh) | 一种氟尼辛葡甲胺掩味口腔崩解制剂及其制备方法 | |
| JP2007008872A (ja) | 造粒粒子の製造方法およびその造粒粒子、並びに固形製剤 | |
| TWI850539B (zh) | 顆粒及使用其之製劑 | |
| JP2702938B2 (ja) | 徐放性坐剤 | |
| US5505963A (en) | Slow release pharmaceutical preparation | |
| JPS58192817A (ja) | 棒状製剤の製造方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FH91 | Appointment of a representative |
Free format text: FORMER REPRESENTATIVE(S): OLCHVARY GEZANE, DANUBIA SZABADALMI ES VEDJEGY IRODA KFT., HU Representative=s name: DANUBIA SZABADALMI ES JOGI IRODA KFT., HU |
|
| GB9A | Succession in title |
Owner name: AVENTISUB II INC., US Free format text: FORMER OWNER(S): AVENTIS PHARMACEUTICALS INC., US |
|
| MM4A | Lapse of definitive patent protection due to non-payment of fees |