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HUP0000475A2 - Ketobenzamidok mint kalpain-inhibitorok - Google Patents

Ketobenzamidok mint kalpain-inhibitorok

Info

Publication number
HUP0000475A2
HUP0000475A2 HU0000475A HUP0000475A HUP0000475A2 HU P0000475 A2 HUP0000475 A2 HU P0000475A2 HU 0000475 A HU0000475 A HU 0000475A HU P0000475 A HUP0000475 A HU P0000475A HU P0000475 A2 HUP0000475 A2 HU P0000475A2
Authority
HU
Hungary
Prior art keywords
phenyl
powder
membered
alkoxy
units
Prior art date
Application number
HU0000475A
Other languages
English (en)
Inventor
Wilfried Lubisch
Achim Möller
Hans-Jörg Treiber
Original Assignee
Basf Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Aktiengesellschaft filed Critical Basf Aktiengesellschaft
Publication of HUP0000475A2 publication Critical patent/HUP0000475A2/hu
Publication of HUP0000475A3 publication Critical patent/HUP0000475A3/hu

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07C237/36—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
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    • C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

A találmány tárgyát az (I) általánős képletű ketőbenzamidők -, ahől R1 fenil- vagy naftilcsőpőrt, tővábbá különféle 6-10-tagú, egy vagykét heterőatőmőt tartalmazó heterőciklűsős csőpőrt, amelyek mindegyikemég 1-3 szűbsztitűenst is hőrdőzhat; R2 klór-, bróm- vagy flűőratőm, alkil-, alkenil-, alkinil-,alkilfenil-, alkenilfenil-, alkinilfenil-, fenil-, alkil-karbőnil-aminő-, benzőil-aminő- vagy naftilkarbőnil-aminő-, karbőxi-,alkőxikarbőnil-, alkőxi-, nitrő- vagy aminőcsőpőrt; R3 fenil-, 3-7-tagú ciklőalkil-, indőlil-, piridil- vagynaftilcsőpőrttal szűbsztitűált rövid szénláncú alkilcsőpőrt; R4 alkőxi- vagy N-diszűbsztitűált aminőcsőpőrt, tővábbá telített, 5-6-tagú, egy vagy két heterőatőmőt tartalmazó heterőciklűsős csőpőrt; X kémiai kötés, tővábbá vinilén-, etinilén-, alkilén- vagyheterőatőmőkat is tartalmazó alkiléncsőpőrt; n értéke 0, 1 vagy 2; és m és ő értéke 0, 1, 2, 3 vagy 4 - az előállításűkra szőlgáló eljárásés kalpain-inhibitőrőkként gyógyszerhatóanyagként való alkalmazásűkképezi. ŕ
HU0000475A 1996-12-11 1997-11-28 Ketobenzamides as calpain inhibitors HUP0000475A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19651316 1996-12-11

Publications (2)

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HUP0000475A2 true HUP0000475A2 (hu) 2000-05-28
HUP0000475A3 HUP0000475A3 (en) 2002-11-28

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HU0000475A HUP0000475A3 (en) 1996-12-11 1997-11-28 Ketobenzamides as calpain inhibitors

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US (1) US6103720A (hu)
EP (1) EP0944582B1 (hu)
JP (1) JP4099237B2 (hu)
KR (1) KR20000057495A (hu)
CN (1) CN1245486A (hu)
AR (1) AR010348A1 (hu)
AT (1) ATE244216T1 (hu)
AU (1) AU721620B2 (hu)
BG (1) BG63382B1 (hu)
BR (1) BR9713704A (hu)
CA (1) CA2274464C (hu)
CO (1) CO4910159A1 (hu)
DE (1) DE59710384D1 (hu)
ES (1) ES2202663T3 (hu)
HR (1) HRP970680B1 (hu)
HU (1) HUP0000475A3 (hu)
ID (1) ID22426A (hu)
IL (1) IL130124A0 (hu)
NO (1) NO992821L (hu)
NZ (1) NZ335981A (hu)
PL (1) PL334059A1 (hu)
RU (1) RU2190599C2 (hu)
SK (1) SK282680B6 (hu)
TR (1) TR199901305T2 (hu)
TW (1) TW536530B (hu)
WO (1) WO1998025883A1 (hu)
ZA (1) ZA9711141B (hu)

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US6143931A (en) 1997-04-16 2000-11-07 Arqule, Inc. Synthesis and use of α-ketoamide derivatives and arrays
WO1998046559A1 (en) * 1997-04-16 1998-10-22 Arqule, Inc. SYNTHESIS AND USE OF α-KETOAMIDE DERIVATIVES AND ARRAYS
US6150378A (en) * 1997-10-07 2000-11-21 Cephalon, Inc. Peptidyl-containing α-ketoamide cysteine and serine protease inhibitors
DE19817461A1 (de) 1998-04-20 1999-10-21 Basf Ag Neue substituierte Benzamide, deren Herstellung und Anwendung
TR200003004T2 (tr) * 1998-04-20 2001-02-21 Basf Aktiengesellschaft Kalpain önleyicileri olarak heterosiklik ikame edilmiş amidler
CN1306526A (zh) * 1998-04-20 2001-08-01 Basf公司 具有半胱氨酸蛋白酶抑制作用的新的杂环取代酰胺
HUP0102146A3 (en) * 1998-05-25 2003-01-28 Basf Ag New heterocyclically substituted amides, their production and their use
US6686335B1 (en) * 1998-09-22 2004-02-03 Cephalon, Inc. Hydroxamate-containing cysteine and serine protease inhibitors
WO2000021550A2 (en) * 1998-10-13 2000-04-20 President And Fellows Of Harvard College Methods and compositions for treating neurodegenerative diseases
US6410563B1 (en) 1999-12-22 2002-06-25 Merck Frosst Canada & Co. Substituted 8-arylquinoline phosphodiesterase-4 inhibitors
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ZA9711141B (en) 1999-06-11
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