[go: up one dir, main page]

HUE059493T2 - Eljárás optikailag aktív Beraprost elõállítására - Google Patents

Eljárás optikailag aktív Beraprost elõállítására

Info

Publication number
HUE059493T2
HUE059493T2 HUE17714464A HUE17714464A HUE059493T2 HU E059493 T2 HUE059493 T2 HU E059493T2 HU E17714464 A HUE17714464 A HU E17714464A HU E17714464 A HUE17714464 A HU E17714464A HU E059493 T2 HUE059493 T2 HU E059493T2
Authority
HU
Hungary
Prior art keywords
preparation
optically active
active beraprost
beraprost
optically
Prior art date
Application number
HUE17714464A
Other languages
English (en)
Inventor
Iren Hortobagyi
Istvan Laszlofi
Zsuzsanna Kardos
Jozsef Molnar
Laszlo Takacs
Tamas Ban
Original Assignee
Euroapi Hungary Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euroapi Hungary Llc filed Critical Euroapi Hungary Llc
Publication of HUE059493T2 publication Critical patent/HUE059493T2/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/557Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Steroid Compounds (AREA)
HUE17714464A 2016-04-05 2017-03-30 Eljárás optikailag aktív Beraprost elõállítására HUE059493T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU1600232A HU231080B1 (hu) 2016-04-05 2016-04-05 Eljárás optikailag aktív Beraprost előállítására

Publications (1)

Publication Number Publication Date
HUE059493T2 true HUE059493T2 (hu) 2022-11-28

Family

ID=89992131

Family Applications (2)

Application Number Title Priority Date Filing Date
HU1600232A HU231080B1 (hu) 2016-04-05 2016-04-05 Eljárás optikailag aktív Beraprost előállítására
HUE17714464A HUE059493T2 (hu) 2016-04-05 2017-03-30 Eljárás optikailag aktív Beraprost elõállítására

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HU1600232A HU231080B1 (hu) 2016-04-05 2016-04-05 Eljárás optikailag aktív Beraprost előállítására

Country Status (9)

Country Link
US (1) US10421737B2 (hu)
EP (1) EP3440065B1 (hu)
JP (1) JP6925366B2 (hu)
KR (1) KR102373051B1 (hu)
CN (1) CN109219601B (hu)
ES (1) ES2925739T3 (hu)
HU (2) HU231080B1 (hu)
TW (1) TWI698431B (hu)
WO (1) WO2017174439A1 (hu)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3870285A1 (en) * 2018-10-22 2021-09-01 United Therapeutics Corporation Synthesis of esuberaprost prodrugs
US10577341B1 (en) * 2018-11-26 2020-03-03 Chirogate International Inc. Beraprost-314d monohydrate crystals and methods for preparation thereof
US10577340B1 (en) * 2018-11-26 2020-03-03 Chirogate International Inc. Beraprost-314d crystals and methods for preparation thereof
CN111087284A (zh) * 2019-12-27 2020-05-01 安庆润科生物医药科技有限公司 一种贝前列环素中间体的制备方法
CN118496185A (zh) * 2020-03-19 2024-08-16 江西科睿药业有限公司 一种贝前列素及其盐的中间体及其制备方法
US11884640B2 (en) 2021-06-02 2024-01-30 Chirogate International Inc. Processes and intermediates for the preparations of benzoprostacyclin analogues and benzoprostacyclin analogues prepared therefrom
CN115611838A (zh) * 2021-07-15 2023-01-17 四川国为制药有限公司 一种前列环素衍生物的晶型

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU227158B1 (en) 2001-07-30 2010-09-28 Chinoin Gyogyszer Es Vegyeszet Production of beraprost ester by selective reduction
HU227157B1 (en) * 2001-07-30 2010-09-28 Chinoin Gyogyszer Es Vegyeszet Production of beraprost ester by selective oxidation
EP2094273B1 (en) * 2006-11-16 2013-03-06 Gemmus Pharma Inc. EP2 and EP4 agonists as agents for the treatment of influenza A viral infection
WO2012174407A1 (en) * 2011-06-16 2012-12-20 Lung LLC Method of producing beraprost
US9388154B2 (en) * 2011-09-12 2016-07-12 Lund Biotechnology PBC Process for preparing synthetic prostacyclins
AU2014235346A1 (en) * 2013-03-15 2015-10-08 Gemmus Pharma Inc. Beraprost isomer as agent for the treatment of viral infection
ES2676447T3 (es) 2013-03-25 2018-07-19 United Therapeutics Corporation Procedimiento de fabricación de compuestos de prostaciclina con tiol de unión y formas pegiladas
US10005753B2 (en) 2014-05-20 2018-06-26 Lung Biotechnology Pbc Methods for producing beraprost and its derivatives

Also Published As

Publication number Publication date
TW201808927A (zh) 2018-03-16
EP3440065A1 (en) 2019-02-13
HU231080B1 (hu) 2020-07-28
US10421737B2 (en) 2019-09-24
TWI698431B (zh) 2020-07-11
JP2019513729A (ja) 2019-05-30
ES2925739T3 (es) 2022-10-19
CN109219601A (zh) 2019-01-15
HUP1600232A2 (en) 2017-10-30
KR20180131596A (ko) 2018-12-10
JP6925366B2 (ja) 2021-08-25
WO2017174439A1 (en) 2017-10-12
EP3440065B1 (en) 2022-06-08
CN109219601B (zh) 2022-08-09
US20190062295A1 (en) 2019-02-28
KR102373051B1 (ko) 2022-03-11

Similar Documents

Publication Publication Date Title
SI3433285T1 (sl) Izboljšan postopek za pripravo sugamadeksa
HUE064612T2 (hu) Eljárás brivaracetam elõállítására
IL251613B (en) A process for the preparation of terprostinil
HUE059493T2 (hu) Eljárás optikailag aktív Beraprost elõállítására
ZA201706795B (en) Process for the preparation of dicycloplatin
ZA201700254B (en) Process for the preparation of 4-alkoxy-3-hydroxypicolinic acids
IL248267A0 (en) A process for preparing converted cycloserines
ZA201804783B (en) Process for the preparation of 4-alkoxy-3-acetoxypicolinic acids
IL250211B (en) A process for the preparation of optically active isoxazoline compounds
IL247443B (en) Process for the preparation of 5-fluorotryptophol
ZA201804877B (en) Process for the preparation of 4-alkoxy-3-hydroxypicolinic acids
IL260070B (en) A method for the preparation of converted 2-aryl-ethanols
IL256402A (en) A process for the preparation of microcapsules of the colloidosome type
GB2564185B (en) Process for the preparation of derivatives of benzodioxole
HUP1400518A2 (hu) Eljárás tofacitinib elõállítására
FI20146104A (fi) Prosessi spirosyklisten substituoitujen bentsofurokinolitsiinien valmistamiseksi
GB2587294B (en) Processes for the preparation of desflurane