SI3433285T1 - Izboljšan postopek za pripravo sugamadeksa - Google Patents
Izboljšan postopek za pripravo sugamadeksaInfo
- Publication number
- SI3433285T1 SI3433285T1 SI201730346T SI201730346T SI3433285T1 SI 3433285 T1 SI3433285 T1 SI 3433285T1 SI 201730346 T SI201730346 T SI 201730346T SI 201730346 T SI201730346 T SI 201730346T SI 3433285 T1 SI3433285 T1 SI 3433285T1
- Authority
- SI
- Slovenia
- Prior art keywords
- sugammadex
- preparation
- improved process
- improved
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
- C07C319/12—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols by reactions not involving the formation of mercapto groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- General Health & Medical Sciences (AREA)
- Sustainable Development (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN201611009993 | 2016-03-22 | ||
| PCT/IB2017/051594 WO2017163165A1 (en) | 2016-03-22 | 2017-03-20 | An improved process for the preparation of sugammadex |
| EP17720572.1A EP3433285B1 (en) | 2016-03-22 | 2017-03-20 | An improved process for the preparation of sugammadex |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI3433285T1 true SI3433285T1 (sl) | 2020-10-30 |
Family
ID=58645335
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201730346T SI3433285T1 (sl) | 2016-03-22 | 2017-03-20 | Izboljšan postopek za pripravo sugamadeksa |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10577433B2 (sl) |
| EP (2) | EP3733717A3 (sl) |
| JP (1) | JP6829304B2 (sl) |
| KR (1) | KR20180127428A (sl) |
| CN (1) | CN108779186B (sl) |
| AU (1) | AU2017236669B2 (sl) |
| ES (1) | ES2810980T3 (sl) |
| SI (1) | SI3433285T1 (sl) |
| WO (1) | WO2017163165A1 (sl) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2016359420B2 (en) | 2015-11-25 | 2020-10-01 | Fresenius Kabi Ipsum S.R.L. | An improved process for the preparation of sugammadex and its intermediates |
| SI3380554T2 (sl) | 2015-11-25 | 2024-01-31 | Fresenius Kabi Ipsum S.R.L. | Kristalne oblike per-kloro-gama-ciklodekstrinov |
| WO2017144734A2 (en) | 2016-06-23 | 2017-08-31 | Synthon B.V. | Process for making sugammadex |
| US10385142B2 (en) * | 2017-01-23 | 2019-08-20 | Scinopharm Taiwan, Ltd. | Method for preparing sugammadex sodium |
| US10336835B2 (en) * | 2017-08-23 | 2019-07-02 | Formosa Laboratories, Inc. | Polymorphs of sugammadex and process for preparation of sugammadex |
| US11104746B2 (en) | 2017-11-27 | 2021-08-31 | Medichem, S.A. | Process for the synthesis of a cyclodextrin derivative |
| CN107892727B (zh) * | 2017-11-27 | 2019-12-24 | 合肥博思科创医药科技有限公司 | 一种舒更葡糖钠的纯化方法 |
| WO2019193198A1 (en) | 2018-04-06 | 2019-10-10 | Synthon B.V. | Purification of sugammadex |
| AU2019281969B2 (en) * | 2018-06-07 | 2024-03-07 | Merck Sharp & Dohme Llc | Processes for the preparation of sugammadex |
| CN110655594B (zh) * | 2018-06-29 | 2021-04-30 | 江苏海悦康医药科技有限公司 | 一种单羟基舒更葡糖钠的制备方法 |
| WO2020013759A1 (en) * | 2018-07-12 | 2020-01-16 | Scinopharm Taiwan Ltd. | Method for preparing sugammadex sodium |
| CN109053933B (zh) * | 2018-08-01 | 2020-10-23 | 合肥博思科创医药科技有限公司 | 一种无定型舒更葡糖钠的制备方法 |
| US11845811B2 (en) | 2018-09-20 | 2023-12-19 | Natco Pharma Limited | Process for the preparation of Sugammadex sodium and its novel polymorphic form |
| KR20210087934A (ko) * | 2018-09-27 | 2021-07-13 | 베르텐스타인 바이오파마 게엠베하 | 슈가마덱스의 신규한 결정질 형태 |
| CN109593143B (zh) * | 2018-12-29 | 2021-02-09 | 博瑞生物医药（苏州）股份有限公司 | 一种舒更葡糖钠制备中间体的纯化方法 |
| CN109824800A (zh) * | 2018-12-29 | 2019-05-31 | 鼎元(天津)生物医药科技有限公司 | 一种选择性肌松拮抗药舒更葡萄糖钠的制备方法 |
| EP3753946A1 (en) | 2019-06-18 | 2020-12-23 | Fresenius Kabi iPSUM S.r.l. | Improved process for the preparation of high purity glucagon |
| US11324692B2 (en) | 2019-07-03 | 2022-05-10 | Galenicum Health S.L.U. | Method to prepare pharmaceutical compositions of suggamadex |
| WO2021039084A1 (ja) * | 2019-08-30 | 2021-03-04 | テルモ株式会社 | 注射液製剤 |
| EP4110832A1 (en) | 2020-02-28 | 2023-01-04 | Medichem, S.A. | Method for drying sugammadex |
| CN113456598B (zh) * | 2020-03-31 | 2024-04-02 | 鲁南制药集团股份有限公司 | 一种舒更葡糖钠冻干粉针剂及其制备方法 |
| US11097023B1 (en) | 2020-07-02 | 2021-08-24 | Par Pharmaceutical, Inc. | Pre-filled syringe containing sugammadex |
| ES2949710T1 (es) | 2020-07-03 | 2023-10-02 | Galenicum Health S L U | Método para preparar composiciones farmacéuticas |
| JP2023541583A (ja) * | 2020-09-09 | 2023-10-03 | メルク・シャープ・アンド・ドーム・エルエルシー | スガマデクスの製造方法 |
| CN112279938A (zh) * | 2020-10-26 | 2021-01-29 | 江苏阿尔法药业有限公司 | 一种舒更葡糖钠药物中间体的制备方法 |
| CN115266968B (zh) * | 2022-03-30 | 2024-07-16 | 上海上药创新医药技术有限公司 | 一种hplc分离测定舒更葡糖钠中间体及其杂质的方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI242015B (en) * | 1999-11-29 | 2005-10-21 | Akzo Nobel Nv | 6-mercapto-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block |
| CN101864003B (zh) | 2010-06-11 | 2012-05-02 | 漆又毛 | 一种6-脱氧硫醚氨基酸环糊精衍生物的合成方法 |
| ES2551585T3 (es) * | 2010-08-25 | 2015-11-20 | Davuluri, Ramamohan Rao | Procedimiento mejorado para la preparación de Sugammadex |
| US9879096B2 (en) | 2013-02-14 | 2018-01-30 | Neuland Laboratories Limited | Process for preparation of sugammadex sodium |
| CN105273095A (zh) * | 2014-05-28 | 2016-01-27 | 四川海思科制药有限公司 | 一种舒更葡糖钠及其中间体的制备方法 |
| CN104844732B (zh) * | 2015-03-27 | 2017-05-03 | 山东滨州智源生物科技有限公司 | 一种舒更葡糖钠的制备方法 |
| EP3303413A4 (en) | 2015-05-29 | 2019-02-06 | Alaparthi, Lakshmi Prasad | PROCESS FOR THE PREPARATION OF SUGAMMADEX AND INTERMEDIATE PRODUCTS THEREOF |
| CN106749771A (zh) * | 2015-11-23 | 2017-05-31 | 成都渊源生物科技有限公司 | 一种高纯度的舒更葡糖钠制备方法 |
| AU2016359420B2 (en) | 2015-11-25 | 2020-10-01 | Fresenius Kabi Ipsum S.R.L. | An improved process for the preparation of sugammadex and its intermediates |
| SI3380554T2 (sl) | 2015-11-25 | 2024-01-31 | Fresenius Kabi Ipsum S.R.L. | Kristalne oblike per-kloro-gama-ciklodekstrinov |
-
2017
- 2017-03-20 JP JP2019501771A patent/JP6829304B2/ja active Active
- 2017-03-20 AU AU2017236669A patent/AU2017236669B2/en active Active
- 2017-03-20 US US16/087,065 patent/US10577433B2/en active Active
- 2017-03-20 SI SI201730346T patent/SI3433285T1/sl unknown
- 2017-03-20 CN CN201780018634.1A patent/CN108779186B/zh active Active
- 2017-03-20 WO PCT/IB2017/051594 patent/WO2017163165A1/en not_active Ceased
- 2017-03-20 EP EP20175964.4A patent/EP3733717A3/en not_active Withdrawn
- 2017-03-20 ES ES17720572T patent/ES2810980T3/es active Active
- 2017-03-20 KR KR1020187030271A patent/KR20180127428A/ko not_active Ceased
- 2017-03-20 EP EP17720572.1A patent/EP3433285B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3733717A3 (en) | 2020-12-30 |
| JP2019510128A (ja) | 2019-04-11 |
| US20190284308A1 (en) | 2019-09-19 |
| AU2017236669B2 (en) | 2021-02-18 |
| KR20180127428A (ko) | 2018-11-28 |
| ES2810980T3 (es) | 2021-03-10 |
| WO2017163165A1 (en) | 2017-09-28 |
| US10577433B2 (en) | 2020-03-03 |
| JP6829304B2 (ja) | 2021-02-10 |
| AU2017236669A1 (en) | 2018-09-27 |
| CN108779186A (zh) | 2018-11-09 |
| CN108779186B (zh) | 2021-07-13 |
| EP3733717A2 (en) | 2020-11-04 |
| EP3433285B1 (en) | 2020-06-03 |
| EP3433285A1 (en) | 2019-01-30 |
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