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HUE051977T2 - Kalóriamentes édesítõk elõállítása mesterséges egész sejtes katalizátorok használatával - Google Patents

Kalóriamentes édesítõk elõállítása mesterséges egész sejtes katalizátorok használatával

Info

Publication number
HUE051977T2
HUE051977T2 HUE16780713A HUE16780713A HUE051977T2 HU E051977 T2 HUE051977 T2 HU E051977T2 HU E16780713 A HUE16780713 A HU E16780713A HU E16780713 A HUE16780713 A HU E16780713A HU E051977 T2 HUE051977 T2 HU E051977T2
Authority
HU
Hungary
Prior art keywords
production
caloric sweeteners
cell catalysts
engineered whole
engineered
Prior art date
Application number
HUE16780713A
Other languages
English (en)
Inventor
Guohong Mao
Jacob Edward Vick
shi-yan Li
Xiaodan Yu
Original Assignee
Conagen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Conagen Inc filed Critical Conagen Inc
Publication of HUE051977T2 publication Critical patent/HUE051977T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents
    • A23L27/33—Artificial sweetening agents containing sugars or derivatives
    • A23L27/36—Terpene glycosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C12N9/1062—Sucrose synthase (2.4.1.13)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
HUE16780713A 2015-04-14 2016-04-14 Kalóriamentes édesítõk elõállítása mesterséges egész sejtes katalizátorok használatával HUE051977T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562147160P 2015-04-14 2015-04-14

Publications (1)

Publication Number Publication Date
HUE051977T2 true HUE051977T2 (hu) 2021-04-28

Family

ID=57126486

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE16780713A HUE051977T2 (hu) 2015-04-14 2016-04-14 Kalóriamentes édesítõk elõállítása mesterséges egész sejtes katalizátorok használatával

Country Status (13)

Country Link
US (1) US10752928B2 (hu)
EP (1) EP3283614B1 (hu)
JP (1) JP6793957B2 (hu)
KR (1) KR102569053B1 (hu)
CN (1) CN107548417B (hu)
AU (1) AU2016250184B2 (hu)
BR (1) BR112017022019A2 (hu)
CA (1) CA2977541A1 (hu)
HK (1) HK1249543A1 (hu)
HU (1) HUE051977T2 (hu)
MX (1) MX2017013210A (hu)
MY (1) MY190212A (hu)
WO (1) WO2016168413A1 (hu)

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US9522929B2 (en) 2014-05-05 2016-12-20 Conagen Inc. Non-caloric sweetener
CN108884484A (zh) * 2015-11-30 2018-11-23 谱赛科有限责任公司 用于制备高纯度甜菊醇糖苷的方法
WO2017205750A1 (en) * 2016-05-26 2017-11-30 The Regents Of The University Of Michigan Compositions and methods for microbial co-culture
CN106701606B (zh) * 2016-12-19 2021-03-26 广东利世康低碳科技有限公司 一种能降解利用餐厨废弃物的基因工程产朊假丝酵母及其构建方法
US20180223264A1 (en) * 2017-02-03 2018-08-09 Codexis, Inc. Engineered glycosyltransferases and steviol glycoside glucosylation methods
US11946059B2 (en) 2017-07-11 2024-04-02 Trait Biosciences, Inc. In vivo generation of water-soluble cannabinoids in plant cell suspension cultures
EP3679153A4 (en) * 2017-07-11 2021-01-06 Trait Biosciences, Inc. GENERATION OF WATER-SOLUBLE CANNABINOID COMPOUNDS IN YEAST AND PLANT CELL SUSPENSION CULTURES AND COMPOSITIONS
US11905543B2 (en) 2017-07-11 2024-02-20 Trait Biosceinces, Inc. In vivo generation of water-soluble acetylated cannabinoid glycoside compounds in plant cell suspension cultures
WO2019178116A1 (en) 2018-03-12 2019-09-19 Conagen Inc. Biosynthetic production of steviol glycosides rebaudioside j and rebaudioside n
JP7432533B2 (ja) * 2018-03-16 2024-02-16 ピュアサークル ユーエスエー インコーポレイテッド 高純度ステビオール配糖体
EP3801041A4 (en) * 2018-06-08 2022-05-25 PureCircle USA Inc. HIGH PURITY STEVIOL GLYCOSIDES
MX2021001260A (es) * 2018-07-30 2021-04-12 Tate & Lyle Solutions Usa Llc Glucosiltransferasas modificadas con ingenieria genetica y metodos de glucosilacion de glucosido de esteviol.
CN109234341A (zh) * 2018-09-29 2019-01-18 四川盈嘉合生科技有限公司 全细胞催化合成甜味剂组合物的方法
EP3877519A4 (en) 2018-11-09 2022-08-24 Ginkgo Bioworks, Inc. BIOSYNTHESIS OF MOGROSIDS
CN109750072B (zh) * 2019-01-31 2022-04-19 南京工业大学 一种酶法制备莱鲍迪苷e的方法
CN109750071A (zh) * 2019-01-31 2019-05-14 南京工业大学 一种生物催化合成莱鲍迪苷m的方法
CN110564658B (zh) * 2019-09-06 2021-08-17 广西大学 一株大肠杆菌工程菌及其全细胞催化生产甜菊醇的方法
CN110846363B (zh) * 2019-11-11 2023-02-17 天津大学 一锅法生产莱鲍迪苷d的方法
CN110734944B (zh) * 2019-11-11 2023-02-21 中化健康产业发展有限公司 一步法合成莱鲍迪苷m的方法
CN113186141B (zh) * 2021-04-08 2023-01-06 华南理工大学 一种一锅法高效合成莱鲍迪苷m的方法
CN114196696B (zh) * 2021-12-06 2023-10-20 天津大学 一种与特定短肽标签融合能高效催化Reb M生成的重组酶
CN114836447B (zh) * 2022-04-29 2024-05-07 中山大学 一种重组大肠杆菌催化合成莱鲍迪苷d的方法
CN118064459A (zh) * 2022-05-27 2024-05-24 中化健康产业发展有限公司 一种催化Reb A生产Reb M的重组糖基转移酶

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JPH04149191A (ja) 1990-10-09 1992-05-22 Nakano Vinegar Co Ltd ステビオサイド糖転移化合物及びその製造方法
AU2001289843A1 (en) 2001-08-28 2002-02-13 Bayer Cropscience Ag Polypeptides for identifying herbicidally active compounds
US20090183270A1 (en) 2002-10-02 2009-07-16 Adams Thomas R Transgenic plants with enhanced agronomic traits
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US9107436B2 (en) 2011-02-17 2015-08-18 Purecircle Sdn Bhd Glucosylated steviol glycoside as a flavor modifier
SG178376A1 (en) 2009-09-04 2012-03-29 Redpoint Bio Corp Sweetness enhancers including rebaudioside a or d
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SG10201606565XA (en) * 2011-08-08 2016-10-28 Evolva Sa Recombinant production of steviol glycosides
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FR2984743B1 (fr) 2011-12-23 2014-08-22 Oreal Utilisation cosmetique du steviol, d'un derive glycoside du steviol, ou un de leurs isomeres pour stimuler, restaurer ou reguler le metabolisme des cellules de la peau et des semi-muqueuses.
FR2984742A1 (fr) 2011-12-23 2013-06-28 Oreal Utilisation de steviol, d'un derive glycoside du steviol, ou d'un de leurs isomeres, pour prevenir, reduire et/ou traiter une alteration du teint de la peau.
CN104203005A (zh) 2012-01-23 2014-12-10 帝斯曼知识产权资产管理有限公司 二萜的生产
CN102559528B (zh) * 2012-02-09 2013-08-21 南京工业大学 一种产甜叶菊糖基转移酶ugt76g1的基因工程菌及其应用
EP4012041A1 (en) 2012-05-22 2022-06-15 PureCircle SDN BHD High-purity steviol glycosides
US9752174B2 (en) 2013-05-28 2017-09-05 Purecircle Sdn Bhd High-purity steviol glycosides
CN102766667B (zh) 2012-08-14 2014-06-11 成都南诺格生物科技有限责任公司 甜菊苷转化为莱鲍迪苷e的方法
EP3892728A1 (en) 2013-02-06 2021-10-13 Evolva SA Methods for improved production of rebaudioside d and rebaudioside m
KR101404728B1 (ko) * 2013-02-28 2014-06-09 씨제이제일제당 (주) 스테비오사이드로부터 리바우디오사이드 a를 제조하는 방법
EP2980211B1 (en) * 2013-03-26 2018-06-13 National University Corporation Nagoya University Method for immobilizing and releasing microorganism
CN103397064B (zh) 2013-08-14 2015-04-15 苏州汉酶生物技术有限公司 一种酶法制备瑞鲍迪甙m的方法
WO2015065650A2 (en) 2013-11-01 2015-05-07 Conagen Inc. Recombinant production of steviol glycosides
US9522929B2 (en) 2014-05-05 2016-12-20 Conagen Inc. Non-caloric sweetener
CN104232496B (zh) 2014-09-18 2017-06-06 广州康琳奈生物科技有限公司 一种重组毕赤酵母工程菌及其在合成莱鲍迪苷a中的应用
KR102536036B1 (ko) 2014-10-03 2023-05-23 코나겐 인크. 비칼로리 감미료 및 합성 방법

Also Published As

Publication number Publication date
US10752928B2 (en) 2020-08-25
AU2016250184A1 (en) 2017-09-14
KR20170135848A (ko) 2017-12-08
HK1249543A1 (zh) 2018-11-02
CN107548417B (zh) 2021-11-09
KR102569053B1 (ko) 2023-08-21
JP2018511335A (ja) 2018-04-26
CA2977541A1 (en) 2016-10-20
MX2017013210A (es) 2018-03-01
EP3283614B1 (en) 2020-07-08
US20180080055A1 (en) 2018-03-22
JP6793957B2 (ja) 2020-12-02
CN107548417A (zh) 2018-01-05
WO2016168413A1 (en) 2016-10-20
EP3283614A4 (en) 2018-08-29
AU2016250184B2 (en) 2020-07-30
MY190212A (en) 2022-04-05
EP3283614A1 (en) 2018-02-21
BR112017022019A2 (pt) 2018-07-31

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