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SG10201606565XA - Recombinant production of steviol glycosides - Google Patents

Recombinant production of steviol glycosides

Info

Publication number
SG10201606565XA
SG10201606565XA SG10201606565XA SG10201606565XA SG10201606565XA SG 10201606565X A SG10201606565X A SG 10201606565XA SG 10201606565X A SG10201606565X A SG 10201606565XA SG 10201606565X A SG10201606565X A SG 10201606565XA SG 10201606565X A SG10201606565X A SG 10201606565XA
Authority
SG
Singapore
Prior art keywords
recombinant production
steviol glycosides
steviol
glycosides
recombinant
Prior art date
Application number
SG10201606565XA
Inventor
Jens Houghton-Larsen
Paula M Hicks
Michael Naesby
Tange Thomas Ostergaard
Jorgen Hansen
Mikkelsen Michael Dalgaard
Hansen Esben Halkjaer
Ernesto Simon
Andrade Pereira Tavares Sabina De
Original Assignee
Evolva Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46724642&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG10201606565X(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Evolva Sa filed Critical Evolva Sa
Publication of SG10201606565XA publication Critical patent/SG10201606565XA/en

Links

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C—CHEMISTRY; METALLURGY
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0026—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5)
    • C12N9/0032—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5) with oxygen as acceptor (1.5.3)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
    • C—CHEMISTRY; METALLURGY
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Seasonings (AREA)
SG10201606565XA 2011-08-08 2012-08-08 Recombinant production of steviol glycosides SG10201606565XA (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201161521084P 2011-08-08 2011-08-08
US201161521051P 2011-08-08 2011-08-08
US201161521203P 2011-08-08 2011-08-08
US201161523487P 2011-08-15 2011-08-15
US201161567929P 2011-12-07 2011-12-07
US201261603639P 2012-02-27 2012-02-27

Publications (1)

Publication Number Publication Date
SG10201606565XA true SG10201606565XA (en) 2016-10-28

Family

ID=46724642

Family Applications (4)

Application Number Title Priority Date Filing Date
SG10201606563PA SG10201606563PA (en) 2011-08-08 2012-08-08 Recombinant production of steviol glycosides
SG10201606569VA SG10201606569VA (en) 2011-08-08 2012-08-08 Recombinant production of steviol glycosides
SG10201606567TA SG10201606567TA (en) 2011-08-08 2012-08-08 Recombinant production of steviol glycosides
SG10201606565XA SG10201606565XA (en) 2011-08-08 2012-08-08 Recombinant production of steviol glycosides

Family Applications Before (3)

Application Number Title Priority Date Filing Date
SG10201606563PA SG10201606563PA (en) 2011-08-08 2012-08-08 Recombinant production of steviol glycosides
SG10201606569VA SG10201606569VA (en) 2011-08-08 2012-08-08 Recombinant production of steviol glycosides
SG10201606567TA SG10201606567TA (en) 2011-08-08 2012-08-08 Recombinant production of steviol glycosides

Country Status (11)

Country Link
US (5) US9631215B2 (en)
EP (3) EP3009508B1 (en)
JP (5) JP6262653B2 (en)
KR (2) KR102114493B1 (en)
CN (2) CN108396044A (en)
AU (5) AU2012294452C1 (en)
BR (4) BR112014003037B1 (en)
CA (2) CA2843606C (en)
MY (1) MY173212A (en)
SG (4) SG10201606563PA (en)
WO (1) WO2013022989A2 (en)

Families Citing this family (145)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9392799B2 (en) 2011-02-17 2016-07-19 Purecircle Sdn Bhd Glucosyl stevia composition
US8257948B1 (en) 2011-02-17 2012-09-04 Purecircle Usa Method of preparing alpha-glucosyl Stevia composition
US9107436B2 (en) 2011-02-17 2015-08-18 Purecircle Sdn Bhd Glucosylated steviol glycoside as a flavor modifier
US9386797B2 (en) 2011-02-17 2016-07-12 Purecircle Sdn Bhd Glucosyl stevia composition
US8790730B2 (en) 2005-10-11 2014-07-29 Purecircle Usa Process for manufacturing a sweetener and use thereof
US8318459B2 (en) 2011-02-17 2012-11-27 Purecircle Usa Glucosyl stevia composition
PL2498625T3 (en) 2009-11-12 2019-07-31 Purecircle Usa Inc. Granulation of a stevia sweetener
US10696706B2 (en) 2010-03-12 2020-06-30 Purecircle Usa Inc. Methods of preparing steviol glycosides and uses of the same
EP2544538B1 (en) 2010-03-12 2022-06-15 PureCircle USA Inc. High-purity steviol glycosides
CN103179850B (en) 2010-06-02 2016-03-16 沃维公司 The recombinant production of steviol glycoside
US9510611B2 (en) 2010-12-13 2016-12-06 Purecircle Sdn Bhd Stevia composition to improve sweetness and flavor profile
MX346137B (en) 2010-12-13 2017-03-08 Purecircle Usa Inc Highly soluble rebaudioside d.
WO2012108894A1 (en) 2011-02-10 2012-08-16 Purecircle Usa Stevia composition
US9603373B2 (en) 2011-02-17 2017-03-28 Purecircle Sdn Bhd Glucosyl stevia composition
US9474296B2 (en) 2011-02-17 2016-10-25 Purecircle Sdn Bhd Glucosyl stevia composition
US11690391B2 (en) 2011-02-17 2023-07-04 Purecircle Sdn Bhd Glucosylated steviol glycoside as a flavor modifier
US9894922B2 (en) 2011-05-18 2018-02-20 Purecircle Sdn Bhd Glucosyl rebaudioside C
BR112013030701B1 (en) 2011-05-31 2021-07-20 Purecircle Usa Inc PROCESS FOR PRODUCING A STEVIA COMPOSITION COMPRISING REBAUDIOSIDE B WHICH MAY BE USED AS A SWEETENER BOOST, A FLAVOR BOOST AND/OR A SWEETENER
BR122018015762B1 (en) 2011-06-03 2021-03-16 Purecircle Usa Inc composition of soluble stevia and composition of food, drink, pharmaceutical or cosmetic comprising said composition
US20140199246A1 (en) 2011-06-20 2014-07-17 Purecircle Usa Inc. Stevia composition
US9771434B2 (en) 2011-06-23 2017-09-26 Purecircle Sdn Bhd Products from stevia rebaudiana
CA2843606C (en) 2011-08-08 2021-10-05 Evolva Sa Recombinant production of steviol glycosides
US10480019B2 (en) 2011-08-10 2019-11-19 Purecircle Sdn Bhd Process for producing high-purity rubusoside
EP2753189B1 (en) 2011-09-07 2020-12-16 Purecircle Usa Inc. Highly soluble stevia sweetener
FR2984743B1 (en) * 2011-12-23 2014-08-22 Oreal COSMETIC USE OF STEVIOL, STEVIOL GLYCOSIDE DERIVATIVE, OR ONE OF THEIR ISOMERS FOR STIMULATING, RESTORING OR REGULATING METABOLISM OF SKIN CELLS AND SEMI-MUCOUS MEMBRANES
EP2806754B1 (en) * 2012-01-23 2018-10-24 DSM IP Assets B.V. Diterpene production
EP2826861B1 (en) * 2012-03-16 2020-04-29 Suntory Holdings Limited Steviol glycosyltransferase and gene encoding same
CA2867572C (en) 2012-03-27 2023-02-21 Suntory Holdings Limited Method for producing steviol glycoside
US20130338348A1 (en) * 2012-03-30 2013-12-19 J.R. Simplot Company Steviol and steviol glycoside formation in plants
EP2852296B1 (en) 2012-05-22 2021-12-15 PureCircle SDN BHD Process for producing a high-purity steviol glycoside
US9752174B2 (en) * 2013-05-28 2017-09-05 Purecircle Sdn Bhd High-purity steviol glycosides
US20150342234A1 (en) * 2012-12-05 2015-12-03 Evolva Sa Steviol Glycoside Compositions Sensory Properties
EP3892728A1 (en) 2013-02-06 2021-10-13 Evolva SA Methods for improved production of rebaudioside d and rebaudioside m
EP2954061B1 (en) 2013-02-11 2023-11-22 Evolva SA Efficient production of steviol glycosides in recombinant hosts
KR101404728B1 (en) * 2013-02-28 2014-06-09 씨제이제일제당 (주) A method for preparation of Rebaudioside A from stevioside
BR112015023476A8 (en) * 2013-03-15 2019-12-03 Cargill Inc composition, process for preparing a composition and extract
MX381124B (en) * 2013-05-15 2025-03-12 Purecircle Usa Inc Stevia composition
CN105452476B (en) * 2013-05-31 2020-08-14 帝斯曼知识产权资产管理有限公司 Microorganism for diterpene production
BR112015029601A2 (en) * 2013-05-31 2017-09-26 Dsm Ip Assets Bv extracellular diterpene production
BR112015030650B1 (en) 2013-06-07 2021-02-23 Purecircle Usa Inc flavor and aroma modifying composition comprising steviol glycosides, their food or drink product and their method for increasing the flavor and aroma intensity or improving salt perception and reducing the sodium content of a food or drink product
US10952458B2 (en) 2013-06-07 2021-03-23 Purecircle Usa Inc Stevia extract containing selected steviol glycosides as flavor, salty and sweetness profile modifier
US10039834B2 (en) 2013-07-12 2018-08-07 The Coca-Cola Company Compositions and methods using rebaudioside X to provide sweetness enhancement
CN108064135A (en) * 2013-07-15 2018-05-22 帝斯曼知识产权资产管理有限公司 The production of diterpene
EP3024941B1 (en) * 2013-07-23 2019-07-03 DSM IP Assets B.V. Diterpene production in yarrowia
WO2015014969A1 (en) * 2013-07-31 2015-02-05 Dsm Ip Assets B.V. Steviol glycosides
CN103397064B (en) * 2013-08-14 2015-04-15 苏州汉酶生物技术有限公司 Method for preparing rebaudioside M through enzyme method
JP6530760B2 (en) * 2013-11-01 2019-06-12 コナゲン インコーポレーテッド Recombinant production of steviol glycosides
WO2015113231A1 (en) * 2014-01-28 2015-08-06 苏州汉酶生物技术有限公司 Rebaudioside m enzymatic preparation method
WO2015162305A1 (en) * 2014-04-25 2015-10-29 Dsm Ip Assets B.V. Stabilization of cytochrome p450 reductase
US9522929B2 (en) * 2014-05-05 2016-12-20 Conagen Inc. Non-caloric sweetener
CA2957331A1 (en) 2014-08-11 2016-02-18 Evolva Sa Production of steviol glycosides in recombinant hosts
EP3183349B1 (en) * 2014-08-19 2020-03-25 Purecircle SDN BHD Method for preparing rebaudioside i
CN107105686B (en) 2014-09-02 2021-12-24 谱赛科美国股份有限公司 Stevia extract rich in rebaudioside D, E, N and/or O and preparation method thereof
CN105850750B (en) * 2015-01-23 2018-06-12 谱赛科美国公司 STEVIA REBAUDIANA new varieties 814011 compose the preparation of star 3 and high RM contents steviol glycoside
CN107109358B (en) * 2014-09-09 2022-08-02 埃沃尔瓦公司 Production of steviol glycosides in recombinant hosts
CN104232496B (en) * 2014-09-18 2017-06-06 广州康琳奈生物科技有限公司 A kind of recombinant yeast pichia pastoris engineering bacteria and its application in rebaudioside A is synthesized
BR112017005656A2 (en) * 2014-09-19 2018-07-31 Purecircle Sdn Bhd high purity steviol glycosides
EP3201212B1 (en) 2014-10-03 2018-09-19 Conagen Inc. Non-caloric sweeteners and methods for synthesizing
CN107109453A (en) 2014-11-05 2017-08-29 马努斯生物合成股份有限公司 The microorganism of steviol glycoside produces
BR112017013051B1 (en) 2014-12-17 2022-10-04 Cargill, Incorporated COMPOUND, COMPOSITION, METHOD FOR SUPPLYING OR IMPROVING THE SWEETNESS TO A COMPOSITION AND METHOD FOR IMPROVING THE SOLUBILITY OF A STEVIOL GLYCOSIDE
CN108337892B (en) 2015-01-30 2022-06-24 埃沃尔瓦公司 Production of steviol glycosides in recombinant hosts
BR112017017207B1 (en) * 2015-02-10 2022-10-18 Purecircle Usa Inc. PROCESS FOR PRODUCING A TERPENOID GLYCOSIDE, FLAVOR COMPOSITION, FOOD INGREDIENT, FOOD, BEVERAGE OR OTHER CONSUMABLES, COSMETIC AND PHARMACEUTICAL PRODUCT COMPRISING SUCH TERPENOID GLYCOSIDE
EP3265577A1 (en) 2015-03-03 2018-01-10 The Regents of the University of California Protecting group chemistry for clean, reductant-free dyeing
CN107567492B (en) 2015-03-16 2022-10-14 帝斯曼知识产权资产管理有限公司 UDP-glycosyltransferase
BR112017020308A2 (en) * 2015-03-23 2018-07-10 Dsm Ip Assets Bv udp-glycosyltransferases
BR112017021066B1 (en) 2015-04-03 2022-02-08 Dsm Ip Assets B.V. STEVIOL GLYCOSIDES, METHOD FOR THE PRODUCTION OF A STEVIOL GLYCOSIDE, COMPOSITION, RELATED USES, FOOD, PET FOOD AND BEVERAGE
MX387022B (en) * 2015-04-14 2025-03-19 Conagen Inc Production of non-caloric sweeteners using engineered whole-cell catalysts
WO2016170045A1 (en) * 2015-04-21 2016-10-27 Dsm Ip Assets B.V. Geranylgeranyl pyrophosphate synthase
CA2987587C (en) 2015-05-29 2022-05-03 Cargill, Incorporated Heat treatment to produce glycosides
AU2016270656B2 (en) * 2015-05-29 2019-12-19 Cargill, Incorporated Fermentation methods for producing steviol glycosides with multi-phase feeding
AU2016271628B2 (en) 2015-05-29 2020-01-30 Cargill, Incorporated Fermentation methods for producing steviol glycosides using high pH and compositions obtained therefrom
CN105200098A (en) * 2015-06-30 2015-12-30 苏州汉酶生物技术有限公司 Method for preparing rebaudioside M according to saccharomyces cerevisiae enzymatic method
WO2017024313A1 (en) * 2015-08-06 2017-02-09 Cargill, Incorporated Fermentation methods for producing steviol glycosides
JP2018522569A (en) 2015-08-07 2018-08-16 エヴォルヴァ エスアー．Ｅｖｏｌｖａ Ｓａ． Production of steviol glycosides in recombinant hosts
WO2017025648A1 (en) 2015-08-13 2017-02-16 Dsm Ip Assets B.V. Steviol glycoside transport
US9765117B2 (en) 2015-08-24 2017-09-19 Romek Figa Peptides for treating cancer
EP3359654B1 (en) 2015-10-05 2022-01-05 DSM IP Assets B.V. Kaurenoic acid hydroxylases
CN115336734A (en) 2015-10-26 2022-11-15 谱赛科美国股份有限公司 Steviol glycoside compositions
CN108884484A (en) * 2015-11-30 2018-11-23 谱赛科有限责任公司 Method for preparing high-purity steviol glycosides
AU2016367317A1 (en) * 2015-12-10 2018-05-24 Evolva Sa Production of steviol glycosides in recombinant hosts
EP3389403A4 (en) 2015-12-15 2019-09-04 PureCircle USA Inc. Steviol glycoside compositions
RU2733441C2 (en) * 2016-03-01 2020-10-01 Вм. Ригли Джр. Компани Sweetener compositions with prolonged sweetening effect
CN109154010A (en) * 2016-03-11 2019-01-04 埃沃尔瓦公司 Steviol glycoside is produced in the recombination host
SG11201808856TA (en) 2016-04-13 2018-11-29 Evolva Sa Production of steviol glycosides in recombinant hosts
SG11201809483UA (en) * 2016-05-16 2018-11-29 Evolva Sa Production of steviol glycosides in recombinant hosts
CN109312378A (en) * 2016-05-16 2019-02-05 埃沃尔瓦公司 Production of steviol glycosides in recombinant hosts
MY198930A (en) * 2016-06-17 2023-10-03 Cargill Inc Steviol glycoside compositions for oral ingestion or use
ES2906310T3 (en) 2016-08-12 2022-04-18 Amyris Inc UDP-dependent glycosyltransferase for high-efficiency production of rebaudiosides
JP7177048B2 (en) 2016-10-14 2022-11-22 コナゲン インコーポレイテッド Biosynthetic production of steviol glycosides and process therefor
EP3530745A4 (en) 2016-10-21 2020-07-22 Pepsico, Inc. Method for preparing rebaudioside n using enzymatic method
MX2019004629A (en) * 2016-10-21 2019-06-06 Pepsico Inc Method for preparing rebaudioside c using enzymatic method.
CN116574775A (en) 2016-10-21 2023-08-11 百事可乐公司 Method for preparing rebaudioside J by enzyme method
BR112019008237A2 (en) * 2016-10-27 2019-07-16 Dsm Ip Assets Bv geranylgeranyl pyrophosphate synthases
WO2018083338A1 (en) 2016-11-07 2018-05-11 Evolva Sa Production of steviol glycosides in recombinant hosts
WO2018111194A1 (en) * 2016-12-16 2018-06-21 Temasek Life Sciences Laboratory Limited Targets for improving terpene production in rhodosporidium toruloides
WO2018124141A1 (en) * 2016-12-27 2018-07-05 サントリーホールディングス株式会社 Steviol glycoside hexose transferase and gene coding for same
CA3175100A1 (en) 2017-02-03 2018-08-09 Codexis, Inc. Engineered glycosyltransferases and steviol glycoside glucosylation methods
AU2017402700A1 (en) * 2017-03-06 2019-10-17 Conagen Inc. Biosynthetic production of steviol glycoside rebaudioside D4 from rebaudioside E
US11284577B2 (en) 2017-03-08 2022-03-29 Purecircle Usa Inc. High rebaudioside M stevia plant cultivars and methods of producing the same
WO2018190378A1 (en) * 2017-04-12 2018-10-18 サントリーホールディングス株式会社 Rhamnose synthase derived from stevia and gene
WO2018211032A1 (en) 2017-05-17 2018-11-22 Evolva Sa Production of steviol glycosides in recombinant hosts
BR112019027992B1 (en) 2017-06-30 2024-02-27 Conagen Inc METHOD FOR ALTERING THE GLYCOSYLATION OF A STEVIOL GLYCOSIDE
MX2020001537A (en) 2017-08-11 2020-07-13 Amyris Inc Pisum sativum kaurene oxidase for high efficiency production of rebaudiosides.
WO2019055325A2 (en) * 2017-09-12 2019-03-21 Biocapital Holdings, Llc Biological devices and methods for using the same to produce steviol glycosides
CN107446874B (en) * 2017-09-25 2020-07-28 四川盈嘉合生科技有限公司 Recombinant Escherichia coli and its use in the synthesis of rebaudioside D
BR112020009838A2 (en) 2017-12-05 2020-11-17 Evolva Sa production of steviol glycosides in recombinant hosts
EP3765627A4 (en) 2018-03-12 2021-10-13 Conagen Inc. BIOSYNTHETIC PRODUCTION OF STEVIOL GLYCOSIDES REBAUDIOSIDE J AND REBAUDIOSIDE N
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
WO2020018506A2 (en) * 2018-07-16 2020-01-23 Manus Bio, Inc. Production of steviol glycosides through whole cell biotransformation
CN109393426A (en) * 2018-09-29 2019-03-01 四川盈嘉合生科技有限公司 A kind of composite sweetener
CN113260699A (en) * 2018-10-15 2021-08-13 阿迈瑞斯公司 Stevia rebaudiana isoburenic acid hydroxylase variants for efficient rebaudioside production
EP3877519A4 (en) 2018-11-09 2022-08-24 Ginkgo Bioworks, Inc. Biosynthesis of mogrosides
US12365928B2 (en) 2018-12-04 2025-07-22 The Regents Of The University Of California Scalable biosynthesis of the seaweed neurochemical kainic acid
MX2021006986A (en) * 2018-12-12 2021-08-16 Conagen Inc Biosynthetic production of variant steviol glycosides.
KR102618015B1 (en) * 2018-12-21 2023-12-26 주식회사 삼양사 production of steviol and its precursors
US20220106619A1 (en) 2019-01-24 2022-04-07 Amyris, Inc. Abc transporters for the high efficiency production of rebaudiosides
CN109913380B (en) * 2019-03-25 2021-12-10 南京工业大学 Recombinant yarrowia lipolytica for producing (-) -alpha-bisabolol and construction method and application thereof
AU2020268897A1 (en) * 2019-05-03 2021-11-18 Amyris, Inc. Kaurenoic acid 13-hydroxylase (KAH) variants and uses thereof
US12065685B1 (en) 2019-05-13 2024-08-20 Amyris, Inc. UDP-glycosyltransferase variants and uses thereof
CN114174501A (en) 2019-06-25 2022-03-11 马努斯生物合成股份有限公司 uridine diphosphate-dependent glycosyltransferase enzyme
KR102379608B1 (en) * 2019-10-29 2022-03-29 주식회사 삼양사 Improved production of steviol glycoside and its precursors
CN111088176B (en) * 2019-12-30 2022-03-25 北京化工大学 Genetically engineered bacterium for producing beta-carotene and application thereof
CN112006035B (en) * 2020-07-24 2021-07-30 江西新龙生物科技股份有限公司 Microbial source bactericide for preventing and treating plant diseases and preparation method thereof
WO2023006179A1 (en) 2020-07-27 2023-02-02 Dsm Ip Assets B.V. Method to produce retinyl acetate
WO2022084482A1 (en) 2020-10-22 2022-04-28 Dsm Ip Assets B.V. Microorganisms for diterpene production
WO2022115527A1 (en) * 2020-11-24 2022-06-02 Manus Bio Inc. Glycoside product biosynthesis and recovery
JP7210626B2 (en) * 2021-02-18 2023-01-23 ペプシコ・インク Method for preparing rebaudioside J using enzymatic methods
US11299700B1 (en) 2021-02-19 2022-04-12 Acequia Biotechnology, Llc Bioreactor containers and methods of growing hairy roots using the same
EP4301866A1 (en) 2021-03-01 2024-01-10 Cargill, Incorporated Xylosylated steviol glycosides and enzymatic methods for production
CN115478060B (en) * 2021-06-16 2023-11-28 弈柯莱生物科技(集团)股份有限公司 A kind of glycosyltransferase and its application
WO2023006851A1 (en) 2021-07-27 2023-02-02 Dsm Ip Assets B.V. Fermentative production of retinyl acetate in the presence of ethanol
KR102564619B1 (en) 2021-08-10 2023-08-07 이재준 Square box
WO2023044368A1 (en) * 2021-09-17 2023-03-23 Doublerainbow Biosciences Inc. Method for producing glycosylated therapeutics by using an immobilized enzyme preparation
CN113930377B (en) * 2021-10-14 2023-12-26 广西大学 Engineering bacterium for improving rebaudioside A content by whole-cell catalysis
CN114196696B (en) * 2021-12-06 2023-10-20 天津大学 Recombinant enzyme fused with specific short peptide tag and capable of efficiently catalyzing generation of Reb M
US20250066831A1 (en) * 2021-12-21 2025-02-27 Syracuse University Temperature-responsive nano-biomaterials from genetically encoded farnesylated proteins
CN114561310B (en) * 2022-03-17 2022-12-02 江南大学 Saccharomyces cerevisiae for producing rubusoside and application thereof
WO2024010442A1 (en) * 2022-07-07 2024-01-11 Purecircle Sdn Bhd High-purity steviol glycosides
WO2024011263A2 (en) * 2022-07-08 2024-01-11 Cibus Us Llc Producing sesquiterpenes and other terpenes using plant-based biomasses
WO2024042486A1 (en) 2022-08-26 2024-02-29 Amyris Bio Products Portugal, Unipessoal, Ltda. Compositions and methods for the production of polyurethanes
WO2024042405A1 (en) 2022-08-26 2024-02-29 Amyris Bio Products Portugal, Unipessoal, Ltda. Compositions and methods for the synthesis of bio-based polymers
WO2024118831A1 (en) * 2022-11-30 2024-06-06 Velozbio Company Compositions and methods for protein production
WO2024116153A1 (en) 2022-12-02 2024-06-06 Amyris Bio Products Portugal, Unipessoal, Ltda. Compositions and methods for using previously cultured cells
CN118755690B (en) * 2024-09-06 2024-11-19 四川盈嘉合生科技有限公司 A sucrose synthase and its application in biosynthesis of steviol glycosides
CN119265154B (en) * 2024-12-10 2025-05-13 诸城市浩天药业有限公司 Glycosyltransferase UGT76G4 mutant and application thereof

Family Cites Families (134)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58149697A (en) * 1982-02-27 1983-09-06 Dainippon Ink & Chem Inc Method for producing β-1,3 glycosyl stevioside
JPS59101408A (en) 1982-12-02 1984-06-12 Junichi Iwamura Plant growth regulator
US6946587B1 (en) 1990-01-22 2005-09-20 Dekalb Genetics Corporation Method for preparing fertile transgenic corn plants
US5484956A (en) 1990-01-22 1996-01-16 Dekalb Genetics Corporation Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin
JPH03277275A (en) 1990-03-28 1991-12-09 Dainippon Ink & Chem Inc Novel enzyme and method for producing glycoside using the enzyme
US5204253A (en) 1990-05-29 1993-04-20 E. I. Du Pont De Nemours And Company Method and apparatus for introducing biological substances into living cells
US5306862A (en) 1990-10-12 1994-04-26 Amoco Corporation Method and composition for increasing sterol accumulation in higher plants
US5460949A (en) 1990-11-15 1995-10-24 Amoco Corporation Method and composition for increasing the accumulation of squalene and specific sterols in yeast
US5712112A (en) 1992-11-04 1998-01-27 National Science Council Of R.O.C. Gene expression system comprising the promoter region of the alpha-amylase genes
FI960173L (en) 1993-07-15 1996-03-15 Neose Pharm Inc Method for synthesizing saccharide compositions
US7186891B1 (en) 1996-04-12 2007-03-06 University Of Kentucky, Research Foundation Plant cells and plants expressing chimeric isoprenoid synthases
JPH10117776A (en) 1996-10-22 1998-05-12 Japan Tobacco Inc Transformation of indica rice
CA2309791A1 (en) * 1997-10-06 1999-04-15 The Centre National De Recherche Scientifique Plant fatty acid hydroxylase genes
US6255557B1 (en) 1998-03-31 2001-07-03 Her Majesty The Queen In Right Of Canada As Represented By The Ministerof Agriculture And Agri-Food Canada Stevia rebaudiana with altered steviol glycoside composition
US6806076B1 (en) 1998-04-14 2004-10-19 Kyowa Hakko Kogyo Co., Ltd. Process for producing isoprenoid compounds by microorganisms and a method for screening compounds with antibiotic or weeding activity
EP0955363A3 (en) 1998-05-06 2004-01-28 F. Hoffmann-La Roche Ag Dna sequences encoding enzymes involved in production of isoprenoids
TWI250210B (en) 1998-05-06 2006-03-01 Dsm Ip Assets Bv An isolated DNA sequence coding for an enzyme involved in the mevalonate pathway or the pathway from isopentenyl pyrophosphate to farnesyl pyrophosphate
MX219130B (en) 1998-07-06 2004-02-10 Dcv Inc Haciendo Negocios Como Method of vitamin production.
EP2305825B1 (en) 1998-07-06 2015-01-14 DCV Inc. doing business as Bio-Technical Resourses Method of vitamin production
JP3277275B2 (en) 1998-07-28 2002-04-22 有限会社シャトウバッグ Patterned surface material used for bags and the like and method for producing the same
AR021636A1 (en) 1998-12-17 2002-07-31 Rubicon Forests Holdings Ltd MATERIALS AND METHODS FOR THE MODIFICATION OF CONTENT, COMPOSITION AND METABOLISM OF ISOPRENOIDS
AU2594300A (en) 1998-12-23 2000-07-12 Samuel Roberts Noble Foundation, Inc., The Plant transformation process
BRPI0009763B8 (en) 1999-04-15 2020-03-10 Calgene Llc nucleic acid sequence encoding a prenyltransferase, construction comprising it, as well as methods for changing the tocopherol content, producing a tocopherol compound, and increasing the biosynthetic flow in a cell
EP1171618A2 (en) 1999-04-21 2002-01-16 The Samuel Roberts Noble Foundation Plant transformation process
EP1198575B1 (en) 1999-08-04 2007-09-19 Adelbert Bacher Isoprenoid biosynthesis
WO2001012828A1 (en) 1999-08-18 2001-02-22 Paradigm Genetics, Inc. Methods and apparatus for transformation of monocotyledenous plants using agrobacterium in combination with vacuum filtration
WO2001083769A2 (en) 2000-05-03 2001-11-08 The Salk Institute For Biological Studies Crystallization of 4-diphosphocytidyl-2-c-methylerythritol synthesis
DE10027821A1 (en) 2000-06-05 2001-12-06 Adelbert Bacher New intermediate in isoprenoid biosynthesis, useful in screening for potential herbicides, comprises mutant encoding-enzymes sequences for imparting herbicide resistance
EP2281890A1 (en) 2000-07-31 2011-02-09 Danisco US Inc. Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms
WO2002016655A2 (en) 2000-08-24 2002-02-28 The Scripps Research Institute Stress-regulated genes of plants, transgenic plants containing same, and methods of use
US6660507B2 (en) 2000-09-01 2003-12-09 E. I. Du Pont De Nemours And Company Genes involved in isoprenoid compound production
US6818424B2 (en) 2000-09-01 2004-11-16 E. I. Du Pont De Nemours And Company Production of cyclic terpenoids
US6689601B2 (en) 2000-09-01 2004-02-10 E. I. Du Pont De Nemours And Company High growth methanotropic bacterial strain
US7229784B2 (en) 2000-09-19 2007-06-12 Microbia, Inc. Modulation of secondary metabolite production by zinc binuclear cluster proteins
ATE384119T1 (en) 2000-09-29 2008-02-15 Cargill Inc ISOPRENOID PRODUCTION
US6949362B2 (en) 2000-12-12 2005-09-27 E. I. Du Pont De Nemours And Company Rhodococcus cloning and expression vectors
US7838287B2 (en) 2001-01-25 2010-11-23 Evolva Sa Library of a collection of cells
US20050003474A1 (en) 2001-01-26 2005-01-06 Desouza Mervyn L. Carotenoid biosynthesis
US20040078846A1 (en) 2002-01-25 2004-04-22 Desouza Mervyn L. Carotenoid biosynthesis
DE10201458A1 (en) 2001-04-11 2002-10-17 Adelbert Bacher New proteins involved in isoprenoid biosynthesis, useful in screening for inhibitors, also new intermediates, potential therapeutic agents, nucleic acids and antibodies
US7034140B2 (en) 2001-04-24 2006-04-25 E.I. Du Pont De Nemours And Company Genes involved in isoprenoid compound production
KR100704072B1 (en) 2001-06-06 2007-04-05 디에스엠 아이피 어셋츠 비.브이. Improved Isoprenoid Manufacturing Method
WO2003008540A2 (en) * 2001-06-22 2003-01-30 Syngenta Participations Ag Abiotic stress responsive polynucleotides and polypeptides
US20040072311A1 (en) 2001-08-28 2004-04-15 Dicosimo Deana J. Production of cyclic terpenoids
US20040010815A1 (en) 2001-09-26 2004-01-15 Lange B. Markus Identification and characterization of plant genes
US7172886B2 (en) 2001-12-06 2007-02-06 The Regents Of The University Of California Biosynthesis of isopentenyl pyrophosphate
JP2005185101A (en) * 2002-05-30 2005-07-14 National Institute Of Agrobiological Sciences Plant full-length cDNA and use thereof
ATE444367T1 (en) 2002-08-20 2009-10-15 Suntory Holdings Ltd NEW GLYCOSYLTRANSFERASE GENES
JP2006500054A (en) * 2002-09-27 2006-01-05 ディーエスエム アイピー アセッツ ビー．ブイ． SQS gene
US7098000B2 (en) 2003-06-04 2006-08-29 E. I. Du Pont De Nemoure And Company Method for production of C30-aldehyde carotenoids
ATE426662T1 (en) 2003-06-12 2009-04-15 Dsm Ip Assets Bv FEEDBACK RESISTANT MEVALONATE KINASE
US7569389B2 (en) 2004-09-30 2009-08-04 Ceres, Inc. Nucleotide sequences and polypeptides encoded thereby useful for modifying plant characteristics
US20060150283A1 (en) 2004-02-13 2006-07-06 Nickolai Alexandrov Sequence-determined DNA fragments and corresponding polypeptides encoded thereby
ATE537269T1 (en) 2004-05-21 2011-12-15 Univ California METHOD FOR IMPROVING THE PRODUCTION OF ISOPRENOID COMPOSITIONS
US20060014264A1 (en) 2004-07-13 2006-01-19 Stowers Institute For Medical Research Cre/lox system with lox sites having an extended spacer region
JPWO2006016395A1 (en) 2004-08-09 2008-05-01 国立大学法人東北大学 UDP-glucuronyltransferase and gene thereof
KR101169824B1 (en) 2004-08-19 2012-07-30 디에스엠 아이피 어셋츠 비.브이. Production of isoprenoids
US7923552B2 (en) 2004-10-18 2011-04-12 SGF Holdings, LLC High yield method of producing pure rebaudioside A
JP4841562B2 (en) 2004-12-14 2011-12-21 ディーエスエム アイピー アセッツ ビー．ブイ． Improved mevalonate kinase
WO2006093289A1 (en) 2005-03-04 2006-09-08 National Institute Of Advanced Industrial Science And Technology Process for prpduction of udp-xylose
WO2006096392A2 (en) 2005-03-04 2006-09-14 Diversa Corporation Enzymes involved in astaxanthin, carotenoid and isoprenoid biosynthetic pathways, genes encoding them and methods of making and using them
US7989677B2 (en) 2005-08-17 2011-08-02 Nestec S. A. Nucleic acids and proteins associated with sucrose accumulation in coffee
US8293307B2 (en) 2005-10-11 2012-10-23 Purecircle Sdn Bhd Process for manufacturing a sweetener and use thereof
KR101374346B1 (en) 2005-11-23 2014-03-14 더 코카콜라 컴파니 Natural high-potency sweetener compositions with improved temporal profile and/or flavor profile, methods for their formulation, and uses
US7927851B2 (en) † 2006-03-21 2011-04-19 Vineland Research And Innovation Centre Compositions having ent-kaurenoic acid 13-hydroxylase activity and methods for producing same
CA2644273A1 (en) 2006-04-05 2008-03-27 Metanomics Gmbh Process for the production of a fine chemical
US8114645B2 (en) 2006-05-19 2012-02-14 The Regents Of The University Of California Methods for increasing isoprenoid and isoprenoid precursor production by modulating fatty acid levels
KR101440639B1 (en) 2006-06-19 2014-09-22 지보당 에스아 Nucleic acids, polypeptides and uses thereof
WO2008008256A2 (en) 2006-07-07 2008-01-17 The Regents Of The University Of California Methods for enhancing production of isoprenoid compounds by host cells
US8257957B2 (en) 2006-09-26 2012-09-04 The Regents Of The University Of California Production of isoprenoids and isoprenoid precursors
US7741119B2 (en) 2006-09-28 2010-06-22 E. I. Du Pont De Nemours And Company Xylitol synthesis mutant of xylose-utilizing zymomonas for ethanol production
US7629156B2 (en) 2006-09-28 2009-12-08 E.I. Du Pont De Nemours And Company Ethanol production in fermentation of mixed sugars containing xylose
CN101200480B (en) 2006-12-15 2011-03-30 成都华高药业有限公司 Rebaudioside A extraction method
JP4915917B2 (en) * 2006-12-22 2012-04-11 独立行政法人農業・食品産業技術総合研究機構 Method for producing lacto-N-biose I and galacto-N-biose
AU2008209573B2 (en) 2007-01-22 2013-08-22 Cargill, Incorporated Method of producing purified rebaudioside A compositions using solvent/antisolvent crystallization
JP2008237110A (en) 2007-03-27 2008-10-09 Institute Of Physical & Chemical Research Steviol synthase gene and method for producing steviol
BRPI0811747A2 (en) 2007-05-17 2014-10-14 Tetravitae Bioscience Inc METHODS AND COMPOSITIONS FOR SOLVENT PRODUCTION
US20080292775A1 (en) 2007-05-22 2008-11-27 The Coca-Cola Company Delivery Systems for Natural High-Potency Sweetener Compositions, Methods for Their Formulation, and Uses
WO2009005704A1 (en) 2007-07-03 2009-01-08 The Regents Of The University Of California Methods of increasing isoprenoid or isoprenoid precursor production
JP2009034080A (en) 2007-08-03 2009-02-19 Sanei Gen Ffi Inc Production of novel glycosyltransferases and glycosides using the same
US7964232B2 (en) 2007-09-17 2011-06-21 Pepsico, Inc. Steviol glycoside isomers
WO2009071277A1 (en) 2007-12-03 2009-06-11 Dsm Ip Assets B.V. Novel nutraceutical compositions containing stevia extract or stevia extract constituents and uses thereof
WO2009086049A2 (en) 2007-12-27 2009-07-09 Mc Neil Nutritionals, Llc Synergistic sweetening compositions
CN102007214A (en) 2008-02-20 2011-04-06 塞瑞斯公司 Nucleotide sequences and corresponding polypeptides conferring improved nitrogen use efficiency characteristics in plants
TWI475963B (en) 2008-02-25 2015-03-11 Coca Cola Co Rebaudioside a derivative products and methods for making
WO2009140394A1 (en) 2008-05-13 2009-11-19 Cargill, Incorporated Separation of rebaudioside a from stevia glycosides using chromatography
CN101314776B (en) * 2008-07-11 2010-11-03 南京农业大学 Diphosphoric uridine glucosyl transferase gene and encoded protein thereof
WO2010021001A2 (en) 2008-08-19 2010-02-25 Kaushik Ramakrishnan S Process for preparing sweetener from stevia rebaudiana
PL2350110T3 (en) 2008-10-03 2016-12-30 New steviol glycosides
CN101720910B (en) 2008-10-23 2012-07-25 大闽食品（漳州）有限公司 Method for preparing stevioside
US8614085B2 (en) 2009-02-27 2013-12-24 Butamax(Tm) Advanced Biofuels Llc Yeast with increased butanol tolerance involving a multidrug efflux pump gene
US20100297722A1 (en) * 2009-05-20 2010-11-25 Board Of Trustees Of Southern Illinois University Transgenic moss producing terpenoids
AU2009347610B2 (en) 2009-06-08 2013-02-21 Chr. Hansen HMO GmbH HMO synthesis
EP2482676B1 (en) 2009-06-16 2014-10-22 EPC (Beijing) Natural Products Co., Ltd. Reducing or eliminating aftertaste in a sweetener using rebaudioside d
BR112012004854A2 (en) * 2009-09-04 2015-09-01 Redpoint Bio Corp A method for enhancing a sweet taste of a carbohydrate sweetener, for decreasing the amount of a carbohydrate sweetener in a consumable product, and for enhancing the sweetening of a consumable product.
AU2010298437B2 (en) 2009-09-22 2014-06-19 Redpoint Bio Corporation Novel polymorphs of rebaudioside C and methods for making and using the same
US8299224B2 (en) † 2009-10-15 2012-10-30 Purecircle Sdn Bhd High-purity Rebaudioside D
EP2358730B1 (en) * 2009-10-15 2014-01-15 Purecircle SDN BHD Method for preparing high-purity rebaudioside d
US8703224B2 (en) 2009-11-04 2014-04-22 Pepsico, Inc. Method to improve water solubility of Rebaudioside D
US8993840B2 (en) 2009-11-23 2015-03-31 E I du Pont de Nemours and Compay Sucrose transporter genes for increasing plant seed lipids
DK2816112T3 (en) 2009-12-10 2018-11-19 Univ Minnesota TAL effector-mediated DNA modification
JP2013515492A (en) 2009-12-28 2013-05-09 ザ コカ・コーラ カンパニー Sweetness enhancer, composition containing sweetness enhancer, and methods of use thereof
US9441233B2 (en) 2010-05-06 2016-09-13 Ceres, Inc. Transgenic plants having increased biomass
EP2571991A1 (en) 2010-05-20 2013-03-27 Evolva SA Method of producing isoprenoid compounds in yeast
WO2011153144A1 (en) 2010-05-31 2011-12-08 Gevo, Inc. Isobutanol production using yeasts with modified transporter expression
CN103179850B (en) 2010-06-02 2016-03-16 沃维公司 The recombinant production of steviol glycoside
US20120021111A1 (en) 2010-07-23 2012-01-26 Aexelon Therapeutics, Inc. Natural Low Caloric Sweetener Compositions for Use in Beverages, Foods and Pharmaceuticals, and Their Methods of Manufacture
US20120083593A1 (en) 2010-10-01 2012-04-05 Shanghai Yongyou Bioscience Inc. Separation and Purification of Stevioside and Rebaudioside A
CA2819253A1 (en) * 2010-11-30 2012-06-07 Massachusetts Institute Of Technology Microbial production of natural sweeteners, diterpenoid steviol glycosides
KR20130014227A (en) 2011-07-29 2013-02-07 한국생명공학연구원 NOVEL α-GLUCOSYL STEVIOSIDES AND PROCESS FOR PRODUCING THE SAME
CA2843606C (en) * 2011-08-08 2021-10-05 Evolva Sa Recombinant production of steviol glycosides
AU2012342114B2 (en) 2011-11-23 2017-12-21 Evolva Sa Methods and materials for enzymatic synthesis of mogroside compounds
CN103159808B (en) 2011-12-09 2017-03-29 上海泓博智源医药股份有限公司 A kind of process for preparing natural sweetener
SMT201800078T1 (en) 2011-12-19 2018-05-02 Coca Cola Co Beverage comprising steviol glycosides
EP2806754B1 (en) 2012-01-23 2018-10-24 DSM IP Assets B.V. Diterpene production
CN102559528B (en) * 2012-02-09 2013-08-21 南京工业大学 Genetic engineering bacterium for producing stevia glycosyltransferase UGT76G1 and application thereof
EP2826861B1 (en) 2012-03-16 2020-04-29 Suntory Holdings Limited Steviol glycosyltransferase and gene encoding same
EP2852296B1 (en) 2012-05-22 2021-12-15 PureCircle SDN BHD Process for producing a high-purity steviol glycoside
EP2902410B1 (en) 2012-09-29 2022-01-05 Sichuan Ingia Biosynthetic Co., Ltd. Method for producing stevioside compounds by microorganism
US20150342234A1 (en) 2012-12-05 2015-12-03 Evolva Sa Steviol Glycoside Compositions Sensory Properties
EP3892728A1 (en) 2013-02-06 2021-10-13 Evolva SA Methods for improved production of rebaudioside d and rebaudioside m
EP2954061B1 (en) 2013-02-11 2023-11-22 Evolva SA Efficient production of steviol glycosides in recombinant hosts
KR101559478B1 (en) 2013-06-24 2015-10-13 한국생명공학연구원 Method for Preparing Natural High Intensity Sweetener Rebaudiside A by Using Enzymatic Conversion
EP3024941B1 (en) 2013-07-23 2019-07-03 DSM IP Assets B.V. Diterpene production in yarrowia
WO2015014969A1 (en) 2013-07-31 2015-02-05 Dsm Ip Assets B.V. Steviol glycosides
CA2917699C (en) 2013-07-31 2021-12-07 Dsm Ip Assets B.V. Recovery of steviol glycosides
WO2015016393A1 (en) 2013-08-02 2015-02-05 サントリーホールディングス株式会社 Method for using hexenol glycosyl transferase
CN103397064B (en) 2013-08-14 2015-04-15 苏州汉酶生物技术有限公司 Method for preparing rebaudioside M through enzyme method
WO2015028324A2 (en) 2013-08-30 2015-03-05 Evolva Sa A method for producing modified resveratrol
US20170067063A1 (en) 2014-03-07 2017-03-09 Evolva Sa Methods for Recombinant Production of Saffron Compounds
CA2957331A1 (en) 2014-08-11 2016-02-18 Evolva Sa Production of steviol glycosides in recombinant hosts
CN107109358B (en) 2014-09-09 2022-08-02 埃沃尔瓦公司 Production of steviol glycosides in recombinant hosts
CN108337892B (en) 2015-01-30 2022-06-24 埃沃尔瓦公司 Production of steviol glycosides in recombinant hosts
JP2018522569A (en) 2015-08-07 2018-08-16 エヴォルヴァ エスアー．Ｅｖｏｌｖａ Ｓａ． Production of steviol glycosides in recombinant hosts

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