[go: up one dir, main page]

SG10201606567TA - Recombinant production of steviol glycosides - Google Patents

Recombinant production of steviol glycosides

Info

Publication number
SG10201606567TA
SG10201606567TA SG10201606567TA SG10201606567TA SG10201606567TA SG 10201606567T A SG10201606567T A SG 10201606567TA SG 10201606567T A SG10201606567T A SG 10201606567TA SG 10201606567T A SG10201606567T A SG 10201606567TA SG 10201606567T A SG10201606567T A SG 10201606567TA
Authority
SG
Singapore
Prior art keywords
recombinant production
steviol glycosides
steviol
glycosides
recombinant
Prior art date
Application number
SG10201606567TA
Inventor
Jens Houghton-Larsen
Paula M Hicks
Michael Naesby
Tange Thomas Ostergaard
Jorgen Hansen
Mikkelsen Michael Dalgaard
Hansen Esben Halkjaer
Ernesto Simon
Andrade Pereira Tavares Sabina De
Original Assignee
Evolva Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46724642&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG10201606567T(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Evolva Sa filed Critical Evolva Sa
Publication of SG10201606567TA publication Critical patent/SG10201606567TA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/44Preparation of O-glycosides, e.g. glucosides
    • C12P19/56Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0012Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0026Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5)
    • C12N9/0032Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5) with oxygen as acceptor (1.5.3)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0071Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0071Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0073Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1048Glycosyltransferases (2.4)
    • C12N9/1051Hexosyltransferases (2.4.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1085Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88Lyases (4.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90Isomerases (5.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/44Preparation of O-glycosides, e.g. glucosides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/52Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Nutrition Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Seasonings (AREA)
SG10201606567TA 2011-08-08 2012-08-08 Recombinant production of steviol glycosides SG10201606567TA (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201161521084P 2011-08-08 2011-08-08
US201161521203P 2011-08-08 2011-08-08
US201161521051P 2011-08-08 2011-08-08
US201161523487P 2011-08-15 2011-08-15
US201161567929P 2011-12-07 2011-12-07
US201261603639P 2012-02-27 2012-02-27

Publications (1)

Publication Number Publication Date
SG10201606567TA true SG10201606567TA (en) 2016-10-28

Family

ID=46724642

Family Applications (4)

Application Number Title Priority Date Filing Date
SG10201606569VA SG10201606569VA (en) 2011-08-08 2012-08-08 Recombinant production of steviol glycosides
SG10201606565XA SG10201606565XA (en) 2011-08-08 2012-08-08 Recombinant production of steviol glycosides
SG10201606567TA SG10201606567TA (en) 2011-08-08 2012-08-08 Recombinant production of steviol glycosides
SG10201606563PA SG10201606563PA (en) 2011-08-08 2012-08-08 Recombinant production of steviol glycosides

Family Applications Before (2)

Application Number Title Priority Date Filing Date
SG10201606569VA SG10201606569VA (en) 2011-08-08 2012-08-08 Recombinant production of steviol glycosides
SG10201606565XA SG10201606565XA (en) 2011-08-08 2012-08-08 Recombinant production of steviol glycosides

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10201606563PA SG10201606563PA (en) 2011-08-08 2012-08-08 Recombinant production of steviol glycosides

Country Status (11)

Country Link
US (5) US9631215B2 (en)
EP (3) EP3009508B1 (en)
JP (5) JP6262653B2 (en)
KR (2) KR102114493B1 (en)
CN (2) CN108396044A (en)
AU (5) AU2012294452C1 (en)
BR (4) BR122021015508B1 (en)
CA (2) CA2843606C (en)
MY (1) MY173212A (en)
SG (4) SG10201606569VA (en)
WO (1) WO2013022989A2 (en)

Families Citing this family (150)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9107436B2 (en) 2011-02-17 2015-08-18 Purecircle Sdn Bhd Glucosylated steviol glycoside as a flavor modifier
US9392799B2 (en) 2011-02-17 2016-07-19 Purecircle Sdn Bhd Glucosyl stevia composition
US8318459B2 (en) 2011-02-17 2012-11-27 Purecircle Usa Glucosyl stevia composition
US9386797B2 (en) 2011-02-17 2016-07-12 Purecircle Sdn Bhd Glucosyl stevia composition
US8257948B1 (en) 2011-02-17 2012-09-04 Purecircle Usa Method of preparing alpha-glucosyl Stevia composition
US8790730B2 (en) 2005-10-11 2014-07-29 Purecircle Usa Process for manufacturing a sweetener and use thereof
US10888099B2 (en) 2009-11-12 2021-01-12 Purecircle Sdn Bhd. Granulation of a Stevia sweetener
EP3461342A1 (en) 2009-11-12 2019-04-03 PureCircle USA Inc. Granulation of a stevia sweetener
EP2544538B1 (en) 2010-03-12 2022-06-15 PureCircle USA Inc. High-purity steviol glycosides
WO2013096420A1 (en) 2011-12-19 2013-06-27 The Coca-Cola Company Methods for purifying steviol glycosides and uses of the same
US10696706B2 (en) 2010-03-12 2020-06-30 Purecircle Usa Inc. Methods of preparing steviol glycosides and uses of the same
US20150344512A1 (en) 2011-12-19 2015-12-03 Purecircle Usa Inc. Methods of purifying steviol glycosides and uses of the same
MX349121B (en) 2010-06-02 2017-07-12 Evolva Inc Recombinant Production of Steviol Glycosides.
MX389987B (en) 2010-12-13 2025-03-20 Purecircle Usa Inc HIGHLY SOLUBLE REBAUDIOSIDE D.
US9510611B2 (en) 2010-12-13 2016-12-06 Purecircle Sdn Bhd Stevia composition to improve sweetness and flavor profile
MX391906B (en) 2011-02-10 2025-03-19 Purecircle Usa COMPOSITION OF STEVIA.
US11690391B2 (en) 2011-02-17 2023-07-04 Purecircle Sdn Bhd Glucosylated steviol glycoside as a flavor modifier
US9603373B2 (en) 2011-02-17 2017-03-28 Purecircle Sdn Bhd Glucosyl stevia composition
US9474296B2 (en) 2011-02-17 2016-10-25 Purecircle Sdn Bhd Glucosyl stevia composition
US9894922B2 (en) 2011-05-18 2018-02-20 Purecircle Sdn Bhd Glucosyl rebaudioside C
WO2012166163A1 (en) 2011-05-31 2012-12-06 Purecircle Usa Stevia composition
MX341095B (en) 2011-06-03 2016-08-08 Purecircle Usa Stevia composition.
WO2014185931A1 (en) * 2013-05-15 2014-11-20 Purecircle Usa, Inc. Stevia composition
EP3915394A1 (en) 2011-06-20 2021-12-01 PureCircle USA Inc. Stevia composition
US9771434B2 (en) 2011-06-23 2017-09-26 Purecircle Sdn Bhd Products from stevia rebaudiana
JP6262653B2 (en) * 2011-08-08 2018-01-17 エヴォルヴァ エスアー.Evolva Sa. Recombinant production of steviol glycosides
US10480019B2 (en) 2011-08-10 2019-11-19 Purecircle Sdn Bhd Process for producing high-purity rubusoside
US20140171520A1 (en) 2011-09-07 2014-06-19 Avetik Markosyan Highly soluble stevia sweetener
FR2984743B1 (en) * 2011-12-23 2014-08-22 Oreal COSMETIC USE OF STEVIOL, STEVIOL GLYCOSIDE DERIVATIVE, OR ONE OF THEIR ISOMERS FOR STIMULATING, RESTORING OR REGULATING METABOLISM OF SKIN CELLS AND SEMI-MUCOUS MEMBRANES
HK1204529A1 (en) * 2012-01-23 2015-11-27 帝斯曼知识产权资产管理有限公司 Diterpene production
US10000783B2 (en) 2012-03-16 2018-06-19 Suntory Holdings Limited Steviol glucosyltransferases and genes encoding the same
WO2013146555A1 (en) * 2012-03-27 2013-10-03 サントリーホールディングス株式会社 Method for producing steviol glycoside
WO2013148257A1 (en) * 2012-03-30 2013-10-03 J.R. Simplot Company Steviol and steviol glycoside formation in plants
CN103974628B (en) * 2012-05-22 2019-04-05 谱赛科有限责任公司 High purity steviol glycosides
US9752174B2 (en) * 2013-05-28 2017-09-05 Purecircle Sdn Bhd High-purity steviol glycosides
US20150342234A1 (en) * 2012-12-05 2015-12-03 Evolva Sa Steviol Glycoside Compositions Sensory Properties
KR20150115002A (en) * 2013-02-06 2015-10-13 에볼바 에스아 Methods for improved production of rebaudioside d and rebaudioside m
MX2015010098A (en) 2013-02-11 2016-04-19 Evolva Sa Efficient production of steviol glycosides in recombinant hosts.
KR101404728B1 (en) * 2013-02-28 2014-06-09 씨제이제일제당 (주) A method for preparation of Rebaudioside A from stevioside
HK1220080A1 (en) * 2013-03-15 2017-04-28 Cargill, Incorporated Stevia plants with an increased rebaudioside d content
AU2014273055A1 (en) 2013-05-31 2015-12-17 Dsm Ip Assets B.V. Microorganisms for diterpene production
AU2014273054A1 (en) * 2013-05-31 2015-12-03 Dsm Ip Assets B.V. Extracellular diterpene production
DK3714699T3 (en) 2013-06-07 2025-01-20 Purecircle Usa Inc STEVIA EXTRACT CONTAINING SELECTED STEVIOLGLYCOSIDES AS A FLAVOR, SALT AND SWEETNESS PROFILE MODIFIER
US10952458B2 (en) 2013-06-07 2021-03-23 Purecircle Usa Inc Stevia extract containing selected steviol glycosides as flavor, salty and sweetness profile modifier
US10039834B2 (en) 2013-07-12 2018-08-07 The Coca-Cola Company Compositions and methods using rebaudioside X to provide sweetness enhancement
MX2016000452A (en) * 2013-07-15 2016-05-12 Dsm Ip Assets Bv Diterpene production.
EP3024941B1 (en) * 2013-07-23 2019-07-03 DSM IP Assets B.V. Diterpene production in yarrowia
WO2015014969A1 (en) * 2013-07-31 2015-02-05 Dsm Ip Assets B.V. Steviol glycosides
CN103397064B (en) * 2013-08-14 2015-04-15 苏州汉酶生物技术有限公司 Method for preparing rebaudioside M through enzyme method
CA2928940C (en) * 2013-11-01 2021-12-14 Guohong MAO Recombinant production of steviol glycosides
JP6541159B2 (en) * 2014-01-28 2019-07-10 ペプシコ, インコーポレイテッドPepsiCo Inc. Method of preparing rebaudioside M by using an enzymatic method
WO2015162305A1 (en) * 2014-04-25 2015-10-29 Dsm Ip Assets B.V. Stabilization of cytochrome p450 reductase
US9522929B2 (en) 2014-05-05 2016-12-20 Conagen Inc. Non-caloric sweetener
CN114410493A (en) 2014-08-11 2022-04-29 埃沃尔瓦公司 Production of steviol glycosides in recombinant hosts
CN106795523B (en) * 2014-08-19 2021-11-26 谱赛科有限责任公司 Method for preparing rebaudioside I and application
CN107072237B (en) 2014-09-02 2021-12-14 谱赛科有限责任公司 Stevia Extract
US10612064B2 (en) * 2014-09-09 2020-04-07 Evolva Sa Production of steviol glycosides in recombinant hosts
CN104232496B (en) * 2014-09-18 2017-06-06 广州康琳奈生物科技有限公司 A kind of recombinant yeast pichia pastoris engineering bacteria and its application in rebaudioside A is synthesized
US11653679B2 (en) 2014-09-19 2023-05-23 Purecircle Sdn Bhd High-purity steviol glycosides
US9567619B2 (en) 2014-10-03 2017-02-14 Conagen Inc. Non-caloric sweeteners and methods for synthesizing
JP6946183B2 (en) 2014-11-05 2021-10-06 マナス バイオシンセシス インコーポレイテッド Microbial production of steviol glycosides
WO2016100689A1 (en) 2014-12-17 2016-06-23 Cargill, Incorporated Steviol glycoside compounds, compositions for oral ingestion or use, and method for enhancing steviol glycoside solubility
CN108522291B (en) * 2015-01-23 2022-01-04 谱赛科美国公司 Method for preparing stevioside with high RM content by using new stevia variety 814011 Puxing No. 3
SG11201705606PA (en) 2015-01-30 2017-08-30 Evolva Sa Production of steviol glycosides in recombinant hosts
CN107404911A (en) * 2015-02-10 2017-11-28 谱赛科美国股份有限公司 Rebaudiodside A M biosynthesis production and recovery method
EP3265577A1 (en) 2015-03-03 2018-01-10 The Regents of the University of California Protecting group chemistry for clean, reductant-free dyeing
US10604743B2 (en) 2015-03-16 2020-03-31 Dsm Ip Assets B.V. UDP-glycosyltransferases
CA2979957A1 (en) * 2015-03-23 2016-09-29 Dsm Ip Assets B.V. Udp-glycosyltransferases from solanum lycopersicum
CN113683712B (en) 2015-04-03 2022-10-21 帝斯曼知识产权资产管理有限公司 steviol glycosides
BR112017022019A2 (en) * 2015-04-14 2018-07-31 Conagen Inc. production of non-caloric sweeteners by use of modified whole cell catalysts
BR112017022298A2 (en) * 2015-04-21 2018-07-10 Dsm Ip Assets Bv geranylgeranyl pyrophosphate synthase
EP3303552A4 (en) * 2015-05-29 2019-01-16 Cargill, Incorporated FERMENTATION PROCESSES FOR THE PRODUCTION OF STEVIOL GLYCOSIDES WITH MULTI-PHASE FEEDING
EP4063513A1 (en) 2015-05-29 2022-09-28 Cargill, Incorporated Heat treatment to produce glycosides
CN107949632B (en) 2015-05-29 2021-06-01 嘉吉公司 Fermentation method for the production of steviol glycosides using high pH and compositions obtained therefrom
CN105200098A (en) * 2015-06-30 2015-12-30 苏州汉酶生物技术有限公司 Method for preparing rebaudioside M according to saccharomyces cerevisiae enzymatic method
AU2016301190A1 (en) * 2015-08-06 2018-02-15 Cargill, Incorporated Fermentation methods for producing steviol glycosides
CN108271391A (en) 2015-08-07 2018-07-10 埃沃尔瓦公司 The generation of steviol glycoside in recombinant host
CN107922465B (en) * 2015-08-13 2021-12-24 帝斯曼知识产权资产管理有限公司 Steviol glycoside transport
US9765117B2 (en) 2015-08-24 2017-09-19 Romek Figa Peptides for treating cancer
CA2999638A1 (en) 2015-10-05 2017-04-13 Dsm Ip Assets B.V. Kaurenoic acid hydroxylases
BR112018008489B1 (en) 2015-10-26 2023-03-14 Purecircle Usa Inc METHOD TO IMPROVE THE SWEETNESS PROFILE OF A STEVIA SWEETENER
WO2017093895A1 (en) * 2015-11-30 2017-06-08 Purecircle Sdn Bhd Process for producing high purity steviol glycosides
SG11201803918VA (en) * 2015-12-10 2018-06-28 Evolva Sa Production of steviol glycosides in recombinant hosts
US11653686B2 (en) 2015-12-15 2023-05-23 Purecircle Usa Inc. Steviol glycoside compositions
WO2017151616A1 (en) * 2016-03-01 2017-09-08 Wm. Wrigley Jr. Company Long-lasting sweetener formulations
US20190048356A1 (en) * 2016-03-11 2019-02-14 Evolva Sa Production of steviol glycosides in recombinant hosts
WO2017178632A1 (en) 2016-04-13 2017-10-19 Evolva Sa Production of steviol glycosides in recombinant hosts
WO2017198682A1 (en) 2016-05-16 2017-11-23 Evolva Sa Production of steviol glycosides in recombinant hosts
CA3023399A1 (en) * 2016-05-16 2017-11-23 Evolva Sa Production of steviol glycosides in recombinant hosts
US20190320699A1 (en) * 2016-06-17 2019-10-24 Cargill, Incorporated Steviol glycoside compositions for oral ingestion or use
WO2018031955A2 (en) * 2016-08-12 2018-02-15 Amyris, Inc. Udp-dependent glycosyltransferase for high efficiency production of rebaudiosides
CN110191643B (en) 2016-10-14 2023-06-06 科纳根公司 Biosynthesis production of steviol glycoside and process thereof
EP3530745A4 (en) 2016-10-21 2020-07-22 Pepsico, Inc. Method for preparing rebaudioside n using enzymatic method
CN110199029B (en) * 2016-10-21 2023-09-05 百事可乐公司 A method for enzymatically preparing rebaudioside C
RU2736352C1 (en) * 2016-10-21 2020-11-16 Пепсико, Инк. Method for producing rebaudioside j using an enzymatic method
CA3040585A1 (en) * 2016-10-27 2018-05-03 Dsm Ip Assets B.V. Geranylgeranyl pyrophosphate synthases
WO2018083338A1 (en) 2016-11-07 2018-05-11 Evolva Sa Production of steviol glycosides in recombinant hosts
WO2018111194A1 (en) * 2016-12-16 2018-06-21 Temasek Life Sciences Laboratory Limited Targets for improving terpene production in rhodosporidium toruloides
US11702641B2 (en) 2016-12-27 2023-07-18 Suntory Holdings Limited Steviol glycoside hexose transferase and gene coding for same
CN110914445B (en) 2017-02-03 2024-08-27 泰莱解决方案美国有限责任公司 Engineered glycosyltransferase and method for glucosylation of steviol glycosides
WO2018164747A1 (en) * 2017-03-06 2018-09-13 Conagen Inc. Biosynthetic production of steviol glycoside rebaudioside d4 from rebaudioside e
US11284577B2 (en) 2017-03-08 2022-03-29 Purecircle Usa Inc. High rebaudioside M stevia plant cultivars and methods of producing the same
JP7011649B2 (en) 2017-04-12 2022-02-10 サントリーホールディングス株式会社 Stevia-derived rhamnose synthase and genes
WO2018211032A1 (en) 2017-05-17 2018-11-22 Evolva Sa Production of steviol glycosides in recombinant hosts
CA3068440A1 (en) * 2017-06-30 2019-01-03 Conagen Inc. Hydrolysis of steviol glycosides by beta-glucosidase
SG11202001058TA (en) 2017-08-11 2020-03-30 Amyris Inc Pisum sativum kaurene oxidase for high efficiency production of rebaudiosides
US11365417B2 (en) 2017-09-12 2022-06-21 Bio Capital Holdings, LLC Biological devices and methods of use thereof to produce steviol glycosides
CN107446874B (en) * 2017-09-25 2020-07-28 四川盈嘉合生科技有限公司 Recombinant Escherichia coli and its use in the synthesis of rebaudioside D
BR112020009838A2 (en) 2017-12-05 2020-11-17 Evolva Sa production of steviol glycosides in recombinant hosts
EP3765627A4 (en) * 2018-03-12 2021-10-13 Conagen Inc. BIOSYNTHETIC PRODUCTION OF STEVIOL GLYCOSIDES REBAUDIOSIDE J AND REBAUDIOSIDE N
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
KR102532079B1 (en) * 2018-07-16 2023-05-12 마누스 바이오, 인크. Production of steviol glycosides through whole-cell biotransformation
JP7584401B2 (en) 2018-07-30 2024-11-15 テイト アンド ライル ソリューションズ ユー・エス・エー エル・エル・シー Engineered glycosyltransferases and methods for glucosylating steviol glycosides
CN109393426A (en) * 2018-09-29 2019-03-01 四川盈嘉合生科技有限公司 A kind of composite sweetener
AU2019360932A1 (en) * 2018-10-15 2021-05-06 Amyris, Inc. Stevia rebaudiana kaurenoic acid hydroxylase variants for high efficiency production of rebaudiosides
EP3877519A4 (en) 2018-11-09 2022-08-24 Ginkgo Bioworks, Inc. BIOSYNTHESIS OF MOGROSIDES
WO2020117792A2 (en) * 2018-12-04 2020-06-11 The Regents Of The University Of California Scalable biosynthesis of the seaweed neurochemical kainic acid
MX2021006986A (en) * 2018-12-12 2021-08-16 Conagen Inc Biosynthetic production of variant steviol glycosides.
KR102618015B1 (en) * 2018-12-21 2023-12-26 주식회사 삼양사 production of steviol and its precursors
BR112021014143A2 (en) 2019-01-24 2021-10-19 Amyris, Inc. ABC CONVEYORS FOR HIGH EFFICIENCY PRODUCTION OF REBAUDIOSIDES
CN109913380B (en) * 2019-03-25 2021-12-10 南京工业大学 Recombinant yarrowia lipolytica for producing (-) -alpha-bisabolol and construction method and application thereof
CA3134729A1 (en) 2019-05-03 2020-11-12 Andrew P. Klein Kaurenoic acid 13-hydroxylase (kah) variants and uses thereof
US12065685B1 (en) 2019-05-13 2024-08-20 Amyris, Inc. UDP-glycosyltransferase variants and uses thereof
CN114174501A (en) 2019-06-25 2022-03-11 马努斯生物合成股份有限公司 Uridine diphosphate dependent glycosyltransferase enzyme
KR102379608B1 (en) * 2019-10-29 2022-03-29 주식회사 삼양사 Improved production of steviol glycoside and its precursors
CN111088176B (en) * 2019-12-30 2022-03-25 北京化工大学 Genetically engineered bacterium for producing beta-carotene and application thereof
CN112006035B (en) * 2020-07-24 2021-07-30 江西新龙生物科技股份有限公司 Microbial source bactericide for preventing and treating plant diseases and preparation method thereof
WO2023006179A1 (en) 2020-07-27 2023-02-02 Dsm Ip Assets B.V. Method to produce retinyl acetate
CA3198626A1 (en) 2020-10-22 2022-04-28 Dsm Ip Assets B.V. Microorganisms for diterpene production
MX2023006019A (en) * 2020-11-24 2023-08-04 Manus Bio Inc BIOSYNTHESIS AND RECOVERY OF GLUCOSIDE PRODUCT.
JP7210626B2 (en) * 2021-02-18 2023-01-23 ペプシコ・インク Method for preparing rebaudioside J using enzymatic methods
US11299700B1 (en) 2021-02-19 2022-04-12 Acequia Biotechnology, Llc Bioreactor containers and methods of growing hairy roots using the same
WO2022187819A1 (en) 2021-03-01 2022-09-09 Cargill, Incorporated Xylosylated steviol glycosides and enzymatic methods for production
KR102600520B1 (en) * 2021-06-09 2023-11-09 씨제이제일제당 주식회사 Geranylgeranyl pyrophosphate synthase variant and method of producing tetraterpene, precursor thereof and compounds in which the precursor is tetraterpene using the variant
CN115478060B (en) * 2021-06-16 2023-11-28 弈柯莱生物科技(集团)股份有限公司 A kind of glycosyltransferase and its application
WO2023006851A1 (en) 2021-07-27 2023-02-02 Dsm Ip Assets B.V. Fermentative production of retinyl acetate in the presence of ethanol
KR102564619B1 (en) 2021-08-10 2023-08-07 이재준 Square box
WO2023044368A1 (en) * 2021-09-17 2023-03-23 Doublerainbow Biosciences Inc. Method for producing glycosylated therapeutics by using an immobilized enzyme preparation
CN113930377B (en) * 2021-10-14 2023-12-26 广西大学 An engineering strain that catalyzes whole-cell catalysis to increase the content of rebaudioside A
CN114196696B (en) * 2021-12-06 2023-10-20 天津大学 A recombinase fused to a specific short peptide tag that can efficiently catalyze the generation of Reb M
US20250066831A1 (en) * 2021-12-21 2025-02-27 Syracuse University Temperature-responsive nano-biomaterials from genetically encoded farnesylated proteins
CN114561310B (en) * 2022-03-17 2022-12-02 江南大学 Saccharomyces cerevisiae for producing rubusoside and application thereof
US20260009063A1 (en) * 2022-07-07 2026-01-08 Purecircle Sdn. Bhd. High-purity steviol glycosides
WO2024011263A2 (en) * 2022-07-08 2024-01-11 Cibus Us Llc Producing sesquiterpenes and other terpenes using plant-based biomasses
WO2024042486A1 (en) 2022-08-26 2024-02-29 Amyris Bio Products Portugal, Unipessoal, Ltda. Compositions and methods for the production of polyurethanes
WO2024042405A1 (en) 2022-08-26 2024-02-29 Amyris Bio Products Portugal, Unipessoal, Ltda. Compositions and methods for the synthesis of bio-based polymers
EP4627091A1 (en) * 2022-11-30 2025-10-08 Velozbio Company Compositions and methods for protein production
WO2024116153A1 (en) 2022-12-02 2024-06-06 Amyris Bio Products Portugal, Unipessoal, Ltda. Compositions and methods for using previously cultured cells
CN118755690B (en) * 2024-09-06 2024-11-19 四川盈嘉合生科技有限公司 A sucrose synthase and its application in biosynthesis of steviol glycosides
CN119265154B (en) * 2024-12-10 2025-05-13 诸城市浩天药业有限公司 Glycosyltransferase UGT76G4 mutant and application thereof

Family Cites Families (146)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58149697A (en) * 1982-02-27 1983-09-06 Dainippon Ink & Chem Inc Preparation of beta-1,3-glycosyl stevioside
JPS59101408A (en) 1982-12-02 1984-06-12 Junichi Iwamura Plant growth regulator
US5198360A (en) 1990-01-19 1993-03-30 Eli Lilly And Company Dna sequence conferring a plaque inhibition phenotype
US6946587B1 (en) 1990-01-22 2005-09-20 Dekalb Genetics Corporation Method for preparing fertile transgenic corn plants
US5484956A (en) 1990-01-22 1996-01-16 Dekalb Genetics Corporation Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin
JPH03277275A (en) 1990-03-28 1991-12-09 Dainippon Ink & Chem Inc Novel enzyme and method for preparing glycoside with same enzyme
US5204253A (en) 1990-05-29 1993-04-20 E. I. Du Pont De Nemours And Company Method and apparatus for introducing biological substances into living cells
US5306862A (en) 1990-10-12 1994-04-26 Amoco Corporation Method and composition for increasing sterol accumulation in higher plants
US5460949A (en) 1990-11-15 1995-10-24 Amoco Corporation Method and composition for increasing the accumulation of squalene and specific sterols in yeast
US5712112A (en) 1992-11-04 1998-01-27 National Science Council Of R.O.C. Gene expression system comprising the promoter region of the alpha-amylase genes
FI960173L (en) 1993-07-15 1996-03-15 Neose Pharm Inc Method for synthesizing saccharide compositions
US7186891B1 (en) 1996-04-12 2007-03-06 University Of Kentucky, Research Foundation Plant cells and plants expressing chimeric isoprenoid synthases
JPH10117776A (en) 1996-10-22 1998-05-12 Japan Tobacco Inc Transformation of indica rice
WO1999018224A1 (en) 1997-10-06 1999-04-15 The Centre National De Recherche Scientifique Plant fatty acid hydroxylase genes
US6255557B1 (en) 1998-03-31 2001-07-03 Her Majesty The Queen In Right Of Canada As Represented By The Ministerof Agriculture And Agri-Food Canada Stevia rebaudiana with altered steviol glycoside composition
EP1072683B1 (en) 1998-04-14 2013-08-28 Kyowa Hakko Bio Co., Ltd. Process for producing isoprenoid compounds by using microorganisms
EP0955363A3 (en) 1998-05-06 2004-01-28 F. Hoffmann-La Roche Ag Dna sequences encoding enzymes involved in production of isoprenoids
TWI250210B (en) 1998-05-06 2006-03-01 Dsm Ip Assets Bv An isolated DNA sequence coding for an enzyme involved in the mevalonate pathway or the pathway from isopentenyl pyrophosphate to farnesyl pyrophosphate
US6531303B1 (en) 1998-07-06 2003-03-11 Arkion Life Sciences Llc Method of producing geranylgeraniol
JP4579415B2 (en) 1998-07-06 2010-11-10 ディーシーブイ・インコーポレイテッド・ドゥーイング・ビジネス・アズ・バイオ−テクニカル・リソーシィズ Vitamin production method
JP3277275B2 (en) 1998-07-28 2002-04-22 有限会社シャトウバッグ Patterned surface material used for bags and the like and method for producing the same
AR021636A1 (en) 1998-12-17 2002-07-31 Rubicon Forests Holdings Ltd MATERIALS AND METHODS FOR THE MODIFICATION OF CONTENT, COMPOSITION AND METABOLISM OF ISOPRENOIDS
JP2002533090A (en) 1998-12-23 2002-10-08 ザ、サミュアル、ラバツ、ノゥブル、ファウンデイシャン、インク Plant transformation method
CA2370616C (en) 1999-04-15 2013-04-09 Calgene Llc Nucleic acid sequences to proteins involved in isoprenoid synthesis
CA2370638A1 (en) 1999-04-21 2000-10-26 Igor Kardailsky Plant transformation process
WO2001011055A1 (en) 1999-08-04 2001-02-15 Adelbert Bacher Isoprenoid biosynthesis
WO2001012828A1 (en) 1999-08-18 2001-02-22 Paradigm Genetics, Inc. Methods and apparatus for transformation of monocotyledenous plants using agrobacterium in combination with vacuum filtration
AU2001269685A1 (en) 2000-05-03 2001-11-12 The Salk Institute For Biological Studies Crystallization of 4-diphosphocytidyl-2-c-methylerythritol synthesis
DE10027821A1 (en) 2000-06-05 2001-12-06 Adelbert Bacher New intermediate in isoprenoid biosynthesis, useful in screening for potential herbicides, comprises mutant encoding-enzymes sequences for imparting herbicide resistance
AU2001278098A1 (en) 2000-07-31 2002-02-13 Frederick M. Hahn Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms
EP1313867A2 (en) 2000-08-24 2003-05-28 The Scripps Research Institute Stress-regulated genes of plants, transgenic plants containing same, and methods of use
US6660507B2 (en) 2000-09-01 2003-12-09 E. I. Du Pont De Nemours And Company Genes involved in isoprenoid compound production
US6689601B2 (en) 2000-09-01 2004-02-10 E. I. Du Pont De Nemours And Company High growth methanotropic bacterial strain
US6818424B2 (en) 2000-09-01 2004-11-16 E. I. Du Pont De Nemours And Company Production of cyclic terpenoids
CA2422730A1 (en) 2000-09-19 2002-03-28 Microbia, Inc. Modulation of secondary metabolite production by zinc binuclear cluster proteins
AU2001296359B2 (en) 2000-09-29 2006-04-27 Cargill Incorporated Isoprenoid production
US6949362B2 (en) 2000-12-12 2005-09-27 E. I. Du Pont De Nemours And Company Rhodococcus cloning and expression vectors
EP1356037B1 (en) 2001-01-25 2011-03-09 Evolva Ltd. A library of a collection of cells
US20050003474A1 (en) 2001-01-26 2005-01-06 Desouza Mervyn L. Carotenoid biosynthesis
US20040078846A1 (en) 2002-01-25 2004-04-22 Desouza Mervyn L. Carotenoid biosynthesis
DE10201458A1 (en) 2001-04-11 2002-10-17 Adelbert Bacher New proteins involved in isoprenoid biosynthesis, useful in screening for inhibitors, also new intermediates, potential therapeutic agents, nucleic acids and antibodies
US7034140B2 (en) 2001-04-24 2006-04-25 E.I. Du Pont De Nemours And Company Genes involved in isoprenoid compound production
KR100704072B1 (en) 2001-06-06 2007-04-05 디에스엠 아이피 어셋츠 비.브이. Improved Isoprenoid Manufacturing Method
EP1402042A2 (en) * 2001-06-22 2004-03-31 Syngenta Participations AG Abiotic stress responsive polynucleotides and polypeptides
NZ513755A (en) 2001-08-24 2001-09-28 Ann Rachel Holmes Protein expression system in yeast comprising a vector encoding a heterologous membrane protein and its application in screening for drugs
US20040072311A1 (en) 2001-08-28 2004-04-15 Dicosimo Deana J. Production of cyclic terpenoids
US20040010815A1 (en) 2001-09-26 2004-01-15 Lange B. Markus Identification and characterization of plant genes
US7172886B2 (en) 2001-12-06 2007-02-06 The Regents Of The University Of California Biosynthesis of isopentenyl pyrophosphate
JP2005185101A (en) * 2002-05-30 2005-07-14 National Institute Of Agrobiological Sciences Plant full-length cDNA and use thereof
ATE444367T1 (en) 2002-08-20 2009-10-15 Suntory Holdings Ltd NEW GLYCOSYLTRANSFERASE GENES
ATE394477T1 (en) * 2002-09-27 2008-05-15 Dsm Ip Assets Bv SQUALENE SYNTHASE (SQS) GENE
US7098000B2 (en) 2003-06-04 2006-08-29 E. I. Du Pont De Nemoure And Company Method for production of C30-aldehyde carotenoids
JP4643569B2 (en) 2003-06-12 2011-03-02 ディーエスエム アイピー アセッツ ビー.ブイ. Feedback resistant mevalonate kinase
US20060150283A1 (en) 2004-02-13 2006-07-06 Nickolai Alexandrov Sequence-determined DNA fragments and corresponding polypeptides encoded thereby
US7569389B2 (en) 2004-09-30 2009-08-04 Ceres, Inc. Nucleotide sequences and polypeptides encoded thereby useful for modifying plant characteristics
WO2006085899A2 (en) 2004-05-21 2006-08-17 The Regents Of The University Of California Method for enhancing production of isoprenoid compounds
EP1765857A2 (en) 2004-07-02 2007-03-28 Metanomics GmbH Process for the production of fine chemicals
US20060014264A1 (en) 2004-07-13 2006-01-19 Stowers Institute For Medical Research Cre/lox system with lox sites having an extended spacer region
WO2006016395A1 (en) 2004-08-09 2006-02-16 National University Corporation Tohoku University Udp-glucuronyl transferase and gene encoding the same
WO2006018211A1 (en) 2004-08-19 2006-02-23 Dsm Ip Assets B.V. Production of isoprenoids
US7923552B2 (en) 2004-10-18 2011-04-12 SGF Holdings, LLC High yield method of producing pure rebaudioside A
JP4841562B2 (en) 2004-12-14 2011-12-21 ディーエスエム アイピー アセッツ ビー.ブイ. Improved mevalonate kinase
WO2006093289A1 (en) 2005-03-04 2006-09-08 National Institute Of Advanced Industrial Science And Technology Process for prpduction of udp-xylose
WO2006096392A2 (en) 2005-03-04 2006-09-14 Diversa Corporation Enzymes involved in astaxanthin, carotenoid and isoprenoid biosynthetic pathways, genes encoding them and methods of making and using them
WO2007022318A2 (en) 2005-08-17 2007-02-22 Cornell Research Foundation Nucleic acids and proteins associated with sucrose accumulation in coffee
WO2007024816A2 (en) 2005-08-22 2007-03-01 Co2 Boost Llc A device and process to generate co2 used for indoor crop production and underwater gardening
US8293307B2 (en) 2005-10-11 2012-10-23 Purecircle Sdn Bhd Process for manufacturing a sweetener and use thereof
DK2526778T3 (en) 2005-11-23 2017-03-27 Coca Cola Co Natural High Strength Sweetener Compositions with Improved Time Profile and / or Taste Profile, Methods of Formulation thereof and Applications thereof
KR100784261B1 (en) 2006-01-02 2007-12-11 한국과학기술원 Microbial surface expression method of target protein using spore envelope membrane protein of anthrax
US7927851B2 (en) 2006-03-21 2011-04-19 Vineland Research And Innovation Centre Compositions having ent-kaurenoic acid 13-hydroxylase activity and methods for producing same
CA2644273A1 (en) 2006-04-05 2008-03-27 Metanomics Gmbh Process for the production of a fine chemical
US8114645B2 (en) 2006-05-19 2012-02-14 The Regents Of The University Of California Methods for increasing isoprenoid and isoprenoid precursor production by modulating fatty acid levels
US7964376B2 (en) 2006-06-19 2011-06-21 Givaudan Sa Chimeric proteins and their use in methods to screen for sweet taste modulators
WO2008008256A2 (en) 2006-07-07 2008-01-17 The Regents Of The University Of California Methods for enhancing production of isoprenoid compounds by host cells
WO2008039499A2 (en) 2006-09-26 2008-04-03 The Regents Of The University Of California Production of isoprenoids and isoprenoid precursors
US7741119B2 (en) 2006-09-28 2010-06-22 E. I. Du Pont De Nemours And Company Xylitol synthesis mutant of xylose-utilizing zymomonas for ethanol production
US7629156B2 (en) 2006-09-28 2009-12-08 E.I. Du Pont De Nemours And Company Ethanol production in fermentation of mixed sugars containing xylose
CN101200480B (en) 2006-12-15 2011-03-30 成都华高药业有限公司 Extraction method of rebaudioside A
JP4915917B2 (en) * 2006-12-22 2012-04-11 独立行政法人農業・食品産業技術総合研究機構 Method for producing lacto-N-biose I and galacto-N-biose
BRPI0807794A2 (en) 2007-01-22 2014-07-01 Cargill Inc METHOD FOR PRODUCTING PURIFIED REBAUDIOSIDE COMPOSITIONS USING SOLVENT / ANTISOLVENT CRYSTALIZATION.
JP2008237110A (en) * 2007-03-27 2008-10-09 Institute Of Physical & Chemical Research Steviol synthase gene and method for producing steviol
BRPI0811747A8 (en) 2007-05-17 2014-10-14 Univ Illinois METHODS AND COMPOSITIONS FOR THE PRODUCTION OF SOLVENTS
US20080292775A1 (en) 2007-05-22 2008-11-27 The Coca-Cola Company Delivery Systems for Natural High-Potency Sweetener Compositions, Methods for Their Formulation, and Uses
WO2009005704A1 (en) 2007-07-03 2009-01-08 The Regents Of The University Of California Methods of increasing isoprenoid or isoprenoid precursor production
JP2009034080A (en) 2007-08-03 2009-02-19 Sanei Gen Ffi Inc Production of novel glycosyltransferases and glycosides using the same
US7964232B2 (en) 2007-09-17 2011-06-21 Pepsico, Inc. Steviol glycoside isomers
EP2193202A2 (en) 2007-09-21 2010-06-09 BASF Plant Science GmbH Plants with increased yield
WO2009071277A1 (en) 2007-12-03 2009-06-11 Dsm Ip Assets B.V. Novel nutraceutical compositions containing stevia extract or stevia extract constituents and uses thereof
US20100285201A1 (en) 2007-12-27 2010-11-11 Catani Steven J Synergistic sweetening compositions
CA2715397A1 (en) 2008-02-20 2009-08-27 Ceres, Inc. Nucleotide sequences and corresponding polypeptides conferring improved nitrogen use efficiency characteristics in plants
TWI475963B (en) 2008-02-25 2015-03-11 可口可樂公司 Stevioside A derivative product and method for producing same
US7981647B2 (en) 2008-03-03 2011-07-19 Joule Unlimited, Inc. Engineered CO2 fixing microorganisms producing carbon-based products of interest
WO2009140394A1 (en) 2008-05-13 2009-11-19 Cargill, Incorporated Separation of rebaudioside a from stevia glycosides using chromatography
CN101314776B (en) * 2008-07-11 2010-11-03 南京农业大学 Diphosphourea nucleoglucosyltransferase gene and its encoded protein
WO2010021001A2 (en) 2008-08-19 2010-02-25 Kaushik Ramakrishnan S Process for preparing sweetener from stevia rebaudiana
CN116102603A (en) 2008-10-03 2023-05-12 守田化学工业株式会社 new steviol glycosides
CN101720910B (en) 2008-10-23 2012-07-25 大闽食品(漳州)有限公司 Method for preparing stevioside
US8614085B2 (en) 2009-02-27 2013-12-24 Butamax(Tm) Advanced Biofuels Llc Yeast with increased butanol tolerance involving a multidrug efflux pump gene
US20100297722A1 (en) 2009-05-20 2010-11-25 Board Of Trustees Of Southern Illinois University Transgenic moss producing terpenoids
DK2440661T3 (en) 2009-06-08 2018-03-12 Jennewein Biotechnologie Gmbh HMO synthesis
PL2482676T3 (en) 2009-06-16 2015-03-31 Epc Beijing Natural Products Co Ltd Reducing or eliminating aftertaste in a sweetener using rebaudioside d
WO2011028671A1 (en) * 2009-09-04 2011-03-10 Redpoint Bio Corporation Sweetness enhancers including rebaudioside a or d
EP2480097A1 (en) 2009-09-22 2012-08-01 Redpoint Bio Corporation Novel polymorphs of rebaudioside c and methods for making and using the same
PL2708548T4 (en) 2009-10-15 2018-07-31 Purecircle Sdn Bhd High-Purity Rebaudioside D and Applications
US8299224B2 (en) 2009-10-15 2012-10-30 Purecircle Sdn Bhd High-purity Rebaudioside D
US8703224B2 (en) 2009-11-04 2014-04-22 Pepsico, Inc. Method to improve water solubility of Rebaudioside D
BR112012012374A2 (en) 2009-11-23 2015-09-15 Du Pont higher oil plant seed, plant, method for further increasing oil content in a high oil plant seed, method for evaluating the increased oil content in a plant seed, isolated polynucleotide isolated polypeptide
TR201815882T4 (en) 2009-12-10 2018-11-21 Univ Iowa State Res Found Inc Tal effector mediated DNA modification.
RU2719036C2 (en) 2009-12-28 2020-04-16 Дзе Кока-Кола Компани Sweetness enhancers, compositions and methods thereof
WO2013096420A1 (en) 2011-12-19 2013-06-27 The Coca-Cola Company Methods for purifying steviol glycosides and uses of the same
KR101244315B1 (en) 2010-10-19 2013-03-14 이화여자대학교 산학협력단 Ethanol―Resistant Yeast Genes and Uses Thereof
WO2011140329A1 (en) 2010-05-06 2011-11-10 Ceres, Inc. Transgenic plants having increased biomass
EP2571991A1 (en) 2010-05-20 2013-03-27 Evolva SA Method of producing isoprenoid compounds in yeast
WO2011151326A2 (en) 2010-05-31 2011-12-08 Vib Vzw The use of transporters to modulate flavor production by yeast
MX349121B (en) 2010-06-02 2017-07-12 Evolva Inc Recombinant Production of Steviol Glycosides.
US20120021111A1 (en) 2010-07-23 2012-01-26 Aexelon Therapeutics, Inc. Natural Low Caloric Sweetener Compositions for Use in Beverages, Foods and Pharmaceuticals, and Their Methods of Manufacture
US20120083593A1 (en) 2010-10-01 2012-04-05 Shanghai Yongyou Bioscience Inc. Separation and Purification of Stevioside and Rebaudioside A
EP2645847B1 (en) * 2010-11-30 2018-01-17 Massachusetts Institute of Technology Microbial production of natural sweeteners, diterpenoid steviol glycosides
KR20130014227A (en) 2011-07-29 2013-02-07 한국생명공학연구원 NOVEL α-GLUCOSYL STEVIOSIDES AND PROCESS FOR PRODUCING THE SAME
JP6262653B2 (en) * 2011-08-08 2018-01-17 エヴォルヴァ エスアー.Evolva Sa. Recombinant production of steviol glycosides
BR112014012543A2 (en) 2011-11-23 2017-06-13 Evolva Sa methods and materials for enzymatic synthesis of mogroside compounds
CN103159808B (en) 2011-12-09 2017-03-29 上海泓博智源医药股份有限公司 A kind of process for preparing natural sweetener
HK1204529A1 (en) 2012-01-23 2015-11-27 帝斯曼知识产权资产管理有限公司 Diterpene production
CN102559528B (en) * 2012-02-09 2013-08-21 南京工业大学 Genetic engineering bacterium for producing stevia glycosyltransferase UGT76G1 and application thereof
US10000783B2 (en) 2012-03-16 2018-06-19 Suntory Holdings Limited Steviol glucosyltransferases and genes encoding the same
CN103974628B (en) 2012-05-22 2019-04-05 谱赛科有限责任公司 High purity steviol glycosides
WO2014048392A1 (en) 2012-09-29 2014-04-03 中国科学院上海生命科学研究院 Method for producing stevioside compounds by microorganism
US20150342234A1 (en) 2012-12-05 2015-12-03 Evolva Sa Steviol Glycoside Compositions Sensory Properties
KR20150115002A (en) 2013-02-06 2015-10-13 에볼바 에스아 Methods for improved production of rebaudioside d and rebaudioside m
MX2015010098A (en) 2013-02-11 2016-04-19 Evolva Sa Efficient production of steviol glycosides in recombinant hosts.
AU2014273054A1 (en) 2013-05-31 2015-12-03 Dsm Ip Assets B.V. Extracellular diterpene production
KR101559478B1 (en) 2013-06-24 2015-10-13 한국생명공학연구원 Method for Preparing Natural High Intensity Sweetener Rebaudiside A by Using Enzymatic Conversion
EP3024941B1 (en) 2013-07-23 2019-07-03 DSM IP Assets B.V. Diterpene production in yarrowia
CA2917699C (en) 2013-07-31 2021-12-07 Dsm Ip Assets B.V. Recovery of steviol glycosides
WO2015014969A1 (en) 2013-07-31 2015-02-05 Dsm Ip Assets B.V. Steviol glycosides
AU2014297224A1 (en) 2013-08-02 2016-03-03 Suntory Holdings Limited Method for using hexenol glycosyl transferase
CN103397064B (en) 2013-08-14 2015-04-15 苏州汉酶生物技术有限公司 Method for preparing rebaudioside M through enzyme method
EP3039132A2 (en) 2013-08-30 2016-07-06 Evolva SA A method for producing modified resveratrol
WO2015132411A2 (en) 2014-03-07 2015-09-11 Evolva Sa Methods for recombinant production of saffron compounds
CN114410493A (en) 2014-08-11 2022-04-29 埃沃尔瓦公司 Production of steviol glycosides in recombinant hosts
US10612064B2 (en) 2014-09-09 2020-04-07 Evolva Sa Production of steviol glycosides in recombinant hosts
SG11201705606PA (en) 2015-01-30 2017-08-30 Evolva Sa Production of steviol glycosides in recombinant hosts
US10604743B2 (en) 2015-03-16 2020-03-31 Dsm Ip Assets B.V. UDP-glycosyltransferases
CN108271391A (en) 2015-08-07 2018-07-10 埃沃尔瓦公司 The generation of steviol glycoside in recombinant host
WO2017198682A1 (en) 2016-05-16 2017-11-23 Evolva Sa Production of steviol glycosides in recombinant hosts
WO2018083338A1 (en) 2016-11-07 2018-05-11 Evolva Sa Production of steviol glycosides in recombinant hosts

Also Published As

Publication number Publication date
JP2022101592A (en) 2022-07-06
AU2022203048B2 (en) 2024-03-28
US20220228185A1 (en) 2022-07-21
AU2012294452A8 (en) 2014-03-06
AU2012294452B2 (en) 2017-08-10
US9631215B2 (en) 2017-04-25
SG10201606569VA (en) 2016-09-29
BR112014003037A2 (en) 2018-09-04
AU2022203048A1 (en) 2022-05-26
CN103732753A (en) 2014-04-16
EP2742142A2 (en) 2014-06-18
JP7057765B2 (en) 2022-04-20
SG10201606565XA (en) 2016-10-28
CA3128532A1 (en) 2013-02-14
WO2013022989A2 (en) 2013-02-14
AU2020200157B2 (en) 2022-02-10
AU2012294452C1 (en) 2017-11-30
KR102114493B1 (en) 2020-05-26
MY173212A (en) 2020-01-06
SG10201606563PA (en) 2016-10-28
US12416034B2 (en) 2025-09-16
BR112014003037B1 (en) 2022-04-05
BR122021015509B1 (en) 2022-03-29
AU2024204171A1 (en) 2024-07-11
WO2013022989A3 (en) 2013-07-04
JP2019205445A (en) 2019-12-05
BR122020019161B1 (en) 2022-04-05
AU2012294452A1 (en) 2014-02-06
CN103732753B (en) 2018-03-30
AU2017258907A1 (en) 2017-11-30
AU2020200157A1 (en) 2020-01-30
US20140329281A1 (en) 2014-11-06
US20170321238A1 (en) 2017-11-09
EP2742142B2 (en) 2020-03-25
JP2018019715A (en) 2018-02-08
EP3792350A1 (en) 2021-03-17
JP2024112815A (en) 2024-08-21
JP2014524247A (en) 2014-09-22
JP6554518B2 (en) 2019-07-31
CN108396044A (en) 2018-08-14
BR122021015508B1 (en) 2022-03-29
US10435730B2 (en) 2019-10-08
KR20140057322A (en) 2014-05-12
CA2843606A1 (en) 2013-02-14
US20230407360A1 (en) 2023-12-21
JP6262653B2 (en) 2018-01-17
JP7803999B2 (en) 2026-01-21
EP2742142B1 (en) 2016-06-01
EP3009508A1 (en) 2016-04-20
CA2843606C (en) 2021-10-05
EP3009508B1 (en) 2020-11-25
US20200123583A1 (en) 2020-04-23
KR20200057799A (en) 2020-05-26

Similar Documents

Publication Publication Date Title
SG10201606567TA (en) Recombinant production of steviol glycosides
SG10201709458QA (en) Recombinant production of steviol glycosides
EP3063286A4 (en) Recombinant production of steviol glycosides
EP2852296A4 (en) High-purity steviol glycosides
SG10201705993YA (en) Efficient production of steviol glycosides in recombinant hosts
PL2675294T3 (en) Glucosyl stevia composition
PL2720561T3 (en) Stevia composition
EP2713763A4 (en) Stevia composition
PL2713762T3 (en) Stevia composition
SMT201800078T1 (en) Beverage comprising steviol glycosides
PL2486806T3 (en) Stevia composition
EP2754025A4 (en) Pinch to adjust
EP2672840A1 (en) Stevia composition
PL3272861T3 (en) Alpha-galactosidase compositions
PL2768320T3 (en) Glucosyl stevia composition
SG2014013999A (en) Improved mcm-56 manufacture
IL232418A0 (en) Process for the preparation of beta-c-aryl glucosides
GB2512737B (en) Micro-Fermentation of cocoa
EP2684869A4 (en) Preparation of 3-mercaptopropionates
GB201101794D0 (en) Protein production
GB201103801D0 (en) Movement of aircraft
AU2011092V (en) WG001 Westringia glabra
TWM433301U (en) Improvement structure of cloth
AU2011901299A0 (en) Preparation of saponin aglycones
ZA201206900B (en) Production of chromium oxide