SG10201606567TA - Recombinant production of steviol glycosides - Google Patents
Recombinant production of steviol glycosidesInfo
- Publication number
- SG10201606567TA SG10201606567TA SG10201606567TA SG10201606567TA SG10201606567TA SG 10201606567T A SG10201606567T A SG 10201606567TA SG 10201606567T A SG10201606567T A SG 10201606567TA SG 10201606567T A SG10201606567T A SG 10201606567TA SG 10201606567T A SG10201606567T A SG 10201606567TA
- Authority
- SG
- Singapore
- Prior art keywords
- recombinant production
- steviol glycosides
- steviol
- glycosides
- recombinant
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0026—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5)
- C12N9/0032—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5) with oxygen as acceptor (1.5.3)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Nutrition Science (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Seasonings (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161521084P | 2011-08-08 | 2011-08-08 | |
| US201161521203P | 2011-08-08 | 2011-08-08 | |
| US201161521051P | 2011-08-08 | 2011-08-08 | |
| US201161523487P | 2011-08-15 | 2011-08-15 | |
| US201161567929P | 2011-12-07 | 2011-12-07 | |
| US201261603639P | 2012-02-27 | 2012-02-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201606567TA true SG10201606567TA (en) | 2016-10-28 |
Family
ID=46724642
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201606569VA SG10201606569VA (en) | 2011-08-08 | 2012-08-08 | Recombinant production of steviol glycosides |
| SG10201606565XA SG10201606565XA (en) | 2011-08-08 | 2012-08-08 | Recombinant production of steviol glycosides |
| SG10201606567TA SG10201606567TA (en) | 2011-08-08 | 2012-08-08 | Recombinant production of steviol glycosides |
| SG10201606563PA SG10201606563PA (en) | 2011-08-08 | 2012-08-08 | Recombinant production of steviol glycosides |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201606569VA SG10201606569VA (en) | 2011-08-08 | 2012-08-08 | Recombinant production of steviol glycosides |
| SG10201606565XA SG10201606565XA (en) | 2011-08-08 | 2012-08-08 | Recombinant production of steviol glycosides |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201606563PA SG10201606563PA (en) | 2011-08-08 | 2012-08-08 | Recombinant production of steviol glycosides |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US9631215B2 (en) |
| EP (3) | EP3009508B1 (en) |
| JP (5) | JP6262653B2 (en) |
| KR (2) | KR102114493B1 (en) |
| CN (2) | CN108396044A (en) |
| AU (5) | AU2012294452C1 (en) |
| BR (4) | BR122021015508B1 (en) |
| CA (2) | CA2843606C (en) |
| MY (1) | MY173212A (en) |
| SG (4) | SG10201606569VA (en) |
| WO (1) | WO2013022989A2 (en) |
Families Citing this family (150)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9107436B2 (en) | 2011-02-17 | 2015-08-18 | Purecircle Sdn Bhd | Glucosylated steviol glycoside as a flavor modifier |
| US9392799B2 (en) | 2011-02-17 | 2016-07-19 | Purecircle Sdn Bhd | Glucosyl stevia composition |
| US8318459B2 (en) | 2011-02-17 | 2012-11-27 | Purecircle Usa | Glucosyl stevia composition |
| US9386797B2 (en) | 2011-02-17 | 2016-07-12 | Purecircle Sdn Bhd | Glucosyl stevia composition |
| US8257948B1 (en) | 2011-02-17 | 2012-09-04 | Purecircle Usa | Method of preparing alpha-glucosyl Stevia composition |
| US8790730B2 (en) | 2005-10-11 | 2014-07-29 | Purecircle Usa | Process for manufacturing a sweetener and use thereof |
| US10888099B2 (en) | 2009-11-12 | 2021-01-12 | Purecircle Sdn Bhd. | Granulation of a Stevia sweetener |
| EP3461342A1 (en) | 2009-11-12 | 2019-04-03 | PureCircle USA Inc. | Granulation of a stevia sweetener |
| EP2544538B1 (en) | 2010-03-12 | 2022-06-15 | PureCircle USA Inc. | High-purity steviol glycosides |
| WO2013096420A1 (en) | 2011-12-19 | 2013-06-27 | The Coca-Cola Company | Methods for purifying steviol glycosides and uses of the same |
| US10696706B2 (en) | 2010-03-12 | 2020-06-30 | Purecircle Usa Inc. | Methods of preparing steviol glycosides and uses of the same |
| US20150344512A1 (en) | 2011-12-19 | 2015-12-03 | Purecircle Usa Inc. | Methods of purifying steviol glycosides and uses of the same |
| MX349121B (en) | 2010-06-02 | 2017-07-12 | Evolva Inc | Recombinant Production of Steviol Glycosides. |
| MX389987B (en) | 2010-12-13 | 2025-03-20 | Purecircle Usa Inc | HIGHLY SOLUBLE REBAUDIOSIDE D. |
| US9510611B2 (en) | 2010-12-13 | 2016-12-06 | Purecircle Sdn Bhd | Stevia composition to improve sweetness and flavor profile |
| MX391906B (en) | 2011-02-10 | 2025-03-19 | Purecircle Usa | COMPOSITION OF STEVIA. |
| US11690391B2 (en) | 2011-02-17 | 2023-07-04 | Purecircle Sdn Bhd | Glucosylated steviol glycoside as a flavor modifier |
| US9603373B2 (en) | 2011-02-17 | 2017-03-28 | Purecircle Sdn Bhd | Glucosyl stevia composition |
| US9474296B2 (en) | 2011-02-17 | 2016-10-25 | Purecircle Sdn Bhd | Glucosyl stevia composition |
| US9894922B2 (en) | 2011-05-18 | 2018-02-20 | Purecircle Sdn Bhd | Glucosyl rebaudioside C |
| WO2012166163A1 (en) | 2011-05-31 | 2012-12-06 | Purecircle Usa | Stevia composition |
| MX341095B (en) | 2011-06-03 | 2016-08-08 | Purecircle Usa | Stevia composition. |
| WO2014185931A1 (en) * | 2013-05-15 | 2014-11-20 | Purecircle Usa, Inc. | Stevia composition |
| EP3915394A1 (en) | 2011-06-20 | 2021-12-01 | PureCircle USA Inc. | Stevia composition |
| US9771434B2 (en) | 2011-06-23 | 2017-09-26 | Purecircle Sdn Bhd | Products from stevia rebaudiana |
| JP6262653B2 (en) * | 2011-08-08 | 2018-01-17 | エヴォルヴァ エスアー.Evolva Sa. | Recombinant production of steviol glycosides |
| US10480019B2 (en) | 2011-08-10 | 2019-11-19 | Purecircle Sdn Bhd | Process for producing high-purity rubusoside |
| US20140171520A1 (en) | 2011-09-07 | 2014-06-19 | Avetik Markosyan | Highly soluble stevia sweetener |
| FR2984743B1 (en) * | 2011-12-23 | 2014-08-22 | Oreal | COSMETIC USE OF STEVIOL, STEVIOL GLYCOSIDE DERIVATIVE, OR ONE OF THEIR ISOMERS FOR STIMULATING, RESTORING OR REGULATING METABOLISM OF SKIN CELLS AND SEMI-MUCOUS MEMBRANES |
| HK1204529A1 (en) * | 2012-01-23 | 2015-11-27 | 帝斯曼知识产权资产管理有限公司 | Diterpene production |
| US10000783B2 (en) | 2012-03-16 | 2018-06-19 | Suntory Holdings Limited | Steviol glucosyltransferases and genes encoding the same |
| WO2013146555A1 (en) * | 2012-03-27 | 2013-10-03 | サントリーホールディングス株式会社 | Method for producing steviol glycoside |
| WO2013148257A1 (en) * | 2012-03-30 | 2013-10-03 | J.R. Simplot Company | Steviol and steviol glycoside formation in plants |
| CN103974628B (en) * | 2012-05-22 | 2019-04-05 | 谱赛科有限责任公司 | High purity steviol glycosides |
| US9752174B2 (en) * | 2013-05-28 | 2017-09-05 | Purecircle Sdn Bhd | High-purity steviol glycosides |
| US20150342234A1 (en) * | 2012-12-05 | 2015-12-03 | Evolva Sa | Steviol Glycoside Compositions Sensory Properties |
| KR20150115002A (en) * | 2013-02-06 | 2015-10-13 | 에볼바 에스아 | Methods for improved production of rebaudioside d and rebaudioside m |
| MX2015010098A (en) | 2013-02-11 | 2016-04-19 | Evolva Sa | Efficient production of steviol glycosides in recombinant hosts. |
| KR101404728B1 (en) * | 2013-02-28 | 2014-06-09 | 씨제이제일제당 (주) | A method for preparation of Rebaudioside A from stevioside |
| HK1220080A1 (en) * | 2013-03-15 | 2017-04-28 | Cargill, Incorporated | Stevia plants with an increased rebaudioside d content |
| AU2014273055A1 (en) | 2013-05-31 | 2015-12-17 | Dsm Ip Assets B.V. | Microorganisms for diterpene production |
| AU2014273054A1 (en) * | 2013-05-31 | 2015-12-03 | Dsm Ip Assets B.V. | Extracellular diterpene production |
| DK3714699T3 (en) | 2013-06-07 | 2025-01-20 | Purecircle Usa Inc | STEVIA EXTRACT CONTAINING SELECTED STEVIOLGLYCOSIDES AS A FLAVOR, SALT AND SWEETNESS PROFILE MODIFIER |
| US10952458B2 (en) | 2013-06-07 | 2021-03-23 | Purecircle Usa Inc | Stevia extract containing selected steviol glycosides as flavor, salty and sweetness profile modifier |
| US10039834B2 (en) | 2013-07-12 | 2018-08-07 | The Coca-Cola Company | Compositions and methods using rebaudioside X to provide sweetness enhancement |
| MX2016000452A (en) * | 2013-07-15 | 2016-05-12 | Dsm Ip Assets Bv | Diterpene production. |
| EP3024941B1 (en) * | 2013-07-23 | 2019-07-03 | DSM IP Assets B.V. | Diterpene production in yarrowia |
| WO2015014969A1 (en) * | 2013-07-31 | 2015-02-05 | Dsm Ip Assets B.V. | Steviol glycosides |
| CN103397064B (en) * | 2013-08-14 | 2015-04-15 | 苏州汉酶生物技术有限公司 | Method for preparing rebaudioside M through enzyme method |
| CA2928940C (en) * | 2013-11-01 | 2021-12-14 | Guohong MAO | Recombinant production of steviol glycosides |
| JP6541159B2 (en) * | 2014-01-28 | 2019-07-10 | ペプシコ, インコーポレイテッドPepsiCo Inc. | Method of preparing rebaudioside M by using an enzymatic method |
| WO2015162305A1 (en) * | 2014-04-25 | 2015-10-29 | Dsm Ip Assets B.V. | Stabilization of cytochrome p450 reductase |
| US9522929B2 (en) | 2014-05-05 | 2016-12-20 | Conagen Inc. | Non-caloric sweetener |
| CN114410493A (en) | 2014-08-11 | 2022-04-29 | 埃沃尔瓦公司 | Production of steviol glycosides in recombinant hosts |
| CN106795523B (en) * | 2014-08-19 | 2021-11-26 | 谱赛科有限责任公司 | Method for preparing rebaudioside I and application |
| CN107072237B (en) | 2014-09-02 | 2021-12-14 | 谱赛科有限责任公司 | Stevia Extract |
| US10612064B2 (en) * | 2014-09-09 | 2020-04-07 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| CN104232496B (en) * | 2014-09-18 | 2017-06-06 | 广州康琳奈生物科技有限公司 | A kind of recombinant yeast pichia pastoris engineering bacteria and its application in rebaudioside A is synthesized |
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| SG11201705606PA (en) | 2015-01-30 | 2017-08-30 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| CN107404911A (en) * | 2015-02-10 | 2017-11-28 | 谱赛科美国股份有限公司 | Rebaudiodside A M biosynthesis production and recovery method |
| EP3265577A1 (en) | 2015-03-03 | 2018-01-10 | The Regents of the University of California | Protecting group chemistry for clean, reductant-free dyeing |
| US10604743B2 (en) | 2015-03-16 | 2020-03-31 | Dsm Ip Assets B.V. | UDP-glycosyltransferases |
| CA2979957A1 (en) * | 2015-03-23 | 2016-09-29 | Dsm Ip Assets B.V. | Udp-glycosyltransferases from solanum lycopersicum |
| CN113683712B (en) | 2015-04-03 | 2022-10-21 | 帝斯曼知识产权资产管理有限公司 | steviol glycosides |
| BR112017022019A2 (en) * | 2015-04-14 | 2018-07-31 | Conagen Inc. | production of non-caloric sweeteners by use of modified whole cell catalysts |
| BR112017022298A2 (en) * | 2015-04-21 | 2018-07-10 | Dsm Ip Assets Bv | geranylgeranyl pyrophosphate synthase |
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