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HUE043514T2 - Heterociklusos vegyület - Google Patents

Heterociklusos vegyület

Info

Publication number
HUE043514T2
HUE043514T2 HUE11744685A HUE11744685A HUE043514T2 HU E043514 T2 HUE043514 T2 HU E043514T2 HU E11744685 A HUE11744685 A HU E11744685A HU E11744685 A HUE11744685 A HU E11744685A HU E043514 T2 HUE043514 T2 HU E043514T2
Authority
HU
Hungary
Prior art keywords
heterocyclic compound
heterocyclic
compound
Prior art date
Application number
HUE11744685A
Other languages
English (en)
Inventor
Misaki Homma
Toru Miyazaki
Yuya Oguro
Osamu Kurasawa
Original Assignee
Takeda Pharmaceuticals Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44482985&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUE043514(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceuticals Co filed Critical Takeda Pharmaceuticals Co
Publication of HUE043514T2 publication Critical patent/HUE043514T2/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541Non-condensed thiazines containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
HUE11744685A 2010-02-17 2011-02-16 Heterociklusos vegyület HUE043514T2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2010031899 2010-02-17
JP2010131950 2010-06-09

Publications (1)

Publication Number Publication Date
HUE043514T2 true HUE043514T2 (hu) 2019-08-28

Family

ID=44482985

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE11744685A HUE043514T2 (hu) 2010-02-17 2011-02-16 Heterociklusos vegyület

Country Status (37)

Country Link
US (6) US8722660B2 (hu)
EP (2) EP3533797B1 (hu)
JP (1) JP5689454B2 (hu)
KR (1) KR101735868B1 (hu)
CN (1) CN102844320B (hu)
AU (1) AU2011216404B2 (hu)
BR (1) BR112012020311B1 (hu)
CA (1) CA2790284C (hu)
CL (1) CL2012002250A1 (hu)
CO (1) CO6592104A2 (hu)
CR (1) CR20120448A (hu)
CY (1) CY1121792T1 (hu)
DK (1) DK2540728T3 (hu)
DO (1) DOP2012000224A (hu)
EA (1) EA020724B1 (hu)
EC (1) ECSP12012160A (hu)
ES (1) ES2733221T3 (hu)
GE (1) GEP20146202B (hu)
HR (1) HRP20190947T1 (hu)
HU (1) HUE043514T2 (hu)
IL (1) IL221442A0 (hu)
LT (1) LT2540728T (hu)
MA (1) MA34064B1 (hu)
ME (1) ME03410B (hu)
MX (1) MX353500B (hu)
MY (1) MY164776A (hu)
NZ (1) NZ602089A (hu)
PE (1) PE20130184A1 (hu)
PH (1) PH12012501650B1 (hu)
PL (1) PL2540728T3 (hu)
PT (1) PT2540728T (hu)
RS (1) RS58796B1 (hu)
SG (1) SG183304A1 (hu)
SI (1) SI2540728T1 (hu)
SM (1) SMT201900385T1 (hu)
TN (1) TN2012000401A1 (hu)
WO (1) WO2011102399A1 (hu)

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US10174032B2 (en) * 2014-05-05 2019-01-08 Signalrx Pharmaceuticals, Inc. Heterocyclic compound classes for signaling modulation
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CA3016708A1 (en) * 2016-03-28 2017-10-05 Takeda Pharmaceutical Company Limited Crystalline forms of 2-[(2s)-1-azabicyclo[2.2.2]oct-2-yl]-6-(3-methyl-1h- pyrazol-4-yl)thieno[3,2-d]pyrimidin-4(3h)-one hemihydrate
EA035560B1 (ru) * 2016-07-28 2020-07-07 Такеда Фармасьютикал Компани Лимитед Кристаллические формы гемигидрата 2-[(2s)-1-азабицикло[2.2.2]окт-2-ил]-6-(3-метил-1h-пиразол-4-ил)тиено[3,2- d]пиримидин-4(3h)-она
CA3042929A1 (en) 2016-11-08 2018-05-17 Cancer Research Technology Limited Pyrimidinone derivatives as cdc7 inhibitors
US11155879B2 (en) 2017-03-01 2021-10-26 Takeda Pharmaceutical Company Limited Method of predicting effects of CDC7 inhibitor
CN112409373A (zh) * 2017-05-21 2021-02-26 南京正济医药研究有限公司 作为抗癌剂的取代的[5,6]环-4(3h)-嘧啶酮
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CA3095264A1 (en) * 2018-04-02 2019-10-10 Takeda Pharmaceutical Company Limited Process for the synthesis of 2-[(2s)-1-azabicyclo[2.2.2]oct-2-yl]-6- (3-methyl-1 h-pyrazol-4-yl)thieno[3,2-d]pyrimidin-4(3h)-one
TWI846703B (zh) 2018-06-19 2024-07-01 日商武田藥品工業股份有限公司 癌症治療方法
AU2019305828A1 (en) 2018-07-19 2021-01-28 Takeda Pharmaceutical Company Limited Pharmaceutical compositions with a CDC7 inhibitor
KR20220027883A (ko) * 2019-05-30 2022-03-08 치아타이 티안큉 파마수티컬 그룹 주식회사 Cdc7 억제제로서의 테트라사이클릭 화합물
CA3146792A1 (en) * 2019-07-19 2021-01-28 Takeda Pharmaceutical Company Limited Combination therapy for cancer treatment
WO2021032170A1 (zh) * 2019-08-20 2021-02-25 南京明德新药研发有限公司 用作Cdc7抑制剂的四并环类化合物
WO2021113492A1 (en) 2019-12-06 2021-06-10 Schrödinger, Inc. Cyclic compounds and methods of using same
WO2022055963A1 (en) * 2020-09-10 2022-03-17 Schrödinger, Inc. Heterocyclic pericondensed cdc7 kinase inhibitors for the treatment of cancer
EP4253388A1 (en) * 2020-11-30 2023-10-04 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Salt form used as cdc7 inhibitor and crystal form thereof
CN112661770B (zh) * 2020-12-24 2022-11-08 南京正济医药研究有限公司 一种化合物及利用其制备取代的[5,6]环-4(3h)-嘧啶酮化合物的方法
US20240173323A1 (en) 2021-02-08 2024-05-30 Takeda Pharmaceutical Company Limited Combination therapy for cancer treatment
TW202300150A (zh) * 2021-03-18 2023-01-01 美商薛定諤公司 環狀化合物及其使用方法
EP4416156A1 (en) * 2021-10-13 2024-08-21 Remix Therapeutics Inc. Compounds and methods for modulating nucleic acid splicing

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Also Published As

Publication number Publication date
KR20130001246A (ko) 2013-01-03
LT2540728T (lt) 2019-06-25
SMT201900385T1 (it) 2019-09-09
JPWO2011102399A1 (ja) 2013-06-17
CA2790284C (en) 2019-01-08
US20160310494A1 (en) 2016-10-27
US8933069B2 (en) 2015-01-13
US20130029969A1 (en) 2013-01-31
PH12012501650B1 (en) 2018-11-07
US20150158882A1 (en) 2015-06-11
EP2540728A4 (en) 2013-11-06
CY1121792T1 (el) 2020-07-31
EP2540728A1 (en) 2013-01-02
WO2011102399A1 (ja) 2011-08-25
US20140235615A1 (en) 2014-08-21
JP5689454B2 (ja) 2015-03-25
MX2012009602A (es) 2012-12-17
US8722660B2 (en) 2014-05-13
AU2011216404A1 (en) 2012-09-20
CL2012002250A1 (es) 2013-02-08
TN2012000401A1 (en) 2014-01-30
CN102844320B (zh) 2016-03-23
BR112012020311A2 (pt) 2017-03-01
HRP20190947T1 (hr) 2019-07-26
US9655900B2 (en) 2017-05-23
RS58796B1 (sr) 2019-07-31
GEP20146202B (en) 2014-11-25
MX353500B (es) 2018-01-16
PL2540728T3 (pl) 2019-09-30
DK2540728T3 (da) 2019-05-13
SG183304A1 (en) 2012-09-27
US9388195B2 (en) 2016-07-12
ECSP12012160A (es) 2013-03-28
DOP2012000224A (es) 2013-01-31
CR20120448A (es) 2012-11-13
EA020724B1 (ru) 2015-01-30
NZ602089A (en) 2014-05-30
BR112012020311B1 (pt) 2019-01-29
MY164776A (en) 2018-01-30
CN102844320A (zh) 2012-12-26
KR101735868B1 (ko) 2017-05-15
US20140228352A1 (en) 2014-08-14
SI2540728T1 (sl) 2019-06-28
PH12012501650A1 (en) 2012-10-22
EP3533797B1 (en) 2023-12-20
ES2733221T3 (es) 2019-11-28
EA201290800A1 (ru) 2013-03-29
EP3533797A1 (en) 2019-09-04
IL221442A0 (en) 2012-10-31
CO6592104A2 (es) 2013-01-02
PE20130184A1 (es) 2013-03-09
ME03410B (me) 2020-01-20
MA34064B1 (fr) 2013-03-05
US20170209452A1 (en) 2017-07-27
EP2540728B1 (en) 2019-04-10
CA2790284A1 (en) 2011-08-25
PT2540728T (pt) 2019-07-11
AU2011216404B2 (en) 2016-04-07
US8921354B2 (en) 2014-12-30

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