DK2648516T3 - Substituerede pyridinon-pyridinylforbindelser - Google Patents
Substituerede pyridinon-pyridinylforbindelser Download PDFInfo
- Publication number
- DK2648516T3 DK2648516T3 DK11847595.3T DK11847595T DK2648516T3 DK 2648516 T3 DK2648516 T3 DK 2648516T3 DK 11847595 T DK11847595 T DK 11847595T DK 2648516 T3 DK2648516 T3 DK 2648516T3
- Authority
- DK
- Denmark
- Prior art keywords
- pyridinon
- substituted
- pyridinyl compounds
- pyridinyl
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42007410P | 2010-12-06 | 2010-12-06 | |
| PCT/US2011/063608 WO2012078684A1 (en) | 2010-12-06 | 2011-12-06 | Substituted pyridinone-pyridinyl compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2648516T3 true DK2648516T3 (da) | 2019-01-02 |
Family
ID=46162793
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK11847595.3T DK2648516T3 (da) | 2010-12-06 | 2011-12-06 | Substituerede pyridinon-pyridinylforbindelser |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20120142709A1 (da) |
| EP (2) | EP2648516B1 (da) |
| JP (1) | JP5848775B2 (da) |
| CN (1) | CN103391718A (da) |
| CA (1) | CA2819889C (da) |
| DK (1) | DK2648516T3 (da) |
| ES (2) | ES2873029T3 (da) |
| HR (1) | HRP20181788T1 (da) |
| HU (1) | HUE040101T2 (da) |
| PL (1) | PL2648516T3 (da) |
| PT (1) | PT2648516T (da) |
| SI (1) | SI2648516T1 (da) |
| WO (1) | WO2012078684A1 (da) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE054178T2 (hu) * | 2013-06-07 | 2021-08-30 | Aclaris Therapeutics Inc | Metil/fluor-piridinil-metoxi-szubsztituált piridinon-piridinil-vegyületek és fluor-pirimidinil-metoxi-szubsztituált piridinon-piridinil-vegyületek |
| CN104860932B (zh) * | 2015-05-13 | 2018-01-12 | 安阳师范学院 | 一种吡唑啉酮类化合物及其应用 |
| CN104892499B (zh) * | 2015-06-26 | 2017-07-21 | 江西省科学院应用化学研究所 | 一种2‑吡啶酮类衍生物的合成方法 |
| CN110678471B (zh) * | 2017-03-16 | 2022-09-13 | 西建卡尔有限责任公司 | Mk2抑制剂及其合成和中间体 |
| WO2021022186A1 (en) * | 2019-07-31 | 2021-02-04 | Aclaris Therapeutics, Inc. | Deuterated mk2 pathway inhibitors and methods of using the same |
| WO2021195475A1 (en) * | 2020-03-27 | 2021-09-30 | Aclaris Therapeutics, Inc. | Process, compositions, and crystalline forms of substituted pyridinone-pyridinyl compounds |
| CN116685322A (zh) * | 2020-11-23 | 2023-09-01 | 阿克拉瑞斯治疗股份有限公司 | 合成被取代的吡啶酮-吡啶基化合物的方法 |
| KR20230112696A (ko) * | 2020-11-23 | 2023-07-27 | 어클라리스 쎄라퓨틱스, 인코포레이티드 | 치환된 피리디논-피리디닐 화합물의 합성 방법 |
| BR112023019861A2 (pt) * | 2021-03-31 | 2023-11-07 | Xinthera Inc | Inibidores de mk2 e usos dos mesmos |
| KR20240035830A (ko) | 2021-07-09 | 2024-03-18 | 신테라, 인크. | 피리디논 mk2 저해제 및 이의 용도 |
| WO2023001282A1 (zh) * | 2021-07-23 | 2023-01-26 | 南京明德新药研发有限公司 | 杂环取代的嘧啶衍生物 |
| TW202315625A (zh) * | 2021-08-13 | 2023-04-16 | 大陸商深圳信立泰藥業股份有限公司 | 三聯吡啶二酮化合物或其鹽、包括其藥物組合物及其用途 |
| CN116444492A (zh) * | 2021-12-29 | 2023-07-18 | 上海美悦生物科技发展有限公司 | 一种p38 MAPK/MK2通路调节剂及其组合物、制备方法和用途 |
| CN116354935A (zh) * | 2021-12-29 | 2023-06-30 | 上海美悦生物科技发展有限公司 | 一种p38 MAPK/MK2通路调节剂及其组合物、制备方法和用途 |
| CN116396274B (zh) * | 2022-01-06 | 2025-11-11 | 深圳信立泰药业股份有限公司 | 一种取代的联吡啶酮类化合物及其制备方法与应用 |
| WO2023134764A1 (zh) | 2022-01-14 | 2023-07-20 | 上海翰森生物医药科技有限公司 | 含吡啶多环类衍生物、其制备方法和应用 |
| WO2023134765A1 (zh) * | 2022-01-14 | 2023-07-20 | 上海翰森生物医药科技有限公司 | 含五元环类衍生物、其制备方法和应用 |
| US20230286950A1 (en) * | 2022-02-04 | 2023-09-14 | Aclaris Therapeutics, Inc. | Methods of synthesizing deuterated substituted pyridinone-pyridinyl compounds |
| CN117800948A (zh) * | 2022-05-12 | 2024-04-02 | 上海美悦生物科技发展有限公司 | 取代的吡啶或嘧啶类衍生物及其药物组合物、制备方法和用途 |
| CN119546296A (zh) * | 2022-07-28 | 2025-02-28 | 深圳信立泰药业股份有限公司 | 一种式（i）所示的三联吡啶二酮化合物晶型及其制备方法与应用 |
| TW202412792A (zh) * | 2022-08-30 | 2024-04-01 | 大陸商長春金賽藥業有限責任公司 | ｐ３８α－ＭＫ２抑制劑化合物、藥物組合物及其用途 |
| CN118047757A (zh) * | 2022-11-16 | 2024-05-17 | 上海美悦生物科技发展有限公司 | 吡啶氮氧化物类衍生物及其药物组合物、制备方法和用途 |
| WO2024149359A1 (zh) * | 2023-01-13 | 2024-07-18 | 上海美悦生物科技发展有限公司 | 苯基取代的杂芳基类化合物及其药物组合物、制备方法和用途 |
| WO2025092739A1 (zh) * | 2023-10-30 | 2025-05-08 | 浙江星浩澎博医药有限公司 | 二氢苯并呋喃类衍生物、其制备方法和用途 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1114039A1 (en) | 1998-09-18 | 2001-07-11 | Vertex Pharmaceuticals Incorporated | INHIBITORS OF p38 |
| JP2003500403A (ja) | 1999-05-21 | 2003-01-07 | サイオス，インコーポレーテッド | ｐ３８キナーゼのインヒビターとしてのインドール型誘導体 |
| DE60137426D1 (de) * | 2000-06-12 | 2009-03-05 | Eisai R&D Man Co Ltd | 1,2-dihydropyridinverbindungen, verfahren zu deren herstellung und deren verwendung |
| AU2002226911A1 (en) | 2000-11-20 | 2002-06-03 | Scios Inc. | Indol derivative and their use as inhibitors of p38 kinase |
| US7314752B2 (en) | 2001-07-19 | 2008-01-01 | Common Sense, Ltd. | Secretion-monitoring article |
| CN1578767A (zh) * | 2001-11-22 | 2005-02-09 | 小野药品工业株式会社 | 哌啶－2－酮衍生化合物及包含其作为活性成分的药学组合物 |
| CA2474578C (en) * | 2002-02-13 | 2009-08-25 | F. Hoffmann-La Roche Ag | Novel pyridin- and pyrimidin-derivatives |
| EP1490064B1 (en) * | 2002-02-14 | 2009-11-18 | Pharmacia Corporation | Substituted pyridinones as modulators of p38 map kinase |
| WO2003091246A1 (en) | 2002-04-26 | 2003-11-06 | Vertex Pharmaceuticals Incorporated | Pyrrole derivatives as inhibitors of erk2 and uses thereof |
| GB0218630D0 (en) | 2002-08-10 | 2002-09-18 | Tanabe Seiyaku Co | Novel compounds |
| EP1549315A4 (en) | 2002-09-11 | 2007-05-23 | Merck & Co Inc | DIHYDROXYPYRIDOPYRAZINE-1,6-DION COMPOUNDS AS HIV INTEGRASE INHIBITORS |
| US7183287B2 (en) | 2003-04-03 | 2007-02-27 | Pharmacia Corporation | Substituted pyrimidinones |
| US20070167621A1 (en) | 2003-04-03 | 2007-07-19 | Pharmacia Corporation | Substituted pyrimidinones |
| NL1026826C2 (nl) | 2003-08-13 | 2007-01-04 | Pharmacia Corp | Gesubstitueerde pyridinonen. |
| JP2005255675A (ja) | 2004-02-09 | 2005-09-22 | Tanabe Seiyaku Co Ltd | 医薬組成物 |
| CN1976915A (zh) | 2004-02-11 | 2007-06-06 | 史密丝克莱恩比彻姆公司 | Hiv整合酶抑制剂 |
| JPWO2005105743A1 (ja) * | 2004-04-28 | 2008-03-13 | 小野薬品工業株式会社 | 含窒素複素環化合物およびその医薬用途 |
| BRPI0607913A2 (pt) | 2005-04-08 | 2010-03-23 | Eisai R&D Man Co Ltd | agente terapÊutico para discinesia |
| WO2007006591A2 (fr) | 2005-07-13 | 2007-01-18 | Bayer Cropscience Sa | Dihalogenation d'hydroxipyridones n,o-disubstituees et leurs utilisations |
| WO2007081901A2 (en) | 2006-01-05 | 2007-07-19 | The Scripps Research Institute | Pyrimidinone derivatives as protein kinase inhibitors |
| UY30378A1 (es) | 2006-06-02 | 2008-01-02 | Janssen Pharmaceutica Nv | Nuevos derivados de piridinona n-aril y n-heteroaril sustituidos para usar en enfermedades mediadas por mch-1 |
| WO2008041090A1 (en) * | 2006-10-06 | 2008-04-10 | Pfizer Limited | Malanin concentrating hormone receptor-1 antagonist pyridinones |
| WO2008062905A2 (en) | 2006-11-24 | 2008-05-29 | Takeda Pharmaceutical Company Limited | Heteromonocyclic compound and use thereof |
| JP2010512322A (ja) | 2006-12-07 | 2010-04-22 | ノバルティス アーゲー | 有機化合物 |
| WO2008153942A1 (en) | 2007-06-06 | 2008-12-18 | Xcovery, Inc. | Kinase inhibitor compounds |
| CA2693444A1 (en) | 2007-07-17 | 2009-01-22 | Bristol-Myers Squibb Company | Method for modulating gpr119 g protein-coupled receptor and selected compounds |
| PE20110136A1 (es) | 2008-06-27 | 2011-03-17 | Novartis Ag | Compuestos organicos |
| WO2011003007A1 (en) | 2009-07-01 | 2011-01-06 | Albany Molecular Research, Inc. | Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof |
| US8618299B2 (en) | 2009-07-01 | 2013-12-31 | Albany Molecular Research, Inc. | Azinone-substituted azapolycycle MCH-1 antagonists, methods of making, and use thereof |
| US9073925B2 (en) | 2009-07-01 | 2015-07-07 | Albany Molecular Research, Inc. | Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof |
| US8221753B2 (en) * | 2009-09-30 | 2012-07-17 | Tracon Pharmaceuticals, Inc. | Endoglin antibodies |
-
2011
- 2011-12-06 HR HRP20181788TT patent/HRP20181788T1/hr unknown
- 2011-12-06 PL PL11847595T patent/PL2648516T3/pl unknown
- 2011-12-06 HU HUE11847595A patent/HUE040101T2/hu unknown
- 2011-12-06 CA CA2819889A patent/CA2819889C/en active Active
- 2011-12-06 JP JP2013543290A patent/JP5848775B2/ja not_active Expired - Fee Related
- 2011-12-06 DK DK11847595.3T patent/DK2648516T3/da active
- 2011-12-06 US US13/312,924 patent/US20120142709A1/en not_active Abandoned
- 2011-12-06 WO PCT/US2011/063608 patent/WO2012078684A1/en not_active Ceased
- 2011-12-06 ES ES18192593T patent/ES2873029T3/es active Active
- 2011-12-06 CN CN201180066860XA patent/CN103391718A/zh active Pending
- 2011-12-06 EP EP11847595.3A patent/EP2648516B1/en active Active
- 2011-12-06 PT PT11847595T patent/PT2648516T/pt unknown
- 2011-12-06 SI SI201131605T patent/SI2648516T1/sl unknown
- 2011-12-06 EP EP18192593.4A patent/EP3469907B1/en not_active Not-in-force
- 2011-12-06 ES ES11847595T patent/ES2697607T3/es active Active
-
2014
- 2014-01-07 US US14/149,659 patent/US9365546B2/en not_active Expired - Fee Related
- 2014-01-07 US US14/149,741 patent/US9365547B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP2648516B1 (en) | 2018-09-05 |
| ES2873029T3 (es) | 2021-11-03 |
| JP5848775B2 (ja) | 2016-01-27 |
| EP2648516A4 (en) | 2014-04-30 |
| US9365546B2 (en) | 2016-06-14 |
| ES2697607T3 (es) | 2019-01-25 |
| US20140171449A1 (en) | 2014-06-19 |
| US9365547B2 (en) | 2016-06-14 |
| PL2648516T3 (pl) | 2019-04-30 |
| HRP20181788T1 (hr) | 2018-12-28 |
| CN103391718A (zh) | 2013-11-13 |
| US20120142709A1 (en) | 2012-06-07 |
| EP3469907A1 (en) | 2019-04-17 |
| CA2819889C (en) | 2020-12-15 |
| JP2013544889A (ja) | 2013-12-19 |
| HUE040101T2 (hu) | 2019-02-28 |
| US20140171450A1 (en) | 2014-06-19 |
| CA2819889A1 (en) | 2012-06-14 |
| EP2648516A1 (en) | 2013-10-16 |
| SI2648516T1 (sl) | 2019-01-31 |
| WO2012078684A1 (en) | 2012-06-14 |
| PT2648516T (pt) | 2018-11-29 |
| EP3469907B1 (en) | 2021-03-03 |
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