DK1641803T3 - Thienopyrimidinderivater som kaliumkanalinhibitorer - Google Patents
Thienopyrimidinderivater som kaliumkanalinhibitorerInfo
- Publication number
- DK1641803T3 DK1641803T3 DK04736524T DK04736524T DK1641803T3 DK 1641803 T3 DK1641803 T3 DK 1641803T3 DK 04736524 T DK04736524 T DK 04736524T DK 04736524 T DK04736524 T DK 04736524T DK 1641803 T3 DK1641803 T3 DK 1641803T3
- Authority
- DK
- Denmark
- Prior art keywords
- potassium channel
- channel inhibitors
- thienopyrimidine derivatives
- thienopyrimidine
- derivatives
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- RBNBDIMXFJYDLQ-UHFFFAOYSA-N thieno[3,2-d]pyrimidine Chemical class C1=NC=C2SC=CC2=N1 RBNBDIMXFJYDLQ-UHFFFAOYSA-N 0.000 title abstract 2
- 102000004257 Potassium Channel Human genes 0.000 title 1
- 108020001213 potassium channel Proteins 0.000 title 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 230000006793 arrhythmia Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47751803P | 2003-06-11 | 2003-06-11 | |
| GBGB0315950.6A GB0315950D0 (en) | 2003-06-11 | 2003-06-11 | Compounds |
| PCT/GB2004/002454 WO2004111057A1 (en) | 2003-06-11 | 2004-06-10 | Thienopyrimidine derivatives as potassium channel inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1641803T3 true DK1641803T3 (da) | 2009-06-29 |
Family
ID=33554173
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04736524T DK1641803T3 (da) | 2003-06-11 | 2004-06-10 | Thienopyrimidinderivater som kaliumkanalinhibitorer |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1641803B3 (da) |
| KR (1) | KR101186678B1 (da) |
| CN (1) | CN1823071B (da) |
| AT (1) | ATE425982T1 (da) |
| AU (1) | AU2004247470B2 (da) |
| BR (1) | BRPI0411239A (da) |
| CA (1) | CA2528848C (da) |
| DE (1) | DE602004020070D1 (da) |
| DK (1) | DK1641803T3 (da) |
| ES (1) | ES2324536T7 (da) |
| MX (1) | MXPA05013549A (da) |
| PL (1) | PL1641803T6 (da) |
| SI (1) | SI1641803T1 (da) |
| WO (1) | WO2004111057A1 (da) |
| ZA (1) | ZA200600225B (da) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0315950D0 (en) | 2003-06-11 | 2003-08-13 | Xention Discovery Ltd | Compounds |
| US7776867B2 (en) | 2004-06-29 | 2010-08-17 | Amgen Inc. | Furanopyrimidines |
| KR20140094626A (ko) * | 2004-10-21 | 2014-07-30 | 다우 아그로사이언시즈 엘엘씨 | 살진균 활성을 갖는 티에노-피리미딘 화합물 |
| US7576212B2 (en) | 2004-12-09 | 2009-08-18 | Xention Limited | Thieno[2,3-B] pyridines as potassium channel inhibitors |
| US7576080B2 (en) | 2004-12-23 | 2009-08-18 | Memory Pharmaceuticals Corporation | Certain thienopyrimidine derivatives as phosphodiesterase 10 inhibitors |
| US7915410B2 (en) | 2005-09-09 | 2011-03-29 | Bristol-Myers Squibb Company | Acyclic IKur inhibitors |
| GB0525164D0 (en) | 2005-12-09 | 2006-01-18 | Xention Discovery Ltd | Compounds |
| DE102007027800A1 (de) | 2007-06-16 | 2008-12-18 | Bayer Healthcare Ag | Substituierte bicyclische Heteroaryl-Verbindungen und ihre Verwendung |
| WO2010048287A2 (en) | 2008-10-22 | 2010-04-29 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Radioprotective agents |
| EP2405973B1 (en) | 2009-03-13 | 2015-04-22 | Katholieke Universiteit Leuven, K.U. Leuven R&D | Thiazolopyrimidine modulators as immunosuppressive agents |
| US8575184B2 (en) | 2009-09-03 | 2013-11-05 | Bristol-Myers Squibb Company | Quinazolines as potassium ion channel inhibitors |
| MA34064B1 (fr) * | 2010-02-17 | 2013-03-05 | Takeda Pharmaceutical | Compose heterocyclique |
| GB201012889D0 (en) | 2010-08-02 | 2010-09-15 | Univ Leuven Kath | Antiviral activity of novel bicyclic heterocycles |
| GB201015411D0 (en) | 2010-09-15 | 2010-10-27 | Univ Leuven Kath | Anti-cancer activity of novel bicyclic heterocycles |
| WO2012044993A1 (en) * | 2010-09-30 | 2012-04-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Compounds, pharmaceutical compositions, and methods of treating or preventing neurodegenerative diseases or disorders |
| GB201105659D0 (en) * | 2011-04-01 | 2011-05-18 | Xention Ltd | Compounds |
| NO3175985T3 (da) | 2011-07-01 | 2018-04-28 | ||
| AR090037A1 (es) * | 2011-11-15 | 2014-10-15 | Xention Ltd | Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio |
| EP2780344A1 (en) * | 2011-11-15 | 2014-09-24 | Xention Limited | Thieno [2, 3 - c]pyrazoles for use as potassium channel inhibitors |
| CA2855446C (en) | 2011-11-23 | 2021-04-20 | Cancer Research Technology Limited | Thienopyrimidine inhibitors of atypical protein kinase c |
| JP2015504923A (ja) | 2012-01-27 | 2015-02-16 | ギリアード サイエンシーズ， インコーポレイテッド | 後期ナトリウムイオンチャネル遮断剤およびカリウムイオンチャネル遮断剤を使用する併用療法 |
| WO2014134419A1 (en) | 2013-03-01 | 2014-09-04 | Gilead Sciences, Inc. | Use of ikach blockers for the treatment of cardiac diseases |
| US20160002273A1 (en) * | 2013-03-07 | 2016-01-07 | Glaxosmithkline Llc | Thieno[3,2-d]pyrimidine-6-carboxamides and analogues as sirtuin modulators |
| FR3015483B1 (fr) * | 2013-12-23 | 2016-01-01 | Servier Lab | Nouveaux derives de thienopyrimidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| CN106727587A (zh) * | 2016-11-28 | 2017-05-31 | 李娜 | 一种治疗心律失常的药物组合物 |
| MX2019014875A (es) * | 2017-06-21 | 2021-01-29 | SHY Therapeutics LLC | Compuestos que interaccionan con la superfamilia ras para el tratamiento de cancer, enfermedades inflamatorias, rasopatias y enfermedad fibrotica. |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD248593A1 (de) * | 1985-01-11 | 1987-08-12 | Univ Halle Wittenberg | Verfahren zur herstellung von 4-basischsubstituierten thieno/2,3-d/pyrimidin-6-ylcarbonsaeureestern |
| JP2003518101A (ja) | 1999-12-21 | 2003-06-03 | アイカゲン インコーポレイテッド | カリウムチャネル阻害剤 |
| US6566380B2 (en) | 2000-07-25 | 2003-05-20 | Icagen, Inc. | Potassium channel inhibitors |
| US6849634B2 (en) * | 2000-12-21 | 2005-02-01 | Icagen | Potassium channel inhibitors |
-
2004
- 2004-06-10 DK DK04736524T patent/DK1641803T3/da active
- 2004-06-10 ES ES04736524T patent/ES2324536T7/es active Active
- 2004-06-10 CN CN2004800201950A patent/CN1823071B/zh not_active Expired - Fee Related
- 2004-06-10 AT AT04736524T patent/ATE425982T1/de active
- 2004-06-10 AU AU2004247470A patent/AU2004247470B2/en not_active Ceased
- 2004-06-10 KR KR1020057023928A patent/KR101186678B1/ko not_active Expired - Fee Related
- 2004-06-10 PL PL04736524T patent/PL1641803T6/pl unknown
- 2004-06-10 EP EP04736524A patent/EP1641803B3/en not_active Expired - Lifetime
- 2004-06-10 WO PCT/GB2004/002454 patent/WO2004111057A1/en active Application Filing
- 2004-06-10 DE DE602004020070T patent/DE602004020070D1/de not_active Expired - Lifetime
- 2004-06-10 BR BRPI0411239-3A patent/BRPI0411239A/pt not_active Application Discontinuation
- 2004-06-10 CA CA2528848A patent/CA2528848C/en not_active Expired - Fee Related
- 2004-06-10 MX MXPA05013549A patent/MXPA05013549A/es active IP Right Grant
- 2004-06-10 SI SI200431150T patent/SI1641803T1/sl unknown
-
2006
- 2006-01-10 ZA ZA200600225A patent/ZA200600225B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA05013549A (es) | 2006-04-05 |
| PL1641803T3 (pl) | 2009-08-31 |
| AU2004247470B2 (en) | 2009-04-23 |
| SI1641803T1 (sl) | 2009-08-31 |
| PL1641803T6 (pl) | 2011-04-29 |
| CN1823071A (zh) | 2006-08-23 |
| AU2004247470A1 (en) | 2004-12-23 |
| CA2528848C (en) | 2012-09-04 |
| CA2528848A1 (en) | 2004-12-23 |
| ZA200600225B (en) | 2007-04-25 |
| KR101186678B1 (ko) | 2012-09-27 |
| KR20060057539A (ko) | 2006-05-26 |
| ATE425982T1 (de) | 2009-04-15 |
| ES2324536T7 (es) | 2012-03-16 |
| ES2324536T3 (es) | 2009-08-10 |
| EP1641803B3 (en) | 2010-12-08 |
| WO2004111057A1 (en) | 2004-12-23 |
| BRPI0411239A (pt) | 2006-07-18 |
| EP1641803A1 (en) | 2006-04-05 |
| DE602004020070D1 (de) | 2010-10-07 |
| CN1823071B (zh) | 2012-12-19 |
| HK1093064A1 (en) | 2007-02-23 |
| EP1641803B1 (en) | 2009-03-18 |
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