HRP950524B1 - Quinoxaline, process for its preparation and the use thereof - Google Patents

Quinoxaline, process for its preparation and the use thereof

Info

Publication number: HRP950524B1
Authority: HR; Croatia
Prior art keywords: quinoxaline; alkoxy; preparation; formula; carbonyl
Prior art date: 1994-10-19

Application number

HR950524A

Other languages

English (en)

Inventor

Manfred Roesner

Uta-Maria Billhardt-Troughton

Reinhard Kirsch

Joerg-Peter Kleim

Cristoph Meichsner

Guenther Riess

Irvin Winkler

Original Assignee

Aventis Pharma Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-10-19

Filing date

1995-10-18

Publication date

2002-06-30

1995-10-18 Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh

1997-10-31 Publication of HRP950524A2 publication Critical patent/HRP950524A2/hr

2002-06-30 Publication of HRP950524B1 publication Critical patent/HRP950524B1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Dental Preparations (AREA)
Medicinal Preparation (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Compounds Of Unknown Constitution (AREA)
Plural Heterocyclic Compounds (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

HR950524A 1994-10-19 1995-10-18 Quinoxaline, process for its preparation and the use thereof HRP950524B1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4437406A DE4437406A1 (de)	1994-10-19	1994-10-19	Chinoxaline, Verfahren zu ihrer Herstellung und ihre Verwendung

Publications (2)

Publication Number	Publication Date
HRP950524A2 HRP950524A2 (en)	1997-10-31
HRP950524B1 true HRP950524B1 (en)	2002-06-30

Family

ID=6531202

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR950524A HRP950524B1 (en)	1994-10-19	1995-10-18	Quinoxaline, process for its preparation and the use thereof

Country Status (27)

Country	Link
US (1)	US5723461A (fi)
EP (1)	EP0708093B1 (fi)
JP (1)	JPH08225544A (fi)
KR (1)	KR960014108A (fi)
CN (1)	CN1094930C (fi)
AT (1)	ATE198747T1 (fi)
AU (1)	AU708293B2 (fi)
BR (1)	BR9504456A (fi)
CA (1)	CA2160859A1 (fi)
CZ (1)	CZ271295A3 (fi)
DE (2)	DE4437406A1 (fi)
DK (1)	DK0708093T3 (fi)
ES (1)	ES2154311T3 (fi)
FI (1)	FI954946L (fi)
GR (1)	GR3035673T3 (fi)
HR (1)	HRP950524B1 (fi)
HU (1)	HUT73485A (fi)
IL (1)	IL115641A0 (fi)
MY (1)	MY132057A (fi)
NO (1)	NO306615B1 (fi)
NZ (1)	NZ280258A (fi)
PL (1)	PL184860B1 (fi)
PT (1)	PT708093E (fi)
SI (1)	SI9500329A (fi)
SK (1)	SK128495A3 (fi)
TW (1)	TW328954B (fi)
ZA (1)	ZA958783B (fi)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6369057B1 (en) *	1991-04-15	2002-04-09	Aventis Pharma Deutschland Gmbh	Quinoxalines, processes for their preparation and their use
US6015800A (en) *	1997-09-03	2000-01-18	Warner-Lambert Company	Substituted quinoxaline-2-ones as glutamate receptor antagonists
WO1999025327A2 (en) *	1997-11-14	1999-05-27	Warner-Lambert Company	Small molecule intervention in hiv-1 replication
GB9901795D0 (en) *	1999-01-28	1999-03-17	Glaxo Group Ltd	Chemical compounds
GB9911887D0 (en) *	1999-05-21	1999-07-21	Glaxo Group Ltd	Methods and medicaments for post exposure prophylaxis of an hiv infection
WO2002087500A2 (en) *	2001-04-27	2002-11-07	Newbiotics, Inc.	Viral enzyme activated prototoxophores and use of same to treat viral infections
WO2005018531A2 (en) *	2003-08-26	2005-03-03	'chemical Diversity Research Institute', Ltd.	Pharmaceutical compositions, azo-heterocyclic compounds and method for the production and use thereof
US7351709B2 (en) *	2004-06-09	2008-04-01	Wyeth	Estrogen receptor ligands
SI3459942T1 (sl)	2012-04-24	2021-05-31	Vertex Pharmaceuticals Incorporated	Inhibitorji DNA-PK
SG11201507203RA (en)	2013-03-12	2015-10-29	Vertex Pharma	Dna-pk inhibitors
JP6408569B2 (ja)	2013-10-17	2018-10-17	バーテックスファーマシューティカルズインコーポレイテッドＶｅｒｔｅｘＰｈａｒｍａｃｅｕｔｉｃａｌｓＩｎｃｏｒｐｏｒａｔｅｄ	Ｄｎａ−ｐｋ阻害剤としての（ｓ）−ｎ−メチル−８−（１−（（２’−メチル−［４，５’−ビピリミジン］−６−イル）アミノ）プロパン−２−イル）キノリン−４−カルボキサミドおよびその重水素化誘導体の共結晶
US11110108B2 (en)	2016-09-27	2021-09-07	Vertex Pharmaceuticals Incorporated	Method for treating cancer using a combination of DNA-damaging agents and DNA-PK inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT509398E (pt) *	1991-04-15	2002-02-28	Aventis Pharma Gmbh	Quinoxalinas processo para a sua preparacao e sua utilizacao
DE4342024A1 (de) *	1993-12-09	1995-06-14	Hoechst Ag	Kombinationspräparate, enthaltend ein Chinoxalin und ein Nukleosid

1994
- 1994-10-19 DE DE4437406A patent/DE4437406A1/de not_active Withdrawn
1995
- 1995-10-12 PT PT95116094T patent/PT708093E/pt unknown
- 1995-10-12 DE DE59508969T patent/DE59508969D1/de not_active Expired - Fee Related
- 1995-10-12 EP EP95116094A patent/EP0708093B1/de not_active Expired - Lifetime
- 1995-10-12 AT AT95116094T patent/ATE198747T1/de not_active IP Right Cessation
- 1995-10-12 DK DK95116094T patent/DK0708093T3/da active
- 1995-10-12 ES ES95116094T patent/ES2154311T3/es not_active Expired - Lifetime
- 1995-10-15 IL IL11564195A patent/IL115641A0/xx unknown
- 1995-10-16 TW TW084110841A patent/TW328954B/zh active
- 1995-10-17 SK SK1284-95A patent/SK128495A3/sk unknown
- 1995-10-17 NZ NZ280258A patent/NZ280258A/en unknown
- 1995-10-17 CZ CZ952712A patent/CZ271295A3/cs unknown
- 1995-10-17 US US08/544,290 patent/US5723461A/en not_active Expired - Fee Related
- 1995-10-17 FI FI954946A patent/FI954946L/fi unknown
- 1995-10-17 MY MYPI95003112A patent/MY132057A/en unknown
- 1995-10-17 AU AU34316/95A patent/AU708293B2/en not_active Ceased
- 1995-10-18 CN CN95120372A patent/CN1094930C/zh not_active Expired - Fee Related
- 1995-10-18 PL PL95311016A patent/PL184860B1/pl unknown
- 1995-10-18 CA CA002160859A patent/CA2160859A1/en not_active Abandoned
- 1995-10-18 HU HU9503005A patent/HUT73485A/hu unknown
- 1995-10-18 ZA ZA958783A patent/ZA958783B/xx unknown
- 1995-10-18 NO NO954139A patent/NO306615B1/no not_active IP Right Cessation
- 1995-10-18 KR KR1019950035876A patent/KR960014108A/ko not_active Abandoned
- 1995-10-18 HR HR950524A patent/HRP950524B1/xx not_active IP Right Cessation
- 1995-10-19 SI SI9500329A patent/SI9500329A/sl unknown
- 1995-10-19 JP JP7271019A patent/JPH08225544A/ja active Pending
- 1995-10-19 BR BR9504456A patent/BR9504456A/pt not_active IP Right Cessation
2001
- 2001-03-30 GR GR20010400523T patent/GR3035673T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
HK1011988A1 (en)	1999-07-23
NO306615B1 (no)	1999-11-29
DK0708093T3 (da)	2001-04-30
AU708293B2 (en)	1999-07-29
ZA958783B (en)	1996-05-09
MY132057A (en)	2007-09-28
FI954946A0 (fi)	1995-10-17
HU9503005D0 (en)	1995-12-28
GR3035673T3 (en)	2001-06-29
IL115641A0 (en)	1996-01-19
SI9500329A (en)	1996-04-30
EP0708093A1 (de)	1996-04-24
NO954139D0 (no)	1995-10-18
CZ271295A3 (en)	1996-08-14
HUT73485A (en)	1996-08-28
US5723461A (en)	1998-03-03
TW328954B (en)	1998-04-01
AU3431695A (en)	1996-05-02
KR960014108A (ko)	1996-05-22
NO954139L (no)	1996-04-22
DE59508969D1 (de)	2001-02-22
ATE198747T1 (de)	2001-02-15
HRP950524A2 (en)	1997-10-31
DE4437406A1 (de)	1996-04-25
JPH08225544A (ja)	1996-09-03
CN1094930C (zh)	2002-11-27
SK128495A3 (en)	1996-06-05
EP0708093B1 (de)	2001-01-17
PL311016A1 (en)	1996-04-29
CA2160859A1 (en)	1996-04-20
ES2154311T3 (es)	2001-04-01
CN1135483A (zh)	1996-11-13
FI954946A7 (fi)	1996-04-20
FI954946L (fi)	1996-04-20
PL184860B1 (pl)	2003-01-31
BR9504456A (pt)	1997-05-20
NZ280258A (en)	1997-09-22
PT708093E (pt)	2001-06-29

Publication	Publication Date	Title
HU9302696D0 (en)	1993-12-28	Process for producing aza quinoxaline derivatives and medical preparatives containing these compounds
EP0493608A4 (en)	1992-08-12	Quinolonecarboxylic acid derivative
HRP950524B1 (en)	2002-06-30	Quinoxaline, process for its preparation and the use thereof
EP0342675A3 (en)	1990-12-27	Novel quinolonecarboxylic acid derivatives
NZ290389A (en)	1999-03-29	Substituted pyrimidines typically substituted by -piperazin-1-yl
ES8602754A1 (es)	1985-12-01	Un procedimiento para la obtencion de agentes antibacteria- nos a base de acidos 7-amino-1-ciclopropil-6,8-difluor-1, 4-dihidro-4-oxo-3-quinolincarboxilicos
AU1485392A (en)	1992-10-22	Quinoxalines, processes for their preparation, and their use
IL118368A (en)	1997-09-30	N-oxide quinoxaline derivatives
DE3682032D1 (de)	1991-11-21	Propylamine, verfahren zu ihrer herstellung und ihre verwendung als fungizide.
MX9708696A (es)	1998-08-30	Cefalosporinas antibacterianas.
MX9702203A (es)	1997-06-28	Derivados de pirazolil-pirazol substituidos, procedimientos para su preparacion y su uso como agentes con accion herbicida.
IL117150A (en)	2001-03-19	Substituted benzenesulfonylureas and - thioureas processes for their preparation their use in the preparation of medicaments and pharmaceutical compositions containing them
ATE189806T1 (de)	2000-03-15	Substituierte benzylderivate von polyalkylenpolyaminen und ihre verwendung in kosmetischen und pharmazeutischen zusammensetzungen
EP0487996B1 (de)	1998-07-22	3-substituierte Cephalosporine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
MX9705379A (es)	1997-10-31	Uso de los 3,4-difenil-cromanos para la fabricacion de una composicion farmaceutica para el tratamiento o profilaxis vasodilatadora.
ES8202811A1 (es)	1982-03-01	Un procedimiento para la preparacion de derivados de benzo (1,4) dioxina
MX9705390A (es)	1997-10-31	Uso de los 3,4-difenil-cromanos para la fabricacion de una composicion farmaceutica para el tratamiento o profilaxis de desordenes degenerativos cerebrales.
IL99369A0 (en)	1992-08-18	Pharmaceutical compositions containing substituted 2-cyclohexene derivatives
ZA908309B (en)	1991-08-28	Dibenzodioxazecine and dibenzodioxaazacycloundecine derivatives
ES459471A1 (es)	1978-04-16	Procedimiento para la preparacion de nuevas-9-alcohilamino- eritromicinas.

Legal Events

Date	Code	Title	Description
1997-10-31	A1OB	Publication of a patent application
1998-04-30	AIPI	Request for the grant of a patent on the basis of a substantive examination of a patent application
2001-03-21	PPPP	Transfer of rights	Owner name: AVENTIS PHARMA DEUTSCHLAND GMBH, DE
2002-06-30	B1PR	Patent granted
2002-10-18	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20021018 Year of fee payment: 8
2004-04-19	PBON	Lapse due to non-payment of renewal fee	Effective date: 20031019