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HRP20171236T1 - Upotreba prolijekova kanabidiola u topičkoj i transdermalnoj primjeni s mikroiglama - Google Patents

Upotreba prolijekova kanabidiola u topičkoj i transdermalnoj primjeni s mikroiglama Download PDF

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Publication number
HRP20171236T1
HRP20171236T1 HRP20171236TT HRP20171236T HRP20171236T1 HR P20171236 T1 HRP20171236 T1 HR P20171236T1 HR P20171236T T HRP20171236T T HR P20171236TT HR P20171236 T HRP20171236 T HR P20171236T HR P20171236 T1 HRP20171236 T1 HR P20171236T1
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Croatia
Prior art keywords
pharmaceutical preparation
hours
administration
group
microneedles
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HRP20171236TT
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English (en)
Inventor
Audra Lynn Stinchcomb
Stan Lee Banks
Miroslaw Jerzy Golinski
Jeffrey Lynn Howard
Dana Carmel Hammell
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Zynerba Pharmaceuticals, Inc.
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Publication of HRP20171236T1 publication Critical patent/HRP20171236T1/hr

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    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
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Claims (14)

1. Sustav s mikroiglama za isporuku lijeka za transdermalnu ili topičku primjenu predlijeka kanabidiola kod sisavca, naznačen time, da sadržava: a) farmaceutski pripravak koji sadržava predlijek kanabidiola koji ima formulu: [image] Pri čemu je X- protuion izveden iz farmaceutski prihvatljivih kiselina, i b) niz mikroigala, pri čemu je farmaceutski pripravak namijenjen za primjenu na kožu sisavca povezan s nizom mikroigala, bilo prije davanja nizom mikroigala, nakon davanja nizom mikroigala ili istovremeno s davanjem nizom mikroigala.
2. Sustav za primjenu lijeka u skladu s patentnim zahtjevom 1, naznačen time, da je predlijek kanabidiola prisutan u količini od oko 0,1 % do oko 50 % (težinski), oko 1 % do oko 40 % (tež. / tež.), oko 5 % do oko 30 % (tež. / tež.) ili oko 10 % do oko 20 % (tež. / tež.) farmaceutskog pripravka.
3. Sustav za primjenu lijeka u skladu s patentnim zahtjevom 1, naznačen time, da je farmaceutski pripravak u obliku hidrogela, poželjno je da je hidrogel ugrađen u naljepke tipa matrice ili rezervoara.
4. Sustav za primjenu lijeka u skladu sa zahtjevom 1, naznačen time, da farmaceutski pripravak nadalje sadrži inhibitor COX bira iz skupine koju čine: aspirin, diklofenak, diflunisal, fenoprofen, flurbiprofen, ibuprofen, indometacin, ketoprofen, ketorolak, mefenaminska kiselina, meloksikam, nabumeton naproksen, olsalzin, oksaprozin, piroksikam, salsalat, sulfasalazin, sulindak, tolmetin, mofezolak, SC-560, FR 122047, etodolak, celekoksib, rofekoksib, valdekoksib, parekoksib, lumirakoksib i etorikoksib.
5. Sustav za primjenu lijeka u skladu sa zahtjevom 1, naznačen time, da farmaceutski pripravak nadalje sadrži pojačivač prodiranja koji je odabran iz skupine koja se sastoji od sljedećeg: izostearinska kiselina, oktanoična kiselina, oleinska kiselina, oleil alkohol, lauril alkohol, etil-oleat, izopropil miristat, butil stearat, metil laurat, diizopropil adipat, gliceril monolaurat, tetrahidrofurfuril alkohol polietilen glikol eter, polietilen glikol, propilen glikol, 2-(2-etoksietoksi) etanol, dietilen glikol monometil eter, alkilaril eteri polietilen oksida, polietilen oksida monometil etera, polietilen oksid dimetil etera, dimetilsulfoksid, glicerol, ester acetooctene kiseline, N- alkil-pirolidon, terpeni, noktanol, natrijev oleat, D-limonen, monoolein, cineol, oleil oleat, etanol, propanol, butanol, 2-butanol, pentanol, 2-pentanol, heksanol, oktanol, nonanol, dekanol, benzil alkohol, Poliksamer 231, Poliksamer 182, Poliksamer 184, Polisorbat 20, Polisorbat 60, Brij 30, Brij 93, Brij 96, Brij 99, Span 20, Span 40, Span 60, Span 80, Span 85, Tween 20, Tween 40, Tween 60, Tween 80, Myrj 45, Myrj 51, Myrj 52 i Miglyol 840, pri čemu je poželjno da promotor prolaska bude prisutan u količini od oko 0,1 % do oko 40 % (tež. / tež.), oko 0,1 % do oko 30 % (tež. / tež.), oko 1 % do oko 20 % (tež. / tež.) ili od 1 % do oko 10 % (tež. / tež.) farmaceutskog pripravka.
6. Sustav za primjenu lijeka prema zahtjevu 1, naznačen time, da farmaceutski pripravak nadalje sadrži niži alkohol odabran iz skupine koju čine: etanol i izopropanol.
7. Sustav za primjenu lijeka u skladu s patentnim zahtjevom 1, naznačen time, da farmaceutski pripravak daje terapeutski učinkovitu količinu predlijeka kanabidiola tijekom vremenskog razdoblja odabranog iz skupine koju čine: oko 1 sat, oko 2 sata, oko 3 sata, oko 4 sata, oko 6 sati, oko 12 sati, oko 24 sata, oko 48 sati, oko 72 sata, oko 96 sati, oko 5 dana, oko 6 dana ili oko 7 dana.
8. Sustav s mikroiglama za isporuku lijeka u skladu s bilo kojim od zahtjeva 1 do 7, naznačen time, da je bolesno stanje odabrano iz skupine koju čine: akutni pankreatitis, kronični pankreatitis, rak gušterače, mučnina, povraćanje, bol, sindrom propadanja, propadanje uzrokovano HIV-om, kemoterapijom izazvane mučnine i povraćanja, poremećaji zbog upotrebe alkohola, distonija, multipla skleroza, upalne crijevne bolesti, artritis, dermatitis, reumatoidni artritis, sistemski eritematozni lupus, melanom, periferna neuropatska bol, neuropatska bol povezana s post- herpetičkom neuralgijom, dijabetička neuropatija, crvenilo, opekline, aktinska keratoza, rane i čirevi u usnoj šupljini, bol nakon epiziotomije, psorijaza, svrbež, kontaktni dermatitis, ekcem, bulozni dermatitis herpetiformis, eksfolijativni dermatitis, mycosis fungoides, pemfigus, teški multiformni eritem (npr. Stevens- Johnsonov sindrom), seboreični dermatitis, ankilozantni spondilitis, psorijatični artritis, Reiterov sindrom, giht, hondrokalcinoza, bol u zglobovima nakon dismenoreje, fibromijalgija, mišićno-koštana bol, neuropatske postoperativne komplikacije, polimiozitis, akutni nespecifični tenosinovitis, bursitis, epikondilitis, posttraumatski osteoartritis, osteoartritis, reumatoidni artritis, sinovitis, juvenilni reumatoidni artritis i inhibicija rasta dlačica.
9. Sustav za primjenu lijeka prema zahtjevu 1, naznačen time, da farmaceutski pripravak sadržava i. oko 0,1 % do oko 40 % predlijeka kanabidiola, ii. oko 0,1 % do oko 20 % jednog ili više kootapala, iii. oko 15 % do oko 95 % nižeg alkohola i iv. vodu u količini dovoljnoj da pripravak dostigne do 100 % (tež. / tež.).
10. Sustav za primjenu lijeka prema zahtjevu 9, naznačen time, da je predlijek kanabidiola prisutan u količini od oko 5 % do oko 30 % (tež. / tež.) ili oko 10 % do oko 20 % (tež. / tež.) farmaceutskog pripravka.
11. Sustav za primjenu lijeka prema zahtjevu 9, naznačen time, da je svako od kootapala odabrano iz skupine koju čine: etanol, benzil alkohol i njihove smjese.
12. Sustav za primjenu lijeka prema zahtjevu 9, naznačen time, da je farmaceutski pripravak u obliku hidrogela, poželjno je da je hidrogel ugrađen u matricu ili naljepak sa spremnikom.
13. Sustav za primjenu lijeka prema zahtjevu 9, naznačen time, da farmaceutski pripravak nadalje sadrži inhibitor COX odabran iz skupine koju čine: nespecifični inhibitor COX, inhibitor COX-1 i inhibitor COX-2.
14. Spoj, naznačen time, da je to spoj odabran iz skupine koju čine: [image] i pri čemu je X- protuion izveden iz farmaceutski prihvatljivih kiselin
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US20110052694A1 (en) 2011-03-03
CA2772634C (en) 2017-11-21
PT2473475T (pt) 2017-08-02
US9533942B2 (en) 2017-01-03
LT2473475T (lt) 2017-08-10
CY1119059T1 (el) 2018-01-10
CA2772634A1 (en) 2011-03-03
PL2473475T3 (pl) 2018-02-28
EP2473475B1 (en) 2017-05-31
SMT201700391T1 (it) 2017-09-07
ES2635084T3 (es) 2017-10-02
EP2473475A1 (en) 2012-07-11
WO2011026144A1 (en) 2011-03-03
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DK2473475T3 (en) 2017-06-26
JP2013503206A (ja) 2013-01-31

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