HRP20090012T3 - 2h or 3h-benzo[e]indazol-1-yle carbamate derivatives, the preparation and therapeutic use thereof - Google Patents

2h or 3h-benzo[e]indazol-1-yle carbamate derivatives, the preparation and therapeutic use thereof

Info

Publication number: HRP20090012T3
Authority: HR; Croatia
Prior art keywords: group; alkyl; aryl; fluoroalkyl; atom
Prior art date: 2004-05-11

Application number

HR20090012T

Other languages

English (en)

Croatian (hr)

Inventor

Dubois Laurent

Evanno Yannick

Maloizel Christian

Sevrin Mireille

Original Assignee

Sanofi-Aventis

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-05-11

Filing date

2005-05-10

Publication date

2009-02-28

2005-05-10 Application filed by Sanofi-Aventis filed Critical Sanofi-Aventis

2009-02-28 Publication of HRP20090012T3 publication Critical patent/HRP20090012T3/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
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- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
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- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Psychiatry (AREA)
Psychology (AREA)
Hematology (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Transplantation (AREA)
Anesthesiology (AREA)
Obesity (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Toxicology (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)

HR20090012T 2004-05-11 2005-05-10 2h or 3h-benzo[e]indazol-1-yle carbamate derivatives, the preparation and therapeutic use thereof HRP20090012T3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0405055A FR2870239B1 (fr)	2004-05-11	2004-05-11	Derives de carbamate de 2h- ou 3h-benzo[e]indazol-1-yle, leur preparation et leur application en therapeutique.
PCT/FR2005/001154 WO2005121099A1 (fr)	2004-05-11	2005-05-10	Derives de carbamate de 2h- ou 3h-benzo[e]indazol-1-yle, leur preparation et leur application en therapeutique

Publications (1)

Publication Number	Publication Date
HRP20090012T3 true HRP20090012T3 (en)	2009-02-28

Family

ID=34947852

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20090012T HRP20090012T3 (en)	2004-05-11	2005-05-10	2h or 3h-benzo[e]indazol-1-yle carbamate derivatives, the preparation and therapeutic use thereof

Country Status (32)

Country	Link
US (3)	US7501449B2 (xx)
EP (1)	EP1747201B8 (xx)
JP (1)	JP4909889B2 (xx)
KR (1)	KR101165483B1 (xx)
CN (1)	CN100577648C (xx)
AR (1)	AR049090A1 (xx)
AT (1)	ATE411295T1 (xx)
AU (1)	AU2005251982B2 (xx)
BR (1)	BRPI0508563A (xx)
CA (1)	CA2557942C (xx)
CR (1)	CR8570A (xx)
CY (1)	CY1108710T1 (xx)
DE (1)	DE602005010418D1 (xx)
DK (1)	DK1747201T3 (xx)
EC (1)	ECSP066810A (xx)
ES (1)	ES2315898T3 (xx)
FR (1)	FR2870239B1 (xx)
HR (1)	HRP20090012T3 (xx)
IL (1)	IL177632A (xx)
MA (1)	MA28372A1 (xx)
NO (1)	NO20064073L (xx)
NZ (1)	NZ549330A (xx)
PL (1)	PL1747201T3 (xx)
PT (1)	PT1747201E (xx)
RS (1)	RS50724B (xx)
RU (1)	RU2379293C2 (xx)
SI (1)	SI1747201T1 (xx)
TN (1)	TNSN06258A1 (xx)
TW (1)	TWI349004B (xx)
UA (1)	UA85866C2 (xx)
WO (1)	WO2005121099A1 (xx)
ZA (1)	ZA200607244B (xx)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2870239B1 (fr) *	2004-05-11	2006-06-16	Sanofi Synthelabo	Derives de carbamate de 2h- ou 3h-benzo[e]indazol-1-yle, leur preparation et leur application en therapeutique.
WO2007088528A1 (en) *	2006-02-03	2007-08-09	The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth, Near Dublin	Microtubule targeting agents
CL2008000793A1 (es) *	2007-03-23	2008-05-30	Xenon Pharmaceuticals Inc	Compuestos derivados de dihidroindazol; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar un trastorno del hierro.
BR112016000869B1 (pt) *	2013-07-15	2021-07-06	Basf Se	composto, composição agrícola, composição veterinária e usos de um composto

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0607076A1 (fr) *	1993-01-15	1994-07-20	Synthelabo	Dérivés de 9h-imidazo 1,2-a benzimidazole-3-acétamide à activité GABA
TW403738B (en) *	1994-08-12	2000-09-01	Hoffmann La Roche	Tricyclic pyrazole derivatives
FR2741073B1 (fr) *	1995-11-09	1997-12-12	Synthelabo	Derives de 4,5-dihydroimidazo(1,2-a)pyrrolo(1,2,3-cd) benzimidazole, leur preparation et leur application en therapeutique
AR006520A1 (es) *	1996-03-20	1999-09-08	Astra Pharma Prod	Derivados de 2-arilpirazolisoquinolina y cinolinona y procedimiento para su preparacion.
ZA9810490B (en) *	1997-12-03	1999-05-20	Dainippon Pharmaceutical Co	2-Aryl-8-oxodihydropurine derivative process for the preparation thereof pharmaceutical composition containing the same and intermediate therefor
WO1999058117A1 (fr) *	1998-05-13	1999-11-18	Sanofi-Synthelabo	Utilisation de composes reduisant l'apoptose
CA2419966A1 (en) *	2000-09-06	2002-03-14	Neurogen Corporation	Aryl substituted tetrahydroindazoles and their use as ligands for the gaba-a receptor
CA2742411A1 (en) *	2000-09-18	2002-03-21	Eisai R&D Management Co., Ltd.	Pyridazinone and triazinone compounds and use thereof as pharmaceutical preparations
FR2870239B1 (fr) *	2004-05-11	2006-06-16	Sanofi Synthelabo	Derives de carbamate de 2h- ou 3h-benzo[e]indazol-1-yle, leur preparation et leur application en therapeutique.

2004
- 2004-05-11 FR FR0405055A patent/FR2870239B1/fr not_active Expired - Fee Related
2005
- 2005-05-09 AR ARP050101865A patent/AR049090A1/es unknown
- 2005-05-10 PL PL05770962T patent/PL1747201T3/pl unknown
- 2005-05-10 BR BRPI0508563-2A patent/BRPI0508563A/pt not_active IP Right Cessation
- 2005-05-10 RU RU2006132325/04A patent/RU2379293C2/ru not_active IP Right Cessation
- 2005-05-10 PT PT05770962T patent/PT1747201E/pt unknown
- 2005-05-10 DK DK05770962T patent/DK1747201T3/da active
- 2005-05-10 WO PCT/FR2005/001154 patent/WO2005121099A1/fr active Application Filing
- 2005-05-10 AU AU2005251982A patent/AU2005251982B2/en not_active Ceased
- 2005-05-10 TW TW094114981A patent/TWI349004B/zh not_active IP Right Cessation
- 2005-05-10 CN CN200580007686A patent/CN100577648C/zh not_active Expired - Fee Related
- 2005-05-10 NZ NZ549330A patent/NZ549330A/en not_active IP Right Cessation
- 2005-05-10 CA CA2557942A patent/CA2557942C/fr not_active Expired - Fee Related
- 2005-05-10 SI SI200530546T patent/SI1747201T1/sl unknown
- 2005-05-10 EP EP05770962A patent/EP1747201B8/fr not_active Expired - Lifetime
- 2005-05-10 JP JP2007512277A patent/JP4909889B2/ja not_active Expired - Fee Related
- 2005-05-10 AT AT05770962T patent/ATE411295T1/de active
- 2005-05-10 DE DE602005010418T patent/DE602005010418D1/de not_active Expired - Lifetime
- 2005-05-10 ES ES05770962T patent/ES2315898T3/es not_active Expired - Lifetime
- 2005-05-10 HR HR20090012T patent/HRP20090012T3/xx unknown
- 2005-05-10 RS RSP-2009/0012A patent/RS50724B/sr unknown
- 2005-05-10 KR KR1020067018339A patent/KR101165483B1/ko not_active Expired - Lifetime
- 2005-10-05 UA UAA200609699A patent/UA85866C2/uk unknown
2006
- 2006-08-15 TN TNP2006000258A patent/TNSN06258A1/fr unknown
- 2006-08-22 IL IL177632A patent/IL177632A/en not_active IP Right Cessation
- 2006-08-24 CR CR8570A patent/CR8570A/es unknown
- 2006-08-29 MA MA29294A patent/MA28372A1/fr unknown
- 2006-08-29 EC EC2006006810A patent/ECSP066810A/es unknown
- 2006-08-30 ZA ZA2006/07244A patent/ZA200607244B/en unknown
- 2006-09-11 NO NO20064073A patent/NO20064073L/no not_active Application Discontinuation
- 2006-10-13 US US11/549,293 patent/US7501449B2/en not_active Expired - Fee Related
2009
- 2009-01-14 CY CY20091100042T patent/CY1108710T1/el unknown
- 2009-01-27 US US12/360,535 patent/US8114899B2/en not_active Expired - Fee Related
2012
- 2012-01-11 US US13/348,241 patent/US8258168B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CR8570A (es)	2007-10-04
ATE411295T1 (de)	2008-10-15
US8258168B2 (en)	2012-09-04
CN100577648C (zh)	2010-01-06
IL177632A (en)	2012-07-31
AR049090A1 (es)	2006-06-28
AU2005251982A1 (en)	2005-12-22
RS50724B (sr)	2010-08-31
MA28372A1 (fr)	2006-12-01
BRPI0508563A (pt)	2007-08-14
NZ549330A (en)	2010-08-27
ES2315898T3 (es)	2009-04-01
ZA200607244B (en)	2008-04-30
US20120108584A1 (en)	2012-05-03
RU2006132325A (ru)	2008-03-20
KR101165483B1 (ko)	2012-07-13
US20090143380A1 (en)	2009-06-04
CA2557942C (fr)	2013-08-06
DE602005010418D1 (de)	2008-11-27
CA2557942A1 (fr)	2005-12-22
TNSN06258A1 (fr)	2007-12-03
DK1747201T3 (da)	2009-02-16
FR2870239A1 (fr)	2005-11-18
CY1108710T1 (el)	2014-04-09
PT1747201E (pt)	2009-01-19
FR2870239B1 (fr)	2006-06-16
AU2005251982B2 (en)	2011-04-28
JP2007537212A (ja)	2007-12-20
TWI349004B (en)	2011-09-21
KR20070007796A (ko)	2007-01-16
UA85866C2 (uk)	2009-03-10
US20070105932A1 (en)	2007-05-10
CN1930131A (zh)	2007-03-14
US7501449B2 (en)	2009-03-10
TW200604181A (en)	2006-02-01
SI1747201T1 (sl)	2009-04-30
EP1747201B1 (fr)	2008-10-15
NO20064073L (no)	2006-11-06
EP1747201A1 (fr)	2007-01-31
HK1104288A1 (en)	2008-01-11
WO2005121099A1 (fr)	2005-12-22
IL177632A0 (en)	2006-12-31
RU2379293C2 (ru)	2010-01-20
PL1747201T3 (pl)	2009-04-30
ECSP066810A (es)	2006-11-16
US8114899B2 (en)	2012-02-14
EP1747201B8 (fr)	2009-02-18
JP4909889B2 (ja)	2012-04-04

Publication	Publication Date	Title
ATE556058T1 (de)	2012-05-15	1-(2h)-isochinolonderivat
NO20090952L (no)	2009-04-23	N-(aminoheteroaryl) - lh - indol-2-karboksamidderivater og fremstilling og terapeutisk anvendelse derav
NO20070555L (no)	2007-01-30	Kinazolinonderivater som parp-inhibitorer
NO20082346L (no)	2008-08-04	Hydrazonderivater og anvendelser derav
CY1118723T1 (el)	2017-07-12	Ενωσεις βενζοθειαζολιου και αζαβενζοθειαζολιου χρησιμες ως αναστολεiς κινασης
NO20076006L (no)	2007-11-21	Acetylenderivater
EA200800873A1 (ru)	2008-08-29	Конденсированные гетероциклические соединения, полезные в качестве модуляторов киназы
BRPI0506817A (pt)	2007-05-29	inibidores seletivos de quinase
ATE478044T1 (de)	2010-09-15	Biphenylderivate und ihre verwendung bei der behandlung von hepatitis c
NO20070557L (no)	2007-01-30	Ftalazinderivater som PARP-inhibitorer
TW200745029A (en)	2007-12-16	Sulfonamide derivatives exhibiting PGD2 receptor antagonism
NO20062269L (no)	2006-05-24	Pyridin-karboksylsyrederivater som glucokinasemodulatorer
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