HRP20020672B1 - Pluraflavins and derivatives thereof, process for their preparation and use thereof - Google Patents

Pluraflavins and derivatives thereof, process for their preparation and use thereof

Info

Publication number: HRP20020672B1
Authority: HR; Croatia
Prior art keywords: groups; group; alkenyl; independently selected; alkyl groups
Prior art date: 2000-02-18

Application number

HR20020672A

Other languages

English (en)

Croatian (hr)

Inventor

Vertesy Laszlo

Ehrlich Klaus

Knauf Martin

Wink Joachim

P. Barbone Francis

A. Powers Elaine

A. Cashman Elizabeth

Original Assignee

Sanofi-Aventis Deutschland Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-02-18

Filing date

2002-08-14

Publication date

2010-12-31

2002-08-14 Application filed by Sanofi-Aventis Deutschland Gmbh filed Critical Sanofi-Aventis Deutschland Gmbh

2004-12-31 Publication of HRP20020672A2 publication Critical patent/HRP20020672A2/hr

2010-12-31 Publication of HRP20020672B1 publication Critical patent/HRP20020672B1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/58—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound through only acyclic carbon atoms to a non-saccharide heterocyclic ring, e.g. bleomycin, phleomycin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biochemistry (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Molecular Biology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Biomedical Technology (AREA)
Virology (AREA)
Tropical Medicine & Parasitology (AREA)
Hematology (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Reproductive Health (AREA)
Obesity (AREA)
Pulmonology (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Saccharide Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

HR20020672A 2000-02-18 2002-08-14 Pluraflavins and derivatives thereof, process for their preparation and use thereof HRP20020672B1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP00103540A EP1125944A1 (de)	2000-02-18	2000-02-18	Pluraflavine und Derivate davon, Verfahren zu ihrer Herstellung und Verwendung derselben
PCT/EP2001/001660 WO2001060832A2 (en)	2000-02-18	2001-02-15	Pluraflavins and derivatives thereof, process for their preparation and use thereof

Publications (2)

Publication Number	Publication Date
HRP20020672A2 HRP20020672A2 (en)	2004-12-31
HRP20020672B1 true HRP20020672B1 (en)	2010-12-31

Family

ID=8167898

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20020672A HRP20020672B1 (en)	2000-02-18	2002-08-14	Pluraflavins and derivatives thereof, process for their preparation and use thereof

Country Status (31)

Country	Link
US (1)	US6500936B2 (pl)
EP (2)	EP1125944A1 (pl)
JP (1)	JP4801307B2 (pl)
KR (1)	KR100743380B1 (pl)
CN (1)	CN1162441C (pl)
AR (1)	AR027436A1 (pl)
AT (1)	ATE255120T1 (pl)
AU (2)	AU4240401A (pl)
BR (1)	BR0108128A (pl)
CA (1)	CA2400237C (pl)
CZ (1)	CZ303810B6 (pl)
DE (1)	DE60101313T2 (pl)
DK (1)	DK1259523T3 (pl)
EE (1)	EE05137B1 (pl)
ES (1)	ES2207609T3 (pl)
HK (1)	HK1052709B (pl)
HR (1)	HRP20020672B1 (pl)
HU (1)	HU228332B1 (pl)
IL (2)	IL151216A0 (pl)
ME (1)	ME00179B (pl)
MX (1)	MXPA02006919A (pl)
NO (1)	NO323413B1 (pl)
PL (1)	PL204842B1 (pl)
PT (1)	PT1259523E (pl)
RS (1)	RS49991B (pl)
RU (1)	RU2255940C2 (pl)
SI (1)	SI1259523T1 (pl)
SK (1)	SK286691B6 (pl)
TR (1)	TR200302180T4 (pl)
WO (1)	WO2001060832A2 (pl)
ZA (1)	ZA200206795B (pl)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6989386B2 (en) *	2002-04-30	2006-01-24	Dana-Farber Cancer Institute	Pharmaceutically active ornithine derivatives, ammonium salts thereof and methods of making same
CN101921300B (zh) *	2009-06-10	2014-04-02	上海来益生物药物研究开发中心有限责任公司	一种异黄酮苷类化合物及其制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1990009435A1 (en) *	1989-02-07	1990-08-23	Abbott Laboratories	Altromycin compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0274545B1 (en) *	1986-07-21	1992-12-02	Kyowa Hakko Kogyo Co., Ltd.	Novel substances dc-92b and dc-92d, and process for their preparation
WO1990000935A1 (en) *	1988-07-22	1990-02-08	Masco Corporation Of Indiana	A small hand-held shower head for domestic sinks connected to a faucet
US5001058A (en) *	1988-09-19	1991-03-19	Bristol-Myers Company	BU-3839T antibiotic
US5168100A (en) *	1990-03-16	1992-12-01	Sapporo Breweries Limited	Hp530 compounds and process for preparing the same
CA2778804C (en) *	2007-07-06	2015-12-22	Rite-Hite Holding Corporation	Retractable safety barriers and methods of operating same

2000
- 2000-02-18 EP EP00103540A patent/EP1125944A1/de not_active Withdrawn
2001
- 2001-02-15 AR ARP010100689A patent/AR027436A1/es not_active Application Discontinuation
- 2001-02-15 CZ CZ20022826A patent/CZ303810B6/cs not_active IP Right Cessation
- 2001-02-15 WO PCT/EP2001/001660 patent/WO2001060832A2/en active IP Right Grant
- 2001-02-15 HU HU0204393A patent/HU228332B1/hu not_active IP Right Cessation
- 2001-02-15 BR BR0108128-4A patent/BR0108128A/pt not_active Application Discontinuation
- 2001-02-15 MX MXPA02006919A patent/MXPA02006919A/es active IP Right Grant
- 2001-02-15 SK SK1180-2002A patent/SK286691B6/sk not_active IP Right Cessation
- 2001-02-15 CN CNB01805207XA patent/CN1162441C/zh not_active Expired - Fee Related
- 2001-02-15 RS YUP-576/02A patent/RS49991B/sr unknown
- 2001-02-15 DE DE60101313T patent/DE60101313T2/de not_active Expired - Lifetime
- 2001-02-15 ME MEP-2008-286A patent/ME00179B/me unknown
- 2001-02-15 AU AU4240401A patent/AU4240401A/xx active Pending
- 2001-02-15 EP EP01915255A patent/EP1259523B1/en not_active Expired - Lifetime
- 2001-02-15 IL IL15121601A patent/IL151216A0/xx unknown
- 2001-02-15 AT AT01915255T patent/ATE255120T1/de active
- 2001-02-15 CA CA002400237A patent/CA2400237C/en not_active Expired - Fee Related
- 2001-02-15 ES ES01915255T patent/ES2207609T3/es not_active Expired - Lifetime
- 2001-02-15 RU RU2002124772/04A patent/RU2255940C2/ru not_active IP Right Cessation
- 2001-02-15 PL PL358297A patent/PL204842B1/pl unknown
- 2001-02-15 DK DK01915255T patent/DK1259523T3/da active
- 2001-02-15 PT PT01915255T patent/PT1259523E/pt unknown
- 2001-02-15 SI SI200130056T patent/SI1259523T1/xx unknown
- 2001-02-15 AU AU2001242404A patent/AU2001242404B2/en not_active Ceased
- 2001-02-15 JP JP2001560216A patent/JP4801307B2/ja not_active Expired - Fee Related
- 2001-02-15 TR TR2003/02180T patent/TR200302180T4/xx unknown
- 2001-02-15 KR KR1020027010629A patent/KR100743380B1/ko not_active IP Right Cessation
- 2001-02-15 EE EEP200200438A patent/EE05137B1/xx not_active IP Right Cessation
- 2001-02-16 US US09/784,035 patent/US6500936B2/en not_active Expired - Lifetime
2002
- 2002-08-12 IL IL151216A patent/IL151216A/en not_active IP Right Cessation
- 2002-08-14 HR HR20020672A patent/HRP20020672B1/xx not_active IP Right Cessation
- 2002-08-14 NO NO20023845A patent/NO323413B1/no not_active IP Right Cessation
- 2002-08-26 ZA ZA200206795A patent/ZA200206795B/en unknown
2003
- 2003-07-09 HK HK03104938.4A patent/HK1052709B/zh not_active IP Right Cessation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1990009435A1 (en) *	1989-02-07	1990-08-23	Abbott Laboratories	Altromycin compounds

Also Published As

Publication number	Publication date
US20020028921A1 (en)	2002-03-07
WO2001060832A2 (en)	2001-08-23
HUP0204393A3 (en)	2007-10-29
HUP0204393A2 (hu)	2003-07-28
BR0108128A (pt)	2003-02-25
DE60101313T2 (de)	2004-09-30
US6500936B2 (en)	2002-12-31
DK1259523T3 (da)	2004-03-22
NO20023845D0 (no)	2002-08-14
AU2001242404B2 (en)	2005-04-14
SK286691B6 (sk)	2009-03-05
NO20023845L (no)	2002-10-10
MXPA02006919A (es)	2004-04-05
EP1125944A1 (de)	2001-08-22
PL204842B1 (pl)	2010-02-26
HU228332B1 (en)	2013-03-28
AR027436A1 (es)	2003-03-26
SI1259523T1 (en)	2004-04-30
ME00179B (me)	2011-02-10
YU57602A (sh)	2005-11-28
WO2001060832A3 (en)	2002-01-31
EE200200438A (et)	2003-12-15
JP4801307B2 (ja)	2011-10-26
CZ303810B6 (cs)	2013-05-15
RU2002124772A (ru)	2004-02-20
PT1259523E (pt)	2004-04-30
HK1052709B (zh)	2005-02-04
CN1162441C (zh)	2004-08-18
AU4240401A (en)	2001-08-27
ZA200206795B (en)	2003-11-19
JP2003523346A (ja)	2003-08-05
IL151216A (en)	2009-12-24
DE60101313D1 (de)	2004-01-08
KR100743380B1 (ko)	2007-07-30
EE05137B1 (et)	2009-02-16
HRP20020672A2 (en)	2004-12-31
NO323413B1 (no)	2007-04-30
PL358297A1 (pl)	2004-08-09
SK11802002A3 (sk)	2003-02-04
EP1259523B1 (en)	2003-11-26
HK1052709A1 (en)	2003-11-21
CZ20022826A3 (cs)	2002-11-13
ATE255120T1 (de)	2003-12-15
RU2255940C2 (ru)	2005-07-10
EP1259523A2 (en)	2002-11-27
ES2207609T3 (es)	2004-06-01
MEP28608A (en)	2010-10-10
KR20020086539A (ko)	2002-11-18
CA2400237A1 (en)	2001-08-23
CN1404484A (zh)	2003-03-19
TR200302180T4 (tr)	2004-03-22
IL151216A0 (en)	2003-04-10
CA2400237C (en)	2008-12-30
RS49991B (sr)	2008-09-29

Publication	Publication Date	Title
FI970317A (fi)	1997-03-05	Antiproliferatiivisina aineina ja Garft-inhibiittoreina käyttökelpoisia yhdisteitä
BR0317094A (pt)	2005-10-25	Sal de alumìnio livre de zircÈnio, e, composição antiperspirante
ES2107698T3 (es)	1997-12-01	Benzoilguanidinas sustituidas, procedimiento para su preparacion, su utilizacion como medicamento, como inhibidores del intercambio celular de na+/h+ o como agente de diagnostico, asi como medicamento que las contiene.
ES542322A0 (es)	1985-12-16	Un procedimiento para la preparacion de derivados de la 2 pirimidinil-1-piperazina
AR012489A1 (es)	2000-10-18	Tiofenopiridinas antagonistas del factor de liberacion de corticotropina. procedimiento para su preparacion, el uso de las mismas en la preparacionde un medicamento, composicion farmaceutica que las comprende, procedimiento para la preparacion de dicha composicion, un compuesto intermediario y
AR028624A1 (es)	2003-05-14	Heterociclilalquilaminas como antagonistas de receptores muscarinicos
ATE175661T1 (de)	1999-01-15	Benzamid-derivate als vasopressin-antagonisten
RS49588B (sr)	2007-06-04	Derivati benzopirana koji poseduju leukotrien-antagonističko dejstvo
MY133445A (en)	2007-11-30	2-arylethyl-(piperidin-4-ylmethyl)amine derivetives
AR064188A1 (es)	2009-03-18	Derivados de indolizina, procesos de obtencion y composiciones farmaceuticas que los contienen.
MA26767A1 (fr)	2004-12-20	Hydroxamates de sulfonamide
ATE245157T1 (de)	2003-08-15	3,9-diazabicyclo-(3.3.1)-nonanylderivate, verfahren und intermediate für ihre darstellung und sie enthaltende pharmazeutische zusammensetzungen
ES2115220T3 (es)	1998-06-16	Nuevo uso de compuestos bis-heterociclicos como agentes antiinflamatorios y composiciones farmaceuticas de los mismos.
ES496038A0 (es)	1981-09-16	Procedimiento para la obtencion de 2-hidroxialquil-3,4,5- trihidroxi-piperidinas
ES503837A0 (es)	1982-06-01	Procedimiento para la preparacion de 3,1-benzoxazin-2-onas
SE8406302L (sv)	1985-06-13	Nya aminoguanidinderivat och ett forfarande for deras framstellning
BR0012478A (pt)	2002-04-02	Derivados de aminotiazóis, sua preparação e composição farmacêuticas contendo os mesmos
CO4770917A1 (es)	1999-04-30	Compuestos de dihalopropeno, su uso e intermedios para su produccion
YU44301A (sh)	2004-07-15	5ht1 antagonisti za antidepresantnu terapiju
HRP20020672B1 (en)	2010-12-31	Pluraflavins and derivatives thereof, process for their preparation and use thereof
ES2146643T3 (es)	2000-08-16	Fenilcarboxamida-isoxazoles y sus sales, su procedimiento de preparacion, su aplicacion como medicamentos y composiciones farmaceuticas que lo contienen.
NO994937L (no)	1999-12-06	Krympingsreduserende middel for sementsammensetninger
PE8497A1 (es)	1997-03-24	Dihidrobenzofurano y compuestos relacionados utiles como agentes antiinflamatorios
FI845095L (fi)	1984-12-21	Aminoimidazolonderivat saosom histamin-h2-antagonister.
HRP20030125B1 (en)	2011-07-31	Prodrugs to nmda receptor ligands

Legal Events

Date	Code	Title	Description
2004-12-31	A1OB	Publication of a patent application
2005-06-29	ARAI	Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
2006-03-08	PNAN	Change of the applicant name, address/residence	Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH, DE
2010-12-31	B1PR	Patent granted
2017-01-11	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20170111 Year of fee payment: 17
2018-08-29	PBON	Lapse due to non-payment of renewal fee	Effective date: 20180215