HK1208377A1 - Lipid-based drug carriers for rapid penetration through mucus linings - Google Patents
Lipid-based drug carriers for rapid penetration through mucus liningsInfo
- Publication number
- HK1208377A1 HK1208377A1 HK15109178.8A HK15109178A HK1208377A1 HK 1208377 A1 HK1208377 A1 HK 1208377A1 HK 15109178 A HK15109178 A HK 15109178A HK 1208377 A1 HK1208377 A1 HK 1208377A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- lipid
- based drug
- drug carriers
- rapid penetration
- mucus linings
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1806—Suspensions, emulsions, colloids, dispersions
- A61K49/1812—Suspensions, emulsions, colloids, dispersions liposomes, polymersomes, e.g. immunoliposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/906—Drug delivery
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/906—Drug delivery
- Y10S977/907—Liposome
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Radiology & Medical Imaging (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261642776P | 2012-05-04 | 2012-05-04 | |
| PCT/US2013/039731 WO2013166498A1 (fr) | 2012-05-04 | 2013-05-06 | Véhicules de médicament à base de lipide pour pénétration rapide à travers les revêtements de mucus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1208377A1 true HK1208377A1 (en) | 2016-03-04 |
Family
ID=48428718
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK15109178.8A HK1208377A1 (en) | 2012-05-04 | 2015-09-18 | Lipid-based drug carriers for rapid penetration through mucus linings |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US9889208B2 (fr) |
| EP (1) | EP2849728A1 (fr) |
| JP (2) | JP6392209B2 (fr) |
| AU (1) | AU2013256008B2 (fr) |
| CA (1) | CA2872519C (fr) |
| HK (1) | HK1208377A1 (fr) |
| WO (1) | WO2013166498A1 (fr) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8957034B2 (en) * | 2004-01-28 | 2015-02-17 | Johns Hopkins University | Drugs and gene carrier particles that rapidly move through mucous barriers |
| CA2791278C (fr) | 2010-02-25 | 2015-11-24 | The Johns Hopkins University | Delivrance prolongee d'agents therapeutiques a un compartiment oculaire |
| CA2807552A1 (fr) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Acides nucleiques modifies et leurs procedes d'utilisation |
| US10307372B2 (en) | 2010-09-10 | 2019-06-04 | The Johns Hopkins University | Rapid diffusion of large polymeric nanoparticles in the mammalian brain |
| PT3590949T (pt) | 2010-10-01 | 2022-08-02 | Modernatx Inc | Ácidos ribonucleicos contendo n1-metilpseudouracilos e suas utilizações |
| US9327037B2 (en) | 2011-02-08 | 2016-05-03 | The Johns Hopkins University | Mucus penetrating gene carriers |
| JP2014511687A (ja) | 2011-03-31 | 2014-05-19 | モデルナ セラピューティクス インコーポレイテッド | 工学操作された核酸の送達および製剤 |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| KR20190099538A (ko) | 2011-10-03 | 2019-08-27 | 모더나 세라퓨틱스, 인코포레이티드 | 변형된 뉴클레오사이드, 뉴클레오타이드, 및 핵산, 및 이들의 용도 |
| SG11201402666WA (en) | 2011-12-16 | 2014-10-30 | Moderna Therapeutics Inc | Modified nucleoside, nucleotide, and nucleic acid compositions |
| AU2013232300B2 (en) | 2012-03-16 | 2015-12-17 | The Johns Hopkins University | Non-linear multiblock copolymer-drug conjugates for the delivery of active agents |
| CA2867381C (fr) | 2012-03-16 | 2016-09-20 | The Johns Hopkins University | Formulations a liberation controlee pour l'administration d'inhibiteurs du hif-1 |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| EP2847329A4 (fr) | 2012-04-02 | 2016-08-10 | Moderna Therapeutics Inc | Polynucléotides modifiés pour la production de protéines cytoplasmiques et cytosquelettiques |
| US9878056B2 (en) | 2012-04-02 | 2018-01-30 | Modernatx, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| KR102140989B1 (ko) | 2012-05-03 | 2020-08-04 | 칼라 파마슈티컬스, 인크. | 개선된 점막 수송을 나타내는 제약 나노입자 |
| US9827191B2 (en) | 2012-05-03 | 2017-11-28 | The Johns Hopkins University | Compositions and methods for ophthalmic and/or other applications |
| US10688041B2 (en) | 2012-05-03 | 2020-06-23 | Kala Pharmaceuticals, Inc. | Compositions and methods utilizing poly(vinyl alcohol) and/or other polymers that aid particle transport in mucus |
| US11596599B2 (en) | 2012-05-03 | 2023-03-07 | The Johns Hopkins University | Compositions and methods for ophthalmic and/or other applications |
| JP6392209B2 (ja) | 2012-05-04 | 2018-09-19 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 粘液内層を通過する迅速な透過のための脂質ベース薬物キャリア |
| RS63237B1 (sr) | 2012-11-26 | 2022-06-30 | Modernatx Inc | Terminalno modifikovana rnk |
| US10568975B2 (en) | 2013-02-05 | 2020-02-25 | The Johns Hopkins University | Nanoparticles for magnetic resonance imaging tracking and methods of making and using thereof |
| WO2014152211A1 (fr) | 2013-03-14 | 2014-09-25 | Moderna Therapeutics, Inc. | Formulation et administration de compositions de nucléosides, de nucléotides, et d'acides nucléiques modifiés |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| EP3052106A4 (fr) | 2013-09-30 | 2017-07-19 | ModernaTX, Inc. | Polynucléotides codant des polypeptides de modulation immunitaire |
| US10323076B2 (en) | 2013-10-03 | 2019-06-18 | Modernatx, Inc. | Polynucleotides encoding low density lipoprotein receptor |
| US10335500B2 (en) | 2014-05-12 | 2019-07-02 | The Johns Hopkins University | Highly stable biodegradable gene vector platforms for overcoming biological barriers |
| RU2729731C2 (ru) | 2014-12-15 | 2020-08-11 | Зе Джонс Хопкинс Юниверсити | Составы на основе сунитиниба и способы их применения для лечения глазных заболеваний |
| JP6846351B2 (ja) | 2015-01-27 | 2021-03-24 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 粘膜表面における活性薬剤の増強された輸送のための低張ヒドロゲル製剤 |
| US20180139997A1 (en) * | 2015-06-15 | 2018-05-24 | Gexnano S.R.L. | Food supplement for use in a process of metabolic rebalancing |
| AR106018A1 (es) | 2015-08-26 | 2017-12-06 | Achillion Pharmaceuticals Inc | Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos |
| ES2908479T3 (es) | 2015-08-26 | 2022-04-29 | Achillion Pharmaceuticals Inc | Compuestos para el tratamiento de trastornos inmunitarios e inflamatorios |
| EP3349729A4 (fr) | 2015-09-14 | 2019-06-26 | VGSK Technologies, Inc. | Support stériquement stabilisé pour agents thérapeutiques sous-cutanés, sublinguaux et oraux, compositions et procédés pour le traitement d'un mammifère |
| PT3350157T (pt) | 2015-09-17 | 2022-03-18 | Modernatx Inc | Compostos e composições para administração intracelular de agentes terapêuticos |
| US9808531B2 (en) | 2015-09-22 | 2017-11-07 | Graybug Vision, Inc. | Compounds and compositions for the treatment of ocular disorders |
| JP2018533579A (ja) * | 2015-10-30 | 2018-11-15 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 高分子量かつ密な被覆を有する粘液浸透粒子 |
| EA038755B1 (ru) | 2015-11-12 | 2021-10-14 | Грейбаг Вижн, Инк. | Агрегирующие микрочастицы для обеспечения замедленного высвобождения терапевтического агента для внутриглазной доставки |
| WO2017090047A1 (fr) * | 2015-11-27 | 2017-06-01 | Technology Innovation Momentum Fund (Israel) Limited Partnership | Glucosamine et ses dérivés en imagerie |
| PL3386484T3 (pl) | 2015-12-10 | 2022-07-25 | Modernatx, Inc. | Kompozycje i sposoby dostarczania środków terapeutycznych |
| LT3394030T (lt) | 2015-12-22 | 2022-04-11 | Modernatx, Inc. | Junginiai ir kompozicijos terapinei medžiagai teikti intraceliuliniu būdu |
| US10901058B2 (en) * | 2016-02-05 | 2021-01-26 | The Trustees Of The University Of Pennsylvania | Chemical exchange saturation transfer (CEST) imaging of lactate (LATEST) |
| WO2017136700A1 (fr) | 2016-02-05 | 2017-08-10 | The Trustees Of The University Of Pennsylvania | Édulcorants non nutritifs et polyols utilisés comme agents d'imagerie |
| EP3426028A1 (fr) * | 2016-03-09 | 2019-01-16 | Technion Research & Development Foundation Ltd. | Formulations liposomales et leurs procédés d'utilisation en agriculture |
| SG11201811491YA (en) | 2016-06-27 | 2019-01-30 | Achillion Pharmaceuticals Inc | Quinazoline and indole compounds to treat medical disorders |
| US10842746B1 (en) * | 2016-08-25 | 2020-11-24 | Verily Life Sciences Llc | Bi-directionally crosslinked liposomes and method of making same |
| WO2018089540A1 (fr) | 2016-11-08 | 2018-05-17 | Modernatx, Inc. | Formulations stabilisées de nanoparticules lipidiques |
| CN110603252A (zh) | 2017-03-01 | 2019-12-20 | 艾其林医药公司 | 用于治疗医学障碍的芳基、杂芳基和杂环药物化合物 |
| CN110520409A (zh) | 2017-03-15 | 2019-11-29 | 摩登纳特斯有限公司 | 用于细胞内递送治疗剂的化合物和组合物 |
| CA3056133A1 (fr) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Formes cristallines d'aminolipides |
| AU2018234828A1 (en) | 2017-03-15 | 2019-09-19 | Modernatx, Inc. | Lipid nanoparticle formulation |
| WO2018175922A1 (fr) | 2017-03-23 | 2018-09-27 | Graybug Vision, Inc. | Composés et compositions pour le traitement de troubles oculaires |
| JP2020519585A (ja) | 2017-05-10 | 2020-07-02 | グレイバグ ビジョン インコーポレイテッド | 医学療法のための延長放出マイクロ粒子及びその懸濁液 |
| US12077501B2 (en) | 2017-06-14 | 2024-09-03 | Modernatx, Inc. | Compounds and compositions for intracellular delivery of agents |
| US11786607B2 (en) | 2017-06-15 | 2023-10-17 | Modernatx, Inc. | RNA formulations |
| JP7275111B2 (ja) | 2017-08-31 | 2023-05-17 | モデルナティエックス インコーポレイテッド | 脂質ナノ粒子の生成方法 |
| BR112020011895A2 (pt) | 2017-12-12 | 2020-11-24 | Lead Biotherapeutics Ltd. | nanopartícula de lipídeo sólido para liberação intracelular de substâncias ativas e método para produção da mesma |
| JP7538113B2 (ja) | 2018-08-20 | 2024-08-21 | アキリオン ファーマシューティカルズ，インコーポレーテッド | 補体ｄ因子の医学的障害の治療のための医薬化合物 |
| US20220054455A1 (en) * | 2018-09-13 | 2022-02-24 | Taiwan Liposome Co., Ltd. | Sustained-release pharmaceutical compositions comprising of a sedative drug and uses thereof |
| EP3852732A1 (fr) | 2018-09-19 | 2021-07-28 | ModernaTX, Inc. | Lipides peg et leurs utilisations |
| CA3113651A1 (fr) | 2018-09-20 | 2020-03-26 | Modernatx, Inc. | Preparation de nanoparticules lipidiques et leurs methodes d'administration |
| EP3866773B1 (fr) | 2018-10-16 | 2024-08-28 | Georgia State University Research Foundation, Inc. | Promédicaments de monoxyde de carbone pour le traitement de troubles médicaux |
| AU2020350759A1 (en) | 2019-09-19 | 2022-03-31 | Modernatx, Inc. | Branched tail lipid compounds and compositions for intracellular delivery of therapeutic agents |
| JP2023515073A (ja) | 2020-02-20 | 2023-04-12 | アキリオン ファーマシューティカルズ， インコーポレーテッド | 補体因子ｄ媒介障害の処置用のヘテロアリール化合物 |
| JP7485584B2 (ja) | 2020-11-02 | 2024-05-16 | 矢崎総業株式会社 | 熱収縮チューブ装着用治具 |
| US11058637B1 (en) * | 2020-11-25 | 2021-07-13 | King Abdulaziz University | Surface-modified emulsomes for intranasal delivery of drugs |
| US11524023B2 (en) | 2021-02-19 | 2022-12-13 | Modernatx, Inc. | Lipid nanoparticle compositions and methods of formulating the same |
| WO2022185993A1 (fr) | 2021-03-02 | 2022-09-09 | 新明和工業株式会社 | Dispositif de chauffage de tube thermorétractable |
| WO2022235907A1 (fr) * | 2021-05-05 | 2022-11-10 | Vgsk Technologies, Inc. | Inhibition de la réplication du sars-cov-2 et réduction de l'inflammation pulmonaire par corticosteriods encapsulés dans des liposomes |
Family Cites Families (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2026989A (en) | 1931-08-12 | 1936-01-07 | T R C Corp | Method of building roads |
| US2005204A (en) | 1933-02-23 | 1935-06-18 | Ralph R Poynter | Lawn mower |
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| US4997652A (en) | 1987-12-22 | 1991-03-05 | Visionex | Biodegradable ocular implants |
| US5356633A (en) * | 1989-10-20 | 1994-10-18 | Liposome Technology, Inc. | Method of treatment of inflamed tissues |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5196522A (en) | 1990-11-01 | 1993-03-23 | Board Of Regents, The University Of Texas System | Anthracycline analogues bearing latent alkylating substituents |
| US5696298A (en) | 1991-03-19 | 1997-12-09 | Cytrx Corporation | Polyoxypropylene/polyoxyethylene copolymers with improved biological activity |
| EP0627911B1 (fr) | 1992-02-28 | 2000-10-25 | Board Of Regents The University Of Texas System | Hydrogels biodegradables, polymerisables utilises en tant que materiaux en contact avec des tissus et excipients a liberation controlee |
| US5565215A (en) | 1993-07-23 | 1996-10-15 | Massachusettes Institute Of Technology | Biodegradable injectable particles for imaging |
| US5540930A (en) | 1993-10-25 | 1996-07-30 | Pharmos Corporation | Suspension of loteprednol etabonate for ear, eye, or nose treatment |
| US6007845A (en) | 1994-07-22 | 1999-12-28 | Massachusetts Institute Of Technology | Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers |
| US5576311A (en) | 1994-11-30 | 1996-11-19 | Pharmos Corporation | Cyclodextrins as suspending agents for pharmaceutical suspensions |
| US5628981A (en) | 1994-12-30 | 1997-05-13 | Nano Systems L.L.C. | Formulations of oral gastrointestinal diagnostic x-ray contrast agents and oral gastrointestinal therapeutic agents |
| US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| US6413539B1 (en) | 1996-10-31 | 2002-07-02 | Poly-Med, Inc. | Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof |
| PT751144E (pt) | 1995-06-27 | 2004-12-31 | Pharmachemie Bv | Novos pro-farmacos antraciclinicos, metodo para preparacao e tambem a sua utilizacao em quimioterapia selectiva |
| KR20000010834A (ko) * | 1996-05-09 | 2000-02-25 | 미셀 지. 베르제롱 | Hiv 및 hsv를 포함하는 병원체 유도질병의 예방용 조성물 |
| US5869130A (en) | 1997-06-12 | 1999-02-09 | Mac Dermid, Incorporated | Process for improving the adhesion of polymeric materials to metal surfaces |
| US7052678B2 (en) | 1997-09-15 | 2006-05-30 | Massachusetts Institute Of Technology | Particles for inhalation having sustained release properties |
| US6270806B1 (en) | 1999-03-03 | 2001-08-07 | Elan Pharma International Limited | Use of peg-derivatized lipids as surface stabilizers for nanoparticulate compositions |
| US6963769B1 (en) | 1999-04-21 | 2005-11-08 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method for enhancing contrast produced by MRI |
| US6287588B1 (en) | 1999-04-29 | 2001-09-11 | Macromed, Inc. | Agent delivering system comprised of microparticle and biodegradable gel with an improved releasing profile and methods of use thereof |
| US6413639B1 (en) | 1999-10-01 | 2002-07-02 | Toda Kogyo Corporation | Mg-Al based hydrotalcite-type particles, chlorine-containing resin stabilizer and process for producing the particles |
| WO2001041738A2 (fr) * | 1999-12-10 | 2001-06-14 | Celator Technologies Inc. | Compositions d'excipient a base de lipides ayant des fonctions de reaction au moyen d'une surface protegee |
| US6589549B2 (en) | 2000-04-27 | 2003-07-08 | Macromed, Incorporated | Bioactive agent delivering system comprised of microparticles within a biodegradable to improve release profiles |
| US6495164B1 (en) | 2000-05-25 | 2002-12-17 | Alkermes Controlled Therapeutics, Inc. I | Preparation of injectable suspensions having improved injectability |
| PE20020146A1 (es) | 2000-07-13 | 2002-03-31 | Upjohn Co | Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2) |
| EP2316490A3 (fr) | 2000-10-31 | 2012-02-01 | PR Pharmaceuticals, Inc. | Methodes et compositions pour améliorer l'administration de molécules bioactives |
| GB0122318D0 (en) | 2001-09-14 | 2001-11-07 | Novartis Ag | Organic compounds |
| US7381426B2 (en) * | 2002-01-24 | 2008-06-03 | Southwest Research Institute | Targeted delivery of bioactive factors to the systemic skeleton |
| DK1519714T3 (da) * | 2002-06-28 | 2011-01-31 | Protiva Biotherapeutics Inc | Fremgangsmåde og apparat til fremstilling af liposomer |
| DE60331860D1 (en) | 2002-12-30 | 2010-05-06 | Nektar Therapeutics | Mehrarmige polypeptid-poly(ethylenglykol)-blockcopolymere als arzneistoffzufuhrvehikel |
| US20050009910A1 (en) | 2003-07-10 | 2005-01-13 | Allergan, Inc. | Delivery of an active drug to the posterior part of the eye via subconjunctival or periocular delivery of a prodrug |
| JP4804923B2 (ja) * | 2003-09-03 | 2011-11-02 | 協和発酵キリン株式会社 | グリセロール誘導体で修飾された化合物 |
| GB0328630D0 (en) | 2003-12-10 | 2004-01-14 | Medpharm Ltd | Metered dose inhalation preparations |
| US8974823B2 (en) | 2003-12-31 | 2015-03-10 | Bend Research, Inc. | Solid compositions of low-solubility drugs and poloxamers |
| US8957034B2 (en) | 2004-01-28 | 2015-02-17 | Johns Hopkins University | Drugs and gene carrier particles that rapidly move through mucous barriers |
| CA2555335A1 (fr) | 2004-02-05 | 2005-08-25 | Intradigm Corporation | Therapeutique par des agents rnai appliquee dans le traitement de maladies oculaires resultant d'une neovascularisation |
| ES2246694B1 (es) | 2004-04-29 | 2007-05-01 | Instituto Cientifico Y Tecnologico De Navarra, S.A. | Nanoparticulas pegiladas. |
| US20050244469A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Extended therapeutic effect ocular implant treatments |
| US8512738B2 (en) | 2004-04-30 | 2013-08-20 | Allergan, Inc. | Biodegradable intravitreal tyrosine kinase implants |
| US7771742B2 (en) | 2004-04-30 | 2010-08-10 | Allergan, Inc. | Sustained release intraocular implants containing tyrosine kinase inhibitors and related methods |
| CA2590098C (fr) | 2004-12-10 | 2015-03-31 | Justin Hanes | Copolymeres sequences de poly(ether-anhydride) fonctionnalises |
| JP2008536944A (ja) * | 2005-04-22 | 2008-09-11 | アルザ・コーポレーシヨン | Ｈｅｒ２細胞受容体を標的とするためのイムノリポソーム組成物 |
| JP2006335745A (ja) * | 2005-06-06 | 2006-12-14 | Fujifilm Holdings Corp | リポソームを含むｍｒｉ造影剤 |
| EP1912676A2 (fr) | 2005-07-28 | 2008-04-23 | (Osi) Eyetech, Inc. | Conjugue de polymere comportant un lieur cyclitol |
| US20070071756A1 (en) | 2005-09-26 | 2007-03-29 | Peyman Gholam A | Delivery of an agent to ameliorate inflammation |
| US20070093461A1 (en) | 2005-10-26 | 2007-04-26 | Bausch & Lomb Incorporated | Effect of Loteprednol etabonate on vascular dysfunction |
| US8658608B2 (en) | 2005-11-23 | 2014-02-25 | Yale University | Modified triple-helix forming oligonucleotides for targeted mutagenesis |
| WO2007076358A1 (fr) | 2005-12-23 | 2007-07-05 | Alcon, Inc. | Preparation pharmaceutique pour l'administration, dans l'oeil, de composes inhibiteurs des récepteurs tyrosine kinases (rtki) |
| WO2007084418A2 (fr) | 2006-01-13 | 2007-07-26 | Surmodics, Inc. | Matrices contenant des microparticules pour l'administration de médicaments |
| US20070231360A1 (en) | 2006-03-28 | 2007-10-04 | Minu, L.L.C. | Neural conduit agent dissemination |
| US20080166411A1 (en) | 2006-04-10 | 2008-07-10 | Pfizer Inc | Injectable Depot Formulations And Methods For Providing Sustained Release Of Poorly Soluble Drugs Comprising Nanoparticles |
| US20070249536A1 (en) | 2006-04-25 | 2007-10-25 | Ma Peter X | Three-component polyanhydride copolymers and a method of forming the same |
| US8858989B2 (en) * | 2006-05-18 | 2014-10-14 | Biolitec Pharma Marketing Ltd | Gel-formulations of hydrophobic photosensitizers for mucosal applications |
| JP2008053276A (ja) | 2006-08-22 | 2008-03-06 | Nec Electronics Corp | 半導体装置の製造方法 |
| ATE498393T1 (de) * | 2006-09-08 | 2011-03-15 | Univ Johns Hopkins | Zusammensetzungen zur transportintensivierung durch die schleimhaut |
| US8394488B2 (en) | 2006-10-06 | 2013-03-12 | Cordis Corporation | Bioabsorbable device having composite structure for accelerating degradation |
| ES2477993T3 (es) | 2006-11-09 | 2014-07-18 | Alcon Research, Ltd. | Matriz de polímero insoluble en agua para el suministro de fármaco |
| WO2008109031A2 (fr) * | 2007-03-02 | 2008-09-12 | Luna Innovations Incorporated | Transporteurs de type liposome pour la distribution in vivo de fullerènes |
| NZ584275A (en) | 2007-10-08 | 2012-06-29 | Fovea Pharmaceuticals | Aqueous cyclosporine ophthalmic formulations |
| JP2009096749A (ja) * | 2007-10-16 | 2009-05-07 | Konica Minolta Holdings Inc | コレステロール誘導体、リポソーム及びｘ線用造影剤 |
| US20090203709A1 (en) | 2008-02-07 | 2009-08-13 | Abbott Laboratories | Pharmaceutical Dosage Form For Oral Administration Of Tyrosine Kinase Inhibitor |
| TW201019963A (en) | 2008-09-10 | 2010-06-01 | Abbott Lab | Polyethylene glycol lipid conjugates and uses thereof |
| EP2355853B1 (fr) | 2008-10-10 | 2016-12-07 | Polyactiva Pty Ltd | Conjugués polymere biodegradable fractions bioactives |
| WO2010091187A2 (fr) | 2009-02-04 | 2010-08-12 | The Brigham And Women's Hospital, Inc. | Nanoparticules polymères dont la charge de médicament est augmentée et procédé d'utilisation |
| ES2508290T3 (es) | 2009-03-03 | 2014-10-16 | Alcon Research, Ltd. | Composición farmacéutica para la administracón de compuestos de inhibición del receptor de tirosina cinasa (RTKI) al ojo |
| US10952965B2 (en) | 2009-05-15 | 2021-03-23 | Baxter International Inc. | Compositions and methods for drug delivery |
| EP2440181A2 (fr) * | 2009-06-08 | 2012-04-18 | Epitarget AS | Particules d'administration de medicament acoustiquement sensibles comprenant de la phosphatidylethanolamine |
| EP2335686A1 (fr) | 2009-12-21 | 2011-06-22 | LEK Pharmaceuticals d.d. | Nanosuspension intraveineuse aqueuse dotée d'effets indésirables diminués |
| CA2791278C (fr) | 2010-02-25 | 2015-11-24 | The Johns Hopkins University | Delivrance prolongee d'agents therapeutiques a un compartiment oculaire |
| US20130071349A1 (en) | 2010-03-02 | 2013-03-21 | Allergan, Inc. | Biodegradable polymers for lowering intraocular pressure |
| WO2011133803A1 (fr) | 2010-04-21 | 2011-10-27 | Helix Therapeutics, Inc. | Compositions et méthodes d'inactivation ciblée de récepteurs de surface cellulaire de vih |
| EP2407157A1 (fr) * | 2010-07-13 | 2012-01-18 | Koninklijke Philips Electronics N.V. | Transporteur de lipides bicouche pour médicaments ou agents d'imagerie |
| US10307372B2 (en) | 2010-09-10 | 2019-06-04 | The Johns Hopkins University | Rapid diffusion of large polymeric nanoparticles in the mammalian brain |
| AU2011323250B2 (en) | 2010-11-05 | 2015-11-19 | The Johns Hopkins University | Compositions and methods relating to reduced mucoadhesion |
| US9327037B2 (en) | 2011-02-08 | 2016-05-03 | The Johns Hopkins University | Mucus penetrating gene carriers |
| CN102379850B (zh) * | 2011-11-04 | 2013-08-28 | 北京泰德制药股份有限公司 | 一种穿越人体粘液屏障的靶向给药脂质体 |
| RU2631599C2 (ru) | 2011-12-14 | 2017-09-25 | Дзе Джонс Хопкинс Юниверсити | Наночастицы, легче проникающие в слизистую оболочку или вызывающие меньше воспаления |
| US20130217657A1 (en) | 2011-12-21 | 2013-08-22 | Insite Vision Incorporated | Combination anti-inflammatory ophthalmic compositions |
| RU2598627C2 (ru) | 2012-01-19 | 2016-09-27 | Дзе Джонс Хопкинс Юниверсити | Композиции на основе наночастиц с улучшенным проникновением через слизистые оболочки |
| EP2819652A1 (fr) * | 2012-02-27 | 2015-01-07 | Epitarget As | Utilisation d'un immunomodulateur particulaire en cancérothérapie |
| AU2013232300B2 (en) | 2012-03-16 | 2015-12-17 | The Johns Hopkins University | Non-linear multiblock copolymer-drug conjugates for the delivery of active agents |
| CA2867381C (fr) | 2012-03-16 | 2016-09-20 | The Johns Hopkins University | Formulations a liberation controlee pour l'administration d'inhibiteurs du hif-1 |
| US20140107025A1 (en) | 2012-04-16 | 2014-04-17 | Jade Therapeutics, Llc | Ocular drug delivery system |
| US10688041B2 (en) | 2012-05-03 | 2020-06-23 | Kala Pharmaceuticals, Inc. | Compositions and methods utilizing poly(vinyl alcohol) and/or other polymers that aid particle transport in mucus |
| NZ741873A (en) | 2012-05-03 | 2019-04-26 | Kala Pharmaceuticals Inc | Pharmaceutical nanoparticles showing improved mucosal transport |
| KR102140989B1 (ko) | 2012-05-03 | 2020-08-04 | 칼라 파마슈티컬스, 인크. | 개선된 점막 수송을 나타내는 제약 나노입자 |
| US9827191B2 (en) | 2012-05-03 | 2017-11-28 | The Johns Hopkins University | Compositions and methods for ophthalmic and/or other applications |
| JP6392209B2 (ja) | 2012-05-04 | 2018-09-19 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 粘液内層を通過する迅速な透過のための脂質ベース薬物キャリア |
| NZ705985A (en) | 2012-09-17 | 2018-08-31 | Pfizer | Therapeutic nanoparticles comprising a therapeutic agent and methods of making and using same |
| AU2013317899A1 (en) | 2012-09-20 | 2015-05-07 | Akina, Inc. | Biodegradable microcapsules containing filling material |
| US9968603B2 (en) | 2013-03-14 | 2018-05-15 | Forsight Vision4, Inc. | Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant |
| KR20150139899A (ko) | 2013-04-01 | 2015-12-14 | 알러간, 인코포레이티드 | 지속적인 안구내 방출을 위한 마이크로스피어 약물 전달 시스템 |
-
2013
- 2013-05-06 JP JP2015510507A patent/JP6392209B2/ja active Active
- 2013-05-06 AU AU2013256008A patent/AU2013256008B2/en active Active
- 2013-05-06 US US14/397,828 patent/US9889208B2/en active Active
- 2013-05-06 WO PCT/US2013/039731 patent/WO2013166498A1/fr active Application Filing
- 2013-05-06 EP EP13722265.9A patent/EP2849728A1/fr not_active Withdrawn
- 2013-05-06 CA CA2872519A patent/CA2872519C/fr active Active
-
2015
- 2015-09-18 HK HK15109178.8A patent/HK1208377A1/xx unknown
-
2017
- 2017-11-16 JP JP2017220782A patent/JP2018039836A/ja not_active Withdrawn
-
2018
- 2018-02-06 US US15/890,156 patent/US10556017B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2013166498A1 (fr) | 2013-11-07 |
| CA2872519C (fr) | 2017-09-05 |
| AU2013256008A1 (en) | 2014-11-20 |
| CA2872519A1 (fr) | 2013-11-07 |
| JP2015515992A (ja) | 2015-06-04 |
| US20180169263A1 (en) | 2018-06-21 |
| JP6392209B2 (ja) | 2018-09-19 |
| US10556017B2 (en) | 2020-02-11 |
| US9889208B2 (en) | 2018-02-13 |
| AU2013256008B2 (en) | 2016-02-25 |
| EP2849728A1 (fr) | 2015-03-25 |
| US20150086484A1 (en) | 2015-03-26 |
| JP2018039836A (ja) | 2018-03-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1208377A1 (en) | Lipid-based drug carriers for rapid penetration through mucus linings | |
| GB2518113B (en) | Biofeedback system | |
| GB2501785B (en) | Synchronisation method | |
| ZA201503280B (en) | Physical channel design for network-assisted d2d | |
| HK1203517A1 (en) | Multispecific antibodies | |
| IL236772A0 (en) | Preparations for directed immunotherapy | |
| GB201505407D0 (en) | Methods for discovering therapeutic targets | |
| IL232989A0 (en) | Syringe holder | |
| IL232988A0 (en) | Syringe holder | |
| HK1198140A1 (en) | Syringe carrier | |
| GB201222970D0 (en) | Synchronization | |
| GB2516389B (en) | Refrigerating Apparatus | |
| ZA201502685B (en) | Capsules | |
| IL237879B (en) | Video-assisted target location | |
| EP2760035A4 (fr) | Procédé de formation d'espace de champ magnétique | |
| SG11201500859QA (en) | Timer for releasing e-dch resources | |
| PL2867530T3 (pl) | Tłok | |
| IL238989B (en) | A combined mediator/target for a neutron activation process | |
| HK1201209A1 (en) | Therapeutic agent for diabetes | |
| PL2861862T3 (pl) | Popychacz | |
| GB2502402B (en) | Controlled drug release | |
| EP2761958A4 (fr) | Types de porteuse supplémentaire pour lte | |
| HK1198141A1 (en) | Syringe carrier | |
| EP2712550A4 (fr) | Lancette | |
| GB2500415B (en) | Retort |