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HK1202541A1 - 2-amino, 6-phenyl substituted pyrido [2, 3 - d] pyrimidine derivatives useful as raf kinase inhibitors raf 2-, 6-[2,3-d] - Google Patents

2-amino, 6-phenyl substituted pyrido [2, 3 - d] pyrimidine derivatives useful as raf kinase inhibitors raf 2-, 6-[2,3-d]

Info

Publication number
HK1202541A1
HK1202541A1 HK15103082.6A HK15103082A HK1202541A1 HK 1202541 A1 HK1202541 A1 HK 1202541A1 HK 15103082 A HK15103082 A HK 15103082A HK 1202541 A1 HK1202541 A1 HK 1202541A1
Authority
HK
Hong Kong
Prior art keywords
raf
amino
kinase inhibitors
phenyl substituted
pyrimidine derivatives
Prior art date
Application number
HK15103082.6A
Other languages
English (en)
Chinese (zh)
Inventor
Matthew Carl Allgeier
Daniel L Flynn
Michael D Kaufman
Phenil J Patel
Craig D Wolfangel
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47884613&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1202541(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of HK1202541A1 publication Critical patent/HK1202541A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
HK15103082.6A 2012-03-07 2015-03-26 2-amino, 6-phenyl substituted pyrido [2, 3 - d] pyrimidine derivatives useful as raf kinase inhibitors raf 2-, 6-[2,3-d] HK1202541A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261607702P 2012-03-07 2012-03-07
PCT/US2013/029084 WO2013134243A1 (fr) 2012-03-07 2013-03-05 Dérivés de 2-amino, 6-phenyl à substitution pyrido [2, 3 - d] pyrimidine utilisés en tant qu'inhibiteurs de la raf kinase

Publications (1)

Publication Number Publication Date
HK1202541A1 true HK1202541A1 (en) 2015-10-02

Family

ID=47884613

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15103082.6A HK1202541A1 (en) 2012-03-07 2015-03-26 2-amino, 6-phenyl substituted pyrido [2, 3 - d] pyrimidine derivatives useful as raf kinase inhibitors raf 2-, 6-[2,3-d]

Country Status (39)

Country Link
US (2) US8741911B2 (fr)
EP (1) EP2850082B1 (fr)
JP (1) JP2015509536A (fr)
KR (1) KR20140129087A (fr)
CN (1) CN104302646B (fr)
AP (1) AP2014007899A0 (fr)
AR (1) AR090151A1 (fr)
AU (1) AU2013230146B2 (fr)
BR (1) BR112014018528A8 (fr)
CA (1) CA2863673A1 (fr)
CL (1) CL2014002220A1 (fr)
CO (1) CO7010837A2 (fr)
CR (1) CR20140378A (fr)
CY (1) CY1117846T1 (fr)
DK (1) DK2850082T3 (fr)
DO (1) DOP2014000200A (fr)
EA (1) EA024824B1 (fr)
EC (1) ECSP14017584A (fr)
ES (1) ES2584387T3 (fr)
HK (1) HK1202541A1 (fr)
HR (1) HRP20160654T1 (fr)
HU (1) HUE028095T2 (fr)
IL (1) IL234052A (fr)
IN (1) IN2014MN01575A (fr)
LT (1) LT2850082T (fr)
MA (1) MA37316B1 (fr)
ME (1) ME02423B (fr)
MX (1) MX2014010701A (fr)
NZ (1) NZ627454A (fr)
PE (1) PE20142338A1 (fr)
PH (1) PH12014501986B1 (fr)
PT (1) PT2850082T (fr)
RS (1) RS54840B1 (fr)
SG (1) SG11201404969YA (fr)
SI (1) SI2850082T1 (fr)
TN (1) TN2014000375A1 (fr)
TW (1) TW201348233A (fr)
UA (1) UA112340C2 (fr)
WO (2) WO2013134252A1 (fr)

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RU2018146886A (ru) * 2016-06-10 2020-07-10 Новартис Аг Пути терапевтического применения ингибитора c-raf
WO2018115380A1 (fr) 2016-12-22 2018-06-28 Boehringer Ingelheim International Gmbh Nouvelles quinazolines à substitution benzylamino et leurs dérivés en tant qu'inhibiteurs de sos1
US10787443B2 (en) * 2017-04-28 2020-09-29 Zamboni Chem Solutions Inc. RAF-degrading conjugate compounds
FI3728254T3 (fi) 2017-12-21 2023-05-05 Boehringer Ingelheim Int Bentsyyliaminosubstituoidut pyridopyrimidinonit ja johdannaiset SOS1-estäjinä
JP7161849B2 (ja) * 2018-01-24 2022-10-27 株式会社クラレ 第一級アミンの製造方法
WO2019152719A1 (fr) 2018-01-31 2019-08-08 Deciphera Pharmaceuticals, Llc Polythérapie pour le traitement de la mastocytose
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WO2020172093A1 (fr) 2019-02-18 2020-08-27 Genentech, Inc. Composés de pyrido-pyrimidinyle et procédés d'utilisation
CA3138300A1 (fr) * 2019-05-03 2020-11-12 Kinnate Biopharma Inc. Inhibiteurs de kinases raf
IL317676A (en) 2019-05-10 2025-02-01 Deciphera Pharmaceuticals Llc Heteroarylaminopyrimidine amides as autophagy inhibitors and methods of using them
MX2021013661A (es) 2019-05-10 2022-03-11 Deciphera Pharmaceuticals Llc Inhibidores de la autofagia de fenilaminopirimidina amida y metodos de uso de estos.
BR112021025544A2 (pt) 2019-06-17 2022-05-17 Deciphera Pharmaceuticals Llc Inibidores de autofagia de aminopirimidina amida e métodos de uso dos mesmos
WO2021030405A1 (fr) 2019-08-12 2021-02-18 Deciphera Pharmaceuticals, Llc Ripretinib pour le traitement de tumeurs stromales gastro-intestinales
CA3150433A1 (fr) 2019-08-12 2021-02-18 Deciphera Pharmaceuticals, Llc Ripretinib pour le traitement de tumeurs stromales gastro-intestinales
FI4084778T3 (fi) 2019-12-30 2023-12-18 Deciphera Pharmaceuticals Llc Amorfisia kinaasi-inhibiittoriformulaatioita ja menetelmiä niiden käyttämiseksi
FI4084779T3 (fi) 2019-12-30 2024-12-16 Deciphera Pharmaceuticals Llc 1-(4-bromi-5-(1-etyyli-7-(metyyliamino)-2-okso-1,2-dihydro-1,6-naftyridin-3-yyli)-2-fluorifenyyli)-3-fenyyliurean koostumuksia
CR20220614A (es) 2020-06-02 2023-05-08 Univ Vanderbilt 2-amino-3-cianotiofenos anulados y derivados para el tratamiento del cáncer
US11407737B2 (en) 2020-09-18 2022-08-09 Kinnate Biopharma Inc. Inhibitors of RAF kinases
WO2022081469A1 (fr) 2020-10-12 2022-04-21 Kinnate Biopharma Inc. Inhibiteurs de kinases raf
EP4237423B1 (fr) 2020-11-02 2024-12-11 Boehringer Ingelheim International GmbH 1h-pyrazolo[4,3-c]pyridines substitués et dérivés en tant qu'inhibiteurs de l'egfr
MX2023005747A (es) 2020-11-18 2023-07-28 Deciphera Pharmaceuticals Llc Inhibidores de gcn2 y perk quinasas y metodos de uso de los mismos.
TW202241885A (zh) 2020-12-22 2022-11-01 大陸商上海齊魯銳格醫藥研發有限公司 Ｓｏｓ１抑制劑及其用途
CA3216104A1 (fr) 2021-04-23 2022-10-27 Aleksandra Franovic Traitement du cancer avec un inhibiteur de raf
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WO2023099623A1 (fr) 2021-12-01 2023-06-08 Boehringer Ingelheim International Gmbh 2-amino-3-cyano-thiophènes annelés et dérivés pour le traitement du cancer
JP2024543983A (ja) 2021-12-01 2024-11-26 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング がんの処置のための縮環２－アミノ－３－シアノチオフェン及び誘導体
TW202337432A (zh) 2021-12-01 2023-10-01 德商百靈佳殷格翰國際股份有限公司 用於治療癌症之環狀2-胺基-3-氰基噻吩及衍生物
EP4441050A1 (fr) 2021-12-01 2024-10-09 Boehringer Ingelheim International GmbH 2-amino-3-cyano thiophènes annelés et leurs dérivés pour le traitement du cancer
TW202337431A (zh) 2021-12-01 2023-10-01 德商百靈佳殷格翰國際股份有限公司 用於治療癌症之環狀2-胺基-3-氰基噻吩及衍生物
US20230357179A1 (en) 2021-12-09 2023-11-09 Deciphera Pharmaceuticals, Llc Raf kinase inhibitors and methods of use thereof
CN118434735A (zh) 2021-12-23 2024-08-02 勃林格殷格翰国际有限公司 8-氮杂喹唑啉作为脑渗透sos1抑制剂
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WO2024088991A1 (fr) 2022-10-26 2024-05-02 Boehringer Ingelheim International Gmbh Composés hétérocycliques capables d'activer le sting
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Also Published As

Publication number Publication date
NZ627454A (en) 2016-09-30
US20130252977A1 (en) 2013-09-26
CR20140378A (es) 2014-11-27
US8741911B2 (en) 2014-06-03
UA112340C2 (uk) 2016-08-25
LT2850082T (lt) 2016-09-12
ECSP14017584A (es) 2016-01-29
HRP20160654T1 (hr) 2016-07-01
EA201491456A1 (ru) 2014-12-30
RS54840B1 (sr) 2016-10-31
MA37316B1 (fr) 2017-03-31
US20150119392A1 (en) 2015-04-30
IN2014MN01575A (fr) 2015-05-08
AU2013230146A1 (en) 2014-08-14
IL234052A (en) 2016-05-31
EP2850082B1 (fr) 2016-05-18
ES2584387T3 (es) 2016-09-27
DOP2014000200A (es) 2014-10-15
WO2013134243A1 (fr) 2013-09-12
MA37316A1 (fr) 2016-06-30
EP2850082A1 (fr) 2015-03-25
DK2850082T3 (en) 2016-08-15
TW201348233A (zh) 2013-12-01
MX2014010701A (es) 2015-03-10
AU2013230146B2 (en) 2015-09-10
SG11201404969YA (en) 2014-10-30
AP2014007899A0 (en) 2014-08-31
EA024824B1 (ru) 2016-10-31
CL2014002220A1 (es) 2015-06-05
BR112014018528A8 (pt) 2017-07-11
CN104302646A (zh) 2015-01-21
KR20140129087A (ko) 2014-11-06
JP2015509536A (ja) 2015-03-30
PE20142338A1 (es) 2015-01-10
PH12014501986A1 (en) 2014-11-24
BR112014018528A2 (fr) 2017-06-20
US9334267B2 (en) 2016-05-10
ME02423B (fr) 2016-09-20
CA2863673A1 (fr) 2013-09-12
CO7010837A2 (es) 2014-07-31
TN2014000375A1 (en) 2015-12-21
AR090151A1 (es) 2014-10-22
CN104302646B (zh) 2016-05-04
CY1117846T1 (el) 2017-05-17
PT2850082T (pt) 2016-07-15
HUE028095T2 (en) 2016-11-28
PH12014501986B1 (en) 2014-11-24
SI2850082T1 (sl) 2016-07-29
WO2013134252A1 (fr) 2013-09-12

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