[go: up one dir, main page]

HK1105126A1 - Monoclonal antibodies to progastrin - Google Patents

Monoclonal antibodies to progastrin

Info

Publication number
HK1105126A1
HK1105126A1 HK07113477.8A HK07113477A HK1105126A1 HK 1105126 A1 HK1105126 A1 HK 1105126A1 HK 07113477 A HK07113477 A HK 07113477A HK 1105126 A1 HK1105126 A1 HK 1105126A1
Authority
HK
Hong Kong
Prior art keywords
progastrin
monoclonal antibodies
monoclonal
antibodies
Prior art date
Application number
HK07113477.8A
Other languages
English (en)
Inventor
Stephen Grimes
Original Assignee
Cancer Advances Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Advances Inc filed Critical Cancer Advances Inc
Publication of HK1105126A1 publication Critical patent/HK1105126A1/xx

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575Hormones
    • G01N2333/595Gastrins; Cholecystokinins [CCK]
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/06Gastro-intestinal diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
HK07113477.8A 2004-09-22 2007-12-11 Monoclonal antibodies to progastrin HK1105126A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61222404P 2004-09-22 2004-09-22
PCT/IB2005/002793 WO2006032980A1 (en) 2004-09-22 2005-09-21 Monoclonal antibolies to progastrin

Publications (1)

Publication Number Publication Date
HK1105126A1 true HK1105126A1 (en) 2008-02-01

Family

ID=35395744

Family Applications (1)

Application Number Title Priority Date Filing Date
HK07113477.8A HK1105126A1 (en) 2004-09-22 2007-12-11 Monoclonal antibodies to progastrin

Country Status (13)

Country Link
US (2) US8158128B2 (zh)
EP (2) EP1794586B1 (zh)
JP (1) JP2008513536A (zh)
KR (1) KR101333168B1 (zh)
CN (1) CN101048659B (zh)
AU (1) AU2005286164B2 (zh)
CA (1) CA2580965C (zh)
DK (1) DK1794586T3 (zh)
ES (1) ES2400058T3 (zh)
HK (1) HK1105126A1 (zh)
IL (1) IL182012A (zh)
WO (1) WO2006032980A1 (zh)
ZA (1) ZA200702926B (zh)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002252456A1 (en) * 2001-03-23 2002-10-08 Aphton Corporation Combination treatment of pancreatic cancer
US20090191232A1 (en) * 2001-05-04 2009-07-30 Gevas Philip C Combination therapy for the treatment of tumors
AU2002326356A1 (en) * 2001-07-09 2003-01-29 Aphton Corporation Treatment and prevention of cancerous and pre-cancerous conditions of the liver, lung and esophagus
EP1608984A2 (en) * 2003-03-28 2005-12-28 Aphton Corporation Gastrin hormone immunoassays
JP5576592B2 (ja) * 2004-03-29 2014-08-20 キャンサー アドヴァンシズ インコーポレイテッド ガストリンホルモンに対するモノクローナル抗体
US8158128B2 (en) 2004-09-22 2012-04-17 Cancer Advances, Inc. Monoclonal antibodies to progastrin
CA2652768A1 (en) * 2006-05-22 2007-11-29 Inserm (Institut National De La Sante Et De La Recherche Medicale) Inhibitors of progastrin-induced repression of icat for treating and/or preventing colorectal cancer, adenomatous polyposis or metastasis displaying progastrin-secreting cells andcells in which the beta-catenin/tcf-4-mediated transcriptional pathway is constitutively active
WO2008076454A1 (en) 2006-12-19 2008-06-26 The Board Of Regents Of The University Of Texas System Immunogenic compositions comprising progastrin and uses thereof
US8136651B2 (en) * 2007-12-14 2012-03-20 The Procter & Gamble Company Method and apparatus for orienting articles
JP5717108B2 (ja) * 2009-09-17 2015-05-13 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 左心室肥大のためのマルチマーカーパネル
IN2012DN03348A (zh) 2009-10-16 2015-10-23 Biorealites
AU2014203017B2 (en) * 2009-10-16 2017-02-02 Centre National De La Recherche Scientifique (Cnrs) Monoclonal antibodies to progastrin and their uses
US9487582B2 (en) * 2010-01-08 2016-11-08 Institut National De La Sante Et De La Recherche Medicale (Inserm) Methods for treating pancreatic cancer
US8900817B2 (en) * 2010-01-08 2014-12-02 Les Laboratories Servier Progastrin and liver pathologies
US9217032B2 (en) * 2010-01-08 2015-12-22 Les Laboratoires Servier Methods for treating colorectal cancer
US8674064B2 (en) 2010-03-03 2014-03-18 Onkologix Ltd Immunogenic compositions against human progastrin peptides
CN101797382B (zh) * 2010-03-03 2013-11-20 戚胜美 抗人前胃液素多肽免疫组合物
AU2011231978B2 (en) 2010-03-24 2014-12-18 Centre National De La Recherche Scientifique (Cnrs) Prophylaxis of colorectal and gastrointestinal cancer
WO2011137389A2 (en) * 2010-04-30 2011-11-03 Fred Hutchinson Cancer Research Center Compositions and methods for reliably detecting and/or measuring the amount of a modified target protein in a sample
CN103261224B (zh) * 2010-07-26 2015-10-07 瑟维尔实验室 用于肝癌治疗的方法和组合物
EP2715364A1 (en) * 2011-06-01 2014-04-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for predicting the risk of developing a colonic neoplasia
CN106338423B (zh) 2015-07-10 2020-07-14 三斯坎公司 组织学染色的空间复用
MA43550A (fr) 2015-12-31 2018-11-07 Syncerus S A R L Compositions et procédés d'évaluation du risque d'apparition d'un cancer
KR102428254B1 (ko) * 2015-12-31 2022-08-03 프로가스트린 에 캔서스 에스.에이 알.엘. 난소암의 검출 및 치료를 위한 조성물 및 방법
AU2017204686B2 (en) * 2015-12-31 2020-04-30 Progastrine Et Cancers S.À R.L. Compositions and methods for detecting and treating esophageal cancer
JP6909795B2 (ja) 2015-12-31 2021-07-28 プロガストリン、エ、カンセル、エス、アー エル、エルProgastrine Et Cancers S.A R.L. 胃癌の検出および治療のための組成物および方法
WO2018178364A1 (en) 2017-03-30 2018-10-04 Progastrine Et Cancers S.À R.L. Compositions and methods for treating lung cancer
EP3601347B1 (en) * 2017-03-30 2021-11-03 Progastrine et Cancers S.à r.l. Compositions and methods for detecting and treating prostate cancer using progastrin binding molecule
US12150978B2 (en) 2017-06-15 2024-11-26 Cancer Advances Inc. Compositions and methods for preventing tumors and cancer
US11583576B2 (en) 2017-06-15 2023-02-21 Cancer Advances Inc. Compositions and methods for inducing humoral and cellular immunities against tumors and cancer
CA3084687C (en) 2017-12-05 2024-01-02 Progastrine Et Cancers S.A R.L. Combination therapy between anti-progastrin antibody and immunotherapy to treat cancer
CN112004560A (zh) * 2017-12-08 2020-11-27 Ecs生物识别系统有限公司 癌症诊断中的放射性标记的前胃液素
TW201940881A (zh) 2018-01-26 2019-10-16 瑞士商Ecs前胃泌激素公司 在癌症診斷中結合前胃泌激素檢測與其他癌症生物標記的技術
CN112368579B (zh) * 2018-02-27 2024-05-03 Ecs前胃泌素股份有限公司 作为生物标记物的前胃泌素用于免疫疗法
CN115639360A (zh) * 2021-07-19 2023-01-24 武汉市朗典精医生物科技有限公司 制备前体胃泌素(pg80)抗体及建立clia检测pg80试剂盒
CN116143920A (zh) * 2022-12-30 2023-05-23 南京岚煜生物科技有限公司 胃泌素17的单克隆抗体及其细胞株的制备方法和应用
US20250059271A1 (en) * 2023-08-16 2025-02-20 Barrelman Biosciences Llc Monoclonal antibodies against veterinary progastrin-like molecules and their uses

Family Cites Families (127)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3391141A (en) 1966-07-07 1968-07-02 Bristol Myers Co Synthetic cephalosporins
DE2256445C3 (de) 1972-11-17 1981-11-05 Hoechst Ag, 6000 Frankfurt Heptapeptide, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Präparate
US4302386A (en) 1978-08-25 1981-11-24 The Ohio State University Antigenic modification of polypeptides
US4384995A (en) 1980-01-16 1983-05-24 The Ohio State University Antigenic modification of polypeptides
US5698201A (en) 1973-05-07 1997-12-16 The Ohio State University Method for treatment of antigenically modified polypeptides
US5006334A (en) 1973-05-07 1991-04-09 The Ohio State University Antigenic modification of polypeptides
US4767842A (en) 1973-05-07 1988-08-30 The Ohio State University Antigenic modification of polypeptides
US4691006A (en) 1983-03-04 1987-09-01 Ohio State University Antigenic modification of polypeptides
US4526716A (en) 1981-11-20 1985-07-02 The Ohio State University Antigenic modification of polypeptides
US4201770A (en) 1973-05-07 1980-05-06 The Ohio State University Antigenic modification of polypeptides
US4762913A (en) 1973-05-07 1988-08-09 The Ohio State University Antigenic modification of polypeptides
US4069313A (en) 1974-11-19 1978-01-17 Merck & Co., Inc. Water-in-oil adjuvant composition
US4196265A (en) 1977-06-15 1980-04-01 The Wistar Institute Method of producing antibodies
SU1414392A1 (ru) 1982-12-29 1988-08-07 Всесоюзный кардиологический научный центр АМН СССР Противо звенное средство
US4925922A (en) 1983-02-22 1990-05-15 Xoma Corporation Potentiation of cytotoxic conjugates
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4828991A (en) 1984-01-31 1989-05-09 Akzo N.V. Tumor specific monoclonal antibodies
US4894443A (en) 1984-02-08 1990-01-16 Cetus Corporation Toxin conjugates
CA1289077C (en) 1984-08-13 1991-09-17 Harry H. Leveen Treatment of cancer with phlorizin and its derivatives
FR2575164B1 (fr) 1984-12-20 1987-03-20 Sanofi Sa Esters de tri- et tetrapeptides inhibiteurs de la secretion gastrique, procede d'obtention et compositions pharmaceutiques les contenant
IT1179894B (it) 1984-12-27 1987-09-16 Rotta Research Lab Proglumide e composizioni farmaceutiche che la contengono per l impiego nella terapia di affezioni neoplastiche
US4803170A (en) 1985-05-09 1989-02-07 Ultra Diagnostics Corporation Competitive immunoassay method, device and test kit
US4713366A (en) 1985-12-04 1987-12-15 The Ohio State University Research Foundation Antigenic modification of polypeptides
IT1204430B (it) 1986-01-10 1989-03-01 Alfio Bertolini Composizioni farmaceutiche comprendenti peptidi del gruppo colecistochinina-cerulina per il trattamento terapeutico degli stati di shock e dell'insufficienza respiratoria e cardiocircolatoria
CA1341281C (en) 1986-07-09 2001-08-07 Hubert J.P. Schoemaker Immunotherapy of tumor with monoclonal antibody against the 17-1a antigen
US5344919A (en) 1987-02-19 1994-09-06 The Scripps Research Institute Integrin from human epithelial cells
US4971792A (en) 1987-03-27 1990-11-20 The Wistar Institute Monoclonal antibodies against glycolipid antigens
US4923819A (en) 1987-03-27 1990-05-08 Chimerix Corporation Time-resolved fluorescence immunoassay
NZ227266A (en) 1987-12-09 1992-02-25 Gen Hospital Corp Method of detecting adenocarcinoma of colon, liver or lung by detecting the antigens af-20 and xf-8
US5035988A (en) 1988-05-12 1991-07-30 Fuji Photo Film Co., Ltd. Silver halide photographic material containing a yellow coupler and a phosphorus compound and color image forming method
US5162504A (en) 1988-06-03 1992-11-10 Cytogen Corporation Monoclonal antibodies to a new antigenic marker in epithelial prostatic cells and serum of prostatic cancer patients
JPH0249596A (ja) 1988-08-09 1990-02-19 Masamichi Ueda ヒト前立腺上皮細胞の表面に特異的に反応するモノクローナル抗体
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5759791A (en) 1989-01-17 1998-06-02 The Johns Hopkins University Cancer related antigen
US5665874A (en) 1989-01-17 1997-09-09 John Hopkins University Cancer related antigen
ATE114160T1 (de) 1989-01-24 1994-12-15 Aphton Corp Immunogenische zusammensetzungen gegen gastrin- peptide.
US6861510B1 (en) 1989-01-24 2005-03-01 Aphton Corporation Immunogenic compositions against gastrin peptides
US5023077A (en) 1989-01-24 1991-06-11 Aphton Corporation Immunogenic compositions and methods for the treatment and prevention of gastric and duodenal ulcer disease
US5120829A (en) 1989-03-20 1992-06-09 La Jolla Cancer Research Foundation Hydrophobic attachment site for adhesion peptides
US4997950A (en) 1989-04-20 1991-03-05 Richard Finbar Murphy Novel C-terminal gastrin antagonists
US6020145A (en) 1989-06-30 2000-02-01 Bristol-Myers Squibb Company Methods for determining the presence of carcinoma using the antigen binding region of monoclonal antibody BR96
US5770576A (en) 1989-08-30 1998-06-23 Cytran, Inc. Pharmaceutical dipeptide compositions and methods of use thereof: systemic toxicity
US5242799A (en) 1989-11-02 1993-09-07 Biomira, Inc. Lectin-antibody immunoassays for TF epitope-bearing antigens
US5110911A (en) 1989-11-02 1992-05-05 Biomira, Inc. Human tumor-associated thomsen-friedenreich antigen
US5164299A (en) 1990-03-20 1992-11-17 E. I. Du Pont De Nemours And Company Use of a mixture of conjugated and unconjugated solid phase binding reagent to enhance the performance of assays
US5932412A (en) 1990-05-11 1999-08-03 Euro-Diagnostica Ab Synthetic peptides in human papillomaviruses 1, 5, 6, 8, 11, 16, 18, 31, 33 and 56, useful in immunoassay for diagnostic purposes
US5733790A (en) 1991-01-15 1998-03-31 The Salk Institute For Biological Studies CRF binding protein antibodies and assays using same
US5668117A (en) 1991-02-22 1997-09-16 Shapiro; Howard K. Methods of treating neurological diseases and etiologically related symptomology using carbonyl trapping agents in combination with previously known medicaments
US6251581B1 (en) 1991-05-22 2001-06-26 Dade Behring Marburg Gmbh Assay method utilizing induced luminescence
DE122004000008I1 (de) 1991-06-14 2005-06-09 Genentech Inc Humanisierter Heregulin Antikörper.
GB9115364D0 (en) 1991-07-16 1991-08-28 Wellcome Found Antibody
US5319073A (en) 1992-02-07 1994-06-07 The United States Of America, As Represented By The Department Of Health & Human Services Method of purifying cholecystokinin receptor protein
US5256542A (en) 1992-03-09 1993-10-26 Tanox Biosystems, Inc. Selecting low frequency antigen-specific single B lymphocytes with correction for background noise
WO1993022343A1 (en) 1992-05-01 1993-11-11 The Rockfeller University Multiple antigen peptide system having adjuvant properties and vaccines prepared therefrom
WO1993023557A1 (en) 1992-05-08 1993-11-25 Receptagen Corporation Anti-receptor agents to the vitamin b12/transcobalamin ii receptor
US5639613A (en) 1992-05-13 1997-06-17 Board Of Regents, University Of Texas System Methods for cancer diagnosis and prognosis
US5736146A (en) 1992-07-30 1998-04-07 Yeda Research And Development Co. Ltd. Conjugates of poorly immunogenic antigens and synthetic peptide carriers and vaccines comprising them
JP3439490B2 (ja) 1992-09-28 2003-08-25 株式会社林原生物化学研究所 蛋白質とその蛋白質をコードするdna並びにその蛋白質の製造方法
WO1994007530A1 (en) 1992-09-30 1994-04-14 The Ohio State University Research Foundation Vaccines and antigenic conjugates
US5879898A (en) 1992-11-20 1999-03-09 Isis Innovation Limited Antibodies specific for peptide corresponding to CD44 exon 6, and use of these antibodies for diagnosis of tumors
US5683695A (en) 1993-02-10 1997-11-04 United Biomedical, Inc. Production of recombinant proteins containing multiple antigenic determinants linked by flexible hinge domains
US5759551A (en) 1993-04-27 1998-06-02 United Biomedical, Inc. Immunogenic LHRH peptide constructs and synthetic universal immune stimulators for vaccines
WO1995004544A1 (en) 1993-08-09 1995-02-16 Edward Baral A method for sensitization of cancer cells for killer cell mediated lysis
US5601990A (en) 1994-09-13 1997-02-11 Thomas Jefferson University Methods of diagnosing colorectal tumors and metastasis thereof
US5468494A (en) 1993-11-12 1995-11-21 Aphton Corp. Immunogenic compositions against human gastrin 17
US5750119A (en) 1994-01-13 1998-05-12 Mount Sinai School Of Medicine Of The City University Of New York Immunotherapeutic stress protein-peptide complexes against cancer
US7300918B2 (en) * 1994-01-14 2007-11-27 Matthias Rath Method of producing vaccines from protein signal oligopeptides
US5688506A (en) 1994-01-27 1997-11-18 Aphton Corp. Immunogens against gonadotropin releasing hormone
US5767242A (en) 1994-04-20 1998-06-16 Boehringer Ingelheim Int'l Gmbh Isolated dimeric fibroblast activation protein alpha, and uses thereof
US5869058A (en) 1994-05-25 1999-02-09 Yeda Research And Development Co. Ltd. Peptides used as carriers in immunogenic constructs suitable for development of synthetic vaccines
EP0772774B1 (de) 1994-07-25 2006-06-28 Roche Diagnostics GmbH Bestimmung von spezifischem immunglobulin unter verwendung multipler antigene
JP3853384B2 (ja) 1994-09-09 2006-12-06 株式会社三菱化学ヤトロン 抗サイモシンα1モノクローナル抗体産生ハイブリドーマ
US5789000A (en) 1994-11-14 1998-08-04 Bionumerik Pharmaceuticals, Inc. Sterile aqueous parenteral formulations of cis-diammine dichloro platinum
FI97304C (fi) 1994-11-16 1996-11-25 Locus Genex Oy Menetelmä mahasyövän riskin seulonnaksi
US5723718A (en) 1994-12-20 1998-03-03 St. Joseph's Hospital And Medical Center Induction of immune tolerance to tumor cells
US5955504A (en) 1995-03-13 1999-09-21 Loma Linda University Medical Center Colorectal chemoprotective composition and method of preventing colorectal cancer
JP2968048B2 (ja) 1995-05-12 1999-10-25 シェーリング コーポレイション 表面プラズモン共鳴に基づく酵素アッセイ
US6359114B1 (en) 1995-06-07 2002-03-19 Aphton Corp. System for method for the modification and purification of proteins
US5712369A (en) 1995-08-24 1998-01-27 Ludwig Institute For Cancer Research Isolated protein which binds to A33 antibody, and peptides corresponding to portions of the protein
ATE180832T1 (de) 1995-08-18 1999-06-15 Us Gov Health & Human Serv Funktionelle rolle von adrenomedullin(am) und dem gen-verwandten produkt(pamp) in der menschlichen pathologie und physiologie
MA24512A1 (fr) 1996-01-17 1998-12-31 Univ Vermont And State Agrienl Procede pour la preparation d'agents anticoagulants utiles dans le traitement de la thrombose
PT889735E (pt) 1996-02-08 2011-07-19 Cancer Advances Inc Métodos imunológicos para o tratamento do cancro gastrointestinal
US5786213A (en) 1996-04-18 1998-07-28 Board Of Regents, The University Of Texas System Inhibition of endogenous gastrin expression for treatment of colorectal cancer
WO1997046668A1 (fr) 1996-06-07 1997-12-11 Takeda Chemical Industries, Ltd. Peptide, procede de production et mode d'utilisation correspondants
IL118626A0 (en) 1996-06-11 1996-10-16 Xtl Biopharmaceuticals Limited Anti HBV antibody
JPH1026621A (ja) 1996-07-12 1998-01-27 Dai Ichi Pure Chem Co Ltd イムノアッセイ法
UA76934C2 (en) 1996-10-04 2006-10-16 Chugai Pharmaceutical Co Ltd Reconstructed human anti-hm 1.24 antibody, coding dna, vector, host cell, method for production of reconstructed human antibody, pharmaceutical composition and drug for treating myeloma containing reconstructed human anti-hm 1.24 antibody
ES2335557T3 (es) 1997-01-21 2010-03-29 Sanofi Pasteur Conjugados de peptido-polisacarido.
AU6659298A (en) 1997-02-18 1998-09-08 Thomas Jefferson University Compositions that bind to pancreatic cancer cells and methods of using the same
US20040001842A1 (en) 1997-05-12 2004-01-01 Dov Michaeli Immunogenic compositions to the CCK-B/gastrin receptor and methods for the treatment of tumors
JP2002511066A (ja) 1997-05-12 2002-04-09 アフトン コーポレーション Cck−b/ガストリン受容体に対する免疫原性組成物および腫瘍の治療方法
US5886128A (en) 1997-06-17 1999-03-23 Union Camp Corporation Modified phenolic resin and uses related thereto
WO1999039829A1 (en) 1998-02-04 1999-08-12 Merck & Co., Inc. Virtual wells for use in high throughput screening assays
JP2002515458A (ja) 1998-05-15 2002-05-28 アフトン・コーポレーシヨン 高ガストリン血症の予防および処置
EP1579863A3 (en) 1998-05-15 2008-03-19 Receptor Biologix, Inc. Combination therapy with anti-gastrin G17 antibodies for the treatment of tumors
US20030068326A1 (en) 1998-05-15 2003-04-10 Aphton Corporation Method for the treatment of gastroesophageal reflux disease
ATE263572T1 (de) 1998-06-18 2004-04-15 Vecta Ltd Verwendung von gastrin fragmenten oder sythetischen analogen von gastrin zur herstellung eines arzneimittels zur behandlung der helicobacter pylori assozierten störungen
WO2000050059A1 (en) 1999-02-24 2000-08-31 The Uab Research Foundation Taxane derivatives for targeted therapy of cancer
FI118653B (fi) 1999-04-30 2008-01-31 Biohit Oyj Menetelmä peptisen haavan riskin määrittämiseksi
FR2797689B1 (fr) 1999-08-16 2003-06-27 Pasteur Sanofi Diagnostics Utilisation de composes synthetiques pour des immunodosages
KR20090024308A (ko) 1999-08-27 2009-03-06 제넨테크, 인크. 항-ErbB2 항체 투여 치료 방법
US20020058040A1 (en) 1999-12-23 2002-05-16 Stephen Grimes Stable immunogenic composition for frozen storage
US20030232399A1 (en) 2000-06-14 2003-12-18 Robertson John Forsyth Russell Cancer detection methods and reagents
US20030138860A1 (en) 2000-06-14 2003-07-24 Robertson John Forsyth Russell Cancer detection methods and reagents
FR2816410B1 (fr) 2000-11-09 2003-04-18 Pasteur Institut Necessaire de detection de la proteine esm-1 et procede de detection mettant en oeuvre ledit necessaire
US6780969B2 (en) 2000-12-22 2004-08-24 United Biomedical, Inc. Synthetic peptide composition as immunogens for prevention of urinary tract infection
CN1312181C (zh) 2001-02-12 2007-04-25 米德列斯公司 抗Fcα受体(CD89)的人单克隆抗体
AU2002252456A1 (en) 2001-03-23 2002-10-08 Aphton Corporation Combination treatment of pancreatic cancer
US20090191232A1 (en) 2001-05-04 2009-07-30 Gevas Philip C Combination therapy for the treatment of tumors
AU2002326356A1 (en) 2001-07-09 2003-01-29 Aphton Corporation Treatment and prevention of cancerous and pre-cancerous conditions of the liver, lung and esophagus
RU2318829C2 (ru) 2001-11-14 2008-03-10 Сентокор, Инк. Антитела против il-6, композиции, способы и применение
EP1837031B1 (en) 2002-06-07 2009-10-14 Waratah Pharmaceuticals, Inc. Compositions and methods for treating diabetes
US20050169979A1 (en) 2002-07-03 2005-08-04 Dov Michaeli Liposomal vaccine
US20040247661A1 (en) 2002-07-03 2004-12-09 Dov Michaeli Liposomal vaccine
US20040208920A1 (en) 2002-07-03 2004-10-21 Dov Michaeli Liposomal vaccine
FI119571B (fi) 2002-09-06 2008-12-31 Biohit Oyj Menetelmä esofagiitin tai Barrettin ruokatorven riskin osoittamiseksi yksilöllä
US20030049698A1 (en) 2002-10-08 2003-03-13 Wang Timothy C. Diagnosis and treatment of gastrointestinal disease
ES2401136T3 (es) 2002-11-15 2013-04-17 Genmab A/S Anticuerpos monoclonales humanos contra CD25
EP1608984A2 (en) 2003-03-28 2005-12-28 Aphton Corporation Gastrin hormone immunoassays
US20070031511A1 (en) 2003-04-08 2007-02-08 Baldwin Graham S Method of treatment
JP5576592B2 (ja) 2004-03-29 2014-08-20 キャンサー アドヴァンシズ インコーポレイテッド ガストリンホルモンに対するモノクローナル抗体
WO2006008649A1 (en) 2004-07-15 2006-01-26 Aphton Corporation Anti-sense polynucleotide therapy for gastrin-promoted tumors
US7662926B2 (en) 2004-09-02 2010-02-16 Genentech, Inc. Anti-Fc-gamma receptor antibodies, bispecific variants and uses therefor
US8158128B2 (en) 2004-09-22 2012-04-17 Cancer Advances, Inc. Monoclonal antibodies to progastrin
EP1971363A1 (en) 2005-12-02 2008-09-24 Waratah Pharmaceuticals, Inc. Combination treatments with gastrin agonists for diabetes and related diseases
US8136651B2 (en) 2007-12-14 2012-03-20 The Procter & Gamble Company Method and apparatus for orienting articles
WO2008076454A1 (en) 2006-12-19 2008-06-26 The Board Of Regents Of The University Of Texas System Immunogenic compositions comprising progastrin and uses thereof

Also Published As

Publication number Publication date
EP2567974A3 (en) 2013-05-22
AU2005286164B2 (en) 2012-05-24
EP1794586A1 (en) 2007-06-13
ZA200702926B (en) 2012-11-28
US8158128B2 (en) 2012-04-17
KR101333168B1 (ko) 2013-11-28
CN101048659B (zh) 2013-03-13
EP1794586B1 (en) 2013-01-30
AU2005286164A1 (en) 2006-03-30
CA2580965A1 (en) 2006-03-30
WO2006032980A1 (en) 2006-03-30
CA2580965C (en) 2014-04-08
KR20070100236A (ko) 2007-10-10
EP2567974A2 (en) 2013-03-13
IL182012A0 (en) 2007-07-24
CN101048659A (zh) 2007-10-03
JP2008513536A (ja) 2008-05-01
IL182012A (en) 2013-10-31
US20070248608A1 (en) 2007-10-25
DK1794586T3 (da) 2013-05-13
ES2400058T3 (es) 2013-04-05
US8808695B2 (en) 2014-08-19
US20120156205A1 (en) 2012-06-21

Similar Documents

Publication Publication Date Title
HK1105126A1 (en) Monoclonal antibodies to progastrin
TWI366570B (en) Antibodies to madcam
IL191340A (en) Monoclonal antibodies against e8o
HRP20181616T1 (hr) Potpuno ljudska anti-vap-1 monoklonska antitijela
IL239947A (en) 21-il monoclonal antibody from human origin
SG10201404801YA (en) Monoclonal antibody
EP2021373A4 (en) MONOCLONAL ANTIBODY VCAM-1 SPECIFIC
ZA200608130B (en) Humanized anti-TGF-beta antibodies
IL189788A0 (en) Human monoclonal antibodies to cd70
IL191217A (en) Anti-17 mantle monoclonal antibody
EP2331579A4 (en) MONOCLONAL ANTIBODIES
IL179672A0 (en) Anti-cd3 antibodies
HRP20130440T1 (en) Anti-p-selectin antibodies
IL200168A0 (en) Monoclonal anti-cxcl13 antibodies
ZA200807903B (en) Humanized monoclonal antibodies to hepatocyte growth factor
ZA200802641B (en) Human monoclonal antibodies to CD70
EP1712564A4 (en) MONOCLONAL ANTIBODY ANTI-NC1
ZA200804254B (en) Human monoclonal antibodies to O8E
GB0415644D0 (en) Monoclonal antibody
GB0413479D0 (en) Novel antibodies

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20230921