PT889735E - Métodos imunológicos para o tratamento do cancro gastrointestinal - Google Patents

Métodos imunológicos para o tratamento do cancro gastrointestinal Download PDF

Info

Publication number: PT889735E
Authority: PT; Portugal
Prior art keywords: treatment; gastrointestinal cancer; immunological methods; gastrin; amidated
Prior art date: 1996-02-08

Application number

PT97905858T

Other languages

English (en)

Inventor

Philip C Gevas

Dov Michaeli

Stephen Grimes

Stephen L Karr

Susan A Watson

Original Assignee

Cancer Advances Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-08

Filing date

1997-02-07

Publication date

2011-07-19

1997-02-07 Application filed by Cancer Advances Inc filed Critical Cancer Advances Inc

2011-07-19 Publication of PT889735E publication Critical patent/PT889735E/pt

Links

206010017993 Gastrointestinal neoplasms Diseases 0.000 title abstract 2
230000001900 immune effect Effects 0.000 title 1
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
108010066264 gastrin 17 Proteins 0.000 abstract 2
GKDWRERMBNGKCZ-RNXBIMIWSA-N gastrin-17 Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 GKDWRERMBNGKCZ-RNXBIMIWSA-N 0.000 abstract 2
102400000921 Gastrin Human genes 0.000 abstract 1
239000004471 Glycine Substances 0.000 abstract 1
230000001419 dependent effect Effects 0.000 abstract 1
108010063604 gastrin immunogen Proteins 0.000 abstract 1
108010017400 glycine-extended gastrin 17 Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/595—Gastrins; Cholecystokinins [CCK]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Endocrinology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Zoology (AREA)
Toxicology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

PT97905858T 1996-02-08 1997-02-07 Métodos imunológicos para o tratamento do cancro gastrointestinal PT889735E (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US1141196P	1996-02-08	1996-02-08
PCT/US1997/002029 WO1997028821A1 (en)	1996-02-08	1997-02-07	Immunological methods for the treatment of gastrointestinal cancer

Publications (1)

Publication Number	Publication Date
PT889735E true PT889735E (pt)	2011-07-19

Family

ID=21750270

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT97905858T PT889735E (pt)	1996-02-08	1997-02-07	Métodos imunológicos para o tratamento do cancro gastrointestinal

Country Status (9)

Country	Link
US (1)	US20050025770A1 (pt)
EP (1)	EP0889735B1 (pt)
JP (3)	JP2000504692A (pt)
AT (1)	ATE505202T1 (pt)
DE (1)	DE69740173D1 (pt)
DK (1)	DK0889735T3 (pt)
ES (1)	ES2361474T3 (pt)
PT (1)	PT889735E (pt)
WO (1)	WO1997028821A1 (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT889735E (pt) *	1996-02-08	2011-07-19	Cancer Advances Inc	Métodos imunológicos para o tratamento do cancro gastrointestinal
US20040001842A1 (en) *	1997-05-12	2004-01-01	Dov Michaeli	Immunogenic compositions to the CCK-B/gastrin receptor and methods for the treatment of tumors
WO1998051337A2 (en) *	1997-05-12	1998-11-19	Aphton Corporation	Immunogenic compositions to the cck-b/gastrin-receptor and methods for the treatment of tumors
ES2286883T3 (es) *	1998-05-15	2007-12-01	Receptor Biologix, Inc.	Prevencion y tratamiento de la hipergastrinemia.
EP1897556A1 (en) *	1998-05-15	2008-03-12	Receptor Biologix, Inc.	Prevention and treatment of hypergastrinemia
US20030068326A1 (en) *	1998-05-15	2003-04-10	Aphton Corporation	Method for the treatment of gastroesophageal reflux disease
EP1372717A2 (en) *	2001-03-23	2004-01-02	Aphton Corporation	Combination treatment of pancreatic cancer
US20090191232A1 (en) *	2001-05-04	2009-07-30	Gevas Philip C	Combination therapy for the treatment of tumors
US20030021786A1 (en) *	2001-07-09	2003-01-30	Gevas Philip C.	Treatment and prevention of cancerous and pre-cancerous conditions of the liver, lung and esophagus
US20050169979A1 (en) *	2002-07-03	2005-08-04	Dov Michaeli	Liposomal vaccine
KR20050118690A (ko)	2003-03-28	2005-12-19	애프톤 코포레이션	가스트린 호르몬 면역어세이
WO2005095459A2 (en) *	2004-03-29	2005-10-13	Receptor Biologix, Inc.	Monoclonal antibodies to gastrin hormone
DK1794586T3 (da) *	2004-09-22	2013-05-13	Cancer Advances Inc	Monoklonale antistoffer til progastrin
JP5558660B2 (ja)	2007-05-11	2014-07-23	日東電工株式会社	両面接着性感圧接着シート
US8674064B2 (en) *	2010-03-03	2014-03-18	Onkologix Ltd	Immunogenic compositions against human progastrin peptides
CN101797382B (zh)	2010-03-03	2013-11-20	戚胜美	抗人前胃液素多肽免疫组合物
RU2664197C2 (ru) *	2013-05-21	2018-08-15	ТиУайДжи ОНКОЛОДЖИ ЛТД.	Иммуногенная композиция, включающая ее вакцина, набор для приготовления вышеуказанной композиции и способ лечения заболеваний, связанных с патологией секреции гастрина
JP6525909B2 (ja)	2016-03-15	2019-06-05	中外炉工業株式会社	工業炉
US12150978B2 (en)	2017-06-15	2024-11-26	Cancer Advances Inc.	Compositions and methods for preventing tumors and cancer
CN111050789A (zh)	2017-06-15	2020-04-21	癌症进展有限公司	用于诱导针对肿瘤和癌症的体液免疫和细胞免疫的组合物和方法

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US140962A (en) *		1873-07-15		Improvement in feeding paper to printing-presses
US1842A (en) *		1840-10-31		Machine fob cutting corks
US20119A (en) *		1858-04-27		Improvement in raking and delivering attachments to harvesters
US187152A (en) *		1877-02-06		Improvement in clothes-wringers
US39911A (en) *		1863-09-15		Improvement in corset skirt-supporters
US91574A (en) *		1869-06-22		Improvement in water-closet valves
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US58040A (en) *		1866-09-18		Improvement in making bolts
US69966A (en) *		1867-10-22		Joseph chadwick
US95028A (en) *		1869-09-21		Improved process for preserving eggs
US86941A (en) *		1869-02-16		Improvement in corn-planter
US21786A (en) *		1858-10-12		Improvement in the manufacture of sugar
US4384995A (en) *	1980-01-16	1983-05-24	The Ohio State University	Antigenic modification of polypeptides
US4526716A (en) *	1981-11-20	1985-07-02	The Ohio State University	Antigenic modification of polypeptides
US4691006A (en) *	1983-03-04	1987-09-01	Ohio State University	Antigenic modification of polypeptides
IT1179894B (it) *	1984-12-27	1987-09-16	Rotta Research Lab	Proglumide e composizioni farmaceutiche che la contengono per l impiego nella terapia di affezioni neoplastiche
ES2063912T3 (es) *	1989-01-24	1995-01-16	Aphton Corp	Composiciones inmunogenicas frente a peptidos de gastrina.
US6861510B1 (en) *	1989-01-24	2005-03-01	Aphton Corporation	Immunogenic compositions against gastrin peptides
US5023077A (en) *	1989-01-24	1991-06-11	Aphton Corporation	Immunogenic compositions and methods for the treatment and prevention of gastric and duodenal ulcer disease
US5319073A (en) *	1992-02-07	1994-06-07	The United States Of America, As Represented By The Department Of Health & Human Services	Method of purifying cholecystokinin receptor protein
US5759551A (en) *	1993-04-27	1998-06-02	United Biomedical, Inc.	Immunogenic LHRH peptide constructs and synthetic universal immune stimulators for vaccines
US5468494A (en) *	1993-11-12	1995-11-21	Aphton Corp.	Immunogenic compositions against human gastrin 17
US5688506A (en) *	1994-01-27	1997-11-18	Aphton Corp.	Immunogens against gonadotropin releasing hormone
FI97304C (fi) *	1994-11-16	1996-11-25	Locus Genex Oy	Menetelmä mahasyövän riskin seulonnaksi
US6359114B1 (en) *	1995-06-07	2002-03-19	Aphton Corp.	System for method for the modification and purification of proteins
PT889735E (pt) *	1996-02-08	2011-07-19	Cancer Advances Inc	Métodos imunológicos para o tratamento do cancro gastrointestinal
WO1998051337A2 (en) *	1997-05-12	1998-11-19	Aphton Corporation	Immunogenic compositions to the cck-b/gastrin-receptor and methods for the treatment of tumors
JP4808846B2 (ja) *	1999-02-24	2011-11-02	ザユーエイビーリサーチファンデイション	癌の標的付けられた治療のためのタキサン誘導体

1997
- 1997-02-07 PT PT97905858T patent/PT889735E/pt unknown
- 1997-02-07 WO PCT/US1997/002029 patent/WO1997028821A1/en active Application Filing
- 1997-02-07 AT AT97905858T patent/ATE505202T1/de active
- 1997-02-07 ES ES97905858T patent/ES2361474T3/es not_active Expired - Lifetime
- 1997-02-07 EP EP97905858A patent/EP0889735B1/en not_active Expired - Lifetime
- 1997-02-07 JP JP9528702A patent/JP2000504692A/ja not_active Withdrawn
- 1997-02-07 DE DE69740173T patent/DE69740173D1/de not_active Expired - Lifetime
- 1997-02-07 DK DK97905858.3T patent/DK0889735T3/da active
2004
- 2004-01-20 US US10/762,226 patent/US20050025770A1/en not_active Abandoned
2006
- 2006-11-16 JP JP2006310647A patent/JP5200251B2/ja not_active Expired - Lifetime
2011
- 2011-02-21 JP JP2011034753A patent/JP5200269B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0889735A1 (en)	1999-01-13
ATE505202T1 (de)	2011-04-15
EP0889735B1 (en)	2011-04-13
DE69740173D1 (de)	2011-05-26
JP2000504692A (ja)	2000-04-18
WO1997028821A1 (en)	1997-08-14
US20050025770A1 (en)	2005-02-03
JP2007126461A (ja)	2007-05-24
JP2012097062A (ja)	2012-05-24
JP5200269B2 (ja)	2013-06-05
ES2361474T3 (es)	2011-06-17
JP5200251B2 (ja)	2013-06-05
DK0889735T3 (da)	2011-08-08

Publication	Publication Date	Title
PT889735E (pt)	2011-07-19	Métodos imunológicos para o tratamento do cancro gastrointestinal
WO1997028821B1 (en)	1997-10-02	Immunological methods for the treatment of gastrointestinal cancer
IL139700A0 (en)	2002-02-10	Immunotherapeutic composition and method for the treatment of prostate cancer
NZ332566A (en)	2000-08-25	Antigen binding fragments that specifically detect cancer cells
PL332742A1 (en)	1999-10-11	Transformed human antibody against hm 1.24
MX9701859A (es)	1998-07-31	Anticuerpos monoclonales en contra de antigenos asociados con carcinoma de colon humano, y usos de los mismos.
IL125590A0 (en)	1999-03-12	Peptide immunogens
EP0380230A3 (en)	1991-06-26	Immunogenic compositions against gastrin peptides
NZ331978A (en)	2000-05-26	Monoclonal antibody to CEA (carcinomembryonic antigen), conjugates comprising said antibody, and their therapeutic use in an adept system
GR3030141T3 (en)	1999-08-31	Diphtheria toxin receptor-binding region.
GB9125768D0 (en)	1992-02-05	Therapeutic method
MD1374G2 (ro)	2000-09-30	Anticorpi monoclonali imunostimulatori, procedeu de obţinere a acestora, linii celulare, metodă de tratare a maladiilor şi compoziţie farmaceutică
EP0823438A3 (en)	1999-09-15	Human mucin cone protein: peptide fragments and antibodies thereto, and uses thereof in diagnostic and therapeutic methods
IL126803A0 (en)	1999-08-17	Method and composition for reconforming multi-epitopic antigens to initiate an immune response
GB9603507D0 (en)	1996-04-17	Antibody variants
NZ205241A (en)	1991-01-29	Synthetic human (pre)prorelaxin; synthetic signal, a, b and c peptide chains thereof; preparation of human preprorelaxin, prorelaxin and relaxin by recombinant dna or other techniques
PL325897A1 (en)	1998-08-17	Patient-specific immunoadsorbents for extracorporeal apherresis and method of obtaining them
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WO2000069915A3 (en)	2001-07-26	COMBINED APPROACH TO TREATMENT OF CANCER WITH hCG VACCINES
BG102513A (en)	1999-02-26	Method for the diagnostics and the treatment of flat cellular cancer
EP0420848A4 (en)	1991-06-05	Carcinoma-associated antigens, and antibodies which recognize these antigens
WO1991010735A3 (fr)	1991-10-03	Recepteur humain de la tsh. sequence codant pour ce recepteur
DE69626642T2 (de)	2004-01-29	Cetp zur erhöhung des hdl-cholesterol-gehalts
HU9300928D0 (en)	1993-06-28	Endothelial-leucocyta adhesion molecule-1 (elam-1) and its antibodies being applicable for treatment of asthma