DE69626642T2 - Cetp zur erhöhung des hdl-cholesterol-gehalts - Google Patents
Cetp zur erhöhung des hdl-cholesterol-gehalts Download PDFInfo
- Publication number
- DE69626642T2 DE69626642T2 DE69626642T DE69626642T DE69626642T2 DE 69626642 T2 DE69626642 T2 DE 69626642T2 DE 69626642 T DE69626642 T DE 69626642T DE 69626642 T DE69626642 T DE 69626642T DE 69626642 T2 DE69626642 T2 DE 69626642T2
- Authority
- DE
- Germany
- Prior art keywords
- cetp
- hdl cholesterol
- increasing
- cholesterol content
- stimulating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- KEWSCDNULKOKTG-UHFFFAOYSA-N 4-cyano-4-ethylsulfanylcarbothioylsulfanylpentanoic acid Chemical compound CCSC(=S)SC(C)(C#N)CCC(O)=O KEWSCDNULKOKTG-UHFFFAOYSA-N 0.000 title abstract 5
- 102100037637 Cholesteryl ester transfer protein Human genes 0.000 title abstract 5
- 101000880514 Homo sapiens Cholesteryl ester transfer protein Proteins 0.000 title abstract 5
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 title abstract 4
- 235000012000 cholesterol Nutrition 0.000 title abstract 2
- 230000028993 immune response Effects 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 230000004936 stimulating effect Effects 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 108010058846 Ovalbumin Proteins 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000003053 immunization Effects 0.000 abstract 1
- 230000005847 immunogenicity Effects 0.000 abstract 1
- 229940092253 ovalbumin Drugs 0.000 abstract 1
- 230000004044 response Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Ink Jet Recording Methods And Recording Media Thereof (AREA)
- Color Television Image Signal Generators (AREA)
- Materials For Photolithography (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48245495A | 1995-06-06 | 1995-06-06 | |
| PCT/US1996/009143 WO1996039168A1 (en) | 1995-06-06 | 1996-06-05 | Method for increasing hdl cholesterol level |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69626642D1 DE69626642D1 (de) | 2003-04-17 |
| DE69626642T2 true DE69626642T2 (de) | 2004-01-29 |
Family
ID=23916145
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69626642T Expired - Fee Related DE69626642T2 (de) | 1995-06-06 | 1996-06-05 | Cetp zur erhöhung des hdl-cholesterol-gehalts |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7074407B1 (de) |
| EP (1) | EP0831881B1 (de) |
| JP (1) | JP3910635B2 (de) |
| AT (1) | ATE234109T1 (de) |
| CA (1) | CA2223177A1 (de) |
| DE (1) | DE69626642T2 (de) |
| DK (1) | DK0831881T3 (de) |
| ES (1) | ES2190470T3 (de) |
| WO (1) | WO1996039168A1 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6410022B1 (en) | 1995-05-01 | 2002-06-25 | Avant Immunotherapeutics, Inc. | Modulation of cholesteryl ester transfer protein (CETP) activity |
| ES2190470T3 (es) | 1995-06-06 | 2003-08-01 | Avant Immunotherapeutics Inc | Cetp para incrementar el nivel de colesterol de las hdl. |
| US6284533B1 (en) | 1996-05-01 | 2001-09-04 | Avant Immunotherapeutics, Inc. | Plasmid-based vaccine for treating atherosclerosis |
| US6846808B1 (en) | 1996-05-01 | 2005-01-25 | Avant Immunotherapeutics, Inc. | Plasmid-based vaccine for treating atherosclerosis |
| AU747709B2 (en) * | 1997-10-20 | 2002-05-23 | Avant Immunotherapeutics, Inc. | Xenogeneic cholesteryl ester transfer protein (CETP) for modulation of CETP activity |
| US6300308B1 (en) * | 1997-12-31 | 2001-10-09 | Board Of Regents, The University Of Texas System | Methods and compositions for inducing autoimmunity in the treatment of cancers |
| WO2002032935A1 (es) * | 1999-12-13 | 2002-04-25 | Universidad Nacional Autonoma De Mexico | Metodo inmunoenzimatico para cuantificar |
| MX347400B (es) * | 2012-06-29 | 2017-04-18 | Univ Nac Autónoma De México | Vacuna de aplicacion nasal contra el desarrollo de la enfermedad aterosclerotica y el higado graso. |
| CN105859837B (zh) | 2014-10-22 | 2020-11-20 | 台北医学大学 | 胆固醇酯转运蛋白抗原肽和融合蛋白以及其组合物和应用 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6143305A (en) | 1973-05-07 | 2000-11-07 | The Ohio State University | Antigenically modified polypeptides composition |
| US5126399A (en) | 1986-04-30 | 1992-06-30 | Board Of Regents, The University Of Texas System | Methods and compositions for the preparation and use of site-directed immunologic reagents |
| US5338829A (en) | 1988-04-20 | 1994-08-16 | Trustees Of The University Of Pennsylvania | Peptides derived from human immunodeficiency virus-1 GP160 |
| GB8812214D0 (en) | 1988-05-24 | 1988-06-29 | Hoffmann La Roche | Use of peptide from circumsporozoite protein of p falciparum as universally recognized t-cell epitope |
| US5242687A (en) | 1989-03-15 | 1993-09-07 | Tkb Associates Limited Partnership | Method of reducing cellular immune response involving T-cells using CD8-bearing antigen presenting cells |
| US5264341A (en) * | 1989-08-30 | 1993-11-23 | Eli Lilly And Company | Selective cloning for high monoclonal antibody secreting hybridomas |
| WO1992010203A1 (en) | 1990-12-10 | 1992-06-25 | Alving Carl R | A vaccine against cholesterol to prevent hypercholesterolemia and atherosclerosis |
| WO1993011782A1 (en) * | 1991-12-19 | 1993-06-24 | Southwest Foundation For Biomedical Research | Cetp inhibitor polypeptide, antibodies against the synthetic polypeptide and prophylactic and therapeutic anti-atherosclerosis treatments |
| AU4377793A (en) | 1992-05-20 | 1993-12-13 | Johns Hopkins University, The | Alternative receptor therapy |
| US5279540A (en) | 1992-09-24 | 1994-01-18 | Davidson Michael H | Method for reducing the risk of atherosclerosis |
| US5618683A (en) | 1993-04-13 | 1997-04-08 | Brocia; Robert W. | Diagnostic kit for cholesteryl ester transfer protein (CETP) activity measurement and a new synthetic particle used therein |
| ES2180576T3 (es) | 1993-04-27 | 2003-02-16 | United Biomedical Inc | Construcciones peptidicas de lhrh inmunogenicas y estimuladores de inmunidad universales sinteticos para vacunas. |
| US5759551A (en) | 1993-04-27 | 1998-06-02 | United Biomedical, Inc. | Immunogenic LHRH peptide constructs and synthetic universal immune stimulators for vaccines |
| CA2145767A1 (en) * | 1993-08-04 | 1995-02-16 | Rampratap S. Kushwaha | Cetp inhibitor polypeptide, antibodies against the synthetic polypeptide and prophylactic and therapeutic anti-atherosclerosis treatments |
| DK96493D0 (da) | 1993-08-26 | 1993-08-26 | Mouritsen Og Elsner Aps | Fremgangsmaade til at inducere antistofresponser mod selvproteiner og autovaccine fremstillet ved fremgangsmaaden |
| JPH09501186A (ja) | 1994-11-12 | 1997-02-04 | 株式会社エルジ化学 | コレステリルエステル運搬蛋白質阻害ペプチドおよびこれを含む動脈硬化症のための予防および治療剤 |
| US5705388A (en) | 1994-12-23 | 1998-01-06 | Ribozyme Pharmaceuticals, Inc. | CETP Ribozymes |
| US6410022B1 (en) | 1995-05-01 | 2002-06-25 | Avant Immunotherapeutics, Inc. | Modulation of cholesteryl ester transfer protein (CETP) activity |
| ES2190470T3 (es) | 1995-06-06 | 2003-08-01 | Avant Immunotherapeutics Inc | Cetp para incrementar el nivel de colesterol de las hdl. |
| JP2001508760A (ja) | 1996-05-01 | 2001-07-03 | アヴァント イムノセラピユーティクス，インコーポレーテッド | アテローム性動脈硬化症治療用のプラスミド型ワクチン |
| US6284533B1 (en) | 1996-05-01 | 2001-09-04 | Avant Immunotherapeutics, Inc. | Plasmid-based vaccine for treating atherosclerosis |
| US5994310A (en) | 1998-09-03 | 1999-11-30 | Bayer Corporation | Peptide ligands for affinity purification of human Factor VIII |
-
1996
- 1996-06-05 ES ES96918201T patent/ES2190470T3/es not_active Expired - Lifetime
- 1996-06-05 WO PCT/US1996/009143 patent/WO1996039168A1/en not_active Ceased
- 1996-06-05 JP JP50153397A patent/JP3910635B2/ja not_active Expired - Fee Related
- 1996-06-05 DE DE69626642T patent/DE69626642T2/de not_active Expired - Fee Related
- 1996-06-05 AT AT96918201T patent/ATE234109T1/de not_active IP Right Cessation
- 1996-06-05 EP EP96918201A patent/EP0831881B1/de not_active Expired - Lifetime
- 1996-06-05 DK DK96918201T patent/DK0831881T3/da active
- 1996-06-05 CA CA002223177A patent/CA2223177A1/en not_active Abandoned
-
2000
- 2000-03-10 US US09/523,033 patent/US7074407B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7074407B1 (en) | 2006-07-11 |
| ES2190470T3 (es) | 2003-08-01 |
| EP0831881B1 (de) | 2003-03-12 |
| AU715410B2 (en) | 2000-02-03 |
| DE69626642D1 (de) | 2003-04-17 |
| ATE234109T1 (de) | 2003-03-15 |
| AU6091296A (en) | 1996-12-24 |
| EP0831881A1 (de) | 1998-04-01 |
| JPH11507910A (ja) | 1999-07-13 |
| DK0831881T3 (da) | 2003-07-07 |
| JP3910635B2 (ja) | 2007-04-25 |
| CA2223177A1 (en) | 1996-12-12 |
| WO1996039168A1 (en) | 1996-12-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |