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HK1056681A1 - Gabapentin analogues for sleep disorders - Google Patents

Gabapentin analogues for sleep disorders

Info

Publication number
HK1056681A1
HK1056681A1 HK03109027A HK03109027A HK1056681A1 HK 1056681 A1 HK1056681 A1 HK 1056681A1 HK 03109027 A HK03109027 A HK 03109027A HK 03109027 A HK03109027 A HK 03109027A HK 1056681 A1 HK1056681 A1 HK 1056681A1
Authority
HK
Hong Kong
Prior art keywords
sleep disorders
gabapentin analogues
gabapentin
analogues
compounds
Prior art date
Application number
HK03109027A
Other languages
English (en)
Inventor
Justin Stephen Bryans
Leonard Theodore Meltzer
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of HK1056681A1 publication Critical patent/HK1056681A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Anesthesiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK03109027A 2000-06-26 2003-12-11 Gabapentin analogues for sleep disorders HK1056681A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21417100P 2000-06-26 2000-06-26
PCT/US2001/016343 WO2002000209A2 (en) 2000-06-26 2001-05-18 Gabapentin analogues for sleep disorders

Publications (1)

Publication Number Publication Date
HK1056681A1 true HK1056681A1 (en) 2004-02-27

Family

ID=22798045

Family Applications (1)

Application Number Title Priority Date Filing Date
HK03109027A HK1056681A1 (en) 2000-06-26 2003-12-11 Gabapentin analogues for sleep disorders

Country Status (24)

Country Link
US (1) US7141606B2 (xx)
EP (1) EP1296671B1 (xx)
JP (1) JP3909842B2 (xx)
KR (1) KR100785182B1 (xx)
CN (1) CN1279900C (xx)
AT (1) ATE390133T1 (xx)
AU (2) AU6473601A (xx)
BR (1) BR0111913A (xx)
CA (1) CA2414008C (xx)
CZ (1) CZ20024110A3 (xx)
DE (1) DE60133389T2 (xx)
DK (1) DK1296671T3 (xx)
ES (1) ES2300332T3 (xx)
HK (1) HK1056681A1 (xx)
HU (1) HUP0300833A3 (xx)
IL (2) IL152770A0 (xx)
MX (1) MXPA02010668A (xx)
NZ (1) NZ522480A (xx)
PL (1) PL359872A1 (xx)
PT (1) PT1296671E (xx)
SK (1) SK17922002A3 (xx)
TW (1) TWI298020B (xx)
WO (1) WO2002000209A2 (xx)
ZA (1) ZA200209418B (xx)

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GEP20053545B (en) 2001-04-19 2005-06-10 Warner Lambert Co Fused Bicyclic or Tricyclic Amino Acids
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
NZ567711A (en) * 2001-06-11 2009-10-30 Xenoport Inc Orally administered dosage forms of GABA analog prodrugs having reduced toxicity
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
JP2005501013A (ja) 2001-06-11 2005-01-13 ゼノポート，インコーポレイテッド Ｇａｂａ類似体の全身濃度が持続するアミノ酸コンジュゲート
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
EP1485082A4 (en) 2002-02-19 2009-12-30 Xenoport Inc PROCESS FOR THE SYNTHESIS OF PROMEDICAMENTS FROM 1-ACYL-ALKYL DERIVATIVES AND CORRESPONDING COMPOSITIONS
AU2003222033A1 (en) 2002-03-20 2003-10-08 Xenoport Cyclic 1-(acyloxy)-alkyl prodrugs of gaba analogs, compositions and uses thereof
US7183259B2 (en) 2002-05-17 2007-02-27 Xenoport Amino acid conjugates providing for sustained systemic concentrations of GABA analogues
US7060727B2 (en) 2002-12-11 2006-06-13 Xenoport, Inc. Prodrugs of fused GABA analogs, pharmaceutical compositions and uses thereof
CA2451267A1 (en) * 2002-12-13 2004-06-13 Warner-Lambert Company Llc Pharmaceutical uses for alpha2delta ligands
NZ540336A (en) * 2002-12-13 2008-03-28 Warner Lambert Co Gabapentin analogues for fibromyalgia and other related disorders
WO2004093827A2 (en) * 2003-03-25 2004-11-04 Kiel Laboratories, Inc. Phenolic acid salts of gabapentin in solid dosage forms and methods of use
CA2537837A1 (en) 2003-09-11 2005-03-24 Xenoport, Inc. Treating and/or preventing urinary incontinence using prodrugs of gaba analogs
KR101157436B1 (ko) 2003-09-17 2012-07-05 제노포트 인코포레이티드 Ｇａｂａ 유사체의 전구약물을 이용한 하지불안 증후군의치료 또는 예방
JP4308263B2 (ja) 2003-10-14 2009-08-05 ゼノポート，インコーポレイティド γ−アミノ酪酸アナログの結晶形
JP4613031B2 (ja) * 2004-05-06 2011-01-12 エスエス製薬株式会社 催眠剤組成物
JP2005325070A (ja) * 2004-05-14 2005-11-24 Ss Pharmaceut Co Ltd 睡眠改善剤
CA2584338C (en) 2004-11-04 2013-08-06 Xenoport, Inc. Gabapentin prodrug sustained release oral dosage forms
JP2009505947A (ja) 2005-06-23 2009-02-12 エモリー・ユニバーシティ 画像化剤
KR20070070307A (ko) * 2005-08-24 2007-07-04 에스에스 세야쿠 가부시키 가이샤 수면 개선 의약 조성물
BRPI0708671A2 (pt) * 2006-03-06 2011-06-07 Pfizer Prod Inc ligantes alfa-2-delta para sono não restaurador
US7868043B2 (en) 2008-01-25 2011-01-11 Xenoport, Inc. Mesophasic forms of (3S)-aminomethyl-5-methyl-hexanoic acid prodrugs and methods of use
US7872046B2 (en) 2008-01-25 2011-01-18 Xenoport, Inc. Crystalline form of a (3S)-aminomethyl-5-methyl-hexanoic acid prodrug and methods of use
TWI369202B (en) 2008-01-25 2012-08-01 Xenoport Inc Enantiomerically resolving acyloxyalkyl thiocarbonates used in synthesizing acyloxyalkyl carbamate prodrugs
ES2589915T3 (es) 2008-10-08 2016-11-17 Xgene Pharmaceutical Inc Conjugados de GABA y métodos de utilización de los mismos
WO2011071995A2 (en) 2009-12-08 2011-06-16 Case Western Reserve University Compounds and methods of treating ocular disorders
US9066853B2 (en) 2013-01-15 2015-06-30 Warsaw Orthopedic, Inc. Clonidine compounds in a biodegradable fiber
CA2903000C (en) 2013-01-28 2021-10-12 Hector L. Lopez Methods of improving tolerability, pharmacodynamics, and efficacy of .beta.-alanine and use therefor
SG10201912843YA (en) 2016-05-26 2020-02-27 Amino Up Chemical Co Ltd Sleep improving agent
TWI837128B (zh) 2018-05-14 2024-04-01 開曼群島商昌郁製藥公司 萘普生(ｎａｐｒｏｘｅｎ)及普加巴林(ｐｒｅｇａｂａｌｉｎ)之1-(醯氧基)-烷基胺甲酸酯之藥物結合物的結晶型

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4087544A (en) * 1974-12-21 1978-05-02 Warner-Lambert Company Treatment of cranial dysfunctions using novel cyclic amino acids
DE2460891C2 (de) * 1974-12-21 1982-09-23 Gödecke AG, 1000 Berlin 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
US5084479A (en) * 1990-01-02 1992-01-28 Warner-Lambert Company Novel methods for treating neurodegenerative diseases
US6197819B1 (en) * 1990-11-27 2001-03-06 Northwestern University Gamma amino butyric acid analogs and optical isomers
US5510381A (en) * 1995-05-15 1996-04-23 Warner-Lambert Company Method of treatment of mania and bipolar disorder
DE19525598C2 (de) * 1995-07-13 1997-09-25 Max Planck Gesellschaft Schlafmittel
KR100487032B1 (ko) * 1996-03-14 2005-12-21 워너-램버트 캄파니 엘엘씨 약제로서신규한브리지된시클릭아미노산
US6372792B1 (en) * 1996-04-26 2002-04-16 Guy Chouinard Method for treating anxiety, anxiety disorders and insomnia
DE69834204T2 (de) 1997-10-27 2007-03-29 Warner-Lambert Co. Llc Zyklische aminosäuren und deren derivate als arzneimittel
CA2333024C (en) * 1998-07-09 2002-03-26 Warner-Lambert Company Method for the treatment of insomnia
DK1187832T3 (da) * 1999-06-02 2003-03-10 Warner Lambert Co Aminoheterocycler, som er anvendelige som farmaceutiske midler
HN2000000224A (es) * 1999-10-20 2001-04-11 Warner Lambert Co Aminoacidos biciclicos como agentes farmaceuticos
MXPA02004829A (es) 1999-12-08 2003-10-14 Warner Lambert Co Metodo para la sintesis estereoselectiva de aminoacidos ciclicos.
GB9930083D0 (en) * 1999-12-20 2000-02-09 Glaxo Group Ltd Medicaments

Also Published As

Publication number Publication date
CN1279900C (zh) 2006-10-18
TWI298020B (en) 2008-06-21
US20030212133A1 (en) 2003-11-13
MXPA02010668A (es) 2003-03-10
IL152770A (en) 2009-12-24
DE60133389D1 (de) 2008-05-08
IL152770A0 (en) 2003-06-24
SK17922002A3 (sk) 2003-11-04
ATE390133T1 (de) 2008-04-15
CN1436075A (zh) 2003-08-13
HUP0300833A3 (en) 2009-08-28
WO2002000209A2 (en) 2002-01-03
EP1296671A2 (en) 2003-04-02
KR100785182B1 (ko) 2007-12-11
WO2002000209A3 (en) 2003-01-16
PL359872A1 (en) 2004-09-06
US7141606B2 (en) 2006-11-28
JP2004501189A (ja) 2004-01-15
AU2001264736B2 (en) 2006-04-27
CZ20024110A3 (cs) 2003-10-15
HUP0300833A2 (hu) 2003-08-28
PT1296671E (pt) 2008-05-09
ZA200209418B (en) 2005-03-10
CA2414008A1 (en) 2002-01-03
DE60133389T2 (de) 2008-06-26
BR0111913A (pt) 2004-01-06
KR20030019455A (ko) 2003-03-06
DK1296671T3 (da) 2008-06-16
NZ522480A (en) 2005-06-24
JP3909842B2 (ja) 2007-04-25
ES2300332T3 (es) 2008-06-16
EP1296671B1 (en) 2008-03-26
CA2414008C (en) 2011-04-26
AU6473601A (en) 2002-01-08

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20130518