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DE60133389D1 - Gabapentinanaloga für schlafstörungen - Google Patents

Gabapentinanaloga für schlafstörungen

Info

Publication number
DE60133389D1
DE60133389D1 DE60133389T DE60133389T DE60133389D1 DE 60133389 D1 DE60133389 D1 DE 60133389D1 DE 60133389 T DE60133389 T DE 60133389T DE 60133389 T DE60133389 T DE 60133389T DE 60133389 D1 DE60133389 D1 DE 60133389D1
Authority
DE
Germany
Prior art keywords
gabapentinaloga
sleeping disorders
compounds
disorders
sleeping
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60133389T
Other languages
English (en)
Other versions
DE60133389T2 (de
Inventor
Justin Stephen Bryans
Leonard Theodore Meltzer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Application granted granted Critical
Publication of DE60133389D1 publication Critical patent/DE60133389D1/de
Publication of DE60133389T2 publication Critical patent/DE60133389T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60133389T 2000-06-26 2001-05-18 Gabapentinanaloga für schlafstörungen Expired - Lifetime DE60133389T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21417100P 2000-06-26 2000-06-26
US214171P 2000-06-26
PCT/US2001/016343 WO2002000209A2 (en) 2000-06-26 2001-05-18 Gabapentin analogues for sleep disorders

Publications (2)

Publication Number Publication Date
DE60133389D1 true DE60133389D1 (de) 2008-05-08
DE60133389T2 DE60133389T2 (de) 2008-06-26

Family

ID=22798045

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60133389T Expired - Lifetime DE60133389T2 (de) 2000-06-26 2001-05-18 Gabapentinanaloga für schlafstörungen

Country Status (23)

Country Link
US (1) US7141606B2 (de)
EP (1) EP1296671B1 (de)
JP (1) JP3909842B2 (de)
KR (1) KR100785182B1 (de)
CN (1) CN1279900C (de)
AT (1) ATE390133T1 (de)
AU (2) AU2001264736B2 (de)
BR (1) BR0111913A (de)
CA (1) CA2414008C (de)
CZ (1) CZ20024110A3 (de)
DE (1) DE60133389T2 (de)
DK (1) DK1296671T3 (de)
ES (1) ES2300332T3 (de)
HU (1) HUP0300833A3 (de)
IL (2) IL152770A0 (de)
MX (1) MXPA02010668A (de)
NZ (1) NZ522480A (de)
PL (1) PL359872A1 (de)
PT (1) PT1296671E (de)
SK (1) SK17922002A3 (de)
TW (1) TWI298020B (de)
WO (1) WO2002000209A2 (de)
ZA (1) ZA200209418B (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0208922A (pt) 2001-04-19 2004-04-20 Warner Lambert Co Aminoácidos bicìclicos ou tricìclicos fundidos
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
WO2002100344A2 (en) 2001-06-11 2002-12-19 Xenoport, Inc. Amino acid conjugates providing for sustained systemic concentrations of gaba analogues
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
KR20070108282A (ko) 2001-06-11 2007-11-08 제노포트 인코포레이티드 감소된 독성을 가진 ｇａｂａ 유사체 프로드러그의 구강투여용 투여 형태물
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US6927036B2 (en) 2002-02-19 2005-08-09 Xero Port, Inc. Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
AU2003222033A1 (en) 2002-03-20 2003-10-08 Xenoport Cyclic 1-(acyloxy)-alkyl prodrugs of gaba analogs, compositions and uses thereof
AU2003243180A1 (en) 2002-05-17 2003-12-12 Xenoport, Inc. Amino acid conjugates providing for sustained systemic concentrations of gaba analogues
AU2003297927A1 (en) 2002-12-11 2004-06-30 Xenoport, Inc. Prodrugs of fused gaba analogs, pharmaceutical compositions and uses thereof
PL377286A1 (pl) * 2002-12-13 2006-01-23 Warner-Lambert Company Llc Analogi gabapentyny do włókniako-mięśniakowych i innych pokrewnych zaburzeń
CA2451267A1 (en) * 2002-12-13 2004-06-13 Warner-Lambert Company Llc Pharmaceutical uses for alpha2delta ligands
EP1622603A4 (de) * 2003-03-25 2010-03-24 Kiel Lab Inc Phenolsäuresalze von gabapentin in festen dosierformen und anwendungsverfahren
WO2005025562A1 (en) 2003-09-11 2005-03-24 Xenoport, Inc. Treating and/or preventing urinary incontinence using prodrugs of gaba analogs
AU2004274002B2 (en) 2003-09-17 2011-04-28 Arbor Pharmaceuticals, Llc Treating or preventing restless legs syndrome using prodrugs of GABA analogs
EP1677767B1 (de) 2003-10-14 2011-07-20 XenoPort, Inc. Kristalline form eines gamma-aminobuttersäure-analogons
JP4613031B2 (ja) * 2004-05-06 2011-01-12 エスエス製薬株式会社 催眠剤組成物
JP2005325070A (ja) * 2004-05-14 2005-11-24 Ss Pharmaceut Co Ltd 睡眠改善剤
WO2006050514A1 (en) 2004-11-04 2006-05-11 Xenoport, Inc. Gabapentin prodrug sustained release oral dosage forms
US7837982B2 (en) 2005-06-23 2010-11-23 Emory University Imaging agents
KR20070070307A (ko) * 2005-08-24 2007-07-04 에스에스 세야쿠 가부시키 가이샤 수면 개선 의약 조성물
US20090069427A1 (en) * 2006-03-06 2009-03-12 Pfizer Inc. Alpha-2-delta ligands for non-restorative sleep
US8062870B2 (en) 2008-01-25 2011-11-22 Xenoport, Inc. Enantiomerically resolving acyloxyalkyl thiocarbonates used in synthesizing acyloxyalkyl carbamate prodrugs
WO2009094577A2 (en) 2008-01-25 2009-07-30 Xenoport, Inc. Mesophasic forms of (3s)-aminomethyl-5-methyl-hexanoic acid prodrugs and methods of use
EP2250148B1 (de) 2008-01-25 2016-08-17 XenoPort, Inc. Kristalline form von kalziumsalzen von (3s)-aminomethyl-5-methylhexansäuren und anwendungsverfahren
CN102216257B (zh) 2008-10-08 2015-11-25 凯飞药业公司 Gaba偶联物及其使用方法
ES2758554T3 (es) 2009-12-08 2020-05-05 Univ Case Western Reserve Aminoácidos gama para tratamiento de trastornos oculares
US9066853B2 (en) 2013-01-15 2015-06-30 Warsaw Orthopedic, Inc. Clonidine compounds in a biodegradable fiber
CA2903000C (en) 2013-01-28 2021-10-12 Hector L. Lopez Methods of improving tolerability, pharmacodynamics, and efficacy of .beta.-alanine and use therefor
SG10201912843YA (en) 2016-05-26 2020-02-27 Amino Up Chemical Co Ltd Sleep improving agent
US20210221768A1 (en) 2018-05-14 2021-07-22 Xgene Pharmaceutical Inc. Crystalline forms of 1-(acyloxy)-alkyl carbamate drug conjugates of naproxen and pregabalin

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2460891C2 (de) 1974-12-21 1982-09-23 Gödecke AG, 1000 Berlin 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
US4087544A (en) 1974-12-21 1978-05-02 Warner-Lambert Company Treatment of cranial dysfunctions using novel cyclic amino acids
US5084479A (en) 1990-01-02 1992-01-28 Warner-Lambert Company Novel methods for treating neurodegenerative diseases
US6197819B1 (en) 1990-11-27 2001-03-06 Northwestern University Gamma amino butyric acid analogs and optical isomers
US5510381A (en) 1995-05-15 1996-04-23 Warner-Lambert Company Method of treatment of mania and bipolar disorder
DE19525598C2 (de) * 1995-07-13 1997-09-25 Max Planck Gesellschaft Schlafmittel
BR9708180A (pt) * 1996-03-14 1999-07-27 Warner Lambert Co Amoniácidos cíclicos em pontes como agentes farmacêuticos
US6372792B1 (en) * 1996-04-26 2002-04-16 Guy Chouinard Method for treating anxiety, anxiety disorders and insomnia
NZ503651A (en) 1997-10-27 2002-09-27 Warner Lambert Co Cyclic amino acids and derivatives thereof useful as pharmaceutical agents
WO2000002546A2 (en) * 1998-07-09 2000-01-20 Warner-Lambert Company Use of caba-analogues for treating insomnia
DE60000833T2 (de) * 1999-06-02 2003-09-18 Warner-Lambert Co., Morris Plains Amino-heterocyclen zur verwendung als pharmazeutische mittel
HN2000000224A (es) * 1999-10-20 2001-04-11 Warner Lambert Co Aminoacidos biciclicos como agentes farmaceuticos
YU41602A (sh) * 1999-12-08 2005-07-19 Warner-Lambert Company Postupak za stereoselektivnu sintezu cikličnih aminokiselina
GB9930083D0 (en) * 1999-12-20 2000-02-09 Glaxo Group Ltd Medicaments

Also Published As

Publication number Publication date
ATE390133T1 (de) 2008-04-15
CA2414008C (en) 2011-04-26
CA2414008A1 (en) 2002-01-03
CN1279900C (zh) 2006-10-18
EP1296671B1 (de) 2008-03-26
PT1296671E (pt) 2008-05-09
JP3909842B2 (ja) 2007-04-25
HUP0300833A2 (hu) 2003-08-28
AU6473601A (en) 2002-01-08
WO2002000209A3 (en) 2003-01-16
NZ522480A (en) 2005-06-24
JP2004501189A (ja) 2004-01-15
DE60133389T2 (de) 2008-06-26
WO2002000209A2 (en) 2002-01-03
CN1436075A (zh) 2003-08-13
TWI298020B (en) 2008-06-21
IL152770A0 (en) 2003-06-24
KR20030019455A (ko) 2003-03-06
BR0111913A (pt) 2004-01-06
US7141606B2 (en) 2006-11-28
EP1296671A2 (de) 2003-04-02
SK17922002A3 (sk) 2003-11-04
KR100785182B1 (ko) 2007-12-11
AU2001264736B2 (en) 2006-04-27
IL152770A (en) 2009-12-24
HUP0300833A3 (en) 2009-08-28
US20030212133A1 (en) 2003-11-13
MXPA02010668A (es) 2003-03-10
HK1056681A1 (en) 2004-02-27
ES2300332T3 (es) 2008-06-16
DK1296671T3 (da) 2008-06-16
ZA200209418B (en) 2005-03-10
CZ20024110A3 (cs) 2003-10-15
PL359872A1 (en) 2004-09-06

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition