HK1051690A1 - Hydroxyphenyl-piperidin-4-ylidene-methyl-benzamidederivatives for the treatment of pain. - Google Patents

Hydroxyphenyl-piperidin-4-ylidene-methyl-benzamidederivatives for the treatment of pain.

Info

Publication number: HK1051690A1
Authority: HK; Hong Kong
Prior art keywords: benzamidederivatives; ylidene; piperidin; hydroxyphenyl; pain
Prior art date: 2000-04-04

Application number

HK03103988A

Other languages

English (en)

Inventor

William Brown

Christopher Walpole

Zhongyong Wei

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-04-04

Filing date

2003-06-05

Publication date

2003-08-15

2003-06-05 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2003-08-15 Publication of HK1051690A1 publication Critical patent/HK1051690A1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)

HK03103988A 2000-04-04 2003-06-05 Hydroxyphenyl-piperidin-4-ylidene-methyl-benzamidederivatives for the treatment of pain. HK1051690A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE0001207A SE0001207D0 (sv)	2000-04-04	2000-04-04	Novel compounds
PCT/SE2001/000707 WO2001074804A1 (fr)	2000-04-04	2001-03-30	Derives d'hydroxyphenyl-piperidine-4-ylidene-methyl-benzamide utilises comme analgesiques

Publications (1)

Publication Number	Publication Date
HK1051690A1 true HK1051690A1 (en)	2003-08-15

Family

ID=20279146

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HK03103988A HK1051690A1 (en)	2000-04-04	2003-06-05	Hydroxyphenyl-piperidin-4-ylidene-methyl-benzamidederivatives for the treatment of pain.

Country Status (29)

Country	Link
US (1)	US6756387B2 (fr)
EP (1)	EP1282616B1 (fr)
JP (1)	JP2003529596A (fr)
KR (1)	KR20020084285A (fr)
CN (1)	CN1185228C (fr)
AR (1)	AR027983A1 (fr)
AT (1)	ATE269324T1 (fr)
AU (1)	AU2001244981A1 (fr)
BR (1)	BR0109816A (fr)
CA (1)	CA2404386A1 (fr)
CZ (1)	CZ20023289A3 (fr)
DE (1)	DE60103889T2 (fr)
DK (1)	DK1282616T3 (fr)
EE (1)	EE200200571A (fr)
ES (1)	ES2220748T3 (fr)
HK (1)	HK1051690A1 (fr)
HU (1)	HUP0300427A2 (fr)
IL (1)	IL151890A0 (fr)
IS (1)	IS6575A (fr)
MX (1)	MXPA02009757A (fr)
NO (1)	NO20024775L (fr)
NZ (1)	NZ522142A (fr)
PL (1)	PL357780A1 (fr)
PT (1)	PT1282616E (fr)
RU (1)	RU2002125495A (fr)
SE (1)	SE0001207D0 (fr)
SK (1)	SK14232002A3 (fr)
WO (1)	WO2001074804A1 (fr)
ZA (1)	ZA200207968B (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW548271B (en)	1996-12-20	2003-08-21	Astra Pharma Inc	Novel piperidine derivatives having an exocyclic double bond with analgesic effects
SE0101765D0 (sv)	2001-05-18	2001-05-18	Astrazeneca Ab	Novel compounds
SE0101768D0 (sv)	2001-05-18	2001-05-18	Astrazeneca Ab	Novel compounds
SE0101769D0 (sv) *	2001-05-18	2001-05-18	Astrazeneca Ab	Novel compounds
SE0101770D0 (sv) *	2001-05-18	2001-05-18	Astrazeneca Ab	Novel compounds
SE0101771D0 (sv) *	2001-05-18	2001-05-18	Astrazeneca Ab	Novel compounds
SE0101766D0 (sv)	2001-05-18	2001-05-18	Astrazeneca Ab	Novel compounds
SE0101773D0 (sv) *	2001-05-18	2001-05-18	Astrazeneca Ab	Novel compounds
SE0101767D0 (sv) *	2001-05-18	2001-05-18	Astrazeneca Ab	Novel compounds
SE0103313D0 (sv) *	2001-10-03	2001-10-03	Astrazeneca Ab	Novel compounds
AU2003214800A1 (en)	2002-01-02	2003-07-24	Ardent Pharmaceuticals, Inc.	Method of treating sexual dysfunctions with delta opioid receptor agonist compounds
US8476280B2 (en) *	2002-05-09	2013-07-02	Versi Group, Llc	Compositions and methods for combating lower urinary tract dysfunctions with delta opioid receptor agonists
SE0203301D0 (sv) *	2002-11-07	2002-11-07	Astrazeneca Ab	Novel Compounds
SE0300105D0 (sv) *	2003-01-16	2003-01-16	Astrazeneca Ab	Diarylmethylidene piperdine derivatives, preparations thereof and uses thereof
SE0300104D0 (sv) *	2003-01-16	2003-01-16	Astrazeneca Ab	Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
SE0300103D0 (sv) *	2003-01-16	2003-01-16	Astrazeneca Ab	Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
SE0300987D0 (sv) *	2003-04-03	2003-04-03	Astrazeneca Ab	Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
KR20060010811A (ko) *	2003-05-16	2006-02-02	아스트라제네카 아베	디아릴메틸리덴 피페리딘 유도체, 그의 제조 및 그의 용도
SE0301445D0 (sv) *	2003-05-16	2003-05-16	Astrazeneca Ab	Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
SE0301442D0 (sv) *	2003-05-16	2003-05-16	Astrazeneca Ab	Diarylmethylidene piperidine derivatives, preparations therof and uses thereof
SE0301443D0 (sv) *	2003-05-16	2003-05-16	Astrazeneca Ab	Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
SE0301441D0 (sv) *	2003-05-16	2003-05-16	Astrazeneca Ab	Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
EA015491B1 (ru) *	2003-06-27	2011-08-30	Янссен Фармацевтика Н.В.	ТРИЦИКЛИЧЕСКИЕ δ-ОПИОИДНЫЕ МОДУЛЯТОРЫ
SE0400026D0 (sv) *	2004-01-09	2004-01-09	Astrazeneca Ab	Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
SE0402485D0 (sv)	2004-10-13	2004-10-13	Astrazeneca Ab	Polymorph of N,N-Diethyl-4-(3-Fluorophenyl-Piperidin-4-Ylidene-Methyl)-Benzamide Hydrochloride salt

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2898339A (en)	1957-07-29	1959-08-04	Wm S Merrell Co	N-substituted benzhydrol, benzhydryl, and benzhydrylidene piperidine
US4581171A (en)	1983-07-27	1986-04-08	Janssen Pharmaceutica, N.V.	[[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones useful for treating psychotropic disorders
US4816586A (en)	1987-07-29	1989-03-28	Regents Of The University Of Minnesota	Delta opioid receptor antagonists
US5140029A (en)	1989-01-09	1992-08-18	Janssen Pharmaceutica N.V.	2-aminopyrimidinone derivatives
US4939137A (en)	1989-06-28	1990-07-03	Ortho Pharmaceutical Corporation	Ring-fused thienopyrimidinedione derivatives
US5683998A (en)	1991-04-23	1997-11-04	Toray Industries, Inc.	Tricyclic triazolo derivatives, processes for producing the same and the uses of the same
US5574159A (en)	1992-02-03	1996-11-12	Delta Pharmaceuticals, Inc.	Opioid compounds and methods for making therefor
GB9202238D0 (en)	1992-02-03	1992-03-18	Wellcome Found	Compounds
US5985880A (en) *	1996-06-05	1999-11-16	Delta Pharmaceuticals	Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds
SE9504661D0 (sv) *	1995-12-22	1995-12-22	Astra Pharma Inc	New compounds
TW548271B (en) *	1996-12-20	2003-08-21	Astra Pharma Inc	Novel piperidine derivatives having an exocyclic double bond with analgesic effects
AU2009799A (en) *	1997-12-24	1999-07-19	Ortho-Mcneil Pharmaceutical, Inc.	4-(aryl(piperidin-4-yl)) aminobenzamides which bind to the delta-opioid receptor

2000
- 2000-04-04 SE SE0001207A patent/SE0001207D0/xx unknown
2001
- 2001-03-28 AR ARP010101477A patent/AR027983A1/es not_active Application Discontinuation
- 2001-03-30 HU HU0300427A patent/HUP0300427A2/hu unknown
- 2001-03-30 MX MXPA02009757A patent/MXPA02009757A/es unknown
- 2001-03-30 KR KR1020027013207A patent/KR20020084285A/ko not_active Application Discontinuation
- 2001-03-30 PT PT01918113T patent/PT1282616E/pt unknown
- 2001-03-30 DK DK01918113T patent/DK1282616T3/da active
- 2001-03-30 AU AU2001244981A patent/AU2001244981A1/en not_active Abandoned
- 2001-03-30 BR BR0109816-0A patent/BR0109816A/pt not_active IP Right Cessation
- 2001-03-30 IL IL15189001A patent/IL151890A0/xx unknown
- 2001-03-30 US US10/240,038 patent/US6756387B2/en not_active Expired - Fee Related
- 2001-03-30 AT AT01918113T patent/ATE269324T1/de not_active IP Right Cessation
- 2001-03-30 CZ CZ20023289A patent/CZ20023289A3/cs unknown
- 2001-03-30 PL PL01357780A patent/PL357780A1/xx not_active Application Discontinuation
- 2001-03-30 EE EEP200200571A patent/EE200200571A/xx unknown
- 2001-03-30 SK SK1423-2002A patent/SK14232002A3/sk not_active Application Discontinuation
- 2001-03-30 NZ NZ522142A patent/NZ522142A/en unknown
- 2001-03-30 EP EP01918113A patent/EP1282616B1/fr not_active Expired - Lifetime
- 2001-03-30 WO PCT/SE2001/000707 patent/WO2001074804A1/fr active IP Right Grant
- 2001-03-30 RU RU2002125495/04A patent/RU2002125495A/ru not_active Application Discontinuation
- 2001-03-30 CN CNB018105939A patent/CN1185228C/zh not_active Expired - Fee Related
- 2001-03-30 DE DE60103889T patent/DE60103889T2/de not_active Expired - Fee Related
- 2001-03-30 ES ES01918113T patent/ES2220748T3/es not_active Expired - Lifetime
- 2001-03-30 CA CA002404386A patent/CA2404386A1/fr not_active Abandoned
- 2001-03-30 JP JP2001572494A patent/JP2003529596A/ja active Pending
2002
- 2002-09-30 IS IS6575A patent/IS6575A/is unknown
- 2002-10-03 NO NO20024775A patent/NO20024775L/no not_active Application Discontinuation
- 2002-10-03 ZA ZA200207968A patent/ZA200207968B/en unknown
2003
- 2003-06-05 HK HK03103988A patent/HK1051690A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
NO20024775D0 (no)	2002-10-03
CA2404386A1 (fr)	2001-10-11
ATE269324T1 (de)	2004-07-15
PT1282616E (pt)	2004-10-29
NO20024775L (no)	2002-12-03
WO2001074804A1 (fr)	2001-10-11
US20030187022A1 (en)	2003-10-02
DE60103889T2 (de)	2005-08-25
ES2220748T3 (es)	2004-12-16
EP1282616B1 (fr)	2004-06-16
KR20020084285A (ko)	2002-11-04
ZA200207968B (en)	2004-04-07
PL357780A1 (en)	2004-07-26
AU2001244981A1 (en)	2001-10-15
EE200200571A (et)	2004-04-15
NZ522142A (en)	2004-06-25
SK14232002A3 (sk)	2003-06-03
IS6575A (is)	2002-09-30
JP2003529596A (ja)	2003-10-07
CN1185228C (zh)	2005-01-19
US6756387B2 (en)	2004-06-29
DK1282616T3 (da)	2004-09-20
MXPA02009757A (es)	2003-05-27
RU2002125495A (ru)	2004-04-10
SE0001207D0 (sv)	2000-04-04
CZ20023289A3 (cs)	2003-03-12
AR027983A1 (es)	2003-04-23
HUP0300427A2 (hu)	2003-06-28
EP1282616A1 (fr)	2003-02-12
IL151890A0 (en)	2003-04-10
BR0109816A (pt)	2003-01-21
DE60103889D1 (de)	2004-07-22
CN1432009A (zh)	2003-07-23

Publication	Publication Date	Title
HK1051690A1 (en)	2003-08-15	Hydroxyphenyl-piperidin-4-ylidene-methyl-benzamidederivatives for the treatment of pain.
IL196301A0 (en)	2009-09-22	Medicament for the treatment of hapatitis c
GB0028264D0 (en)	2001-01-03	Well treatment
AP2004003002A0 (en)	2004-03-31	azabicyclic-substituted fused-heteroaryl compoundsfor the treatment of disease.
GB0028269D0 (en)	2001-01-03	Well treatment
ZA200202449B (en)	2003-03-26	Use of retigabin for treating neuropathic pain.
MXPA03001419A (es)	2003-06-06	Combinacion terapeutica de un inhibidor de la proteina de transferencia de esteres de colesterol y atorvastatina.
PL362855A1 (en)	2004-11-02	Improved treatment
EG25829A (en)	2012-09-02	Novel treatment
GB0030845D0 (en)	2001-01-31	Novel treatment
ZA200307475B (en)	2005-01-03	Carbamate compounds for use in the treatment of pain.
HK1051692A1 (en)	2003-08-15	Quinolinyl-piperidin-4-ylidene-methyl-benzamide derivatives for the treatment of pain.
IL151765A0 (en)	2003-04-10	Hydroxyphenyl-piperazinyl-methyl-benzamide derivatives for the treatment of pain
ZA200105690B (en)	2002-09-25	Novel treatment.
GB0001710D0 (en)	2000-03-15	Therapeutic treatment
HK1041661A1 (en)	2002-07-19	Electromedical treatment applicator.
MXPA03004017A (es)	2004-02-12	Metodo para el tratamiento de inflamacion.
AU2096002A (en)	2002-06-18	Therapeutic treatment
GB0029524D0 (en)	2001-01-17	Disease treatment
HK1056828A1 (en)	2004-03-05	Treatment of burns.
GB0031321D0 (en)	2001-02-07	Treatment
GB0029125D0 (en)	2001-01-10	Novel treatment
GB0025655D0 (en)	2000-12-06	Sludge treatment
ZA200304439B (en)	2004-06-25	Therapeutic treatment.
GB0019728D0 (en)	2000-09-27	Novel treatment

Legal Events

Date	Code	Title	Description
2008-11-07	PC	Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)	Effective date: 20080330