AU2001244981A1 - Hydroxyphenyl-piperidin-4-ylidene-methyl-benzamide derivatives for the treatement of pain - Google Patents

Hydroxyphenyl-piperidin-4-ylidene-methyl-benzamide derivatives for the treatement of pain

Info

Publication number: AU2001244981A1
Authority: AU; Australia
Prior art keywords: compound; methyl; hydroxyphenyl; dιethyl; compound according
Prior art date: 2000-04-04
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

AU2001244981A

Other languages

English (en)

Inventor

William Brown

Christopher Walpole

Zhong Yong Wei

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

AstraZeneca AB

Original Assignee

AstraZeneca AB

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-04-04

Filing date

2001-03-30

Publication date

2001-10-15

2001-03-30 Application filed by AstraZeneca AB filed Critical AstraZeneca AB

2001-10-15 Publication of AU2001244981A1 publication Critical patent/AU2001244981A1/en

Status Abandoned legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)

AU2001244981A 2000-04-04 2001-03-30 Hydroxyphenyl-piperidin-4-ylidene-methyl-benzamide derivatives for the treatement of pain Abandoned AU2001244981A1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
SE0001207		2000-04-04
SE0001207A SE0001207D0 (sv)	2000-04-04	2000-04-04	Novel compounds
PCT/SE2001/000707 WO2001074804A1 (fr)	2000-04-04	2001-03-30	Derives d'hydroxyphenyl-piperidine-4-ylidene-methyl-benzamide utilises comme analgesiques

Publications (1)

Publication Number	Publication Date
AU2001244981A1 true AU2001244981A1 (en)	2001-10-15

Family

ID=20279146

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU2001244981A Abandoned AU2001244981A1 (en)	2000-04-04	2001-03-30	Hydroxyphenyl-piperidin-4-ylidene-methyl-benzamide derivatives for the treatement of pain

Country Status (29)

Country	Link
US (1)	US6756387B2 (fr)
EP (1)	EP1282616B1 (fr)
JP (1)	JP2003529596A (fr)
KR (1)	KR20020084285A (fr)
CN (1)	CN1185228C (fr)
AR (1)	AR027983A1 (fr)
AT (1)	ATE269324T1 (fr)
AU (1)	AU2001244981A1 (fr)
BR (1)	BR0109816A (fr)
CA (1)	CA2404386A1 (fr)
CZ (1)	CZ20023289A3 (fr)
DE (1)	DE60103889T2 (fr)
DK (1)	DK1282616T3 (fr)
EE (1)	EE200200571A (fr)
ES (1)	ES2220748T3 (fr)
HK (1)	HK1051690A1 (fr)
HU (1)	HUP0300427A2 (fr)
IL (1)	IL151890A0 (fr)
IS (1)	IS6575A (fr)
MX (1)	MXPA02009757A (fr)
NO (1)	NO20024775L (fr)
NZ (1)	NZ522142A (fr)
PL (1)	PL357780A1 (fr)
PT (1)	PT1282616E (fr)
RU (1)	RU2002125495A (fr)
SE (1)	SE0001207D0 (fr)
SK (1)	SK14232002A3 (fr)
WO (1)	WO2001074804A1 (fr)
ZA (1)	ZA200207968B (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW548271B (en)	1996-12-20	2003-08-21	Astra Pharma Inc	Novel piperidine derivatives having an exocyclic double bond with analgesic effects
SE0101765D0 (sv)	2001-05-18	2001-05-18	Astrazeneca Ab	Novel compounds
SE0101773D0 (sv) *	2001-05-18	2001-05-18	Astrazeneca Ab	Novel compounds
SE0101770D0 (sv) *	2001-05-18	2001-05-18	Astrazeneca Ab	Novel compounds
SE0101768D0 (sv)	2001-05-18	2001-05-18	Astrazeneca Ab	Novel compounds
SE0101771D0 (sv) *	2001-05-18	2001-05-18	Astrazeneca Ab	Novel compounds
SE0101767D0 (sv) *	2001-05-18	2001-05-18	Astrazeneca Ab	Novel compounds
SE0101769D0 (sv) *	2001-05-18	2001-05-18	Astrazeneca Ab	Novel compounds
SE0101766D0 (sv)	2001-05-18	2001-05-18	Astrazeneca Ab	Novel compounds
SE0103313D0 (sv) *	2001-10-03	2001-10-03	Astrazeneca Ab	Novel compounds
TW200301701A (en)	2002-01-02	2003-07-16	Ardent Pharmaceuticals Inc	Method of treating sexual dysfunctions with delta opioid receptor agonist compounds
US8476280B2 (en) *	2002-05-09	2013-07-02	Versi Group, Llc	Compositions and methods for combating lower urinary tract dysfunctions with delta opioid receptor agonists
SE0203301D0 (sv) *	2002-11-07	2002-11-07	Astrazeneca Ab	Novel Compounds
SE0300103D0 (sv) *	2003-01-16	2003-01-16	Astrazeneca Ab	Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
SE0300105D0 (sv) *	2003-01-16	2003-01-16	Astrazeneca Ab	Diarylmethylidene piperdine derivatives, preparations thereof and uses thereof
SE0300104D0 (sv) *	2003-01-16	2003-01-16	Astrazeneca Ab	Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
SE0300987D0 (sv) *	2003-04-03	2003-04-03	Astrazeneca Ab	Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
SE0301445D0 (sv) *	2003-05-16	2003-05-16	Astrazeneca Ab	Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
SE0301443D0 (sv) *	2003-05-16	2003-05-16	Astrazeneca Ab	Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
SE0301442D0 (sv) *	2003-05-16	2003-05-16	Astrazeneca Ab	Diarylmethylidene piperidine derivatives, preparations therof and uses thereof
SE0301441D0 (sv) *	2003-05-16	2003-05-16	Astrazeneca Ab	Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
US20070099957A1 (en) *	2003-05-16	2007-05-03	Astra Zeneca Ab	Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
BRPI0411998A (pt) *	2003-06-27	2006-09-05	Janssen Pharmaceutica Nv	moduladores delta-opióides tricìclicos
SE0400026D0 (sv) *	2004-01-09	2004-01-09	Astrazeneca Ab	Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
SE0402485D0 (sv)	2004-10-13	2004-10-13	Astrazeneca Ab	Polymorph of N,N-Diethyl-4-(3-Fluorophenyl-Piperidin-4-Ylidene-Methyl)-Benzamide Hydrochloride salt

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2898339A (en)	1957-07-29	1959-08-04	Wm S Merrell Co	N-substituted benzhydrol, benzhydryl, and benzhydrylidene piperidine
US4581171A (en)	1983-07-27	1986-04-08	Janssen Pharmaceutica, N.V.	[[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones useful for treating psychotropic disorders
US4816586A (en)	1987-07-29	1989-03-28	Regents Of The University Of Minnesota	Delta opioid receptor antagonists
US5140029A (en)	1989-01-09	1992-08-18	Janssen Pharmaceutica N.V.	2-aminopyrimidinone derivatives
US4939137A (en)	1989-06-28	1990-07-03	Ortho Pharmaceutical Corporation	Ring-fused thienopyrimidinedione derivatives
US5683998A (en)	1991-04-23	1997-11-04	Toray Industries, Inc.	Tricyclic triazolo derivatives, processes for producing the same and the uses of the same
GB9202238D0 (en)	1992-02-03	1992-03-18	Wellcome Found	Compounds
US5985880A (en) *	1996-06-05	1999-11-16	Delta Pharmaceuticals	Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds
US5574159A (en)	1992-02-03	1996-11-12	Delta Pharmaceuticals, Inc.	Opioid compounds and methods for making therefor
SE9504661D0 (sv)	1995-12-22	1995-12-22	Astra Pharma Inc	New compounds
TW548271B (en)	1996-12-20	2003-08-21	Astra Pharma Inc	Novel piperidine derivatives having an exocyclic double bond with analgesic effects
ZA9811842B (en)	1997-12-24	2000-06-23	Ortho Mcneil Pharm Inc	4-[aryl(piperidin-4-yl)]aminobenzamides.

2000
- 2000-04-04 SE SE0001207A patent/SE0001207D0/xx unknown
2001
- 2001-03-28 AR ARP010101477A patent/AR027983A1/es not_active Application Discontinuation
- 2001-03-30 IL IL15189001A patent/IL151890A0/xx unknown
- 2001-03-30 JP JP2001572494A patent/JP2003529596A/ja active Pending
- 2001-03-30 WO PCT/SE2001/000707 patent/WO2001074804A1/fr active IP Right Grant
- 2001-03-30 AU AU2001244981A patent/AU2001244981A1/en not_active Abandoned
- 2001-03-30 MX MXPA02009757A patent/MXPA02009757A/es unknown
- 2001-03-30 US US10/240,038 patent/US6756387B2/en not_active Expired - Fee Related
- 2001-03-30 SK SK1423-2002A patent/SK14232002A3/sk not_active Application Discontinuation
- 2001-03-30 KR KR1020027013207A patent/KR20020084285A/ko not_active Application Discontinuation
- 2001-03-30 PL PL01357780A patent/PL357780A1/xx not_active Application Discontinuation
- 2001-03-30 CZ CZ20023289A patent/CZ20023289A3/cs unknown
- 2001-03-30 EE EEP200200571A patent/EE200200571A/xx unknown
- 2001-03-30 CN CNB018105939A patent/CN1185228C/zh not_active Expired - Fee Related
- 2001-03-30 NZ NZ522142A patent/NZ522142A/en unknown
- 2001-03-30 ES ES01918113T patent/ES2220748T3/es not_active Expired - Lifetime
- 2001-03-30 RU RU2002125495/04A patent/RU2002125495A/ru not_active Application Discontinuation
- 2001-03-30 DK DK01918113T patent/DK1282616T3/da active
- 2001-03-30 BR BR0109816-0A patent/BR0109816A/pt not_active IP Right Cessation
- 2001-03-30 PT PT01918113T patent/PT1282616E/pt unknown
- 2001-03-30 DE DE60103889T patent/DE60103889T2/de not_active Expired - Fee Related
- 2001-03-30 CA CA002404386A patent/CA2404386A1/fr not_active Abandoned
- 2001-03-30 EP EP01918113A patent/EP1282616B1/fr not_active Expired - Lifetime
- 2001-03-30 AT AT01918113T patent/ATE269324T1/de not_active IP Right Cessation
- 2001-03-30 HU HU0300427A patent/HUP0300427A2/hu unknown
2002
- 2002-09-30 IS IS6575A patent/IS6575A/is unknown
- 2002-10-03 ZA ZA200207968A patent/ZA200207968B/en unknown
- 2002-10-03 NO NO20024775A patent/NO20024775L/no not_active Application Discontinuation
2003
- 2003-06-05 HK HK03103988A patent/HK1051690A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA2404386A1 (fr)	2001-10-11
BR0109816A (pt)	2003-01-21
RU2002125495A (ru)	2004-04-10
SE0001207D0 (sv)	2000-04-04
ES2220748T3 (es)	2004-12-16
HUP0300427A2 (hu)	2003-06-28
PT1282616E (pt)	2004-10-29
JP2003529596A (ja)	2003-10-07
CN1185228C (zh)	2005-01-19
NO20024775L (no)	2002-12-03
PL357780A1 (en)	2004-07-26
EE200200571A (et)	2004-04-15
DE60103889T2 (de)	2005-08-25
DE60103889D1 (de)	2004-07-22
US20030187022A1 (en)	2003-10-02
NO20024775D0 (no)	2002-10-03
KR20020084285A (ko)	2002-11-04
DK1282616T3 (da)	2004-09-20
EP1282616A1 (fr)	2003-02-12
MXPA02009757A (es)	2003-05-27
ATE269324T1 (de)	2004-07-15
US6756387B2 (en)	2004-06-29
IS6575A (is)	2002-09-30
IL151890A0 (en)	2003-04-10
WO2001074804A1 (fr)	2001-10-11
SK14232002A3 (sk)	2003-06-03
EP1282616B1 (fr)	2004-06-16
AR027983A1 (es)	2003-04-23
ZA200207968B (en)	2004-04-07
HK1051690A1 (en)	2003-08-15
CN1432009A (zh)	2003-07-23
CZ20023289A3 (cs)	2003-03-12
NZ522142A (en)	2004-06-25

Publication	Publication Date	Title
EP1282616B1 (fr)	2004-06-16	Derives d'hydroxyphenyl-piperidine-4-ylidene-methyl-benzamide utilises comme analgesiques
NZ539828A (en)	2007-01-26	4 (phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders
EP1395576B1 (fr)	2005-08-31	Derives 4-(phenyl-piperidin-4-ylidene-methyl)-benzamide et utilisation de ceux-ci pour le traitement de douleurs, de l'anxiete ou de troubles gastro-enteriques
WO2003029215A1 (fr)	2003-04-10	Derives de 4(piperidin-4-yliden-(3-carbamoylphenyle)methyle) benzamide et leur utilisation dans le traitement de la douleur, de lesions spinales ou de troubles gastro-intestinaux
EP1286986B1 (fr)	2005-02-23	Derives de quinolinyle-piperidine-4-ylidene-methyle-benzamide pour le traitement de la douleur
US7022715B2 (en)	2006-04-04	4-(phenyl-piperidin-4-ylidene-methyl)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders
AU2001244982A1 (en)	2002-01-03	Quinolinyl-piperidin-4-ylidene-methyl-benzamide derivatives for the treatment of pain
US6838468B2 (en)	2005-01-04	4-(phenyl-piperdin-4-ylidene methyl)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders
EP1395574B1 (fr)	2005-01-19	Derives de 4-(phenyl-piperidin-4-ylidene-methyle)-benzamide et leur utilisation pour le traitement de la douleur, de l'anxiete ou de troubles gastro-intestinaux
US20040152731A1 (en)	2004-08-05	4-(Phenyl-(piperidin-4-yl)-amino)-benzamide derivaties and their use for the treatment of pain, anxiety or gastrointestinal disorders
AU2002305986A1 (en)	2002-12-03	4-(penyl-piperidin-4-ylidene-methyl)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders
AU2002305992A1 (en)	2002-12-03	4-(phenyl-piperidin-4-ylidene-methyl)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders
AU2002305985A1 (en)	2002-12-03	4-(phenyl-piperidin-4-ylidene-methyl)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders
AU2002341487A1 (en)	2003-04-14	4[piperidin-4-yliden-(3-carbamoylphenyl)methyl] benzamide derivatives and their use for the treatment of pain, spinal injuries or gastrointestinal disorders
AU2002307616A1 (en)	2002-12-03	4-(phenyl-piperidin-4-ylidene-methyl)-benzamide derivatives and their use for the treatment of pain anxiety or gastrointestinal disorders