HK1046694A1 - 干擾素-α蛋白作為FC融合蛋白的表達和運輸 - Google Patents
干擾素-α蛋白作為FC融合蛋白的表達和運輸Info
- Publication number
- HK1046694A1 HK1046694A1 HK02108255.1A HK02108255A HK1046694A1 HK 1046694 A1 HK1046694 A1 HK 1046694A1 HK 02108255 A HK02108255 A HK 02108255A HK 1046694 A1 HK1046694 A1 HK 1046694A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- interferon
- alpha
- proteins
- nucleic acid
- expression
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13489599P | 1999-05-19 | 1999-05-19 | |
PCT/US2000/013827 WO2000069913A1 (en) | 1999-05-19 | 2000-05-19 | EXPRESSION AND EXPORT OF INTERFERON-ALPHA PROTEINS AS Fc FUSION PROTEINS |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1046694A1 true HK1046694A1 (zh) | 2003-01-24 |
Family
ID=22465500
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK02108255.1A HK1046694A1 (zh) | 1999-05-19 | 2002-11-14 | 干擾素-α蛋白作為FC融合蛋白的表達和運輸 |
Country Status (22)
Country | Link |
---|---|
US (2) | US20020081664A1 (zh) |
EP (1) | EP1187852B1 (zh) |
JP (1) | JP2003530070A (zh) |
KR (1) | KR20020018197A (zh) |
CN (1) | CN1361793A (zh) |
AT (1) | ATE369384T1 (zh) |
AU (1) | AU777963B2 (zh) |
BR (1) | BR0010725A (zh) |
CA (1) | CA2372400C (zh) |
CZ (1) | CZ20014123A3 (zh) |
DE (1) | DE60035871T2 (zh) |
DK (1) | DK1187852T3 (zh) |
ES (1) | ES2291205T3 (zh) |
HK (1) | HK1046694A1 (zh) |
HU (1) | HUP0201474A3 (zh) |
MX (1) | MXPA01011845A (zh) |
NO (1) | NO20015587L (zh) |
PL (1) | PL352332A1 (zh) |
PT (1) | PT1187852E (zh) |
RU (1) | RU2262510C9 (zh) |
WO (1) | WO2000069913A1 (zh) |
ZA (1) | ZA200109227B (zh) |
Families Citing this family (92)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
ES2221717T3 (es) | 1997-12-08 | 2005-01-01 | Emd Lexigen Research Center Corp. | Proteinas de fusion heterodimeras utiles para inmunoterapia dirigida e inmunoestimulacion general. |
US20030105294A1 (en) * | 1998-02-25 | 2003-06-05 | Stephen Gillies | Enhancing the circulating half life of antibody-based fusion proteins |
HUP0101352A3 (en) * | 1998-04-15 | 2003-08-28 | Lexigen Pharmaceuticals Corp L | Enhancement of antibody-cytokine fusion protein mediated immune responses by co-administration with angiogenesis inhibitor |
CN1361793A (zh) * | 1999-05-19 | 2002-07-31 | 利思进药品公司 | 干扰素-α蛋白作为Fc融合蛋白的表达和运输 |
SK782002A3 (en) | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
US7067110B1 (en) | 1999-07-21 | 2006-06-27 | Emd Lexigen Research Center Corp. | Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
US6617135B1 (en) | 1999-08-09 | 2003-09-09 | Emd Lexigen Research Center Corp. | Multiple cytokine protein complexes |
US20050202538A1 (en) * | 1999-11-12 | 2005-09-15 | Merck Patent Gmbh | Fc-erythropoietin fusion protein with improved pharmacokinetics |
JP2003514552A (ja) | 1999-11-12 | 2003-04-22 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 改善された性質を有するエリトロポエチンの形態 |
PT1252192E (pt) | 2000-02-11 | 2007-01-31 | Merck Patent Gmbh | Melhoramento da semivida de circulação de proteínas de fusão à base de anticorpos |
AU2001264563A1 (en) | 2000-04-12 | 2001-10-30 | Human Genome Sciences, Inc. | Albumin fusion proteins |
PL358582A1 (en) * | 2000-06-29 | 2004-08-09 | Merck Patent Gmbh | Enhancement of antibody-cytokine fusion protein mediated immune responses by combined treatment with immunocytokine uptake enhancing agents |
US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
HUP0303428A2 (hu) * | 2001-03-07 | 2004-01-28 | Merck Patent Gmbh. | Expressziós eljárás hibrid izotípusú antitestcsoportot tartalmazó fehérjékhez |
US6992174B2 (en) | 2001-03-30 | 2006-01-31 | Emd Lexigen Research Center Corp. | Reducing the immunogenicity of fusion proteins |
WO2002088161A1 (en) * | 2001-05-02 | 2002-11-07 | Pepgen Corporation | Method for expression of human interferon alpha 1 in pichia pa storis |
ATE502053T1 (de) * | 2001-05-03 | 2011-04-15 | Merck Patent Gmbh | Rekombinanter, tumorspezifischer antikörper und dessen verwendung |
WO2005047336A1 (en) * | 2003-11-13 | 2005-05-26 | Hanmi Pharmaceutical. Co. Ltd. | Protein complex using immunoglobulin fragment andmethod for the preparation thereof |
DK1454138T3 (da) | 2001-12-04 | 2012-02-13 | Merck Patent Gmbh | Immunocytokiner med moduleret selektivitet |
EP2277889B1 (en) | 2001-12-21 | 2014-07-09 | Human Genome Sciences, Inc. | Fusion proteins of albumin and interferon beta |
KR20050086498A (ko) * | 2002-11-18 | 2005-08-30 | 맥시겐, 인크. | 인터페론-알파 폴리펩티드 및 접합체 |
US7314613B2 (en) | 2002-11-18 | 2008-01-01 | Maxygen, Inc. | Interferon-alpha polypeptides and conjugates |
DE60333121D1 (de) * | 2002-12-17 | 2010-08-05 | Merck Patent Gmbh | Pers 14.18, der gd2 bindet und seine fusion mit il-2 |
CA2513213C (en) | 2003-01-22 | 2013-07-30 | Human Genome Sciences, Inc. | Albumin fusion proteins |
CA2516293A1 (en) * | 2003-02-18 | 2004-09-02 | Tim Jones | Fusion proteins of interferon alpha muteins with improved properties |
US20050176108A1 (en) * | 2003-03-13 | 2005-08-11 | Young-Min Kim | Physiologically active polypeptide conjugate having prolonged in vivo half-life |
US20040180054A1 (en) * | 2003-03-13 | 2004-09-16 | Hanmi Pharm. Co., Ltd. | Physiologically active polypeptide conjugate having prolonged in vivo half-life |
US7348004B2 (en) * | 2003-05-06 | 2008-03-25 | Syntonix Pharmaceuticals, Inc. | Immunoglobulin chimeric monomer-dimer hybrids |
SI2077121T1 (sl) * | 2003-05-06 | 2011-07-29 | Syntonix Pharmaceuticals Inc | Strjevalni faktor VII-Fc himerni proteini za zdravljenje hemostatske motnje |
US20050037947A1 (en) * | 2003-05-06 | 2005-02-17 | Bitonti Alan J. | Inhibition of drug binding to serum albumin |
TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
US20050069521A1 (en) * | 2003-08-28 | 2005-03-31 | Emd Lexigen Research Center Corp. | Enhancing the circulating half-life of interleukin-2 proteins |
US8383132B2 (en) * | 2003-10-16 | 2013-02-26 | The Regents Of The University Of California | Immunostimulatory recombinant intracellular pathogen immunogenic compositions and methods of use |
CA2545603A1 (en) | 2003-11-12 | 2005-05-26 | Biogen Idec Ma Inc. | Neonatal fc receptor (fcrn)-binding polypeptide variants, dimeric fc binding proteins and methods related thereto |
US8110665B2 (en) | 2003-11-13 | 2012-02-07 | Hanmi Holdings Co., Ltd. | Pharmaceutical composition comprising an immunoglobulin FC region as a carrier |
KR101163424B1 (ko) | 2003-12-30 | 2012-07-13 | 메르크 파텐트 게엠베하 | Il-7 융합 단백질 |
CN1902222A (zh) | 2003-12-31 | 2007-01-24 | 默克专利有限公司 | 具有改善药物代谢动力学的Fc-促红细胞生成素融合蛋白质 |
JP2007517506A (ja) | 2004-01-05 | 2007-07-05 | イーエムディー・レキシゲン・リサーチ・センター・コーポレーション | 標的化用化合物 |
JP4987484B2 (ja) * | 2004-01-22 | 2012-07-25 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 補体結合が低下した抗癌抗体 |
NZ548255A (en) | 2004-02-02 | 2010-10-29 | Ambrx Inc | Modified human interferon polypeptides and their uses |
AU2008201682B2 (en) * | 2004-02-02 | 2011-02-24 | Ambrx, Inc. | Modified human interferon polypeptides and their uses |
MXPA06013412A (es) | 2004-05-19 | 2007-01-23 | Maxygen Inc | Polipeptidos de interferon-alfa y conjugados. |
US7670595B2 (en) * | 2004-06-28 | 2010-03-02 | Merck Patent Gmbh | Fc-interferon-beta fusion proteins |
JP5130044B2 (ja) | 2004-08-03 | 2013-01-30 | イナート・ファルマ | 4ig−b7−h3およびその対応するnk細胞受容体を標的化する治療および診断方法ならびに組成物 |
RU2437893C2 (ru) | 2004-12-09 | 2011-12-27 | Мерк Патент Гмбх | Варианты il-7 со сниженной иммуногенностью |
WO2006074397A2 (en) | 2005-01-05 | 2006-07-13 | Biogen Idec Ma Inc. | Cripto binding molecules |
US8158129B2 (en) * | 2005-04-06 | 2012-04-17 | Ibc Pharmaceuticals, Inc. | Dimeric alpha interferon PEGylated site-specifically shows enhanced and prolonged efficacy in vivo |
US20170121692A1 (en) * | 2005-04-06 | 2017-05-04 | Ibc Pharmaceuticals, Inc. | Methods for Generating Stably Linked Complexes Composed of Homodimers, Homotetramers or Dimers of Dimers and Uses |
WO2007044083A2 (en) | 2005-05-18 | 2007-04-19 | Maxygen, Inc. | Evolved interferon-alpha polypeptides |
US7566456B2 (en) * | 2005-06-23 | 2009-07-28 | Haiming Chen | Allergen vaccine proteins for the treatment and prevention of allergic diseases |
RU2423381C2 (ru) | 2005-07-25 | 2011-07-10 | Трабьон Фармасьютикалз, Инк. | Снижение количества в-клеток с использованием cd37-специфических и cd20-специфических связывающих молекул |
UA97628C2 (ru) | 2005-08-16 | 2012-03-12 | Ханми Холдингз Ко., Лтд. | Способ получения fc-фрагмента иммуноглобулина, свободного от начального метионинового остатка, в массовом масштабе |
US20070104689A1 (en) * | 2005-09-27 | 2007-05-10 | Merck Patent Gmbh | Compositions and methods for treating tumors presenting survivin antigens |
DK1966245T3 (da) | 2005-12-30 | 2011-07-18 | Merck Patent Gmbh | Anti-CD19-Antistoffer med reduceret immunogenicitet |
ATE555125T1 (de) * | 2005-12-30 | 2012-05-15 | Merck Patent Gmbh | Interleukin-12p40-varianten mit verbesserter stabilität |
CA2654317A1 (en) | 2006-06-12 | 2007-12-21 | Trubion Pharmaceuticals, Inc. | Single-chain multivalent binding proteins with effector function |
US8454948B2 (en) | 2006-09-14 | 2013-06-04 | Medgenics Medical Israel Ltd. | Long lasting drug formulations |
JP2010504909A (ja) | 2006-09-14 | 2010-02-18 | メドジェニクス・メディカル・イスラエル・リミテッド | 長期持続性の医薬製剤 |
CN1944463B (zh) * | 2006-10-30 | 2010-05-12 | 中国科学技术大学 | 具有α干扰素活性的融合蛋白及其编码基因与应用 |
EP2132228B1 (en) | 2008-04-11 | 2011-06-22 | Emergent Product Development Seattle, LLC | Cd37 immunotherapeutic and combination with bifunctional chemotherapeutic thereof |
CA2759333A1 (en) | 2009-04-22 | 2010-10-28 | Merck Patent Gmbh | Antibody fusion proteins with modified fcrn binding sites |
WO2011064758A2 (en) * | 2009-11-30 | 2011-06-03 | Pfizer Limited | Fusion protein |
LT3338765T (lt) | 2009-12-01 | 2019-06-25 | Translate Bio, Inc. | Steroidiniai dariniai, skirti mrnr tiekimui, esant genetinėms ligoms |
CA2802726A1 (en) | 2010-06-15 | 2011-12-22 | Medgenics Medical Israel Ltd. | Long lasting drug formulations |
CN102585013B (zh) * | 2011-01-07 | 2014-04-23 | 中国人民解放军军事医学科学院生物工程研究所 | 一种含有ω干扰素的融合蛋白及制备方法 |
WO2012170072A1 (en) * | 2011-06-06 | 2012-12-13 | Immungene, Inc. | Engineered antibody-tnfsf member ligand fusion molecules |
EP4458350A3 (en) | 2011-06-08 | 2025-01-22 | Translate Bio, Inc. | Lipid nanoparticle compositions and methods for mrna delivery |
EP2859102A4 (en) | 2012-06-08 | 2016-05-11 | Shire Human Genetic Therapies | NUCLEASE RESISTANT POLYNUCLEOTIDES AND USES THEREOF |
US8956623B2 (en) | 2012-07-24 | 2015-02-17 | Sbc Virbac Limited | Recombinant fusion interferon for animals |
US8784834B2 (en) | 2012-07-24 | 2014-07-22 | Sbc Virbac Biotech Co., Ltd. | Recombinant fusion interferon for animals |
EP2970955B1 (en) | 2013-03-14 | 2018-11-14 | Translate Bio, Inc. | Methods for purification of messenger rna |
EP3431592A1 (en) * | 2013-03-14 | 2019-01-23 | Translate Bio, Inc. | Mrna therapeutic compositions and use to treat diseases and disorders |
SG11201507391VA (en) | 2013-03-14 | 2015-10-29 | Shire Human Genetic Therapies | Cftr mrna compositions and related methods and uses |
LT6164B (lt) | 2013-10-15 | 2015-06-25 | Uab Biotechnologinės Farmacijos Centras "Biotechpharma" | Sulieti interferono-alfa 5 baltymai su kitu citokinu ir jų gamybos būdas |
US9522176B2 (en) | 2013-10-22 | 2016-12-20 | Shire Human Genetic Therapies, Inc. | MRNA therapy for phenylketonuria |
US11224642B2 (en) | 2013-10-22 | 2022-01-18 | Translate Bio, Inc. | MRNA therapy for argininosuccinate synthetase deficiency |
JP6571679B2 (ja) | 2014-04-25 | 2019-09-04 | トランスレイト バイオ, インコーポレイテッド | メッセンジャーrnaの精製方法 |
US11352426B2 (en) | 2015-09-21 | 2022-06-07 | Aptevo Research And Development Llc | CD3 binding polypeptides |
US11661455B2 (en) * | 2016-02-05 | 2023-05-30 | Orionis Biosciences BV | Chimeric protein comprising an interferon alpha 2mutant and a PD-L1 binding moiety |
CA3054062A1 (en) | 2017-02-27 | 2018-08-30 | Translate Bio, Inc. | Novel codon-optimized cftr mrna |
WO2018178215A1 (en) | 2017-03-31 | 2018-10-04 | Accanis Biotech F&E Gmbh & Co Kg | Prevention and treatment of non-melanoma skin cancer (nmsc) |
MA49138A (fr) | 2017-05-16 | 2020-03-25 | Translate Bio Inc | Traitement de la fibrose kystique par administration d'arnm à codons optimisés codant pour la cftr |
RU2650755C1 (ru) * | 2017-05-24 | 2018-04-17 | Федеральное государственное бюджетное учреждение "Государственный научный центр "Институт иммунологии" Федерального медико-биологического агентства России (ФГБУ "ГНЦ Институт иммунологии" ФМБА России) | Способ очистки лекарственного средства пролонгированного действия на основе рекомбинантного аналога интерферона альфа-17 для лечения вирусного гепатита С |
CN107254482A (zh) * | 2017-07-18 | 2017-10-17 | 哈尔滨紫霞生物科技有限公司 | 一种提高重组猪干扰素‑α融合蛋白抗病毒活性的方法 |
CN108727504B (zh) * | 2018-04-16 | 2021-08-27 | 泉州向日葵生物科技有限公司 | 一种ifn与抗pd-l1抗体的融合蛋白及其应用 |
CU24554B1 (es) * | 2018-05-07 | 2021-11-04 | Ct Inmunologia Molecular | Proteínas de fusión compuestas por una muteína de interleucina 2 e interferón tipo 1 |
EP3841208A1 (en) | 2018-08-24 | 2021-06-30 | Translate Bio, Inc. | Methods for purification of messenger rna |
AU2019384557A1 (en) | 2018-11-21 | 2021-06-10 | Translate Bio, Inc. | Treatment of cystic fibrosis by delivery of nebulized mRNA encoding CFTR |
US11136353B2 (en) | 2019-04-15 | 2021-10-05 | Qwixel Therapeutics Llc | Fusion protein composition(s) comprising masked type I interferons (IFNA and IFNB) for use in the treatment of cancer and methods thereof |
RU2764787C1 (ru) * | 2020-12-08 | 2022-01-21 | Федеральное государственное бюджетное научное учреждение "Федеральный исследовательский центр фундаментальной и трансляционной медицины" (ФИЦ ФТМ) | Рекомбинантная плазмидная ДНК, кодирующая химерный интерферон alpha2b, рекомбинантный штамм дрожжей P. pastoris X33 - продуцент химерного интерферона alpha2b и способ получения указанного белка |
Family Cites Families (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4196265A (en) * | 1977-06-15 | 1980-04-01 | The Wistar Institute | Method of producing antibodies |
US4469797A (en) * | 1982-09-23 | 1984-09-04 | Miles Laboratories, Inc. | Digoxigenin immunogens, antibodies, labeled conjugates, and related derivatives |
US4966843A (en) * | 1982-11-01 | 1990-10-30 | Cetus Corporation | Expression of interferon genes in Chinese hamster ovary cells |
US5082658A (en) * | 1984-01-16 | 1992-01-21 | Genentech, Inc. | Gamma interferon-interleukin-2 synergism |
US5679543A (en) * | 1985-08-29 | 1997-10-21 | Genencor International, Inc. | DNA sequences, vectors and fusion polypeptides to increase secretion of desired polypeptides from filamentous fungi |
US4676980A (en) * | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
US4935233A (en) * | 1985-12-02 | 1990-06-19 | G. D. Searle And Company | Covalently linked polypeptide cell modulators |
US5359035A (en) * | 1985-12-21 | 1994-10-25 | Hoechst Aktiengesellschaft | Bifunctional proteins including interleukin-2 (IL-2) and granuloctyte macrophage colony stimulating factor (GM-CSF) |
US5019368A (en) * | 1989-02-23 | 1991-05-28 | Cancer Biologics, Inc. | Detection of necrotic malignant tissue and associated therapy |
DE3883899T3 (de) * | 1987-03-18 | 1999-04-22 | Sb2, Inc., Danville, Calif. | Geänderte antikörper. |
US4732462A (en) * | 1987-04-27 | 1988-03-22 | Ronald Bel | Safety viewing apparatus for crane car |
US5091513A (en) * | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
US5258498A (en) * | 1987-05-21 | 1993-11-02 | Creative Biomolecules, Inc. | Polypeptide linkers for production of biosynthetic proteins |
JP3040121B2 (ja) * | 1988-01-12 | 2000-05-08 | ジェネンテク,インコーポレイテッド | 増殖因子レセプターの機能を阻害することにより腫瘍細胞を処置する方法 |
US5120525A (en) * | 1988-03-29 | 1992-06-09 | Immunomedics, Inc. | Radiolabeled antibody cytotoxic therapy of cancer |
US5601819A (en) * | 1988-08-11 | 1997-02-11 | The General Hospital Corporation | Bispecific antibodies for selective immune regulation and for selective immune cell binding |
US5116964A (en) * | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
US5225538A (en) * | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
US6750329B1 (en) * | 1989-05-05 | 2004-06-15 | Research Development Foundation | Antibody delivery system for biological response modifiers |
US5399346A (en) * | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
EP0406857B1 (en) * | 1989-07-07 | 1995-05-24 | Takeda Chemical Industries, Ltd. | Proteins and production thereof |
US5314995A (en) * | 1990-01-22 | 1994-05-24 | Oncogen | Therapeutic interleukin-2-antibody based fusion proteins |
US5349053A (en) * | 1990-06-01 | 1994-09-20 | Protein Design Labs, Inc. | Chimeric ligand/immunoglobulin molecules and their uses |
US7253264B1 (en) * | 1990-06-28 | 2007-08-07 | Sanofi-Arentideutschland GmbH | Immunoglobulin fusion proteins, their production and use |
US5650150A (en) * | 1990-11-09 | 1997-07-22 | Gillies; Stephen D. | Recombinant antibody cytokine fusion proteins |
US5709859A (en) * | 1991-01-24 | 1998-01-20 | Bristol-Myers Squibb Company | Mixed specificity fusion proteins |
US20020037558A1 (en) * | 1991-10-23 | 2002-03-28 | Kin-Ming Lo | E.coli produced immunoglobulin constructs |
US6627615B1 (en) * | 1991-12-17 | 2003-09-30 | The Regents Of The University Of California | Methods and compositions for in vivo gene therapy |
CA2131003A1 (en) * | 1992-05-26 | 1993-12-09 | Raymond G. Goodwin | Novel cytokine that binds cd30 |
JP3285355B2 (ja) * | 1992-06-04 | 2002-05-27 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | invivo遺伝子治療のための方法及び組成物 |
US5614184A (en) * | 1992-07-28 | 1997-03-25 | New England Deaconess Hospital | Recombinant human erythropoietin mutants and therapeutic methods employing them |
DE69332485T2 (de) * | 1992-08-11 | 2003-11-13 | The President And Fellows Of Harvard College, Cambridge | Immunmodulierende peptide |
DE4228839A1 (de) * | 1992-08-29 | 1994-03-03 | Behringwerke Ag | Verfahren zum Nachweis und zur Bestimmung von Mediatoren |
US5554512A (en) * | 1993-05-24 | 1996-09-10 | Immunex Corporation | Ligands for flt3 receptors |
US5541087A (en) * | 1994-09-14 | 1996-07-30 | Fuji Immunopharmaceuticals Corporation | Expression and export technology of proteins as immunofusins |
US6086875A (en) * | 1995-01-17 | 2000-07-11 | The Brigham And Women's Hospital, Inc. | Receptor specific transepithelial transport of immunogens |
US6485726B1 (en) * | 1995-01-17 | 2002-11-26 | The Brigham And Women's Hospital, Inc. | Receptor specific transepithelial transport of therapeutics |
US6169070B1 (en) * | 1995-03-10 | 2001-01-02 | Genentech, Inc. | Mer receptor activation by gas6 |
US6281010B1 (en) * | 1995-06-05 | 2001-08-28 | The Trustees Of The University Of Pennsylvania | Adenovirus gene therapy vehicle and cell line |
US6620413B1 (en) * | 1995-12-27 | 2003-09-16 | Genentech, Inc. | OB protein-polymer chimeras |
US5723125A (en) * | 1995-12-28 | 1998-03-03 | Tanox Biosystems, Inc. | Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide |
US6750334B1 (en) * | 1996-02-02 | 2004-06-15 | Repligen Corporation | CTLA4-immunoglobulin fusion proteins having modified effector functions and uses therefor |
ATE218143T1 (de) * | 1996-09-03 | 2002-06-15 | Gsf Forschungszentrum Umwelt | Verwendung bi-und trispezifischer antikörper zur induktion einer tumorimmunität |
US6100387A (en) * | 1997-02-28 | 2000-08-08 | Genetics Institute, Inc. | Chimeric polypeptides containing chemokine domains |
US6277375B1 (en) * | 1997-03-03 | 2001-08-21 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
ES2221717T3 (es) * | 1997-12-08 | 2005-01-01 | Emd Lexigen Research Center Corp. | Proteinas de fusion heterodimeras utiles para inmunoterapia dirigida e inmunoestimulacion general. |
US20030105294A1 (en) * | 1998-02-25 | 2003-06-05 | Stephen Gillies | Enhancing the circulating half life of antibody-based fusion proteins |
WO1999054484A1 (en) * | 1998-04-20 | 1999-10-28 | The Regents Of The University Of California | Modified immunoglobulin molecules and methods for use thereof |
AU770555B2 (en) * | 1998-08-17 | 2004-02-26 | Abgenix, Inc. | Generation of modified molecules with increased serum half-lives |
US6646113B1 (en) * | 1998-09-17 | 2003-11-11 | The Trustees Of The University Of Pennsylvania | Nucleic acid molecule encoding human survival of motor neuron-interacting protein 1 (SIP1) deletion mutants |
US6335176B1 (en) * | 1998-10-16 | 2002-01-01 | Pharmacopeia, Inc. | Incorporation of phosphorylation sites |
KR20070091691A (ko) * | 1999-05-06 | 2007-09-11 | 웨이크 포리스트 유니버시티 | 면역 반응을 유발하는 항원을 동정하기 위한 조성물과 방법 |
CN1361793A (zh) * | 1999-05-19 | 2002-07-31 | 利思进药品公司 | 干扰素-α蛋白作为Fc融合蛋白的表达和运输 |
US6617135B1 (en) * | 1999-08-09 | 2003-09-09 | Emd Lexigen Research Center Corp. | Multiple cytokine protein complexes |
PT1252192E (pt) * | 2000-02-11 | 2007-01-31 | Merck Patent Gmbh | Melhoramento da semivida de circulação de proteínas de fusão à base de anticorpos |
MXPA02011016A (es) * | 2000-05-12 | 2004-03-16 | Neose Technologies Inc | Glicopeptidos recombinantes de glucolisacion in vitro. |
PL358582A1 (en) * | 2000-06-29 | 2004-08-09 | Merck Patent Gmbh | Enhancement of antibody-cytokine fusion protein mediated immune responses by combined treatment with immunocytokine uptake enhancing agents |
HUP0303428A2 (hu) * | 2001-03-07 | 2004-01-28 | Merck Patent Gmbh. | Expressziós eljárás hibrid izotípusú antitestcsoportot tartalmazó fehérjékhez |
ATE502053T1 (de) * | 2001-05-03 | 2011-04-15 | Merck Patent Gmbh | Rekombinanter, tumorspezifischer antikörper und dessen verwendung |
-
2000
- 2000-05-19 CN CN00810671A patent/CN1361793A/zh active Pending
- 2000-05-19 WO PCT/US2000/013827 patent/WO2000069913A1/en active IP Right Grant
- 2000-05-19 MX MXPA01011845A patent/MXPA01011845A/es unknown
- 2000-05-19 KR KR1020017014691A patent/KR20020018197A/ko not_active Application Discontinuation
- 2000-05-19 RU RU2001130984/13A patent/RU2262510C9/ru not_active IP Right Cessation
- 2000-05-19 AT AT00932622T patent/ATE369384T1/de active
- 2000-05-19 PT PT00932622T patent/PT1187852E/pt unknown
- 2000-05-19 PL PL00352332A patent/PL352332A1/xx unknown
- 2000-05-19 HU HU0201474A patent/HUP0201474A3/hu unknown
- 2000-05-19 DK DK00932622T patent/DK1187852T3/da active
- 2000-05-19 BR BR0010725-5A patent/BR0010725A/pt not_active IP Right Cessation
- 2000-05-19 JP JP2000618329A patent/JP2003530070A/ja active Pending
- 2000-05-19 EP EP00932622A patent/EP1187852B1/en not_active Expired - Lifetime
- 2000-05-19 CZ CZ20014123A patent/CZ20014123A3/cs unknown
- 2000-05-19 ES ES00932622T patent/ES2291205T3/es not_active Expired - Lifetime
- 2000-05-19 AU AU50318/00A patent/AU777963B2/en not_active Expired
- 2000-05-19 CA CA2372400A patent/CA2372400C/en not_active Expired - Lifetime
- 2000-05-19 DE DE60035871T patent/DE60035871T2/de not_active Expired - Lifetime
-
2001
- 2001-10-11 US US09/977,034 patent/US20020081664A1/en not_active Abandoned
- 2001-11-08 ZA ZA200109227A patent/ZA200109227B/en unknown
- 2001-11-15 NO NO20015587A patent/NO20015587L/no not_active Application Discontinuation
-
2002
- 2002-11-14 HK HK02108255.1A patent/HK1046694A1/zh unknown
-
2004
- 2004-09-29 US US10/953,259 patent/US20050042729A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CZ20014123A3 (cs) | 2002-06-12 |
ATE369384T1 (de) | 2007-08-15 |
DK1187852T3 (da) | 2007-11-26 |
EP1187852B1 (en) | 2007-08-08 |
NO20015587D0 (no) | 2001-11-15 |
US20050042729A1 (en) | 2005-02-24 |
PL352332A1 (en) | 2003-08-11 |
CN1361793A (zh) | 2002-07-31 |
KR20020018197A (ko) | 2002-03-07 |
RU2262510C9 (ru) | 2006-04-20 |
CA2372400A1 (en) | 2000-11-23 |
JP2003530070A (ja) | 2003-10-14 |
MXPA01011845A (es) | 2002-06-21 |
ZA200109227B (en) | 2003-02-03 |
PT1187852E (pt) | 2007-11-14 |
NO20015587L (no) | 2002-01-16 |
AU777963B2 (en) | 2004-11-04 |
DE60035871D1 (de) | 2007-09-20 |
EP1187852A1 (en) | 2002-03-20 |
ES2291205T3 (es) | 2008-03-01 |
AU5031800A (en) | 2000-12-05 |
RU2262510C2 (ru) | 2005-10-20 |
HUP0201474A2 (en) | 2002-08-28 |
CA2372400C (en) | 2010-04-27 |
HUP0201474A3 (en) | 2002-11-28 |
BR0010725A (pt) | 2002-02-19 |
DE60035871T2 (de) | 2008-06-05 |
US20020081664A1 (en) | 2002-06-27 |
WO2000069913A1 (en) | 2000-11-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PL352332A1 (en) | Expression and export of interferon-alpha proteins as fc fusion proteins | |
WO2000040615A3 (en) | EXPRESSION AND EXPORT OF ANTI-OBESITY PROTEINS AS Fc FUSION PROTEINS | |
WO1999020766A3 (en) | NOVEL MODIFIED NUCLEIC ACID SEQUENCES AND METHODS FOR INCREASING mRNA LEVELS AND PROTEIN EXPRESSION IN CELL SYSTEMS | |
Moise et al. | T4 gene 32 protein model for control of activity at replication fork | |
WO2000011033A3 (en) | Expression and export of angiostatin and endostatin as immunofusins | |
DE69836092D1 (de) | Rekombinatorisches klonieren unter verwendung von nukleinsaüren mit rekombinationsstellen | |
DK0724642T3 (da) | Nukleinsyrevektor, sammensætning indeholdende en sådan vektor og vaccine til immunisering mod hepatitis | |
WO1996040915A3 (en) | Novel ctla4/cd28 ligands and uses therefor | |
Lauer et al. | Cloning, nucleotide sequence, and engineered expression of Thermus thermophilus DNA ligase, a homolog of Escherichia coli DNA ligase | |
WO2001038357A3 (en) | Jaffa, a novel fibroblast growth factor family member and uses therefor | |
WO2003076561A3 (en) | Recombinase fusion protein with enhanced cellular uptake | |
WO1993017031A3 (en) | Nucleic acids encoding dystrophin-associated proteins | |
CY1107431T1 (el) | Σωματιδια για γoνιδιακη θεραπεια | |
DK0868435T3 (da) | Höjeffektivt vævsspecifikt forbindelsesindföringssystem ved anvendelse af streptavidin-protein A-fusionsprotein | |
DE59712771D1 (de) | Nebenhoden-spezifisches Rezeptorprotein und dessen Verwendung | |
EP0763205A4 (en) | NUCLEIC ACID SEQUENCES REGULATING THE EXPRESSION OF LUNG SPECIFIC GENES | |
WO2000052164A3 (en) | Potassium channel molecules and uses therefor | |
EP0789563B8 (en) | Hepatitis virus b and c vaccines | |
WO2002006485A3 (en) | 47885, a novel human ubiquitin-activating enzyme and uses therefor | |
WO2001032872A3 (en) | Twik potassium channel molecules and uses therefor | |
ATE547427T1 (de) | Verfahren zur rekombinanten herstellung von ribonukleoproteinen | |
WO2002051992A3 (en) | 21163, a novel human prolyl oligopeptidase and uses therefor | |
WO1999043834A3 (en) | P-selectin ligand protein, including tetrameric fusion proteins | |
WO1999050288A3 (en) | Mammalian blood loss-induced gene, kd312 | |
WO2002040656A3 (en) | 47476, 67210, 49875, 46842, 33201, 83378, 84233, 64708, 85041, and 84234, novel human guanine nucleotide dissociation stimulator, glycosyltransferase, dead type helicase, centaurin, dehydrogenase/reductase, and metal transporter family members and uses thereof |