HK1016964A1 - Benzamides for neurodegenerative disorder treatment - Google Patents

Benzamides for neurodegenerative disorder treatment

Info

Publication number: HK1016964A1
Authority: HK; Hong Kong
Prior art keywords: benzamides; neurodegenerative disorder; disorder treatment; treatment; neurodegenerative
Prior art date: 1995-04-03

Application number

HK98112098A

Other languages

English (en)

Inventor

William D Flitter

William A Garland

Allan L Wilcox

Richard E Paylor

Original Assignee

Centaur Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-04-03

Filing date

1998-11-18

Publication date

1999-11-12

1995-04-03 Priority claimed from US08/415,248 external-priority patent/US5659082A/en

1995-04-03 Priority claimed from US08/415,694 external-priority patent/US5658953A/en

1995-04-03 Priority claimed from US08/415,847 external-priority patent/US5643965A/en

1998-11-18 Application filed by Centaur Pharmaceuticals Inc filed Critical Centaur Pharmaceuticals Inc

1999-11-12 Publication of HK1016964A1 publication Critical patent/HK1016964A1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/38—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to a carbon atom of a ring other than a six-membered aromatic ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

HK98112098A 1995-04-03 1998-11-18 Benzamides for neurodegenerative disorder treatment HK1016964A1 (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US41567795A	1995-04-03	1995-04-03
US08/415,248 US5659082A (en)	1995-04-03	1995-04-03	Nitro- and aminobenzamide compounds for neurodegenerative disorders
US08/415,694 US5658953A (en)	1995-04-03	1995-04-03	Pharmaceutical compositions of acetamidobenzamide compounds for neurodegenerative disorders
US08/415,847 US5643965A (en)	1995-04-03	1995-04-03	Aminobenzamide compounds for the treatment of neurodegenerative disorders
PCT/US1996/004538 WO1996031462A1 (en)	1995-04-03	1996-04-03	Benzamides for neurodegenerative disorder treatment

Publications (1)

Publication Number	Publication Date
HK1016964A1 true HK1016964A1 (en)	1999-11-12

Family

ID=27503636

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HK98112098A HK1016964A1 (en)	1995-04-03	1998-11-18	Benzamides for neurodegenerative disorder treatment

Country Status (39)

Country	Link
EP (1)	EP0819113B1 (xx)
JP (1)	JP3479658B2 (xx)
KR (1)	KR100429120B1 (xx)
CN (1)	CN1073552C (xx)
AR (1)	AR002978A1 (xx)
AT (1)	ATE202552T1 (xx)
AU (1)	AU721045B2 (xx)
BG (1)	BG63384B1 (xx)
CA (1)	CA2215166A1 (xx)
CO (1)	CO4700431A1 (xx)
CZ (1)	CZ295852B6 (xx)
DE (1)	DE69613567T2 (xx)
DK (1)	DK0819113T3 (xx)
DZ (1)	DZ2012A1 (xx)
EA (1)	EA002031B1 (xx)
EE (1)	EE03437B1 (xx)
ES (1)	ES2160240T3 (xx)
GR (1)	GR3036466T3 (xx)
HK (1)	HK1016964A1 (xx)
HR (1)	HRP960156B1 (xx)
HU (1)	HUP9801759A3 (xx)
IL (1)	IL117629A (xx)
IS (1)	IS1919B (xx)
MA (1)	MA23837A1 (xx)
MX (1)	MX9707596A (xx)
MY (1)	MY121206A (xx)
NO (1)	NO318441B1 (xx)
NZ (1)	NZ306204A (xx)
PL (1)	PL184121B1 (xx)
PT (1)	PT819113E (xx)
RO (1)	RO116190B1 (xx)
SA (1)	SA96160739B1 (xx)
SI (1)	SI0819113T1 (xx)
SK (1)	SK282900B6 (xx)
TN (1)	TNSN96051A1 (xx)
TR (1)	TR199701114T1 (xx)
TW (1)	TW381073B (xx)
WO (1)	WO1996031462A1 (xx)
YU (1)	YU21096A (xx)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0912171A1 (en) *	1996-04-17	1999-05-06	Centaur Pharmaceuticals, Inc.	Benzamide treatment of dementia associated with aids virus (hiv-1) infection
WO1999021543A1 (fr)	1997-10-27	1999-05-06	Sumitomo Pharmaceuticals Co., Ltd.	Derives d'amide
EP1079820A1 (en) *	1998-05-19	2001-03-07	Centaur Pharmaceuticals, Inc.	Benzamide therapeutics for the treatment of inflammatory bowel disease
US6271265B1 (en)	1998-05-19	2001-08-07	Centaur Pharmaceuticals, Inc.	Amide therapeutics for the treatment of inflammatory bowel disease
AU3679800A (en) *	1999-04-23	2000-11-10	Sumitomo Pharmaceuticals Company, Limited	Apoptosis inhibitors
CN101817761B (zh) *	2010-01-29	2014-06-25	浙江大学	苯甲酸酯类衍生物及制备方法和应用
JP5850321B2 (ja) *	2010-02-10	2016-02-03	公立大学法人横浜市立大学	神経選択的転写抑制因子ＮＲＳＦに特異的に結合するｍＳｉｎ３Ｂに結合する化合物の利用
WO2014155184A1 (en) *	2013-03-28	2014-10-02	Rhenovia Pharma	Treatment for parkinson's disease
CN115594603A (zh) *	2022-10-09	2023-01-13	湖北师范大学（Cn）	微通道反应器制备n-叔丁基-4-氨基苯甲酰胺的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1069882B (it) *	1975-12-22	1985-03-25	Mallinckrodt Inc	3 5 bis acilammino benzammidi particolarmente utili come agenti di contrasto per raffi x e procedimento per la loro preparazione
JPS5721320A (en) *	1980-07-11	1982-02-04	Chugai Pharmaceut Co Ltd	Blood sugar level depressing agent
JPS5867657A (ja) *	1981-10-15	1983-04-22	Chugai Pharmaceut Co Ltd	ペンズアミド誘導体
US5472983A (en) *	1994-04-14	1995-12-05	Centaur Pharmaceuticals, Inc.	Benzamide-containing pharmaceutical compositions

1996
- 1996-03-24 IL IL11762996A patent/IL117629A/xx active IP Right Grant
- 1996-03-27 DZ DZ960053A patent/DZ2012A1/fr active
- 1996-03-28 AR AR10196396A patent/AR002978A1/es unknown
- 1996-03-28 TW TW085103754A patent/TW381073B/zh active
- 1996-04-01 MA MA24193A patent/MA23837A1/fr unknown
- 1996-04-02 CO CO96016205A patent/CO4700431A1/es unknown
- 1996-04-02 YU YU21096A patent/YU21096A/sh unknown
- 1996-04-03 HR HR960156A patent/HRP960156B1/xx not_active IP Right Cessation
- 1996-04-03 ES ES96911550T patent/ES2160240T3/es not_active Expired - Lifetime
- 1996-04-03 CA CA002215166A patent/CA2215166A1/en not_active Abandoned
- 1996-04-03 EA EA199700287A patent/EA002031B1/ru not_active IP Right Cessation
- 1996-04-03 PL PL96322625A patent/PL184121B1/pl not_active IP Right Cessation
- 1996-04-03 KR KR1019970706966A patent/KR100429120B1/ko not_active IP Right Cessation
- 1996-04-03 NZ NZ306204A patent/NZ306204A/xx unknown
- 1996-04-03 DE DE69613567T patent/DE69613567T2/de not_active Expired - Fee Related
- 1996-04-03 SK SK1325-97A patent/SK282900B6/sk unknown
- 1996-04-03 TN TNTNSN96051A patent/TNSN96051A1/fr unknown
- 1996-04-03 AT AT96911550T patent/ATE202552T1/de not_active IP Right Cessation
- 1996-04-03 JP JP53043896A patent/JP3479658B2/ja not_active Expired - Fee Related
- 1996-04-03 CN CN96193000A patent/CN1073552C/zh not_active Expired - Fee Related
- 1996-04-03 EP EP96911550A patent/EP0819113B1/en not_active Expired - Lifetime
- 1996-04-03 TR TR97/01114T patent/TR199701114T1/xx unknown
- 1996-04-03 RO RO97-01826A patent/RO116190B1/ro unknown
- 1996-04-03 CZ CZ19973098A patent/CZ295852B6/cs not_active IP Right Cessation
- 1996-04-03 DK DK96911550T patent/DK0819113T3/da active
- 1996-04-03 SI SI9630313T patent/SI0819113T1/xx unknown
- 1996-04-03 EE EE9700235A patent/EE03437B1/xx not_active IP Right Cessation
- 1996-04-03 HU HU9801759A patent/HUP9801759A3/hu unknown
- 1996-04-03 WO PCT/US1996/004538 patent/WO1996031462A1/en active IP Right Grant
- 1996-04-03 MY MYPI96001225A patent/MY121206A/en unknown
- 1996-04-03 AU AU54404/96A patent/AU721045B2/en not_active Ceased
- 1996-04-03 PT PT96911550T patent/PT819113E/pt unknown
- 1996-04-15 SA SA96160739A patent/SA96160739B1/ar unknown
1997
- 1997-09-25 IS IS4569A patent/IS1919B/is unknown
- 1997-09-29 BG BG101929A patent/BG63384B1/bg unknown
- 1997-10-02 MX MX9707596A patent/MX9707596A/es not_active IP Right Cessation
- 1997-10-02 NO NO19974569A patent/NO318441B1/no unknown
1998
- 1998-11-18 HK HK98112098A patent/HK1016964A1/xx not_active IP Right Cessation
2001
- 2001-08-30 GR GR20010401321T patent/GR3036466T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
HRP960156A2 (en)	1997-10-31
IS1919B (is)	2004-03-15
SK132597A3 (en)	1998-09-09
CN1182416A (zh)	1998-05-20
ATE202552T1 (de)	2001-07-15
GR3036466T3 (en)	2001-11-30
AR002978A1 (es)	1998-05-27
EP0819113B1 (en)	2001-06-27
AU721045B2 (en)	2000-06-22
HUP9801759A3 (en)	2001-06-28
BG101929A (en)	1998-04-30
SA96160739B1 (ar)	2005-10-15
PT819113E (pt)	2001-10-30
MA23837A1 (fr)	1996-12-31
IS4569A (is)	1997-09-25
CA2215166A1 (en)	1996-10-10
WO1996031462A1 (en)	1996-10-10
TNSN96051A1 (fr)	2005-03-15
AU5440496A (en)	1996-10-23
PL184121B1 (pl)	2002-09-30
ES2160240T3 (es)	2001-11-01
TW381073B (en)	2000-02-01
MX9707596A (es)	1998-06-30
EA199700287A1 (ru)	1998-04-30
BG63384B1 (bg)	2001-12-29
EP0819113A1 (en)	1998-01-21
NO974569D0 (no)	1997-10-02
IL117629A (en)	2000-08-13
CZ309897A3 (cs)	1998-12-16
DK0819113T3 (da)	2001-10-15
KR19980703562A (ko)	1998-11-05
RO116190B1 (ro)	2000-11-30
DZ2012A1 (fr)	2002-07-21
PL322625A1 (en)	1998-02-02
EE03437B1 (et)	2001-06-15
JPH11501319A (ja)	1999-02-02
DE69613567T2 (de)	2002-04-18
CO4700431A1 (es)	1998-12-29
DE69613567D1 (de)	2001-08-02
YU21096A (sh)	1999-03-04
TR199701114T1 (xx)	1998-02-21
MY121206A (en)	2006-01-28
EA002031B1 (ru)	2001-12-24
NO974569L (no)	1997-11-21
JP3479658B2 (ja)	2003-12-15
CZ295852B6 (cs)	2005-11-16
IL117629A0 (en)	1996-07-23
CN1073552C (zh)	2001-10-24
SK282900B6 (sk)	2003-01-09
SI0819113T1 (en)	2001-10-31
NZ306204A (en)	1999-01-28
HUP9801759A2 (hu)	1998-12-28
HRP960156B1 (en)	2002-04-30
EE9700235A (et)	1998-04-15
NO318441B1 (no)	2005-03-21
KR100429120B1 (ko)	2004-08-18

Publication	Publication Date	Title
GB2304196B (en)	1999-09-22	Electroconvulsive therapy
IL114162A (en)	1999-03-12	Submersive therapy apparatus
GB2298440B (en)	1998-08-26	Well treatment
SG44952A1 (en)	1997-12-19	Therapeutic amides
GB9411080D0 (en)	1994-07-20	Treatment
EP0874828A4 (en)	1999-09-01	PAIN TREATMENT COMPOSITIONS
GB2299652B (en)	1999-08-11	Steering apparatus
GB9519033D0 (en)	1995-11-15	Treatment
NZ283957A (en)	1999-06-29	Benzamide-containing medicaments suitable for treating neurodegenerative diseases
SI0819113T1 (en)	2001-10-31	Benzamides for neurodegenerative disorder treatment
ZA962689B (en)	1996-10-09	Benzamides for neurodegenerative disorder treatment
IL124419A0 (en)	1998-12-06	Composition for treating pain
PL324647A1 (en)	1998-06-08	Polyhydroxyalkyl amidobetains
GB2325512B (en)	1999-10-27	Steering apparatus
SI0876818T1 (en)	2003-06-30	Agent for treating neuro-degenerative disorders
GB9518241D0 (en)	1995-11-08	Treatment system
GB9510065D0 (en)	1995-07-12	Treatment
ZA9610204B (en)	1997-06-23	Therapeutic apparatus
GB9418170D0 (en)	1994-10-26	Treatment system
KR960006881Y1 (en)	1996-08-08	Hand-ring for acupuncture
ZA964727B (en)	1997-12-08	Therapeutic Amides.
KR0112621Y1 (en)	1997-12-30	Gap maintaining device
GB9525909D0 (en)	1996-02-21	Treatment of attention-defecit/hyperactivity disorder
GB9505272D0 (en)	1995-05-03	Combination therapy
GB9515618D0 (en)	1995-09-27	Strand treatment

Legal Events

Date	Code	Title	Description
2004-12-15	PF	Patent in force
2006-11-10	PC	Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)	Effective date: 20060403