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HK1004110A1 - Transfer of molecules into the cytosol of cells - Google Patents

Transfer of molecules into the cytosol of cells

Info

Publication number
HK1004110A1
HK1004110A1 HK98103468A HK98103468A HK1004110A1 HK 1004110 A1 HK1004110 A1 HK 1004110A1 HK 98103468 A HK98103468 A HK 98103468A HK 98103468 A HK98103468 A HK 98103468A HK 1004110 A1 HK1004110 A1 HK 1004110A1
Authority
HK
Hong Kong
Prior art keywords
cells
molecules
cytosol
transfer
photodynamic treatment
Prior art date
Application number
HK98103468A
Other languages
English (en)
Inventor
Kristian Berg
Kirsten Sandvik
Johan Moan
Original Assignee
Photocure As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Photocure As filed Critical Photocure As
Publication of HK1004110A1 publication Critical patent/HK1004110A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Catalysts (AREA)
HK98103468A 1994-09-08 1998-04-24 Transfer of molecules into the cytosol of cells HK1004110A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NO943327A NO180167C (no) 1994-09-08 1994-09-08 Fotokjemisk fremgangsmåte til å innföre molekyler i cellers cytosol
PCT/NO1995/000149 WO1996007432A1 (en) 1994-09-08 1995-09-04 Transfer of molecules into the cytosol of cells

Publications (1)

Publication Number Publication Date
HK1004110A1 true HK1004110A1 (en) 1998-11-20

Family

ID=19897382

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98103468A HK1004110A1 (en) 1994-09-08 1998-04-24 Transfer of molecules into the cytosol of cells

Country Status (20)

Country Link
US (3) US5876989A (zh)
EP (1) EP0783323B1 (zh)
JP (1) JP4148328B2 (zh)
KR (2) KR100529967B1 (zh)
CN (1) CN1222309C (zh)
AT (1) ATE209507T1 (zh)
AU (1) AU700797B2 (zh)
BR (1) BRPI9508825B8 (zh)
CA (1) CA2199290C (zh)
CZ (1) CZ65897A3 (zh)
DE (1) DE69524238T2 (zh)
ES (1) ES2163527T3 (zh)
FI (1) FI121328B (zh)
HK (1) HK1004110A1 (zh)
HU (1) HU222984B1 (zh)
MX (1) MX9701676A (zh)
NO (1) NO180167C (zh)
NZ (2) NZ293008A (zh)
PT (1) PT783323E (zh)
WO (1) WO1996007432A1 (zh)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO180167C (no) * 1994-09-08 1997-02-26 Photocure As Fotokjemisk fremgangsmåte til å innföre molekyler i cellers cytosol
US6210356B1 (en) * 1998-08-05 2001-04-03 Ekos Corporation Ultrasound assembly for use with a catheter
US6176842B1 (en) * 1995-03-08 2001-01-23 Ekos Corporation Ultrasound assembly for use with light activated drugs
ATE409005T1 (de) * 1997-03-19 2008-10-15 Lucid Inc Zellchirurgie unter benutzung konfokaler mikroskopie
US6676626B1 (en) 1998-05-01 2004-01-13 Ekos Corporation Ultrasound assembly with increased efficacy
US6582392B1 (en) * 1998-05-01 2003-06-24 Ekos Corporation Ultrasound assembly for use with a catheter
ES2356342T3 (es) * 1998-01-05 2011-04-07 The University Of Washington Mejora de transporte utilizando agentes de alteración de membrana.
US6399769B1 (en) * 1998-01-20 2002-06-04 Kimberly-Clark Worldwide, Inc. Method of making sulfanatophenyl substituted porphines
GB9905911D0 (en) 1999-03-15 1999-05-05 Photocure As Method
US7320885B1 (en) * 1999-09-09 2008-01-22 Toudai Tlo, Ltd. Method of perforating membrane and apparatus therefor
US20040220100A1 (en) * 2000-07-21 2004-11-04 Essentia Biosystems, Inc. Multi-component biological transport systems
EP1301213B1 (en) * 2000-07-21 2017-01-18 ReVance Therapeutics, Inc. Multi-component biological transport systems
ES2383516T3 (es) 2000-11-29 2012-06-21 Pci Biotech As Internalización fotoquímica para suministrar moléculas en el citosol
CN100490902C (zh) 2000-11-29 2009-05-27 Pci生物技术联合股份有限公司 病毒介导的分子传递进入胞质溶胶的光化学内在化
US20020098472A1 (en) * 2000-11-30 2002-07-25 Erlach Julian Van Method for inserting a microdevice or a nanodevice into a body fluid stream
US20020137901A1 (en) * 2001-01-22 2002-09-26 Cavanaugh Philip Gerard Synthesis, and photodynamic therapy-mediated anti-cancer, and other uses of chlorin e6-transferrin
WO2002062989A2 (en) * 2001-02-08 2002-08-15 Sequitur, Inc. Methods of light activated release 0f ligands from endosomes
DE60232149D1 (de) * 2001-06-20 2009-06-10 Dainippon Sumitomo Pharma Co Verfahren zur förderung des nukleinsäuretransfers
GB0121023D0 (en) 2001-08-30 2001-10-24 Norwegian Radium Hospital Res Compound
ATE319378T1 (de) 2001-12-03 2006-03-15 Ekos Corp Katheter mit mehreren ultraschall-abstrahlenden teilen
US7141044B2 (en) 2001-12-11 2006-11-28 Ekos Corporation Alternate site gene therapy
JP4527984B2 (ja) 2002-02-01 2010-08-18 ライフ テクノロジーズ コーポレーション 増強された効力を有するオリゴヌクレオチド組成物
US20060009409A1 (en) 2002-02-01 2006-01-12 Woolf Tod M Double-stranded oligonucleotides
EP1572902B1 (en) * 2002-02-01 2014-06-11 Life Technologies Corporation HIGH POTENCY siRNAS FOR REDUCING THE EXPRESSION OF TARGET GENES
US8226629B1 (en) 2002-04-01 2012-07-24 Ekos Corporation Ultrasonic catheter power control
US20040248094A1 (en) * 2002-06-12 2004-12-09 Ford Lance P. Methods and compositions relating to labeled RNA molecules that reduce gene expression
GB0215534D0 (en) * 2002-07-04 2002-08-14 Ecole Polytech Selective photochemotherapy using oligonucleotide targeting agents
US20040029275A1 (en) * 2002-08-10 2004-02-12 David Brown Methods and compositions for reducing target gene expression using cocktails of siRNAs or constructs expressing siRNAs
US6921371B2 (en) * 2002-10-14 2005-07-26 Ekos Corporation Ultrasound radiating members for catheter
WO2004063342A2 (en) * 2003-01-09 2004-07-29 Invitrogen Corporation Cellular delivery and activation polypeptide-nucleic acid complexes
US7332477B2 (en) * 2003-07-10 2008-02-19 Nitto Denko Corporation Photocleavable DNA transfer agent
EP1667732B1 (en) * 2003-09-29 2010-04-21 Nitto Denko Corporation Biodegradable polyacetals for in vivo polynucleotide delivery
US20080318319A1 (en) * 2003-12-19 2008-12-25 Yoshiko Minakuchi Novel Method of Nucleic Acid Transfer
US9211248B2 (en) 2004-03-03 2015-12-15 Revance Therapeutics, Inc. Compositions and methods for topical application and transdermal delivery of botulinum toxins
JP2007527431A (ja) * 2004-03-03 2007-09-27 ルバンス セラピュティックス 局所的診断及び治療用の輸送のための組成物及び方法
SI2656859T1 (sl) * 2004-03-03 2016-02-29 Revance Therapeutics, Inc. Topična aplikacija in transdermalna dostava botulinskih toksinov
GB0415263D0 (en) * 2004-07-07 2004-08-11 Norwegian Radium Hospital Res Method
US20060094781A1 (en) * 2004-11-04 2006-05-04 Syneron Medical Ltd. Method of treating extracellular matrix
FR2877943B1 (fr) * 2004-11-16 2008-09-05 Univ De Coimbra Nouveaux derives de porphyrine, notamment chlorines et/ou bacteriochlorine, et leurs applications en therapie photodynamique
AU2006218431B2 (en) 2005-03-03 2012-12-06 Revance Therapeutics, Inc. Compositions and methods for topical application and transdermal delivery of botulinum toxins
BRPI0608091A2 (pt) * 2005-03-03 2009-11-10 Revance Therapeutics Inc composições e processos para aplicação tópica e distribuição transdérmica de um oligopeptìdeo
US7674452B2 (en) * 2005-03-16 2010-03-09 Nitto Denko Corporation Polymer coating of cells
BRPI0501037B8 (pt) 2005-03-18 2021-07-27 Fund De Amparo A Pesquisa Do Estado De Sao Paulo uso de crotamina e composição
CA2629499A1 (en) * 2005-11-17 2007-05-24 Revance Therapeutics, Inc. Compositions and methods of topical application and transdermal delivery of botulinum toxins with reduced non-toxin proteins
WO2007109584A1 (en) * 2006-03-16 2007-09-27 University Of Washington Temperature-and ph-responsive polymer compositions
GB0613753D0 (en) 2006-07-11 2006-08-23 Norwegian Radium Hospital Res Method
WO2008073856A2 (en) * 2006-12-08 2008-06-19 Massachusetts Institute Of Technology Delivery of nanoparticles and/or agents to cells
KR20090096735A (ko) * 2006-12-29 2009-09-14 레반스 테라퓨틱스, 아이엔씨. Ｈｉｖ-ｔａｔ로부터 유래된 폴리펩티드 단편에 의해 안정화된 보툴리눔 독소의 국소 적용 및 경피 전달용 조성물 및 방법
MX2009007070A (es) * 2006-12-29 2009-07-10 Revance Therapeutics Inc Moleculas de transporte que utilizan los polipeptidos hiv-tat de secuencia inversa.
US10182833B2 (en) 2007-01-08 2019-01-22 Ekos Corporation Power parameters for ultrasonic catheter
US7981688B2 (en) 2007-03-08 2011-07-19 University Of Washington Stimuli-responsive magnetic nanoparticles and related methods
ES2471118T3 (es) 2007-06-22 2014-06-25 Ekos Corporation Método y aparato para el tratamiento de hemorragias intracraneales
EP2231024A4 (en) * 2007-12-14 2015-03-18 Ekos Corp ULTRASOUND PULSE SHAPING
GB0811955D0 (en) 2008-06-30 2008-07-30 Pci Biotech As Method
US8426214B2 (en) * 2009-06-12 2013-04-23 University Of Washington System and method for magnetically concentrating and detecting biomarkers
GB0914287D0 (en) 2009-08-14 2009-09-30 Pci Biotech As Compositions
GB0914286D0 (en) 2009-08-14 2009-09-30 Pci Biotech As Method
US20110117668A1 (en) * 2009-11-09 2011-05-19 University Of Washington Through Its Center For Commercialization Self-powered smart diagnostic devices
US9080933B2 (en) 2009-11-09 2015-07-14 University Of Washington Through Its Center For Commercialization Stimuli-responsive polymer diagnostic assay comprising magnetic nanoparticles and capture conjugates
GB201208548D0 (en) 2012-05-15 2012-06-27 Pci Biotech As Compound and method
US20160040128A1 (en) 2013-03-15 2016-02-11 Pci Biotech As Method
KR102374556B1 (ko) 2013-08-28 2022-03-14 피씨아이 바이오테크 에이에스 백신접종 및 면역화를 위한 화합물 및 방법
GB2517707B (en) 2013-08-28 2020-09-02 Pci Biotech As A device for light-induced rupture of endocytic vesicles to effect the delivery of an antigen
CA2945220C (en) 2014-04-11 2023-09-26 Pci Biotech As Method of treating melanoma
US10537639B2 (en) 2014-08-28 2020-01-21 Pci Biotech As Compound and method
GB201503776D0 (en) 2015-03-05 2015-04-22 Pci Biotech As Compound and method
WO2016201136A1 (en) 2015-06-10 2016-12-15 Ekos Corporation Ultrasound catheter
US20200338044A1 (en) 2016-10-14 2020-10-29 Pci Biotech As Treatment of cholangiocarcinoma with tpcs-2a induced photochemical internalisation of gemcitabine
GB201718631D0 (en) * 2017-11-10 2017-12-27 Pci Biotech As Method
GB201801169D0 (en) * 2018-01-24 2018-03-07 Pci Biotech As Method
JP2021531345A (ja) 2018-07-16 2021-11-18 ディーシープライム・ベスローテン・フェンノートシャップDcprime B.V. 腫瘍ワクチン接種に用いるための組合せ製品
EP3958894A1 (en) 2019-04-25 2022-03-02 DCPrime B.V. Methods of tumor vaccination
CN110711249B (zh) * 2019-09-19 2020-10-27 北京化工大学 一种溶酶体膜包覆纳米颗粒的制备方法
EP4127139A1 (en) 2020-03-27 2023-02-08 Mendus B.V. Ex vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy
EP4125943A1 (en) 2020-03-27 2023-02-08 Mendus B.V. In vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy
CN114163508B (zh) * 2020-09-11 2024-07-16 王月志 能破坏细胞的氨基酸序列及相关核苷酸序列和相关的应用
CA3196677A1 (en) 2020-11-05 2022-05-12 Erik Hans MANTING Use of tumor-independent antigens in immunotherapies
GB202101726D0 (en) 2021-02-08 2021-03-24 Pci Biotech As Method
JP2024510989A (ja) 2021-03-12 2024-03-12 メンドゥス・ベスローテン・フェンノートシャップ ワクチン接種方法及びｃｄ４７遮断薬の使用
GB202115451D0 (en) 2021-10-27 2021-12-08 Pci Biotech As Method
AU2023348144A1 (en) 2022-09-27 2025-04-03 Pci Biotech As Method for releasing viral vectors
GB202301312D0 (en) 2023-01-30 2023-03-15 Pci Biotech As Method and product
GB202404168D0 (en) 2024-03-22 2024-05-08 Pci Biotech As Method

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU563827B2 (en) 1982-07-01 1987-07-23 Millipore Corp. Filtration apparatus
US4649151A (en) * 1982-09-27 1987-03-10 Health Research, Inc. Drugs comprising porphyrins
US4704255A (en) 1983-07-15 1987-11-03 Pandex Laboratories, Inc. Assay cartridge
US5066274A (en) * 1985-04-30 1991-11-19 Nippon Petrochemicals Company, Ltd. Tetrapyrrole therapeutic agents
US5076950A (en) 1985-12-20 1991-12-31 Syntex (U.S.A.) Inc. Magnetic composition for particle separation
US4895706A (en) 1986-10-28 1990-01-23 Costar Corporation Multi-well filter strip and composite assemblies
US5095030A (en) * 1987-01-20 1992-03-10 University Of British Columbia Wavelength-specific cytotoxic agents
NO891491D0 (no) * 1987-08-12 1989-04-11 Peter Nemeth Prosedyre for befrielse av celleblandinger og vev for uoenskede populasjoner.
HU204856B (en) 1987-08-12 1992-02-28 Orszagos Mueszaki Fejlesztesi Process for releasing cell mixtures and tissues from undesired populations and for producing monoclonal antibody - hematoporphyrin conjugates
GB8721108D0 (en) * 1987-09-08 1987-10-14 Salford University Of Liposomes
US5284647A (en) * 1988-03-18 1994-02-08 Schering Aktiengesellschaft Mesotetraphenylporphyrin complex compounds, process for their production and pharmaceutical agents containing them
US5256532A (en) 1988-05-02 1993-10-26 Zynaxis Technologies, Inc. Methods, reagents and test kits for determination of subpopulations of biological entities
US4925736A (en) * 1988-07-06 1990-05-15 Long Island Jewish Medical Center Topical hematoporphyrin
GB8905001D0 (en) 1989-03-04 1989-04-19 Univ Leicester Screening for natural products of microbial metabolism
US5567687A (en) * 1989-03-06 1996-10-22 University Of Texas Texaphyrins and uses thereof
US4935498A (en) * 1989-03-06 1990-06-19 Board Of Regents, The University Of Texas System Expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles
US5328470A (en) * 1989-03-31 1994-07-12 The Regents Of The University Of Michigan Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
US5059619A (en) * 1989-06-14 1991-10-22 Quadra Logic Technologies, Inc. Stable freeze-dried polyhematoporphyrin ether/ester
DE3919873A1 (de) 1989-06-19 1990-12-20 Behringwerke Ag Magnetische protein-konjugate, verfahren zu ihrer herstellung und ihre verwendung
GB8916859D0 (en) 1989-07-24 1989-09-06 Dynal As Hapten linking
GB8929297D0 (en) 1989-12-29 1990-02-28 Dynal As Method of separation
US5200084A (en) 1990-09-26 1993-04-06 Immunicon Corporation Apparatus and methods for magnetic separation
US5491068A (en) 1991-02-14 1996-02-13 Vicam, L.P. Assay method for detecting the presence of bacteria
US5179120A (en) * 1991-06-28 1993-01-12 Cytopharm, Inc. Porphycene compounds for photodynamic therapy
PL165249B1 (pl) * 1991-10-29 1994-11-30 Wojskowa Akad Tech Sposób otrzymywania soli kompleksowych hematoporfiryny i jej pochodnych PL PL PL PL PL PL PL
US5376546A (en) * 1991-11-04 1994-12-27 Xoma Corporation Analogs of ribosome-inactivating proteins
US5258453A (en) * 1992-01-21 1993-11-02 University Of Utah Drug delivery system for the simultaneous delivery of drugs activatable by enzymes and light
DK0672180T3 (da) * 1992-03-16 2002-03-04 Isis Pharmaceuticals Inc Oligonukleotidmodulering af protein kinase C
JPH07509120A (ja) 1992-03-20 1995-10-12 セルシス・インターナショナル・パブリック・リミテッド・カンパニー 生物学的物質の分析方法およびその装置
DE69333955D1 (de) * 1992-04-24 2006-02-02 Stanford Res Inst Int Targeting homologer sequenzen in eukaryotenzellen
WO1994007138A1 (en) 1992-09-14 1994-03-31 Fodstad Oystein Detection of specific target cells in specialized or mixed cell population and solutions containing mixed cell populations
US5985620A (en) * 1992-11-03 1999-11-16 Gene Shears Pty. Limited TNF-α Ribozymes
FR2700010B1 (fr) 1992-12-24 1995-03-17 Rocher Yves Biolog Vegetale Méthode et dispositif pour tester la réactivité de cellules à l'égard de produits.
US5374531A (en) 1993-03-22 1994-12-20 Zynaxis, Inc. Immunoassay for determination of cells
US5861310A (en) * 1993-11-03 1999-01-19 Dana-Farber Cancer Institute Tumor cells modified to express B7-2 with increased immunogenicity and uses therefor
US5491084A (en) * 1993-09-10 1996-02-13 The Trustees Of Columbia University In The City Of New York Uses of green-fluorescent protein
US6015897A (en) * 1993-12-07 2000-01-18 Neorx Corporation Biotinamido-n-methylglycyl-seryl-o-succinamido-benzyl dota
US5514340A (en) 1994-01-24 1996-05-07 Magnetix Biotechnology, Inc. Device for separating magnetically labelled cells
NO180658C (no) 1994-03-10 1997-05-21 Oeystein Fodstad Fremgangsmåte og anordning for deteksjon av spesifikke målceller i spesialiserte eller blandede cellepopulasjoner og opplösninger som inneholder blandede cellepopulasjoner
NO180167C (no) 1994-09-08 1997-02-26 Photocure As Fotokjemisk fremgangsmåte til å innföre molekyler i cellers cytosol
US5872007A (en) * 1995-02-17 1999-02-16 Hybridon, Inc. CAPL-specific oligonucleotides and methods of inhibiting metastatic cancer

Also Published As

Publication number Publication date
PT783323E (pt) 2002-03-28
DE69524238D1 (de) 2002-01-10
NO943327D0 (no) 1994-09-08
EP0783323B1 (en) 2001-11-28
ES2163527T3 (es) 2002-02-01
MX9701676A (es) 1998-04-30
KR970705415A (ko) 1997-10-09
KR100395615B1 (ko) 2003-12-31
KR100529967B1 (ko) 2005-11-22
AU700797B2 (en) 1999-01-14
DE69524238T2 (de) 2002-07-18
KR20040004402A (ko) 2004-01-13
BRPI9508825B1 (pt) 2020-12-22
NZ509519A (en) 2004-10-29
JPH10508295A (ja) 1998-08-18
ATE209507T1 (de) 2001-12-15
CZ65897A3 (en) 1997-10-15
US5876989A (en) 1999-03-02
HUT77469A (hu) 1998-05-28
AU3534795A (en) 1996-03-27
NO180167C (no) 1997-02-26
NO180167B (no) 1996-11-18
CA2199290A1 (en) 1996-03-14
US20030134813A1 (en) 2003-07-17
NO943327L (no) 1996-03-11
JP4148328B2 (ja) 2008-09-10
HU222984B1 (hu) 2004-01-28
BR9508825A (pt) 1998-01-06
BRPI9508825B8 (pt) 2021-07-06
EP0783323A1 (en) 1997-07-16
CA2199290C (en) 2010-10-26
WO1996007432A1 (en) 1996-03-14
FI970983L (fi) 1997-03-07
US6680301B2 (en) 2004-01-20
CN1222309C (zh) 2005-10-12
FI970983A0 (fi) 1997-03-07
US20020155099A1 (en) 2002-10-24
NZ293008A (en) 2001-04-27
CN1164829A (zh) 1997-11-12
FI121328B (fi) 2010-10-15

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