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GT200700101A - Compuestos para la modulacion de la actividad del c-fms y/o el c-kit y sus usos aplicables - Google Patents

Compuestos para la modulacion de la actividad del c-fms y/o el c-kit y sus usos aplicables

Info

Publication number
GT200700101A
GT200700101A GT200700101A GT200700101A GT200700101A GT 200700101 A GT200700101 A GT 200700101A GT 200700101 A GT200700101 A GT 200700101A GT 200700101 A GT200700101 A GT 200700101A GT 200700101 A GT200700101 A GT 200700101A
Authority
GT
Guatemala
Prior art keywords
fms
kit
compounds
modulation
activity
Prior art date
Application number
GT200700101A
Other languages
English (en)
Inventor
Chao Zhang
Jiazhong Zhang
Prabha N Ibrahim
Dean R Artis
Ryan Bremer
Guoxian Wu
Hongyao Zhu
Marika Nespi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39322825&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GT200700101(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of GT200700101A publication Critical patent/GT200700101A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Dermatology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A COMPUESTOS DE FORMULA GENERAL I EN LA QUE B,A2,D, SON GRUPOS FUNCIONALES DESCRITOS EN EL EXPEDIENTE Y QUE DE CONFORMIDAD CON UNO DE LOS ASPECTOS DE LA INVENCION ACTUAL, SE HA DESCUBIERTO QUE EN EL TRATAMIENTO DE LAS ENFERMEDADES SENSIBLE AL TRATAMIENTO POR MEDIO DE UNA CANTIDAD EFICAZ DE UN MODULADOR DE CUALQUIER C-FMS SOLO O CUALQUIER C-KIT SOLO PARA CUADROS DE CRECIMIENTO CELULAR HIPERPROLIFERATIVO TAL COMO CANCER. T2007
GT200700101A 2006-11-22 2007-11-14 Compuestos para la modulacion de la actividad del c-fms y/o el c-kit y sus usos aplicables GT200700101A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US86074906P 2006-11-22 2006-11-22

Publications (1)

Publication Number Publication Date
GT200700101A true GT200700101A (es) 2008-07-08

Family

ID=39322825

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200700101A GT200700101A (es) 2006-11-22 2007-11-14 Compuestos para la modulacion de la actividad del c-fms y/o el c-kit y sus usos aplicables

Country Status (35)

Country Link
US (8) US7893075B2 (es)
EP (1) EP2086972B1 (es)
JP (4) JP2010510321A (es)
KR (1) KR101506044B1 (es)
CN (2) CN101605787B (es)
AR (1) AR063878A1 (es)
AU (1) AU2007323644B2 (es)
BR (1) BRPI0721137B8 (es)
CA (1) CA2670362C (es)
CL (1) CL2007003326A1 (es)
CO (1) CO6180438A2 (es)
CR (1) CR10817A (es)
DK (1) DK2086972T3 (es)
EC (1) ECSP099357A (es)
ES (1) ES2447779T3 (es)
GT (1) GT200700101A (es)
HK (1) HK1133649A1 (es)
IL (1) IL198624A (es)
MX (1) MX2009005428A (es)
MY (1) MY158447A (es)
NI (1) NI200900093A (es)
NO (1) NO342175B1 (es)
NZ (1) NZ577011A (es)
PE (1) PE20081226A1 (es)
PL (1) PL2086972T3 (es)
PT (1) PT2086972E (es)
RU (1) RU2452738C2 (es)
SG (1) SG176511A1 (es)
SI (1) SI2086972T1 (es)
SV (1) SV2007002813A (es)
TW (1) TWI432431B (es)
UA (1) UA97816C2 (es)
UY (1) UY30732A1 (es)
WO (3) WO2008063888A2 (es)
ZA (1) ZA200903458B (es)

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WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
WO2008079909A1 (en) * 2006-12-21 2008-07-03 Plexxikon, Inc. Pyrrolo [2,3-b] pyridines as kinase modulators
PE20121126A1 (es) * 2006-12-21 2012-08-24 Plexxikon Inc Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa
AU2008276063B2 (en) 2007-07-17 2013-11-28 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
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WO2009106441A1 (en) * 2008-02-25 2009-09-03 F. Hoffmann-La Roche Ag Pyrrolopyrazine kinase inhibitors
WO2009106443A1 (en) * 2008-02-25 2009-09-03 F. Hoffmann-La Roche Ag Pyrrolopyrazine kinase inhibitors
EP2247595B1 (en) * 2008-02-25 2011-07-20 F. Hoffmann-La Roche AG Pyrrolopyrazine kinase inhibitors
WO2009143018A2 (en) 2008-05-19 2009-11-26 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
CA2727389A1 (en) * 2008-06-10 2009-12-17 Prabha N. Ibrahim 5h-pyrrolo [2,3-b] pyrazine derivatives for kinase modulation, and indications therefor
EP2356116A1 (en) * 2008-11-20 2011-08-17 OSI Pharmaceuticals, Inc. Substituted pyrroloý2,3-b¨-pyridines and-pyrazines
WO2010074588A2 (en) * 2008-12-24 2010-07-01 BIAL - PORTELA & Cª, S.A. Pharmaceutical compounds
BRPI1008709B8 (pt) 2009-04-03 2021-05-25 Hoffmann La Roche dispersão sólida, formulação, composição e comprimido compreendendo {3-[5-(4-cloro-fenil)-1h-pirrol[2,3-b]piridina-3-carbonil]-2,4-diflúor-fenil}-amida do ácido propano-1-sulfônico
TW201041888A (en) 2009-05-06 2010-12-01 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
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