DK1107973T3 - Hidtil ukendte thieno(2,3-D)pyrimidindioner, fremgangsmåde til deres fremstilling og anvendelse deraf i terapi - Google Patents

Hidtil ukendte thieno(2,3-D)pyrimidindioner, fremgangsmåde til deres fremstilling og anvendelse deraf i terapi

Info

Publication number: DK1107973T3
Authority: DK; Denmark
Prior art keywords: pyrimidinediones; therapy; preparation; methods; new thieno
Prior art date: 1998-08-28

Application number

DK99944964T

Other languages

English (en)

Inventor

John Bantick

Martin Cooper

Matthew Perry

Philip Thorne

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-08-28

Filing date

1999-08-18

Publication date

2004-02-23

1999-08-18 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2004-02-23 Application granted granted Critical

2004-02-23 Publication of DK1107973T3 publication Critical patent/DK1107973T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/08—Antibacterial agents for leprosy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Diabetes (AREA)
Orthopedic Medicine & Surgery (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Oncology (AREA)
Dermatology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Neurology (AREA)
Endocrinology (AREA)
Otolaryngology (AREA)
Obesity (AREA)
Transplantation (AREA)
Cardiology (AREA)
Tropical Medicine & Parasitology (AREA)
Biomedical Technology (AREA)
Emergency Medicine (AREA)
Neurosurgery (AREA)
Hematology (AREA)
Vascular Medicine (AREA)
Molecular Biology (AREA)

DK99944964T 1998-08-28 1999-08-18 Hidtil ukendte thieno(2,3-D)pyrimidindioner, fremgangsmåde til deres fremstilling og anvendelse deraf i terapi DK1107973T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE9802895		1998-08-28
PCT/SE1999/001400 WO2000012514A1 (en)	1998-08-28	1999-08-18	Novel compounds

Publications (1)

Publication Number	Publication Date
DK1107973T3 true DK1107973T3 (da)	2004-02-23

Family

ID=20412397

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99944964T DK1107973T3 (da)	1998-08-28	1999-08-18	Hidtil ukendte thieno(2,3-D)pyrimidindioner, fremgangsmåde til deres fremstilling og anvendelse deraf i terapi

Country Status (12)

Country	Link
US (1)	US6300334B1 (da)
EP (1)	EP1107973B1 (da)
JP (1)	JP2002523511A (da)
AT (1)	ATE253580T1 (da)
AU (1)	AU763758B2 (da)
CA (1)	CA2339664A1 (da)
DE (1)	DE69912618T2 (da)
DK (1)	DK1107973T3 (da)
ES (1)	ES2211161T3 (da)
NZ (1)	NZ509809A (da)
PT (1)	PT1107973E (da)
WO (1)	WO2000012514A1 (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE9801399D0 (sv)	1998-04-21	1998-04-21	Astra Pharma Prod	Method and apparatus for filling containers
ATE272642T1 (de) *	2000-05-04	2004-08-15	Astrazeneca Ab	Thieno(2,3-d)pyrimidindione und ihre verwendung als pharmazeutische mittel
GB2361917A (en) *	2000-05-04	2001-11-07	Astrazeneca Ab	Novel thieno[2,3-d]pyrimidinediones
GB2363377B (en) *	2000-06-14	2004-06-09	Astrazeneca Ab	Novel thieno[2,3-d]pyrimidinediones and therapeutic uses thereof
EP1370562A1 (en) *	2001-02-14	2003-12-17	Warner-Lambert Company LLC	Thieno[2,3-d]pyrimidindione derivatives as matrix metalloproteinase inhibitors
GB0117583D0 (en) *	2001-07-19	2001-09-12	Astrazeneca Ab	Novel compounds
GB0118479D0 (en) *	2001-07-28	2001-09-19	Astrazeneca Ab	Novel compounds
SE0300119D0 (sv) *	2003-01-17	2003-01-17	Astrazeneca Ab	Novel compounds
SE0300120D0 (sv) *	2003-01-17	2003-01-17	Astrazeneca Ab	Novel compounds
NZ541218A (en) *	2003-01-17	2008-05-30	Astrazeneca Ab	Thienopyrimidinediones and their use in modulation of autoimmune disease
PT1696920E (pt)	2003-12-19	2015-01-14	Plexxikon Inc	Compostos e métodos para o desenvolvimento de moduladores de ret
US7498342B2 (en)	2004-06-17	2009-03-03	Plexxikon, Inc.	Compounds modulating c-kit activity
EP1768662A2 (en)	2004-06-24	2007-04-04	Novartis Vaccines and Diagnostics, Inc.	Small molecule immunopotentiators and assays for their detection
JP2009528389A (ja) *	2006-03-02	2009-08-06	シーブイ・セラピューティクス・インコーポレイテッド	Ａ２ａアデノシン受容体拮抗剤
WO2008063888A2 (en)	2006-11-22	2008-05-29	Plexxikon, Inc.	Compounds modulating c-fms and/or c-kit activity and uses therefor
NZ582772A (en)	2007-07-17	2012-06-29	Plexxikon Inc	Compounds and methods for kinase modulation, and indications therefor
SG184767A1 (en) *	2009-03-23	2012-10-30	Glenmark Pharmaceuticals Sa	Furopyrimidinedione derivatives as trpa1 modulators
CR20170089A (es)	2009-04-03	2017-07-17	Plexxikon Inc	Composiciones del acido propano-1--sulfonico {3-[5-(4-cloro-fenil)-1h-pirrolo [2,3-b] piridina-3-carbonil] -2,4-difluoro-fenil}-amida y el uso de las mismas
NZ599866A (en)	2009-11-06	2014-09-26	Plexxikon Inc	Compounds and methods for kinase modulation, and indications therefor
CN103517710B (zh)	2011-02-07	2017-05-31	普莱希科公司	用于激酶调节的化合物
TWI558702B (zh)	2011-02-21	2016-11-21	普雷辛肯公司	醫藥活性物質的固態形式
US9150570B2 (en)	2012-05-31	2015-10-06	Plexxikon Inc.	Synthesis of heterocyclic compounds
MX2016004250A (es)	2013-10-07	2016-07-12	Bayer Pharma AG	Tienouracilcarboxamidas ciclicas y usos de las mismas.
UY36586A (es) *	2015-03-26	2016-10-31	Bayer Pharma AG	Heterociclilmetiltienouracilos y uso de los mismos
WO2018041771A1 (de)	2016-09-02	2018-03-08	Bayer Pharma Aktiengesellschaft	(1-methylcyclopropyl)methyl-substituierte thienouracile und ihre verwendung
US20200016159A1 (en)	2016-09-23	2020-01-16	Bayer Aktiengesellschaft	N3-cyclically substituted thienouracils and use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH01213284A (ja) *	1988-02-22	1989-08-28	Sankyo Co Ltd	チエノピリミジン−２，４−ジオン誘導体
DD293824A5 (de) *	1990-04-24	1991-09-12	Karl-Marx-Universitaet Leipzig,De	Verfahren zur herstellung von 3-(mercaptoalkyl)=thieno/2,3-d/pyrimidin-2,4(1h,3h)-dionen
TW276256B (da)	1993-08-26	1996-05-21	Takeda Pharm Industry Co Ltd

1999
- 1999-08-18 CA CA002339664A patent/CA2339664A1/en not_active Abandoned
- 1999-08-18 DE DE69912618T patent/DE69912618T2/de not_active Expired - Fee Related
- 1999-08-18 AU AU57677/99A patent/AU763758B2/en not_active Ceased
- 1999-08-18 JP JP2000567536A patent/JP2002523511A/ja active Pending
- 1999-08-18 ES ES99944964T patent/ES2211161T3/es not_active Expired - Lifetime
- 1999-08-18 DK DK99944964T patent/DK1107973T3/da active
- 1999-08-18 NZ NZ509809A patent/NZ509809A/xx unknown
- 1999-08-18 US US09/402,837 patent/US6300334B1/en not_active Expired - Fee Related
- 1999-08-18 PT PT99944964T patent/PT1107973E/pt unknown
- 1999-08-18 AT AT99944964T patent/ATE253580T1/de not_active IP Right Cessation
- 1999-08-18 EP EP99944964A patent/EP1107973B1/en not_active Expired - Lifetime
- 1999-08-18 WO PCT/SE1999/001400 patent/WO2000012514A1/en active IP Right Grant

Also Published As

Publication number	Publication date
ES2211161T3 (es)	2004-07-01
AU763758B2 (en)	2003-07-31
EP1107973B1 (en)	2003-11-05
US6300334B1 (en)	2001-10-09
PT1107973E (pt)	2004-03-31
JP2002523511A (ja)	2002-07-30
AU5767799A (en)	2000-03-21
WO2000012514A1 (en)	2000-03-09
DE69912618D1 (de)	2003-12-11
ATE253580T1 (de)	2003-11-15
CA2339664A1 (en)	2000-03-09
NZ509809A (en)	2002-11-26
DE69912618T2 (de)	2004-10-28
EP1107973A1 (en)	2001-06-20

Publication	Publication Date	Title
DK1107973T3 (da)	2004-02-23	Hidtil ukendte thieno(2,3-D)pyrimidindioner, fremgangsmåde til deres fremstilling og anvendelse deraf i terapi
MY126862A (en)	2006-10-31	Purine derivatives inhibitors of tyrosine protein kinase syk
JO2248B1 (en)	2004-10-07	Pirazolobenzodiazepines
DE60005054D1 (de)	2003-10-09	Chinuclidin-acrylamide
NO20021328L (no)	2002-05-21	Pyrazolopyrimidier som terapeutiske midler
SE9900100D0 (sv)	1999-01-15	New compounds
TR200002218T2 (tr)	2000-12-21	2-(Pürin-9-il)-Tetrahidrofüran -3,4-Diol türevleri
ES2195785A1 (es)	2003-12-01	Nuevos derivados de piridazin-3(2h)-ona.
JO2311B1 (en)	2005-09-12	Alkyl inhibitors Ariel phosphodiesterase-4
CY1107509T1 (el)	2013-03-13	Αμινοθειαζολες ως αναστολεις κυκλινη - εξαρτωμενων κινασεων
AU2003301020A8 (en)	2004-07-22	Isoquinolinone derivatives and their use as therapeutic agents
PL377285A1 (pl)	2006-01-23	Podstawione pochodne pirolo-pirazolowe jako inhibitory kinazy
DE60121461D1 (de)	2006-08-24	Kondensierte pyridoindolderivate
WO2002070469A3 (en)	2004-03-04	Selective pde3b inhibitors and use of the same in therapy
NO20002702L (no)	2000-05-26	Tienopyrimidiner
NO953763L (no)	1995-09-25	Heterocykel-holdige amidin-derivater, deres fremstilling og anvendelse
SE9803518D0 (sv)	1998-10-15	Novel compounds
NO20016201L (no)	2001-12-18	Tienopyrimidiner som fosfodiesteraseinhibitorer
ATE389655T1 (de)	2008-04-15	Pyrimidinderivate
NO20052698L (no)	2005-06-06	4(fenylpiperazinyl-metyl)benzamid-derivater og deres anvendelse ved behandling av smerte og gasatrintestinale lidelser.
AU2001290480A1 (en)	2002-04-08	Cyclized benzamide neurokinin antagonists for use in therapy
SE9803773D0 (sv)	1998-11-05	Compounds
AU2002359150A8 (en)	2003-06-30	Therapeutic heterocycles
MXPA04001419A (es)	2004-05-27	Isoxazolopiridinonas y su uso en el tratamiento de enfermedad de parkinson.
DK0916670T3 (da)	2003-09-15	Pyrrolo[3,2-b]pyridiner og deres anvendelse som 5-HT1f-agonister