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GR3024151T3 - Silylated acetylcholinesterase inhibitors. - Google Patents

Silylated acetylcholinesterase inhibitors.

Info

Publication number
GR3024151T3
GR3024151T3 GR970401801T GR970401801T GR3024151T3 GR 3024151 T3 GR3024151 T3 GR 3024151T3 GR 970401801 T GR970401801 T GR 970401801T GR 970401801 T GR970401801 T GR 970401801T GR 3024151 T3 GR3024151 T3 GR 3024151T3
Authority
GR
Greece
Prior art keywords
silylated
acetylcholinesterase inhibitors
compounds
methods
acetylcholinesterase
Prior art date
Application number
GR970401801T
Other languages
English (en)
Inventor
Jean-Noel Collard
Jean-Marie Hornsperger
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of GR3024151T3 publication Critical patent/GR3024151T3/el

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/0803Compounds with Si-C or Si-Si linkages
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
GR970401801T 1993-02-16 1997-07-16 Silylated acetylcholinesterase inhibitors. GR3024151T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP93400385A EP0611769A1 (en) 1993-02-16 1993-02-16 Silylated acetylcholinesterase inhibitors
PCT/US1994/000720 WO1994019356A1 (en) 1993-02-16 1994-01-25 Silylated acetylcholinesterase inhibitors

Publications (1)

Publication Number Publication Date
GR3024151T3 true GR3024151T3 (en) 1997-10-31

Family

ID=8214682

Family Applications (1)

Application Number Title Priority Date Filing Date
GR970401801T GR3024151T3 (en) 1993-02-16 1997-07-16 Silylated acetylcholinesterase inhibitors.

Country Status (19)

Country Link
EP (2) EP0611769A1 (el)
JP (1) JP3516955B2 (el)
KR (1) KR100336547B1 (el)
CN (1) CN1043575C (el)
AT (1) ATE152725T1 (el)
AU (1) AU672885B2 (el)
CA (1) CA2154870C (el)
DE (1) DE69403068T2 (el)
DK (1) DK0684951T3 (el)
ES (1) ES2104358T3 (el)
FI (1) FI111461B (el)
GR (1) GR3024151T3 (el)
HU (1) HUT72736A (el)
IL (1) IL108623A0 (el)
MX (1) MX9401175A (el)
NO (1) NO305517B1 (el)
NZ (1) NZ262247A (el)
WO (1) WO1994019356A1 (el)
ZA (1) ZA94925B (el)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0627400A1 (en) * 1993-06-04 1994-12-07 Merrell Dow Pharmaceuticals Inc. Aromatic acetylcholinesterase inhibitors
CN100431539C (zh) * 2004-01-12 2008-11-12 和泓生物技术(上海)有限公司 乙酰胆碱酯酶抑制剂在制备治疗帕金森病药物中的应用
JP5379692B2 (ja) 2006-11-09 2013-12-25 プロビオドルグ エージー 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての3−ヒドロキシ−1,5−ジヒドロ−ピロール−2−オン誘導体
EP2091948B1 (en) 2006-11-30 2012-04-18 Probiodrug AG Novel inhibitors of glutaminyl cyclase
EP2481408A3 (en) 2007-03-01 2013-01-09 Probiodrug AG New use of glutaminyl cyclase inhibitors
EP2142514B1 (en) 2007-04-18 2014-12-24 Probiodrug AG Thiourea derivatives as glutaminyl cyclase inhibitors
AU2010294214B2 (en) 2009-09-11 2015-05-07 Vivoryon Therapeutics N.V. Heterocylcic derivatives as inhibitors of glutaminyl cyclase
AU2011215870B2 (en) 2010-02-09 2016-01-28 The Johns Hopkins University Methods and compositions for improving cognitive function
ES2586231T3 (es) 2010-03-03 2016-10-13 Probiodrug Ag Inhibidores de glutaminil ciclasa
MX2012010470A (es) 2010-03-10 2012-10-09 Probiodrug Ag Inhibidores heterociclicos d ciclasa de glutaminilo (qc, ec .3 2. 5).
EP2560953B1 (en) 2010-04-21 2016-01-06 Probiodrug AG Inhibitors of glutaminyl cyclase
EP2686313B1 (en) 2011-03-16 2016-02-03 Probiodrug AG Benzimidazole derivatives as inhibitors of glutaminyl cyclase
WO2014078568A1 (en) 2012-11-14 2014-05-22 The Johns Hopkins University Methods and compositions for treating schizophrenia
EP2968237A4 (en) 2013-03-15 2016-08-31 Univ Johns Hopkins METHOD AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION
US11160785B2 (en) 2013-03-15 2021-11-02 Agenebio Inc. Methods and compositions for improving cognitive function
MX2017014774A (es) 2015-05-22 2018-02-15 Agenebio Inc Composiciones farmaceuticas de levetiracetam de liberacion extendida.
PL3461819T3 (pl) 2017-09-29 2020-11-30 Probiodrug Ag Inhibitory cyklazy glutaminylowej
CN112047973B (zh) * 2019-06-06 2022-11-18 上海科技大学 一种大麻素类化合物,其制备方法、组合物和用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0403713A1 (en) * 1989-06-22 1990-12-27 Merrell Dow Pharmaceuticals Inc. Novel acetylcholinesterase inhibitors

Also Published As

Publication number Publication date
CN1043575C (zh) 1999-06-09
FI953851A0 (fi) 1995-08-15
FI953851L (fi) 1995-08-15
CA2154870A1 (en) 1994-09-01
KR100336547B1 (ko) 2002-11-02
DE69403068T2 (de) 1997-12-11
NO305517B1 (no) 1999-06-14
DK0684951T3 (da) 1997-05-26
CA2154870C (en) 1998-10-27
AU672885B2 (en) 1996-10-17
IL108623A0 (en) 1994-05-30
NZ262247A (en) 1996-01-26
AU6164194A (en) 1994-09-14
HUT72736A (en) 1996-05-28
NO953201L (no) 1995-08-15
EP0684951A1 (en) 1995-12-06
ZA94925B (en) 1994-08-25
JPH08507059A (ja) 1996-07-30
MX9401175A (es) 1994-08-31
WO1994019356A1 (en) 1994-09-01
CN1117733A (zh) 1996-02-28
KR960701068A (ko) 1996-02-24
DE69403068D1 (en) 1997-06-12
ES2104358T3 (es) 1997-10-01
EP0684951B1 (en) 1997-05-07
EP0611769A1 (en) 1994-08-24
FI111461B (fi) 2003-07-31
JP3516955B2 (ja) 2004-04-05
ATE152725T1 (de) 1997-05-15
NO953201D0 (no) 1995-08-15

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