GR3015124T3 - Proteinaseinhibitors, method for their preparation and pharmaceutical compositions containing them. - Google Patents

Proteinaseinhibitors, method for their preparation and pharmaceutical compositions containing them.

Info

Publication number: GR3015124T3
Authority: GR; Greece
Prior art keywords: peptide variants; preparation; trypsin inhibitor; pharmaceutical compositions; compositions containing
Prior art date: 1989-05-13

Application number

GR940403586T

Other languages

English (en)

Inventor

Hans Prof Dr Fritz

Wolfgang Dr Gebhard

Rathindra Dr Das

Original Assignee

Bayer Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-05-13

Filing date

1995-02-22

Publication date

1995-05-31

1995-02-22 Application filed by Bayer Ag filed Critical Bayer Ag

1995-05-31 Publication of GR3015124T3 publication Critical patent/GR3015124T3/el

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Zoology (AREA)
Urology & Nephrology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Endocrinology (AREA)
Dermatology (AREA)
Pulmonology (AREA)
Reproductive Health (AREA)
Physics & Mathematics (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)

GR940403586T 1989-05-13 1995-02-22 Proteinaseinhibitors, method for their preparation and pharmaceutical compositions containing them. GR3015124T3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3915689		1989-05-13
DE4001244		1990-01-18

Publications (1)

Publication Number	Publication Date
GR3015124T3 true GR3015124T3 (en)	1995-05-31

Family

ID=25880860

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GR940403586T GR3015124T3 (en)	1989-05-13	1995-02-22	Proteinaseinhibitors, method for their preparation and pharmaceutical compositions containing them.

Country Status (17)

Country	Link
US (1)	US5407915A (el)
EP (1)	EP0401508B1 (el)
JP (2)	JP3126975B2 (el)
KR (1)	KR0156246B1 (el)
AT (1)	ATE114332T1 (el)
AU (1)	AU623769B2 (el)
CA (1)	CA2016627C (el)
DE (1)	DE59007737D1 (el)
DK (1)	DK0401508T3 (el)
ES (1)	ES2066033T3 (el)
GR (1)	GR3015124T3 (el)
HU (1)	HU214985B (el)
IE (1)	IE65710B1 (el)
IL (1)	IL94349A (el)
NZ (1)	NZ233635A (el)
PH (1)	PH27530A (el)
PT (1)	PT94016B (el)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7078383B2 (en) *	1988-09-02	2006-07-18	Dyax Corp.	ITI-D1 Kunitz domain mutants as HNE inhibitors
US20060134087A1 (en) *	1988-09-02	2006-06-22	Dyax Corp.	ITI-D1 Kunitz domain mutants as hNE inhibitors
US5663143A (en) *	1988-09-02	1997-09-02	Dyax Corp.	Engineered human-derived kunitz domains that inhibit human neutrophil elastase
CA2055425A1 (en) *	1990-11-13	1992-05-14	Hideaki Morishita	Polypeptide, dna fragment encoding the same and process for producing the same, and enzyme inhibition process, drug composition and methods of treating using the same
DE69233108T2 (de) *	1991-03-01	2004-04-29	Dyax Corp., Cambridge	Hemmstoffe für menschliche neutrophile elastase und menschliches kathepsin g
CA2082226A1 (en) *	1991-11-08	1993-05-09	Hideaki Morishita	Polypeptide, dna fragment encoding the same, drug composition containing the same and process for producing the same
IL104327A0 (en) *	1992-01-07	1993-05-13	Novo Nordisk As	Variant of human kunitz-type protease inhibitor
JP2769083B2 (ja) *	1993-02-22	1998-06-25	日清食品株式会社	エラスターゼ阻害活性を有する新規ペプチドおよびその製造方法
JP3570558B2 (ja) *	1993-05-01	2004-09-29	持田製薬株式会社	Ｄｎａ断片およびそれを含むベクター、該ベクターによって形質転換された形質転換体、該ベクターを用いる蛋白質の産生方法
US5650394A (en) *	1993-11-04	1997-07-22	Adeza Biomedical	Use of urinastatin-like compounds to prevent premature delivery
US6010880A (en) *	1994-01-11	2000-01-04	Dyax Corp.	Inhibitors of human plasmin derived from the kunitz domains
US6057287A (en) *	1994-01-11	2000-05-02	Dyax Corp.	Kallikrein-binding "Kunitz domain" proteins and analogues thereof
AU4868096A (en) *	1995-02-23	1996-09-11	Adeza Biomedical Corporation	Polypeptides derived from urinastatin having calcium channel blocking activity and their use to delay premature delivery
JP3469584B2 (ja) *	1996-03-11	2003-11-25	バイエルコーポレイション	ヒトビクニン
CA2356404C (en) *	1998-12-22	2010-03-30	Bayer Aktiengesellschaft	Method for accelerating the rate of mucociliary clearance
US20070140979A1 (en) *	1998-12-22	2007-06-21	Bayer Aktiengesellschaft	Method for accelerating the rate of mucociliary clearance
US6660482B1 (en) *	2000-02-28	2003-12-09	Rhode Island Hospital	Inter-alpha-trypsin inhibitor as a marker for sepsis
US6731695B2 (en) *	2001-03-27	2004-05-04	Aware, Inc.	Systems and methods for implementing receiver transparent Q-mode
ES2372978T3 (es)	2002-06-07	2012-01-30	Dyax Corp.	Polipéptido con dominio de kunitz modificado.
US7153829B2 (en)	2002-06-07	2006-12-26	Dyax Corp.	Kallikrein-inhibitor therapies
ES2395014T3 (es)	2002-08-28	2013-02-07	Dyax Corp.	Métodos para conservar órganos y tejidos
EP2290107A1 (en) *	2003-01-07	2011-03-02	Dyax Corporation	Kunitz domain library
US6989369B2 (en) *	2003-02-07	2006-01-24	Dyax Corp.	Kunitz domain peptides
US7235530B2 (en)	2004-09-27	2007-06-26	Dyax Corporation	Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
WO2010080833A1 (en) *	2009-01-06	2010-07-15	Dyax Corp.	Treatment of mucositis with kallikrein inhibitors
AU2011204349C1 (en)	2010-01-06	2017-02-16	Takeda Pharmaceutical Company Limited	Plasma kallikrein binding proteins
KR102011156B1 (ko)	2011-01-06	2019-08-16	다이액스 코포레이션	혈장 칼리크레인 결합 단백질
SG10201708400QA (en)	2014-02-24	2017-11-29	Takeda Gmbh	Uti fusion proteins
CN106459210A (zh)	2014-03-27	2017-02-22	戴埃克斯有限公司	用于治疗糖尿病黄斑性水肿的组合物和方法
CO2018007151A2 (es)	2015-12-11	2018-09-20	Dyax Corp	Inhibidores de calicreína plasmática y usos de los mismos para tratar ataque de angioedema hereditario
EP4114428A4 (en)	2020-03-05	2025-03-12	Diamedica Usa Inc	ULINASTATIN POLYPEPTIDES

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU560584B2 (en) *	1983-07-28	1987-04-09	Bayer Aktiengesellschaft	Homologues of aprotinin
US4711848A (en) *	1984-03-14	1987-12-08	Zymogenetics, Inc.	Site specific mutagenesis in alpha-1-antitrypsin
FR2599752B1 (fr) *	1986-06-10	1989-11-03	Transgene Sa	Variants de l'alpha1- antitrypsine utiles notamment comme inhibiteurs de la kallikreine
FR2601033B1 (fr) *	1986-07-02	1990-01-19	Transgene Sa	Variants de l'alpha-antitryspine humaine glycosylee et procede pour la preparation
EP0255011A3 (en) *	1986-07-29	1988-11-23	Miles Inc.	Human inter-alpha-trypsin inhibitor gene

1990
- 1990-05-01 ES ES90108284T patent/ES2066033T3/es not_active Expired - Lifetime
- 1990-05-01 EP EP90108284A patent/EP0401508B1/de not_active Expired - Lifetime
- 1990-05-01 DK DK90108284.2T patent/DK0401508T3/da active
- 1990-05-01 DE DE59007737T patent/DE59007737D1/de not_active Expired - Fee Related
- 1990-05-01 AT AT90108284T patent/ATE114332T1/de not_active IP Right Cessation
- 1990-05-02 PH PH40464A patent/PH27530A/en unknown
- 1990-05-10 NZ NZ233635A patent/NZ233635A/en unknown
- 1990-05-10 IL IL94349A patent/IL94349A/en not_active IP Right Cessation
- 1990-05-11 CA CA002016627A patent/CA2016627C/en not_active Expired - Fee Related
- 1990-05-11 JP JP02120186A patent/JP3126975B2/ja not_active Expired - Fee Related
- 1990-05-11 PT PT94016A patent/PT94016B/pt active IP Right Grant
- 1990-05-11 HU HU903010A patent/HU214985B/hu not_active IP Right Cessation
- 1990-05-11 AU AU54970/90A patent/AU623769B2/en not_active Ceased
- 1990-05-11 IE IE171390A patent/IE65710B1/en not_active IP Right Cessation
- 1990-05-12 KR KR1019900006865A patent/KR0156246B1/ko not_active IP Right Cessation
1993
- 1993-03-05 US US08/027,602 patent/US5407915A/en not_active Expired - Fee Related
1995
- 1995-02-22 GR GR940403586T patent/GR3015124T3/el unknown
2000
- 2000-09-13 JP JP2000278172A patent/JP2001112492A/ja active Pending

Also Published As

Publication number	Publication date
US5407915A (en)	1995-04-18
EP0401508B1 (de)	1994-11-23
JP2001112492A (ja)	2001-04-24
NZ233635A (en)	1991-12-23
JP3126975B2 (ja)	2001-01-22
HU903010D0 (en)	1990-09-28
PH27530A (en)	1993-08-18
DK0401508T3 (da)	1995-05-15
IL94349A (en)	1998-01-04
DE59007737D1 (de)	1995-01-05
AU5497090A (en)	1990-11-15
KR0156246B1 (ko)	1998-11-16
EP0401508A2 (de)	1990-12-12
EP0401508A3 (de)	1991-03-27
AU623769B2 (en)	1992-05-21
CA2016627C (en)	2000-08-22
ES2066033T3 (es)	1995-03-01
KR900017607A (ko)	1990-12-19
PT94016B (pt)	1997-05-28
CA2016627A1 (en)	1990-11-13
JPH03255099A (ja)	1991-11-13
IL94349A0 (en)	1991-03-10
IE901713L (en)	1990-11-13
HU214985B (hu)	1998-08-28
ATE114332T1 (de)	1994-12-15
PT94016A (pt)	1991-01-08
IE65710B1 (en)	1995-11-15

Publication	Publication Date	Title
GR3015124T3 (en)	1995-05-31	Proteinaseinhibitors, method for their preparation and pharmaceutical compositions containing them.
Johnson et al.	1986	Cathepsin L inactivates alpha 1-proteinase inhibitor by cleavage in the reactive site region.
Sherman et al.	1992	Saturation mutagenesis of the plasminogen activator inhibitor-1 reactive center.
ATE226636T1 (de)	2002-11-15	Serpin-resistenter t-pa; mutanten; gene
MX9603775A (es)	1997-07-31	Proteinas inhibidoras del dominio de kunitz, derivadas del inhibidor del precursor de la beta-proteina amiloide de alzheimer.
ATE231496T1 (de)	2003-02-15	Saccharinderivate als proteolytische enzyminhibitoren
PL319782A1 (en)	1997-08-18	Inhibitors of serinic proteases and anticoagulative protecins extracted from nematodes
MY122696A (en)	2006-04-29	Novel spiroheterocyclic compounds useful as reversible inhibitors of cysteine proteases.
MY116539A (en)	2004-02-28	New amino acid derivatives
NO930517L (no)	1993-08-16	Benzimidazolylderivater, legemidler inneholdende disse, og fremgangsmaate for deres fremstilling
WO1996035788A3 (en)	1996-12-12	Kunitz type protease inhibitors
AU639257B2 (en)	1993-07-22	Proteins having anticoagulant properties
Rowan et al.	1990	Inhibition of cysteine proteinases by a protein inhibitor from potato
ATE92935T1 (de)	1993-08-15	Serinproteaseinhibitoren und isolierungsverfahren dazu.
NZ319474A (en)	2000-01-28	Guanidino protease inhibitors
AU4720093A (en)	1994-03-03	Inhibitor resistant serine proteases
Schoenberger et al.	1989	Limited proteolysis of Cl‐inhibitor by chymotrypsin‐like proteinases
STIEF et al.	1988	Inactivation of serine proteinase inhibitors (serpins) in human plasma by reactive oxidants
Takahara et al.	1982	Mouse plasma trypsin inhibitors: Inhibitory spectrum of contrapsin and alpha-1-antitrypsin
Marossy et al.	1980	Mapping of the substrate-binding site of the human granulocyte elastase by the aid of tripeptidyl-p-nitroanilide substrates
Knäuper et al.	1991	Inactivation of human plasma C1‐inhibitor by human PMN leucocyte matrix metalloproteinases
Sulikowski et al.	2002	α1‐Proteinase inhibitor mutants with specificity for plasma kallikrein and C1s but not C1
Hayashi et al.	1994	Fibrin (ogen) binding region in urinary protein c inhibitor
Rarabas et al.	1994	Investigations of thrombin inhibitors in fibrinolytic systems
Ecke et al.	1994	Alternative targeting of a serpin-type inhibitor by glycosaminoglycans (GAGs): Heparin binding of protein C inhibitor (pci) prevents its interaction with tissue kallikrein (tk)