GR1001096B - Μέ?οδος παρασκευής 9-υποκατεστημένων παραγώγων της γουανίνης και ενδιαμέσων για χρήση στη μέ?οδο. - Google Patents
Μέ?οδος παρασκευής 9-υποκατεστημένων παραγώγων της γουανίνης και ενδιαμέσων για χρήση στη μέ?οδο.Info
- Publication number
- GR1001096B GR1001096B GR900100212A GR900100212A GR1001096B GR 1001096 B GR1001096 B GR 1001096B GR 900100212 A GR900100212 A GR 900100212A GR 900100212 A GR900100212 A GR 900100212A GR 1001096 B GR1001096 B GR 1001096B
- Authority
- GR
- Greece
- Prior art keywords
- preparation
- compound
- substituted
- temperature
- chemical compound
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 3
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical class O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 title abstract 2
- 239000000543 intermediate Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 abstract 1
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 abstract 1
- 238000010306 acid treatment Methods 0.000 abstract 1
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 abstract 1
- 229910001385 heavy metal Inorganic materials 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- -1 peroxide compound Chemical class 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/052—Imidazole radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Μια μέθοδος για την παρασκευή των 9-υποκατεστημένων παραγώγων της γουανίνης του γενικού τύπου Ι: ΧΗΜΙΚΗ ΕΝΩΣΗ στον οποίο το R είναι C1-C4 αλκύλιο κατ' επιλογήν υποκατεστημένο με μια ή περισσότερες υδροξυλομάδες ή το R είναι: ΧΗΜΙΚΗ ΕΝΩΣΗ βενζύλιο, ριβοζύλιο, 2'-δεοξυριβοζύλιο (SH2)n-CR1 όπου το n είναι 1 ή 2 και το R1 είναι CH2COH2OH ή ΧΗΜΙΚΗ ΕΝΩΣΗ ή των αλάτων αυτών, όπου ένα 1-υποκαταστημένο 5- (θειοκαρβαμοϋλ) αμινο-1H-ιμιδαζολο-4-καρβοξαμίδιο του γενικού τύπου ΙΙΙ: ΧΗΜΙΚΗ ΕΝΩΣΗ στον οποίο το R είναι όπως ορίστηκε για τον τύπο Ι, κυκλοποιείται α)κατά την κατεργασία με ένα άλας βαρέως μετάλλου της ομάδας τωνCu-, Ag-, Pb- και Hg-αλάτων εντός ενός υδατικού αλκαλικού μέσου περιέχοντος τουλάχιστον τέσσερα ισοδύναμα ιόντων OH- σε θερμοκρασία από περίπου 0C ως τη θερμοκρασία επαναρροής, ή β)κατά την κατεργασία με μια υπεροξειδική ένωση εντός ενός υδατικού αλκαλικού μέσου σε θερμοκρασία από περίπου 0 έως 30C και ακολούθως η ένωση Ι απομονώνεται κατά την κατεργασία με οξύ, και, αν επιθυμείται, μετατρέπεται σε άλας. Η εφεύρεση περαιτέρω περιλαμβάνει τη χρήση και την παρασκευή των παραπάνω αναφερομένων ενώσεων. ω
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK135489A DK135489D0 (da) | 1989-03-20 | 1989-03-20 | Fremgangsmaade til fremstilling af 9-substituerede guaninderivater og mellemprodukter til brug ved fremgangsmaaden |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GR900100212A GR900100212A (en) | 1990-07-31 |
| GR1001096B true GR1001096B (el) | 1993-04-28 |
Family
ID=8103930
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR900100212A GR1001096B (el) | 1989-03-20 | 1990-03-20 | Μέ?οδος παρασκευής 9-υποκατεστημένων παραγώγων της γουανίνης και ενδιαμέσων για χρήση στη μέ?οδο. |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US5223619A (el) |
| EP (1) | EP0464112B1 (el) |
| KR (1) | KR0142098B1 (el) |
| AR (1) | AR245719A1 (el) |
| AT (1) | ATE112568T1 (el) |
| BG (1) | BG60590B1 (el) |
| BR (1) | BR9007230A (el) |
| CA (1) | CA2047217A1 (el) |
| CS (1) | CS275359B2 (el) |
| DD (1) | DD293116A5 (el) |
| DE (1) | DE69013146T2 (el) |
| DK (2) | DK135489D0 (el) |
| ES (1) | ES2061023T3 (el) |
| FI (1) | FI97387C (el) |
| GE (1) | GEP19971014B (el) |
| GR (1) | GR1001096B (el) |
| HR (1) | HRP920907B1 (el) |
| HU (1) | HU206715B (el) |
| IE (1) | IE62042B1 (el) |
| LT (1) | LT3183B (el) |
| LV (1) | LV10455B (el) |
| NO (1) | NO178497C (el) |
| PL (1) | PL163313B1 (el) |
| RO (1) | RO109737B1 (el) |
| RU (2) | RU2090566C1 (el) |
| SI (1) | SI9010545A (el) |
| WO (1) | WO1990011283A1 (el) |
| YU (1) | YU47343B (el) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1264599B1 (it) * | 1993-06-14 | 1996-10-04 | Solar Chem Sa | Processo per la sintesi della 9-(2-idrossietossimetil)- guanina |
| GB9520364D0 (en) * | 1995-10-05 | 1995-12-06 | Chiroscience Ltd | Compouundds |
| US6860928B2 (en) | 2002-09-04 | 2005-03-01 | Xerox Corporation | Alkylated urea and triaminotriazine compounds and phase change inks containing same |
| US6811595B2 (en) | 2002-09-04 | 2004-11-02 | Xerox Corporation | Guanidinopyrimidinone compounds and phase change inks containing same |
| US6872243B2 (en) | 2002-09-04 | 2005-03-29 | Xerox Corporation | Phase change inks containing gelator additives |
| US6761758B2 (en) | 2002-09-04 | 2004-07-13 | Xerox Corporation | Alkylated tetrakis(triaminotriazine) compounds and phase change inks containing same |
| US7144450B2 (en) | 2004-12-04 | 2006-12-05 | Xerox Corporation | Phase change inks containing trans-1,2-cyclohexane bis(urea-urethane) compounds |
| US7560587B2 (en) | 2004-12-04 | 2009-07-14 | Xerox Corporation | Bis[urea-urethane] compounds |
| US7314949B2 (en) | 2004-12-04 | 2008-01-01 | Xerox Corporation | Trans-1,2-cyclohexane bis(urea-urethane) compounds |
| US7317122B2 (en) | 2004-12-04 | 2008-01-08 | Xerox Corporation | Curable trans-1,2-cyclohexane bis(urea-urethane) compounds |
| US7153349B2 (en) | 2004-12-04 | 2006-12-26 | Xerox Corporation | Phase change inks containing curable trans-1,2-cyclohexane bis(urea-urethane) compounds |
| US7220300B2 (en) | 2004-12-04 | 2007-05-22 | Xerox Corporation | Phase change inks containing bis(urea-urethane) compounds |
| CN105705284B (zh) | 2013-10-29 | 2019-05-31 | 舒瑞普国际股份公司 | 使用丝网印刷钎焊材料钎焊板式换热器的方法；利用该方法制造的板式换热器 |
| CN115504977B (zh) * | 2022-09-23 | 2024-02-09 | 海南锦瑞制药有限公司 | 更昔洛韦的制备方法及注射用更昔洛韦的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56152437U (el) * | 1980-04-14 | 1981-11-14 | ||
| US4451478A (en) * | 1982-03-12 | 1984-05-29 | Newport Pharmaceuticals International, Inc. | Imidazole compounds |
| US4602089A (en) * | 1982-03-12 | 1986-07-22 | Newport Pharmaceuticals, Inc. | Process for preparing purine compounds |
| JPS6055071B2 (ja) * | 1982-04-16 | 1985-12-03 | 四国化成工業株式会社 | イミダゾリル琥珀酸化合物および該化合物を用いるエポキシ樹脂硬化方法 |
| HUT36464A (en) * | 1983-05-24 | 1985-09-30 | Newport Pharmaceuticals | Process for producing erythro-4-amino-3-/2-hydroxy-3-alkyl/-imidazol-5-carboxamide |
| EP0219838A3 (en) * | 1985-10-22 | 1988-04-06 | Takeda Chemical Industries, Ltd. | Carbocyclic purine nucleosides, their production and use |
| MY101126A (en) * | 1985-12-13 | 1991-07-31 | Beecham Group Plc | Novel compounds |
-
1989
- 1989-03-20 DK DK135489A patent/DK135489D0/da not_active Application Discontinuation
-
1990
- 1990-03-16 IE IE99490A patent/IE62042B1/en unknown
- 1990-03-19 CA CA002047217A patent/CA2047217A1/en not_active Abandoned
- 1990-03-19 KR KR1019910701187A patent/KR0142098B1/ko not_active IP Right Cessation
- 1990-03-19 BR BR909007230A patent/BR9007230A/pt not_active Application Discontinuation
- 1990-03-19 RO RO148411A patent/RO109737B1/ro unknown
- 1990-03-19 WO PCT/DK1990/000077 patent/WO1990011283A1/en active IP Right Grant
- 1990-03-19 EP EP90905442A patent/EP0464112B1/en not_active Expired - Lifetime
- 1990-03-19 AT AT90905442T patent/ATE112568T1/de not_active IP Right Cessation
- 1990-03-19 ES ES90905442T patent/ES2061023T3/es not_active Expired - Lifetime
- 1990-03-19 HU HU902874A patent/HU206715B/hu not_active IP Right Cessation
- 1990-03-19 US US07/761,890 patent/US5223619A/en not_active Expired - Fee Related
- 1990-03-19 DE DE69013146T patent/DE69013146T2/de not_active Expired - Fee Related
- 1990-03-19 DK DK90905442.1T patent/DK0464112T3/da active
- 1990-03-19 RU RU9093004872A patent/RU2090566C1/ru active
- 1990-03-20 CS CS901365A patent/CS275359B2/cs unknown
- 1990-03-20 GR GR900100212A patent/GR1001096B/el unknown
- 1990-03-20 SI SI9010545A patent/SI9010545A/sl unknown
- 1990-03-20 YU YU54590A patent/YU47343B/sh unknown
- 1990-03-20 PL PL90284379A patent/PL163313B1/pl unknown
- 1990-03-20 AR AR90316421A patent/AR245719A1/es active
- 1990-03-20 DD DD90338906A patent/DD293116A5/de not_active IP Right Cessation
-
1991
- 1991-09-19 NO NO913686A patent/NO178497C/no unknown
- 1991-09-19 RU SU915001705A patent/RU2042668C1/ru active
- 1991-09-19 FI FI914418A patent/FI97387C/fi active
- 1991-09-20 BG BG95145A patent/BG60590B1/bg unknown
-
1992
- 1992-10-02 HR HRP-545/90A patent/HRP920907B1/xx not_active IP Right Cessation
- 1992-12-02 LV LVP-92-250A patent/LV10455B/en unknown
-
1993
- 1993-01-27 LT LTIP297A patent/LT3183B/lt not_active IP Right Cessation
- 1993-08-25 GE GEAP19931494A patent/GEP19971014B/en unknown
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