GB750232A - Stabilisation of streptomycin - Google Patents
Stabilisation of streptomycinInfo
- Publication number
- GB750232A GB750232A GB769553A GB769553A GB750232A GB 750232 A GB750232 A GB 750232A GB 769553 A GB769553 A GB 769553A GB 769553 A GB769553 A GB 769553A GB 750232 A GB750232 A GB 750232A
- Authority
- GB
- United Kingdom
- Prior art keywords
- sodium
- salt
- potassium
- formaldehyde sulphoxylate
- sulphurous acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A streptomycin salt such as the sulphate is stabilized by admixture with a salt of sulphurous acid and an addition product of an aldehyde with a salt of sulphurous acid or of hydrosulphurous acid. Specified are sodium and potassium bisulphites and sodium and potassium metabisulphites and sodium formaldehyde sulphoxylate. Preferred is a mixture of sodium metabisulphite and sodium formaldehyde sulphoxylate. The solids may be ground together in the dry state or dissolved in water, the solution so formed being used as such or e.g. freeze-dried to form the stabilized solid. The aqueous solutions may be sterilized by heating to 120 DEG C. for 1 hour. Each of the stabilizers may be used in proportions of 0.05 to 1.0 per cent of the aqueous solution, which may be adjusted to pH 3 to 7 and preferably pH 5. Buffers such as citrate, acetate or phosphate may be present. Specification 684,459 is referred to.ALSO:A streptomycin salt such as the sulphate is stabilised by admixture with a salt of sulphurous acid and an addition product of an aldehyde with a salt of sulphurous acid. Specified are sodium and potassium bisulphites and sodium and potassium metabisulphites and sodium formaldehyde sulphoxylate. Preferred is a mixture of sodium metabisulphite and sodium formaldehyde sulphoxylate. The solids may be ground together in the dry state or dissolved in water, the solution so formed being used as such or e.g. freeze dried to form the desired stabilised solid. The aqueous solutions may be sterilised by heating to 120 DEG C. for 1 hour. Each of the stabilisers may be used in proportions of 0,05 to 1,0 per cent of the aqueous solution which may be adjusted to pH3 to 7 and preferably pH 5,0. Buffers such as citrate, acetate or phosphate may be present. Specification 684,459 is referred to.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB769553A GB750232A (en) | 1953-03-20 | 1953-03-20 | Stabilisation of streptomycin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB769553A GB750232A (en) | 1953-03-20 | 1953-03-20 | Stabilisation of streptomycin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB750232A true GB750232A (en) | 1956-06-13 |
Family
ID=9838012
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB769553A Expired GB750232A (en) | 1953-03-20 | 1953-03-20 | Stabilisation of streptomycin |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB750232A (en) |
-
1953
- 1953-03-20 GB GB769553A patent/GB750232A/en not_active Expired
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