GB623281A - Improvements in or relating to the production of a biguanide - Google Patents
Improvements in or relating to the production of a biguanideInfo
- Publication number
- GB623281A GB623281A GB1102147A GB1102147A GB623281A GB 623281 A GB623281 A GB 623281A GB 1102147 A GB1102147 A GB 1102147A GB 1102147 A GB1102147 A GB 1102147A GB 623281 A GB623281 A GB 623281A
- Authority
- GB
- United Kingdom
- Prior art keywords
- ammonia
- alcoholic
- mercuric
- isopropyl
- starting material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/24—Y being a hetero atom
- C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
N1-p-Chlorophenyl-N5-isopropylbiguanide is manufactured by the action of ammonia, in the presence of a mercuric halide or mercuric oxide, on the compound, believed to be N1-isopropyl-S1 - methyliso - N3 - p - chlorophenyldithiobiuret, obtainable by condensing isopropyl-S-methylisothiourea with p-chlorophenyl isothiocyanate. The process is preferably effected by keeping a solution of the starting material in liquid ammonia in a closed vessel in the presence of mercuric chloride until amination is substantially complete. Alternatively the reaction may take place in alcoholic or other suitable medium (e.g. toluene), either at or around room temperature under a pressure of ammonia gas of not less than 1-3 atmospheres, or at elevated temperature in a closed vessel, e.g. by using a saturated alcoholic or 40 per cent aqueous alcoholic solution of ammonia, with agitation, until amination is substantially complete. Examples describe various methods of carrying out the process, including the preparation of the starting material.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1102147A GB623281A (en) | 1947-04-24 | 1947-04-24 | Improvements in or relating to the production of a biguanide |
| FR965042D FR965042A (en) | 1947-04-24 | 1948-04-22 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1102147A GB623281A (en) | 1947-04-24 | 1947-04-24 | Improvements in or relating to the production of a biguanide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB623281A true GB623281A (en) | 1949-05-16 |
Family
ID=9978600
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1102147A Expired GB623281A (en) | 1947-04-24 | 1947-04-24 | Improvements in or relating to the production of a biguanide |
Country Status (2)
| Country | Link |
|---|---|
| FR (1) | FR965042A (en) |
| GB (1) | GB623281A (en) |
-
1947
- 1947-04-24 GB GB1102147A patent/GB623281A/en not_active Expired
-
1948
- 1948-04-22 FR FR965042D patent/FR965042A/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR965042A (en) | 1950-08-31 |
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