GB455019A - Process for the manufacture of esters of polycyclic alcohols - Google Patents
Process for the manufacture of esters of polycyclic alcoholsInfo
- Publication number
- GB455019A GB455019A GB1308536A GB1308536A GB455019A GB 455019 A GB455019 A GB 455019A GB 1308536 A GB1308536 A GB 1308536A GB 1308536 A GB1308536 A GB 1308536A GB 455019 A GB455019 A GB 455019A
- Authority
- GB
- United Kingdom
- Prior art keywords
- esters
- parent specification
- androsterone
- trans
- yield
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The process of the parent Specification which comprises the reduction of esters of the male sex hormone to produce ester alcohols is modified so as to produce di-esters, which modification consists in subjecting saturated or unsaturated hydroxyketones or diketones of the cyclopentanopolyhydrophenanthrene series having the general formula C17HnX(CO) wherein n is 26 or 28 and X is either a <FORM:0455019/IV/1> or a CO group in one operation to the action of reducing and acylating agents. The reducing agents used are the same as used in the parent Specification. Mono- or di-esters are obtained according to the quantity of acylating agent employed. In examples: (1) Trans-androsterone is treated in a mixture of glacial acetic acid and hydrobromic acid solution with hydrogen and then acetic anhydride added. After 12 hours the product is worked up as described in the parent Specification; (2) androstandione is treated in the same way as the trans-androsterone in example (1) to yield androstandiol-di-acetate; (3) androstendione is hydrogenated and acylated as in example (1) and then the reaction solution is boiled under reflux for 2 hours to yield the same product as obtained in example (2). Specification 455,018 is referred to.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1308536A GB455019A (en) | 1935-04-08 | 1935-04-08 | Process for the manufacture of esters of polycyclic alcohols |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1308536A GB455019A (en) | 1935-04-08 | 1935-04-08 | Process for the manufacture of esters of polycyclic alcohols |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB455019A true GB455019A (en) | 1936-10-08 |
Family
ID=10016549
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1308536A Expired GB455019A (en) | 1935-04-08 | 1935-04-08 | Process for the manufacture of esters of polycyclic alcohols |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB455019A (en) |
-
1935
- 1935-04-08 GB GB1308536A patent/GB455019A/en not_active Expired
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