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GB434390A - Process for the production of therapeutically valuable saturated alcohols from germinal gland hormones - Google Patents

Process for the production of therapeutically valuable saturated alcohols from germinal gland hormones

Info

Publication number
GB434390A
GB434390A GB35287/34A GB3528734A GB434390A GB 434390 A GB434390 A GB 434390A GB 35287/34 A GB35287/34 A GB 35287/34A GB 3528734 A GB3528734 A GB 3528734A GB 434390 A GB434390 A GB 434390A
Authority
GB
United Kingdom
Prior art keywords
hydrogen
formula
action
follicle
schringer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB35287/34A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Schering Kahlbaum AG
Original Assignee
Schering Kahlbaum AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Kahlbaum AG filed Critical Schering Kahlbaum AG
Publication of GB434390A publication Critical patent/GB434390A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Alcohols containing a tertiary hydroxyl group obtained from the follicle hormones according to 30297/34 in so far as they are of aromatic or unsaturated character are hydrogenated to the saturation of the double bonds. The hydrogenation may be carried out catalytically, or by means of atomic hydrogen, or hydrogen in the nacent state obtained by the action of sodium metal on an alcoholic solution of the starting material. In an example 1,5 grams of the tertiary alcohol of the formula C19H26O2 prepared by the action of methyl magnesium iodide on crystalline follicle hormone are dissolved in 150 ccs. of glacial acetic acid and 200 mg. of platinum oxide added according to the methof of Adams-Schringer. The mixture is shaken for 18 hours in a hydrogen atmosphere, and the catalyst removed. A product is obtained of the formula C19H32O2 which gives a physiological activity of 4 mg. per capon unit.ALSO:Alcohols containing a tertiary hydroxyl group obtained from the follicle hormones according to Specification 30297/34 in so far as they are of aromatic or unsaturated character are hydrogenated to the saturation of the double bonds. The hydrogenation may be carried out catalytically, or by means of atomic hydrogen, or hydrogen in the nascent state obtained by the action of sodium metal on an alcoholic solution of the starting material. In an example 1.5 grams of the tertiary alcohol of the formula C19H20O2 prepared by the action of methyl magnesium iodide on crystalline follicle hormone are dissolved in 150 ccs. of glacial acetic acid and 200 mg. of platinum oxide added according to the method of Adams-Schringer. The mixture is shaken for 18 hours in a hydrogen atmosphere, and the catalyst removed. A product is obtained of the formula C19H22O2 which gives a physiological activity of 4 mg. per capon unit.
GB35287/34A 1933-12-07 1934-12-07 Process for the production of therapeutically valuable saturated alcohols from germinal gland hormones Expired GB434390A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE434390X 1933-12-07

Publications (1)

Publication Number Publication Date
GB434390A true GB434390A (en) 1935-08-30

Family

ID=6505817

Family Applications (1)

Application Number Title Priority Date Filing Date
GB35287/34A Expired GB434390A (en) 1933-12-07 1934-12-07 Process for the production of therapeutically valuable saturated alcohols from germinal gland hormones

Country Status (1)

Country Link
GB (1) GB434390A (en)

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