[go: up one dir, main page]

FR2944011B1 - Derives d'aminocyclobutane ou d'aminocyclobutene, leur procede de preparation et leur utilisation a titre de medicaments. - Google Patents

Derives d'aminocyclobutane ou d'aminocyclobutene, leur procede de preparation et leur utilisation a titre de medicaments.

Info

Publication number
FR2944011B1
FR2944011B1 FR0952196A FR0952196A FR2944011B1 FR 2944011 B1 FR2944011 B1 FR 2944011B1 FR 0952196 A FR0952196 A FR 0952196A FR 0952196 A FR0952196 A FR 0952196A FR 2944011 B1 FR2944011 B1 FR 2944011B1
Authority
FR
France
Prior art keywords
aminocyclobutene
aminocyclobutane
medicaments
derivatives
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0952196A
Other languages
English (en)
Other versions
FR2944011A1 (fr
Inventor
Stephane Cuisiat
Adrian Newman-Tancredi
Olivier Vitton
Bernard Vacher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Medicament SA
Original Assignee
Pierre Fabre Medicament SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre Medicament SA filed Critical Pierre Fabre Medicament SA
Priority to FR0952196A priority Critical patent/FR2944011B1/fr
Priority to TW099109391A priority patent/TW201039813A/zh
Priority to ARP100101072A priority patent/AR078316A1/es
Priority to PCT/EP2010/054452 priority patent/WO2010112597A1/fr
Priority to SI201030169T priority patent/SI2414323T1/sl
Priority to US13/258,546 priority patent/US8455550B2/en
Priority to PL10712442T priority patent/PL2414323T3/pl
Priority to JP2012502701A priority patent/JP5635073B2/ja
Priority to PT107124422T priority patent/PT2414323E/pt
Priority to EP10712442A priority patent/EP2414323B1/fr
Priority to ES10712442T priority patent/ES2407259T3/es
Priority to DK10712442.2T priority patent/DK2414323T3/da
Publication of FR2944011A1 publication Critical patent/FR2944011A1/fr
Application granted granted Critical
Publication of FR2944011B1 publication Critical patent/FR2944011B1/fr
Priority to HRP20130379AT priority patent/HRP20130379T1/hr
Priority to CY20131100461T priority patent/CY1114189T1/el
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
FR0952196A 2009-04-03 2009-04-03 Derives d'aminocyclobutane ou d'aminocyclobutene, leur procede de preparation et leur utilisation a titre de medicaments. Expired - Fee Related FR2944011B1 (fr)

Priority Applications (14)

Application Number Priority Date Filing Date Title
FR0952196A FR2944011B1 (fr) 2009-04-03 2009-04-03 Derives d'aminocyclobutane ou d'aminocyclobutene, leur procede de preparation et leur utilisation a titre de medicaments.
TW099109391A TW201039813A (en) 2009-04-03 2010-03-29 Derivatives of aminocyclobutane or aminocyclobutene, their method of preparation and their use as medicinal products
ARP100101072A AR078316A1 (es) 2009-04-03 2010-03-31 Derivados de aminociclobutano o aminociclobuteno, su procedimiento de preparacion y su utilizacion como medicamentos, e intermediarios de sintesis
ES10712442T ES2407259T3 (es) 2009-04-03 2010-04-02 Derivados de aminociclobutano o aminociclobuteno, su método de preparación y su utilización como productos médicos
US13/258,546 US8455550B2 (en) 2009-04-03 2010-04-02 Derivatives of aminocyclobutane or aminocyclobutene, their method of preparation and their use as medical products
PL10712442T PL2414323T3 (pl) 2009-04-03 2010-04-02 Pochodne aminocyklobutanu lub aminocyklobutenu, sposoby ich wytwarzani i ich zastosowanie jako produktów leczniczych
JP2012502701A JP5635073B2 (ja) 2009-04-03 2010-04-02 アミノシクロブタンまたはアミノシクロブテンの誘導体、これらの製造方法、および医薬品としてのこれらの使用
PT107124422T PT2414323E (pt) 2009-04-03 2010-04-02 Derivados de aminociclobutano ou aminociclobuteno, o seu processo de preparação e a sua utilização como medicamentos
PCT/EP2010/054452 WO2010112597A1 (fr) 2009-04-03 2010-04-02 Dérivés d'aminocyclobutane ou d'aminocyclobutène, leur procédé de préparation et leur utilisation comme produits médicaux
SI201030169T SI2414323T1 (sl) 2009-04-03 2010-04-02 Derivati aminociklobutana ali aminociklobutena, postopek njihove priprave in njihova uporaba kot medicinski izdelek
DK10712442.2T DK2414323T3 (da) 2009-04-03 2010-04-02 Derivater af aminocyclobutan eller aminocyclobuten, fremgangsmåde til fremstilling heraf og anvendelse af disse som medicinske produkter
EP10712442A EP2414323B1 (fr) 2009-04-03 2010-04-02 Dérivés d'aminocyclobutane ou d'aminocyclobutène, leur procédé de préparation et leur utilisation comme produits médicaux
HRP20130379AT HRP20130379T1 (en) 2009-04-03 2013-05-02 Derivatives of aminocyclobutane or aminocyclobutene, their method of preparation and their use as medical products
CY20131100461T CY1114189T1 (el) 2009-04-03 2013-06-11 Παραγωγα αμινοκυκλοβουτανιου ή αμινοκυκλοβουτενιου, μεθοδος παρασκευης τους και χρηση τους ως φαρμακευτικων προϊοντων

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0952196A FR2944011B1 (fr) 2009-04-03 2009-04-03 Derives d'aminocyclobutane ou d'aminocyclobutene, leur procede de preparation et leur utilisation a titre de medicaments.

Publications (2)

Publication Number Publication Date
FR2944011A1 FR2944011A1 (fr) 2010-10-08
FR2944011B1 true FR2944011B1 (fr) 2011-05-20

Family

ID=41100606

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0952196A Expired - Fee Related FR2944011B1 (fr) 2009-04-03 2009-04-03 Derives d'aminocyclobutane ou d'aminocyclobutene, leur procede de preparation et leur utilisation a titre de medicaments.

Country Status (13)

Country Link
US (1) US8455550B2 (fr)
EP (1) EP2414323B1 (fr)
JP (1) JP5635073B2 (fr)
AR (1) AR078316A1 (fr)
DK (1) DK2414323T3 (fr)
ES (1) ES2407259T3 (fr)
FR (1) FR2944011B1 (fr)
HR (1) HRP20130379T1 (fr)
PL (1) PL2414323T3 (fr)
PT (1) PT2414323E (fr)
SI (1) SI2414323T1 (fr)
TW (1) TW201039813A (fr)
WO (1) WO2010112597A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2998892B1 (fr) * 2012-12-04 2015-01-02 Pf Medicament Derives d'aminocyclobutane, leur procede de preparation et leur utilisation a titre de medicaments

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995022521A1 (fr) 1994-02-22 1995-08-24 Asahi Kasei Kogyo Kabushiki Kaisha Derive d'aminoalkylcyclopropane
US6635675B2 (en) 2001-11-05 2003-10-21 Cypress Bioscience, Inc. Method of treating chronic fatigue syndrome
US6602911B2 (en) 2001-11-05 2003-08-05 Cypress Bioscience, Inc. Methods of treating fibromyalgia
AU2003284342B2 (en) 2002-10-25 2009-03-05 Collegium Pharmaceutical, Inc. Stereoisomers of p-hydroxy-milnacipran, and methods of use thereof
CN101228163A (zh) * 2005-06-14 2008-07-23 先灵公司 天冬氨酰蛋白酶抑制剂
US20090098085A1 (en) 2006-08-11 2009-04-16 Ying Sun Tetrazolyl acyclic hepatitis c serine protease inhibitors
WO2009105887A1 (fr) 2008-02-26 2009-09-03 Ernest Puil Acides aminés cycliques pour le traitement de la douleur
FR2941454B1 (fr) * 2009-01-29 2011-04-01 Pf Medicament Proced de synthese du (1s,2r)-milnacipran

Also Published As

Publication number Publication date
HRP20130379T1 (en) 2013-05-31
US20120029013A1 (en) 2012-02-02
JP5635073B2 (ja) 2014-12-03
DK2414323T3 (da) 2013-05-27
PT2414323E (pt) 2013-04-11
US8455550B2 (en) 2013-06-04
PL2414323T3 (pl) 2013-08-30
FR2944011A1 (fr) 2010-10-08
EP2414323B1 (fr) 2013-03-13
WO2010112597A1 (fr) 2010-10-07
JP2012522755A (ja) 2012-09-27
AR078316A1 (es) 2011-11-02
SI2414323T1 (sl) 2013-05-31
ES2407259T3 (es) 2013-06-12
EP2414323A1 (fr) 2012-02-08
TW201039813A (en) 2010-11-16

Similar Documents

Publication Publication Date Title
FR2962437B1 (fr) Derives d'imidazopyridine, leur procede de preparation et leur application en therapeutique
IL218989A (en) Processed 3-phenylpropionic acids, their process, their preparations and their use
ZA201201349B (en) Dihydropteridinone derivatives, preparation process amd pharmaceutical use thereof
IL193340A0 (en) Azacyclyl-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments
ZA201208198B (en) Picolinamide and pyrimidine-4-carboxamine compounds, process for preparing and pharmaceutical composition comprising the same
FR2958291B1 (fr) Procede de preparation de derives d'amino-benzofurane
FR2961797B1 (fr) Procede et machine de preparation d'objets du genre bouchons, capsules ou autres
FR2949465B1 (fr) Derives chromones, leur procede de preparation et leurs applications therapeutiques
IL208336A (en) Pyridazinone derivatives, drugs containing them and their uses and process for preparation
IL193341A0 (en) Novel azacyclyl-substituted arylthienopyrimidinones, process for their preparation and their use as medicaments
IL193339A0 (en) Novel aminoalcohol-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments
WO2011009938A3 (fr) Stambomycine et dérivés, leur production et leur utilisation comme médicaments
FR2981931B1 (fr) Procede de preparation d'un compose comprenant au moins un motif beta-hydroxy-urethane et/ou au moins un motif gamma-hydroxy-urethane.
AP3531A (en) 9-[4-(3-chlor-2-fluor-phenylamino)-7-methoxy-quinazolin-6-yloxy]-1,4-diaza-spiro[5.5]undecan-5-one dimaleate, use thereof as a drug, and production thereof
IL212942A (en) History of Rifamycin, Methods of Preparation, Pharmaceutical Preparations Containing Them and Their Uses
EP2883914A4 (fr) Asphalte biologique, composite d'asphalte biologique et procédé de préparation de ces derniers
BRPI1015943A8 (pt) derivados de 1,2,3,4-tetra - hidro - pirimido {1,2-a} pirimidin-6-ona, o respectivo preparo e a respectiva utilização farmacêutica.
EP2292242A4 (fr) Dérivé de scutellarine, procédé d'élaboration, composition pharmaceutique, et utilisation correspondante
FR2925047B1 (fr) Procede de preparation de composes p-hydroxymandeliques eventuellement substitues et derives.
FR2950253B1 (fr) Nanocapsules lipidiques, procede de preparation et utilisation comme medicament
FR2934962B1 (fr) Catalyseurs zeolithiques, leur procede de preparation et leurs applications
FR2930774B1 (fr) Composes de type ether-amide, procede de preparation et utilisation
FR2943057B1 (fr) DERIVES DE 10-AMINO-1,2,3,4-TETRAHYDROPYRIDO°2,1-a!ISOINDOL-6(10bH)- ONES, LEUR PROCEDE DE PREPARATION ET LEURS UTILISATIONS THERAPEUTIQUES
IL222351A (en) Process for making derivatives 4,1-diethylene-di (3-pyroline) -tetrone
FR2957225B1 (fr) Procede d'elevage de coquillages, notamment des huitres.

Legal Events

Date Code Title Description
PLFP Fee payment

Year of fee payment: 8

PLFP Fee payment

Year of fee payment: 9

PLFP Fee payment

Year of fee payment: 10

PLFP Fee payment

Year of fee payment: 11

PLFP Fee payment

Year of fee payment: 12

PLFP Fee payment

Year of fee payment: 13

PLFP Fee payment

Year of fee payment: 14

ST Notification of lapse

Effective date: 20231205