[go: up one dir, main page]

FR2361385A1 - Nouvelles quinazolinones, leurs procedes d'obtention et leur application a la therapeutique - Google Patents

Nouvelles quinazolinones, leurs procedes d'obtention et leur application a la therapeutique

Info

Publication number
FR2361385A1
FR2361385A1 FR7721035A FR7721035A FR2361385A1 FR 2361385 A1 FR2361385 A1 FR 2361385A1 FR 7721035 A FR7721035 A FR 7721035A FR 7721035 A FR7721035 A FR 7721035A FR 2361385 A1 FR2361385 A1 FR 2361385A1
Authority
FR
France
Prior art keywords
quinazolinones
therapeutics
obtaining
new
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7721035A
Other languages
English (en)
Other versions
FR2361385B1 (fr
Inventor
Michel Vincent
Georges Remond
Michel Laubie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Science Union et Cie
Original Assignee
Science Union et Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Science Union et Cie filed Critical Science Union et Cie
Publication of FR2361385A1 publication Critical patent/FR2361385A1/fr
Application granted granted Critical
Publication of FR2361385B1 publication Critical patent/FR2361385B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La présente invention a pour objet de nouvelles quinazolinones substituées à l'azote, répondant à la formule générale I :
FR7721035A 1976-07-14 1977-07-08 Nouvelles quinazolinones, leurs procedes d'obtention et leur application a la therapeutique Granted FR2361385A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB29317/76A GB1583753A (en) 1976-07-14 1976-07-14 Piperidine derivatives processes for their preparation and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
FR2361385A1 true FR2361385A1 (fr) 1978-03-10
FR2361385B1 FR2361385B1 (fr) 1983-10-07

Family

ID=10289639

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7721035A Granted FR2361385A1 (fr) 1976-07-14 1977-07-08 Nouvelles quinazolinones, leurs procedes d'obtention et leur application a la therapeutique

Country Status (12)

Country Link
US (1) US4166117A (fr)
JP (1) JPS5334784A (fr)
BE (1) BE856784A (fr)
CA (1) CA1103671A (fr)
CH (1) CH625518A5 (fr)
DE (1) DE2731299A1 (fr)
ES (2) ES460699A1 (fr)
FR (1) FR2361385A1 (fr)
GB (1) GB1583753A (fr)
NL (1) NL7707785A (fr)
OA (1) OA05707A (fr)
SU (1) SU751324A3 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3066434D1 (en) * 1979-11-21 1984-03-08 Kyowa Hakko Kogyo Kk Novel piperidine derivatives, method for the preparation thereof and pharmaceutical compositions containing them
US4344945A (en) * 1980-03-10 1982-08-17 Kyowa Hakko Kogyo Co., Ltd. Piperidine derivatives
US4684654A (en) * 1985-08-14 1987-08-04 American Cyanamid Company 3-heteroalkyl-2,4-quinzaolinediones
PH23565A (en) * 1986-09-05 1989-08-25 Sumitomo Chemical Co Novel pyrimidinylpyrimidine derivatives and a plant disease protectant containing them as the active ingredient
FI95572C (fi) * 1987-06-22 1996-02-26 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
CA2118117A1 (fr) * 1993-02-18 1994-08-19 Shigeki Fujiwara Inhibiteur de la capture de l'adenosine
JP2959765B2 (ja) * 1997-12-12 1999-10-06 日本たばこ産業株式会社 ３−ピペリジル−４−オキソキナゾリン誘導体及びそれを含有してなる医薬組成物
US6258819B1 (en) * 1999-08-05 2001-07-10 Syntex (U.S.A.) Llc Substituted 2(4-piperidyl)-4(3H)-quinazolinones and 2-(4-piperidyl)-4(3H)-azaquinazolinones
AU2005212092B2 (en) * 2004-02-13 2011-01-20 Msd K.K. Fused-ring 4-oxopyrimidine derivative
TW200836743A (en) * 2007-01-29 2008-09-16 Xenon Pharmaceuticals Inc Quinazolinone and fused pyrimidinone compounds and their use in treating sodium channel-mediated diseases or conditions
WO2014102592A2 (fr) 2012-12-27 2014-07-03 Purdue Pharma L.P. Composés de pipéridine de type quinoxaline substituée par oxime et leurs utilisations
JO3512B1 (ar) 2014-03-26 2020-07-05 Astex Therapeutics Ltd مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز
SI3353164T1 (sl) 2015-09-23 2022-02-28 Janssen Pharmaceutica, N.V. Bi-heteroaril substituiran 1,4-benzodiazepini in njihove uporabe za zdravljenje raka
EP3353177B1 (fr) 2015-09-23 2020-06-03 Janssen Pharmaceutica NV Hétérocycliques tricycliques pour la traitement de cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2694711A (en) * 1952-12-02 1954-11-16 American Cyanamid Co Quinazolone antimalarial compounds
US3086910A (en) * 1960-03-09 1963-04-23 Wallace & Tiernan Inc Central nervous system depressants 3-(2'-pyridyl)-4-quinazolones
US3257397A (en) * 1963-07-26 1966-06-21 Rexall Drug Chemical Substituted 2, 3-dihydro-4(1h)-quinazolinones
US4027028A (en) * 1975-11-10 1977-05-31 Science Union Et Cie Arylethers and pharmaceutical compositions

Also Published As

Publication number Publication date
BE856784A (fr) 1978-01-13
CA1103671A (fr) 1981-06-23
ES472563A1 (es) 1979-10-16
US4166117A (en) 1979-08-28
GB1583753A (en) 1981-02-04
SU751324A3 (ru) 1980-07-23
NL7707785A (nl) 1978-01-17
DE2731299A1 (de) 1978-01-19
OA05707A (fr) 1981-05-31
FR2361385B1 (fr) 1983-10-07
ES460699A1 (es) 1978-12-01
CH625518A5 (fr) 1981-09-30
JPS5334784A (en) 1978-03-31

Similar Documents

Publication Publication Date Title
FR2383157A1 (fr) Derives de chalcone, leur procede de preparation et leur application en therapeutique
FR2445323A2 (fr) Amides d'alkylenediamines et leur application en therapeutique
FR2406629A1 (fr) 5-trifluoromethylpyridines substituees en position 2 et leur procede de preparation
FR2361385A1 (fr) Nouvelles quinazolinones, leurs procedes d'obtention et leur application a la therapeutique
FR2366297A1 (fr) Nouvelles cephalosporines, leur procede de preparation et leur application en therapeutique
FR2394534A1 (fr) Nouveaux 1-aryloxy-2-hydroxy-3-alcoyleneaminopropanes, procedes pour leur preparation et medicaments les renfermant
FR2400517A1 (fr) Triazolo-2,4-benzodiazepines et leur utilisation therapeutique
FR2375218A1 (fr) 2-imidazoline-5-ones a substitution chirale
FR2383187A1 (fr) Derives du cepheme, leur procede de preparation et leur application en therapeutique
FR2361329A1 (fr) Nouvelles fluoroacylresorcines substituees et medicaments, cosmetiques et pesticides les renfermant
FR2359810A1 (fr) Bis-tetrahalogenophtalates d'alkylene ou de cycloalkylene-ammonium, leur preparation et leur application a la preparation d'imides correspondants
FR2362170A1 (fr) Nouvelles polyurees
FR2390446A1 (fr) Nouvelles triazines 1,3,5-s-hexahydrotrisubstituees, leur preparation et leur application a la lutte contre le developpement microbien
FR2361880A1 (fr) Nouvelles 4-amino piperidines, leurs procedes d'obtention et les compositions pharmaceutiques en renfermant
FR2378016A1 (fr) 1-alkylthiophenyl-2,3,4,5-tetrahydro-1h-3-benzazepine substituees et leur application en therapeutique
FR2358890A1 (fr) Nouvelles aryl trifluoroethylamines, leurs procedes d'obtention et les compositions pharmaceutiques en renfermant
FR2360583A1 (fr) B-azolylcetones utiles comme fongicides
BE880743A (fr) Nouvelles trifluoroethylamines substituees, leurs procedes d'obtention et leur emploi comme medicament
FR2381788A1 (fr) 1-thio-beta-d-glucopyrannosides de (phosphine trisubstituee)-or (i) et leur application en therapeutique
FR2355831A1 (fr) Derives de benzazocine, leur procede de preparation et leur application therapeutique
FR2415104A1 (fr) 6-alcoyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepines et leurs applications en therapeutique
FR2390445A1 (fr) Nouveaux derives du chromene, leur procede de preparation et leurs applications en therapeutique
FR2396756A1 (fr) Nouvelles benzylidene-2-benzofurannones-3, leur obtention et leur application a titre de medicaments
FR2378779A1 (fr) Derives de 5-fluoro-uracile et leur application en therapeutique
FR2404635A1 (fr) Nouveaux thioproprionylamides, leurs procedures d'obtention et leur emploi en therapeutique

Legal Events

Date Code Title Description
ST Notification of lapse