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FR21C1028I1 - HUMAN MONOCLONAL ANTIBODIES AGAINST CD20 FOR THE TREATMENT OF MULTIPLE SCLEROSIS - Google Patents

HUMAN MONOCLONAL ANTIBODIES AGAINST CD20 FOR THE TREATMENT OF MULTIPLE SCLEROSIS

Info

Publication number
FR21C1028I1
FR21C1028I1 FR21C1028C FR21C1028C FR21C1028I1 FR 21C1028 I1 FR21C1028 I1 FR 21C1028I1 FR 21C1028 C FR21C1028 C FR 21C1028C FR 21C1028 C FR21C1028 C FR 21C1028C FR 21C1028 I1 FR21C1028 I1 FR 21C1028I1
Authority
FR
France
Prior art keywords
human
monoclonal antibodies
antibodies
human monoclonal
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR21C1028C
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genmab AS
Original Assignee
Genmab AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32110219&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR21C1028(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genmab AS filed Critical Genmab AS
Publication of FR21C1028I1 publication Critical patent/FR21C1028I1/en
Active legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
    • C07K16/4258—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G01N33/686—Anti-idiotype
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54—F(ab')2
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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Abstract

Isolated human monoclonal antibodies which bind to and inhibit human CD20, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
FR21C1028C 2002-10-17 2021-07-07 HUMAN MONOCLONAL ANTIBODIES AGAINST CD20 FOR THE TREATMENT OF MULTIPLE SCLEROSIS Active FR21C1028I1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US41916302P 2002-10-17 2002-10-17
US46002803P 2003-04-02 2003-04-02
EP10013085.5A EP2316856B1 (en) 2002-10-17 2003-10-17 Human monoclonal antibodies against CD20
PCT/US2003/033057 WO2004035607A2 (en) 2002-10-17 2003-10-17 Human monoclonal antibodies against cd20
EP03809145A EP1558648B1 (en) 2002-10-17 2003-10-17 Human monoclonal antibodies against cd20

Publications (1)

Publication Number Publication Date
FR21C1028I1 true FR21C1028I1 (en) 2021-08-27

Family

ID=32110219

Family Applications (1)

Application Number Title Priority Date Filing Date
FR21C1028C Active FR21C1028I1 (en) 2002-10-17 2021-07-07 HUMAN MONOCLONAL ANTIBODIES AGAINST CD20 FOR THE TREATMENT OF MULTIPLE SCLEROSIS

Country Status (25)

Country Link
US (3) US8529902B2 (en)
EP (4) EP2316856B1 (en)
JP (3) JP4662473B2 (en)
KR (7) KR20090088973A (en)
CN (3) CN103709250B (en)
AT (1) ATE540978T1 (en)
AU (1) AU2003301445A1 (en)
BR (1) BRPI0315295C1 (en)
CA (2) CA3029035C (en)
CY (2) CY1112750T1 (en)
DK (2) DK3284753T3 (en)
EA (2) EA201492217A1 (en)
ES (3) ES2524694T3 (en)
FR (1) FR21C1028I1 (en)
HK (1) HK1077590A1 (en)
HU (2) HUE046695T2 (en)
IL (2) IL167851A (en)
LT (2) LT3284753T (en)
LU (1) LU92041I2 (en)
MX (1) MXPA05004022A (en)
NZ (2) NZ581541A (en)
PL (2) PL216630B1 (en)
PT (2) PT3284753T (en)
SI (1) SI1558648T1 (en)
WO (1) WO2004035607A2 (en)

Families Citing this family (458)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69303494T2 (en) * 1992-11-13 1997-01-16 Idec Pharma Corp THERAPEUTIC USE OF CHIMERIC AND LABELED ANTIBODIES AGAINST HUMAN B LYMPHOCYTIC LIMITED DIFFERENTIATION ANTIQUES FOR THE TREATMENT OF B CELL LYMPHOMA
US7744877B2 (en) * 1992-11-13 2010-06-29 Biogen Idec Inc. Expression and use of anti-CD20 Antibodies
CN101695574A (en) 1998-08-11 2010-04-21 拜奥根Idec公司 Combination therapies for b-cell lymphomas comprising administration of anti-cd20 antibody
BR9915164A (en) 1998-11-09 2003-01-07 Idec Pharma Corp Treatment of hematologic malignancies associated with circulating tumor cells using chimeric anti-cd20 antibody
EP1131096B1 (en) * 1998-11-09 2010-01-06 Biogen Idec Inc. Anti-cd20 antibody treatment of patients receiving bmt or pbsc transplants
US8557244B1 (en) 1999-08-11 2013-10-15 Biogen Idec Inc. Treatment of aggressive non-Hodgkins lymphoma with anti-CD20 antibody
US7754208B2 (en) 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
KR20090088973A (en) 2002-10-17 2009-08-20 젠맵 에이/에스 Human monoclonal antibodies against CD20
DE10254601A1 (en) 2002-11-22 2004-06-03 Ganymed Pharmaceuticals Ag Gene products differentially expressed in tumors and their use
EP1944320A1 (en) 2002-12-16 2008-07-16 Genentech, Inc. Immunoglobulin variants and uses thereof
NZ568403A (en) * 2003-05-09 2009-10-30 Univ Duke CD20-specific antibodies and methods of employing same
AR044388A1 (en) * 2003-05-20 2005-09-07 Applied Molecular Evolution CD20 UNION MOLECULES
BRPI0412629A (en) * 2003-08-29 2006-09-26 Genentech Inc Method of treating eye dysfunction in mammals
RS55723B1 (en) 2003-11-05 2017-07-31 Roche Glycart Ag Antigen binding molecules with increased fc receptor binding affinity and effector function
FR2867982B1 (en) * 2004-03-26 2007-07-20 Jean Marie Andrieu METHOD FOR AMPLIFYING THE ACTIVITY OF THERAPEUTIC VACCINES
RU2006140374A (en) * 2004-04-16 2008-05-27 Дженентек, Инк. (Us) TREATMENT OF VIOLATIONS
CA2563432A1 (en) * 2004-04-16 2005-12-01 Genentech, Inc. Method for augmenting b cell depletion
US20060099662A1 (en) * 2004-04-16 2006-05-11 Genentech, Inc. Assay for antibodies
US7850962B2 (en) * 2004-04-20 2010-12-14 Genmab A/S Human monoclonal antibodies against CD20
US20050271658A1 (en) * 2004-05-05 2005-12-08 Genentech, Inc. Preventing autoimmune disease
DE102004024617A1 (en) 2004-05-18 2005-12-29 Ganymed Pharmaceuticals Ag Differentially expressed in tumors gene products and their use
US9228008B2 (en) 2004-05-28 2016-01-05 Idexx Laboratories, Inc. Canine anti-CD20 antibodies
MXPA06014069A (en) * 2004-06-04 2007-04-25 Genentech Inc Method for treating multiple sclerosis.
EP1763509B1 (en) * 2004-07-02 2018-02-21 The Walter And Eliza Hall Institute Of Medical Research Alpha-helical mimetics
WO2006085967A2 (en) * 2004-07-09 2006-08-17 Xencor, Inc. OPTIMIZED ANTI-CD20 MONOCONAL ANTIBODIES HAVING Fc VARIANTS
AU2005274905B2 (en) 2004-08-04 2010-12-23 Mentrik Biotech, Llc Variant Fc regions
KR20070100228A (en) * 2004-10-05 2007-10-10 제넨테크, 인크. How to treat vasculitis
JO3000B1 (en) 2004-10-20 2016-09-05 Genentech Inc Antibody Formulations.
FR2879204B1 (en) 2004-12-15 2007-02-16 Lab Francais Du Fractionnement CYTOTOXIC ANTIBODY AGAINST HEMATOPOIETIC B-TYPE HEMATOPOIETIC PROLIFERATIONS
EP3431503A1 (en) * 2005-01-12 2019-01-23 Proteonova, Inc. Method for making targeted therapeutic agents
US10206998B2 (en) 2005-01-12 2019-02-19 Proteonova, Inc. Modular targeted therapeutic agents and methods of making same
EP3153525A1 (en) 2005-03-23 2017-04-12 Genmab A/S Antibodies against cd38 for treatment of multiple myeloma
AR053579A1 (en) * 2005-04-15 2007-05-09 Genentech Inc TREATMENT OF INTESTINAL INFLAMMATORY DISEASE (IBD)
JP5224707B2 (en) * 2005-04-28 2013-07-03 持田製薬株式会社 Anti-platelet membrane glycoprotein VI monoclonal antibody
US20090041783A1 (en) 2005-04-28 2009-02-12 Mochida Pharmaceutical Co., Ltd. Anti-platelet membrane glycoprotein vi monoclonal antibody
AU2006249087B2 (en) 2005-05-20 2012-05-17 Lonza Biologics Plc High-level expression of recombinant antibody in a mammalian host cell
KR20080046135A (en) 2005-05-20 2008-05-26 제넨테크, 인크. Pretreatment of Biological Samples from Autoimmune Disease Subjects
FR2886298A1 (en) * 2005-05-24 2006-12-01 Ifremer ANTIBODY OR FRAGMENT OF ANTIBODIES COUPLED WITH AN IMMUNOGENIC AGENT
US20110129412A1 (en) * 2005-06-02 2011-06-02 Astrazeneca Ab Antibodies Directed to CD20 and Uses Thereof
JP2009501913A (en) 2005-07-21 2009-01-22 ゲンマブ エー／エス Efficacy assays for antibody drug substances that bind to Fc receptors
CA2616395C (en) 2005-07-25 2016-10-04 Trubion Pharmaceuticals B-cell reduction using cd37-specific and cd20-specific binding molecules
US20090215992A1 (en) * 2005-08-19 2009-08-27 Chengbin Wu Dual variable domain immunoglobulin and uses thereof
EP1762575A1 (en) 2005-09-12 2007-03-14 Ganymed Pharmaceuticals AG Identification of tumor-associated antigens for diagnosis and therapy
MY149159A (en) 2005-11-15 2013-07-31 Hoffmann La Roche Method for treating joint damage
WO2007062090A2 (en) 2005-11-23 2007-05-31 Genentech, Inc. Methods and compositions related to b cell assays
EP1790664A1 (en) 2005-11-24 2007-05-30 Ganymed Pharmaceuticals AG Monoclonal antibodies against claudin-18 for treatment of cancer
TWI461436B (en) 2005-11-25 2014-11-21 Kyowa Hakko Kirin Co Ltd Human monoclonal antibody human cd134 (ox40) and methods of making and using same
KR20080110800A (en) 2006-03-15 2008-12-19 알렉시온 파마슈티칼스, 인코포레이티드 Treatment of patients with paroxysmal nocturnal hematuria with complement inhibitor
EP3345616A1 (en) 2006-03-31 2018-07-11 Chugai Seiyaku Kabushiki Kaisha Antibody modification method for purifying bispecific antibody
TWI390034B (en) 2006-04-06 2013-03-21 Kyowa Hakko Kirin Co Ltd Novel anti-CD98 antibody
EP3805269A1 (en) 2006-06-12 2021-04-14 Aptevo Research and Development LLC Single-chain multivalent binding proteins with effector function
WO2008003319A1 (en) 2006-07-04 2008-01-10 Genmab A/S Cd20 binding molecules for the treatment of copd
US9040050B2 (en) 2006-09-26 2015-05-26 Genmab A/S Combination treatment of CD38-expressing tumors
ES2625798T3 (en) 2006-10-02 2017-07-20 E. R. Squibb & Sons, L.L.C. Human antibodies that bind to CXCR4 and their uses
US9382327B2 (en) 2006-10-10 2016-07-05 Vaccinex, Inc. Anti-CD20 antibodies and methods of use
NZ577933A (en) 2007-01-22 2011-12-22 Genentech Inc Polyelectrolyte precipitation and purification of antibodies
EP1970384A1 (en) 2007-03-14 2008-09-17 Ganymed Pharmaceuticals AG Monoclonal antibodies for treatment of cancer
US7960139B2 (en) 2007-03-23 2011-06-14 Academia Sinica Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells
AR065803A1 (en) * 2007-03-23 2009-07-01 Smithkline Beecham Corp USE OF A HUMAN IL-18 POLYPEPTIDE AND AN ANTI-CD ANTIBODY TO PREPARE A MEDICINE
EP2139924B1 (en) 2007-03-29 2016-07-06 Genmab A/S Bispecific antibodies and methods for production thereof
EP1997832A1 (en) 2007-05-29 2008-12-03 Ganymed Pharmaceuticals AG Monoclonal antibodies against Claudin-18 for treatment of cancer
AU2008257520B2 (en) 2007-05-29 2012-04-05 Novartis Ag New indications for anti- IL-I-beta therapy
EP2666787B1 (en) 2007-05-31 2022-02-09 Genmab A/S STABLE IgG4 ANTIBODIES
AU2008255350B2 (en) 2007-05-31 2014-07-10 Genmab A/S Transgenic animals producing monovalent human antibodies and antibodies obtainable from these animals
UA107557C2 (en) 2007-07-06 2015-01-26 OFATUMUMAB ANTIBODY COMPOSITION
WO2009018411A1 (en) 2007-07-31 2009-02-05 Regeneron Pharmaceuticals, Inc. Human antibodies to human cd20 and method of using thereof
US20110243931A1 (en) 2007-09-02 2011-10-06 Thomas Friess Combination therapy with type i and type ii anti-cd20 antibodies
US20090098118A1 (en) 2007-10-15 2009-04-16 Thomas Friess Combination therapy of a type ii anti-cd20 antibody with an anti-bcl-2 active agent
WO2009052293A1 (en) 2007-10-16 2009-04-23 Zymogenetics, Inc. Combination of blys inhibition and anti-cd 20 agents for treatment of autoimmune disease
WO2009052830A1 (en) * 2007-10-22 2009-04-30 Genmab A/S Novel antibody therapies
PT2215117E (en) 2007-10-30 2015-04-01 Genentech Inc Antibody purification by cation exchange chromatography
US20090169550A1 (en) * 2007-12-21 2009-07-02 Genentech, Inc. Therapy of rituximab-refractory rheumatoid arthritis patients
US7914785B2 (en) 2008-01-02 2011-03-29 Bergen Teknologieverforing As B-cell depleting agents, like anti-CD20 antibodies or fragments thereof for the treatment of chronic fatigue syndrome
EP2077281A1 (en) 2008-01-02 2009-07-08 Bergen Teknologioverforing AS Anti-CD20 antibodies or fragments thereof for the treatment of chronic fatigue syndrome
KR101280716B1 (en) * 2008-03-25 2013-07-01 로슈 글리카트 아게 Use of a type ⅱ anti-cd20 antibody with increased antibody dependent cellular cytotoxicity (adcc) in combination with cyclophosphamide, vincristine and doxorubicine for treating non-hodgkin's lymphomas
KR20110013391A (en) 2008-04-11 2011-02-09 이머전트 프로덕트 디벨롭먼트 시애틀, 엘엘씨 CD37 immunotherapy and bifunctional chemotherapeutic agents and combinations thereof
WO2009134738A1 (en) * 2008-04-29 2009-11-05 Genentech, Inc. Responses to immunizations in rheumatoid arthritis patients treated with a cd20 antibody
EP2318832B1 (en) 2008-07-15 2013-10-09 Academia Sinica Glycan arrays on ptfe-like aluminum coated glass slides and related methods
US8119129B2 (en) 2008-08-01 2012-02-21 Bristol-Myers Squibb Company Combination of anti-CTLA4 antibody with dasatinib for the treatment of proliferative diseases
SI2848625T1 (en) 2008-08-14 2019-11-29 Genentech Inc Methods for removing a contaminant using indigenous protein displacement ion exchange membrane chromatography
MX2011002372A (en) 2008-09-10 2011-04-04 Genentech Inc Compositions and methods for the prevention of oxidative degradation of proteins.
TW201438738A (en) 2008-09-16 2014-10-16 Genentech Inc Method for treating progressive multiple sclerosis
EP2166021A1 (en) 2008-09-16 2010-03-24 Ganymed Pharmaceuticals AG Monoclonal antibodies for treatment of cancer
WO2010042433A1 (en) 2008-10-06 2010-04-15 Bristol-Myers Squibb Company Combination of cd137 antibody and ctla-4 antibody for the treatment of proliferative diseases
SG10201610247QA (en) 2008-12-03 2017-02-27 Genmab As Antibody variants having modifications in the constant region
WO2010075249A2 (en) 2008-12-22 2010-07-01 Genentech, Inc. A method for treating rheumatoid arthritis with b-cell antagonists
JP5828151B6 (en) * 2009-01-06 2018-09-19 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル B cell depleting agent for the treatment of atherosclerosis
SG172792A1 (en) * 2009-01-16 2011-08-29 Glaxosmithkline Llc Treatment of a cancer using a combination of bendamustine and an anti-cd20 antibody
NZ594480A (en) 2009-02-20 2013-11-29 Ganymed Pharmaceuticals Ag Methods and compositions for diagnosis and treatment of cancer
AR075982A1 (en) * 2009-03-31 2011-05-11 Roche Glycart Ag COMBINATION THERAPY OF A AFUCOSILATED ANTIBODY AND ONE OR MORE OF THE SELECTED CYTOKINS OF GM-CSF HUMAN, M-CSF HUMAN AND / OR IL-3 HUMAN AND COMPOSITION
MX2012000851A (en) 2009-07-20 2012-06-08 Squibb Bristol Myers Co Combination of anti-ctla4 antibody with diverse therapeutic regimens for the synergistic treatment of proliferative diseases.
TWI409079B (en) 2009-08-14 2013-09-21 Roche Glycart Ag Combination therapy of atypical fucosylated CD20 antibody and bendamustine
RU2012109451A (en) 2009-08-14 2013-09-27 Роше Гликарт Аг COMBINED THERAPY BASED ON AFUCHOSILY ANTIBODY TO CD20 IN COMBINATION WITH FLUDARABIN AND / OR MITOXANTRON
US8728730B2 (en) 2009-09-03 2014-05-20 Genentech, Inc. Methods for treating, diagnosing, and monitoring rheumatoid arthritis
AR078161A1 (en) 2009-09-11 2011-10-19 Hoffmann La Roche VERY CONCENTRATED PHARMACEUTICAL FORMULATIONS OF AN ANTIBODY ANTI CD20. USE OF THE FORMULATION. TREATMENT METHOD
US20110070227A1 (en) * 2009-09-18 2011-03-24 Anna-Marie Novotney-Barry Treatment of Autoimmune and Inflammatory Diseases
ES2649389T3 (en) 2009-11-11 2018-01-11 Ganymed Pharmaceuticals Gmbh Claudin 6 specific antibodies (CLDN6)
EP2322555A1 (en) 2009-11-11 2011-05-18 Ganymed Pharmaceuticals AG Antibodies specific for claudin 6 (CLDN6)
US10087236B2 (en) 2009-12-02 2018-10-02 Academia Sinica Methods for modifying human antibodies by glycan engineering
US11377485B2 (en) 2009-12-02 2022-07-05 Academia Sinica Methods for modifying human antibodies by glycan engineering
WO2011100403A1 (en) * 2010-02-10 2011-08-18 Immunogen, Inc Cd20 antibodies and uses thereof
US9175086B2 (en) * 2010-02-10 2015-11-03 Immunogen, Inc. CD20 antibodies and uses thereof
CA3027749A1 (en) 2010-03-22 2011-09-29 Junyan Ji Compositions and methods useful for stabilizing protein-containing formulations
EP2371864A1 (en) 2010-03-23 2011-10-05 Ganymed Pharmaceuticals AG Monoclonal antibodies for treatment of cancer
WO2011130332A1 (en) 2010-04-12 2011-10-20 Academia Sinica Glycan arrays for high throughput screening of viruses
RS65965B1 (en) 2010-04-20 2024-10-31 Genmab As Heterodimeric antibody fc-containing proteins and methods for production thereof
WO2011133886A2 (en) † 2010-04-23 2011-10-27 Genentech, Inc. Production of heteromultimeric proteins
EP2563391B1 (en) 2010-04-27 2020-08-26 Roche Glycart AG Combination therapy of an afucosylated cd20 antibody with a mtor inhibitor
JP2013525484A (en) 2010-05-03 2013-06-20 ジェネンテック， インコーポレイテッド Compositions and methods useful for reducing the viscosity of protein-containing formulations
CN103068378B (en) 2010-05-10 2016-07-06 中央研究院 Zanamivirdronate analogs with anti-influenza activity and preparation method thereof
US20130064831A1 (en) 2010-05-17 2013-03-14 Bristol-Myers Squibb Company Immunotherapeutic dosing regimens and combinations thereof
AU2011257121A1 (en) 2010-05-27 2013-01-10 Genmab A/S Monoclonal antibodies against HER2
US9249226B2 (en) 2010-06-09 2016-02-02 Genmab A/S Antibodies against human CD38
AU2011270828B2 (en) 2010-06-24 2015-09-24 Genentech, Inc. Compositions and methods containing alkylgycosides for stabilizing protein- containing formulations
EP2404936A1 (en) 2010-07-06 2012-01-11 Ganymed Pharmaceuticals AG Cancer therapy using CLDN6 target-directed antibodies in vivo
MX2013001302A (en) 2010-08-03 2013-03-08 Hoffmann La Roche Chronic lymphocytic leukemia (cll) biomarkers.
CA2807552A1 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
TW201208703A (en) 2010-08-17 2012-03-01 Roche Glycart Ag Combination therapy of an afucosylated CD20 antibody with an anti-VEGF antibody
PT3590949T (en) 2010-10-01 2022-08-02 Modernatx Inc Ribonucleic acids containing n1-methyl-pseudouracils and uses thereof
TWI603738B (en) 2010-11-08 2017-11-01 建南德克公司 Subcutaneously administered anti-il-6 receptor antibody
KR20240025059A (en) 2010-11-30 2024-02-26 추가이 세이야쿠 가부시키가이샤 Cytotoxicity-inducing therapeutic agent
JP6157045B2 (en) * 2010-12-06 2017-07-05 公益財団法人がん研究会 CD20-recognizing monoclonal antibody, hybridoma, CD20 detection method and determination method
RU2013131444A (en) 2010-12-16 2015-01-27 Рош Гликарт Аг COMBINED THERAPY BY AFUCOSYLED ANTIBODY TO CD20 AND MDM2 INHIBITOR
JP2014506258A (en) * 2011-01-10 2014-03-13 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド New use
RU2013140975A (en) 2011-02-28 2015-04-10 Дженентек, Инк. BIOLOGICAL MARKERS AND METHODS FOR PREDICTING SUSCEPTIBILITY TO B-CELL ANTAGONISTS
JP2014511687A (en) 2011-03-31 2014-05-19 モデルナ セラピューティクス インコーポレイテッド Engineered nucleic acid delivery and formulation
EP2699260B1 (en) 2011-04-20 2024-11-20 Genmab A/S Bispecifc antibodies against her2
CN103796678B (en) 2011-04-20 2018-02-27 健玛保 For HER2 bispecific antibody
CA2832389A1 (en) 2011-04-20 2012-10-26 Genmab A/S Bispecific antibodies against her2 and cd3
HUE028603T2 (en) 2011-05-13 2016-12-28 Ganymed Pharmaceuticals Ag Antibody for treating cancers expressing claudin-6
CA2836857C (en) 2011-05-21 2019-12-03 Macrogenics, Inc. Cd3-binding molecules capable of binding to human and non-human cd3
EP2537933A1 (en) 2011-06-24 2012-12-26 Institut National de la Santé et de la Recherche Médicale (INSERM) An IL-15 and IL-15Ralpha sushi domain based immunocytokines
UA117901C2 (en) 2011-07-06 2018-10-25 Ґенмаб Б.В. METHOD FOR STRENGTHENING THE EFFECTORAL FUNCTION OF THE ORIGINAL POLYEPEPTIDE, ITS OPTIONS AND THEIR APPLICATIONS
EP2729498A1 (en) 2011-07-06 2014-05-14 MorphoSys AG Therapeutic combinations of anti -cd20 and anti - gm - csf antibodies and uses thereof
EP2729496B8 (en) 2011-07-06 2017-10-18 Genmab A/S Modulation of complement-dependent cytotoxicity through modifications of the c-terminus of antibody heavy chains
CN102875678B (en) * 2011-07-13 2014-08-06 无锡天演生物技术有限公司 Human anti-human CD20 monoclonal antibody molecule and application thereof
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
BR112014006390A2 (en) * 2011-09-19 2017-03-28 Kymab Ltd antibodies, variable domains and chains made especially for human use
KR20190099538A (en) 2011-10-03 2019-08-27 모더나 세라퓨틱스, 인코포레이티드 Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
US9790280B2 (en) 2011-10-26 2017-10-17 Elanco Tiergesundheit Ag Monoclonal canine CD20 antibodies and methods of use
PL2771364T3 (en) 2011-10-27 2020-01-31 Genmab A/S Production of heterodimeric proteins
KR102398736B1 (en) 2011-10-31 2022-05-16 추가이 세이야쿠 가부시키가이샤 Antigen-binding molecule having regulated conjugation between heavy-chain and light-chain
US20130302274A1 (en) 2011-11-25 2013-11-14 Roche Glycart Ag Combination therapy
SG11201402666WA (en) 2011-12-16 2014-10-30 Moderna Therapeutics Inc Modified nucleoside, nucleotide, and nucleic acid compositions
MX360453B (en) 2011-12-22 2018-11-01 Genentech Inc Ion exchange membrane chromatography.
CA2863066A1 (en) 2012-01-31 2013-08-08 Genentech, Inc. Anti-ig-e m1' antibodies and methods using same
CN102585000B (en) * 2012-02-22 2013-05-29 尉军 Tumor marker CD25 autoantibody and application thereof
WO2013138702A2 (en) 2012-03-15 2013-09-19 Bristol-Myers Squibb Company Methods for predicting gastrointestinal immune-related adverse events (gi-irae) in patients treated with modulation of the co-stimulatory pathway
EP2847329A4 (en) 2012-04-02 2016-08-10 Moderna Therapeutics Inc MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF CYTOPLASMIC AND CYTOSQUELETTIC PROTEINS
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US9878056B2 (en) 2012-04-02 2018-01-30 Modernatx, Inc. Modified polynucleotides for the production of cosmetic proteins and peptides
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US10130714B2 (en) 2012-04-14 2018-11-20 Academia Sinica Enhanced anti-influenza agents conjugated with anti-inflammatory activity
PL2662386T3 (en) 2012-05-07 2019-08-30 Astellas Pharma Inc. Antibodies that bind to PLAC1 and block interaction between PLAC1 and FGF7
WO2013167153A1 (en) 2012-05-09 2013-11-14 Ganymed Pharmaceuticals Ag Antibodies useful in cancer diagnosis
WO2013169971A1 (en) 2012-05-10 2013-11-14 Bristol-Myers Squibb Company Anti-tumor antibodies as predictive or prognostic biomarkers of efficacy and survival in ipilimumab-treated patients
TR201810930T4 (en) 2012-05-18 2018-08-27 Genentech Inc High concentration monoclonal antibody formulations.
ME02932B (en) 2012-05-23 2018-04-20 Ganymed Pharmaceuticals Gmbh COMBINATION THERAPY WITH ANTIBODIES TO CLAUDIN 18.2 FOR THE TREATMENT OF CANCER
WO2013174404A1 (en) 2012-05-23 2013-11-28 Ganymed Pharmaceuticals Ag Combination therapy involving antibodies against claudin 18.2 for treatment of cancer
EP2852409B1 (en) 2012-05-23 2020-03-25 Astellas Pharma Inc. Combination therapy involving antibodies against claudin 18.2 for treatment of cancer
WO2013174403A1 (en) 2012-05-23 2013-11-28 Ganymed Pharmaceuticals Ag Combination therapy involving antibodies against claudin 18.2 for treatment of cancer
EP3632462A1 (en) 2012-07-06 2020-04-08 Genmab B.V. Dimeric protein with triple mutations
PT2869845T (en) * 2012-07-06 2019-12-09 Genmab Bv Dimeric protein with triple mutations
CN104736174B (en) 2012-07-06 2019-06-14 根马布私人有限公司 Protein dimer with triple mutant
CN103588882B (en) * 2012-08-13 2015-10-28 中国抗体制药有限公司 Anti-idiotypic antibody against human CD22 antibody and application thereof
WO2014031498A1 (en) 2012-08-18 2014-02-27 Academia Sinica Cell-permeable probes for identification and imaging of sialidases
CA2883168A1 (en) 2012-08-21 2014-02-27 Academia Sinica Benzocyclooctyne compounds and uses thereof
US8643360B1 (en) * 2012-09-02 2014-02-04 George S. Cargill, III In-water voltage gradient detector
RU2648476C2 (en) 2012-09-07 2018-03-26 Дженентек, Инк. Combination therapy using type ii anti-cd20 antibody and selective bcl-2 inhibitor
JOP20200236A1 (en) 2012-09-21 2017-06-16 Regeneron Pharma Anti-cd3 antibodies, bispecific antigen-binding molecules that bind cd3 and cd20, and uses thereof
EP2905290B1 (en) 2012-10-05 2019-12-04 Kyowa Kirin Co., Ltd. Heterodimeric protein composition
DK2914633T3 (en) 2012-10-30 2022-03-14 Esperance Pharmaceuticals Inc ANTIBODY / MEDICINAL CONJUGATES AND METHODS OF USE
UA128182C2 (en) 2012-11-13 2024-05-01 Біонтех Аґ Arrowhead List;Diamond List;Endnote Text;Bullet List;Upper Roman List;Lower Roman List;Numbered List;Square List;Dashed List;Tick List;Heart List;Block Text;Upper Case List;Footnote;Hand List;Footnote Text;Normal;Lower Case List;Plain Text;Implies List;Box List;Star List;Triangle List;Endnote;AGENTS FOR THE TREATMENT OF EXPRESSIVE CLAUDINE CANCERS
WO2014075697A1 (en) 2012-11-13 2014-05-22 Biontech Ag Agents for treatment of claudin expressing cancer diseases
EP3766903A3 (en) 2012-11-13 2021-02-17 BioNTech SE Bispecific anti claudin xcd3 antibodies for treatment of claudin expressing cancer diseases
RS63237B1 (en) 2012-11-26 2022-06-30 Modernatx Inc Terminally modified rna
CN103173412B (en) * 2012-12-07 2015-04-22 天津三箭生物技术有限公司 Mouse anti-human CD20 monoclonal antibody and hybridoma cell strain for secreting monoclonal antibody
KR20240123420A (en) 2013-01-10 2024-08-13 젠맵 비. 브이 Human igg1 fc region variants and uses thereof
CN103145847B (en) * 2013-02-05 2014-05-21 浙江大学 A kind of anti-CD20 antibody-dolastatin conjugate and its preparation method and application
EP4177273A1 (en) 2013-02-20 2023-05-10 Astellas Pharma Inc. Combination therapy involving antibodies against claudin 18.2 for treatment of cancer
WO2014127785A1 (en) 2013-02-20 2014-08-28 Ganymed Pharmaceuticals Ag Combination therapy involving antibodies against claudin 18.2 for treatment of cancer
JP6511609B2 (en) 2013-03-13 2019-05-22 ジェネンテック， インコーポレイテッド Antibody preparation
FR3003171B1 (en) * 2013-03-15 2015-04-10 Lab Francais Du Fractionnement NOVEL MEDICAMENTS COMPRISING AN ENHANCED ANTIBODY COMPOSITION IN MAJORITY LOAD ENFORCEMENT
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
PL2976360T3 (en) 2013-03-18 2020-05-18 Astellas Pharma Inc. Therapy involving antibodies against claudin 18.2 for treatment of cancer
WO2014146672A1 (en) 2013-03-18 2014-09-25 Ganymed Pharmaceuticals Ag Therapy involving antibodies against claudin 18.2 for treatment of cancer
CA2908380A1 (en) 2013-04-09 2014-10-16 Boston Biomedical, Inc. Methods for treating cancer
KR20150145260A (en) 2013-04-19 2015-12-29 싸이튠 파마 Cytokine derived treatment with reduced vascular leak syndrome
CN103254317B (en) * 2013-05-08 2014-08-13 浙江大学 Anti-CD20 monoclonal antibody-aplysiatoxin conjugate as well as preparation method and application thereof
WO2014210397A1 (en) 2013-06-26 2014-12-31 Academia Sinica Rm2 antigens and use thereof
WO2014210564A1 (en) 2013-06-27 2014-12-31 Academia Sinica Glycan conjugates and use thereof
KR20230073341A (en) * 2013-07-05 2023-05-25 젠맵 에이/에스 Humanized or chimeric cd3 antibodies
WO2015014376A1 (en) 2013-07-31 2015-02-05 Biontech Ag Diagnosis and therapy of cancer involving cancer stem cells
PL3027208T3 (en) 2013-07-31 2020-11-02 BioNTech SE Diagnosis and therapy of cancer involving cancer stem cells
DK3444271T3 (en) 2013-08-08 2022-01-10 Cytune Pharma IL-15 AND IL-15R ALFA-SUSHI DOMAIN BASED MODULOKINS
JP6794255B2 (en) 2013-08-08 2020-12-02 サイチューン ファーマ Combination pharmaceutical composition
CN103467605B (en) * 2013-09-05 2015-02-04 武汉友芝友生物制药有限公司 CD3 antigen and preparation method and application thereof
US9782476B2 (en) 2013-09-06 2017-10-10 Academia Sinica Human iNKT cell activation using glycolipids with altered glycosyl groups
EP3052106A4 (en) 2013-09-30 2017-07-19 ModernaTX, Inc. Polynucleotides encoding immune modulating polypeptides
US10323076B2 (en) 2013-10-03 2019-06-18 Modernatx, Inc. Polynucleotides encoding low density lipoprotein receptor
WO2015069770A1 (en) 2013-11-05 2015-05-14 Cognate Bioservices, Inc. Combinations of checkpoint inhibitors and therapeutics to treat cancer
US20160264670A1 (en) 2013-11-06 2016-09-15 Bristol-Myers Squibb Company Immunotherapeutic dosing regimens and combinations thereof
PL3066126T3 (en) * 2013-11-07 2019-08-30 F. Hoffmann-La Roche Ag Combination therapy with non-fucosylated anti-CD20 antibody and BTK inhibitor
CN106414494B (en) 2013-11-12 2020-09-18 Ogd2药物 Human IgG 1-derived antibodies with pro-apoptotic activity
AU2014364593A1 (en) 2013-12-17 2016-07-07 Genentech, Inc. Methods of treating cancer using PD-1 axis binding antagonists and an anti-CD20 antibody
CN106459920B (en) 2014-01-16 2020-10-30 中央研究院 Compositions and methods for treating and detecting cancer
US10150818B2 (en) 2014-01-16 2018-12-11 Academia Sinica Compositions and methods for treatment and detection of cancers
EP2910645A1 (en) 2014-02-25 2015-08-26 STRATIFYER Molecular Pathology GmbH Methods and compositions for prediction of therapeutic efficacy of cancer treatments and cancer prognosis upon antibody treatment
EP2915569A1 (en) 2014-03-03 2015-09-09 Cytune Pharma IL-15/IL-15Ralpha based conjugates purification method
TWI754319B (en) 2014-03-19 2022-02-01 美商再生元醫藥公司 Methods and antibody compositions for tumor treatment
CN103880958B (en) * 2014-03-27 2016-01-20 安徽大学 Antibody L4H6 for resisting CD20 antigen and application thereof
CN103880957B (en) * 2014-03-27 2016-01-20 安徽大学 Antibody L1H1 for resisting CD20 antigen and application thereof
TWI797430B (en) 2014-03-27 2023-04-01 中央研究院 Reactive labelling compounds and uses thereof
CN106459206B (en) 2014-04-07 2024-06-07 中外制药株式会社 Immune-activating antigen binding molecules
KR102447958B1 (en) 2014-04-23 2022-09-27 주노 쎄러퓨티크스 인코퍼레이티드 Methods for isolating, culturing, and genetically engineering immune cell populations for adoptive therapy
EP3909602A1 (en) 2014-04-25 2021-11-17 University of Florida Research Foundation, Inc. Methods of permitting a subject to receive multiple doses of recombinant adeno-associated virus
CA2943707A1 (en) 2014-05-06 2015-11-12 Genentech, Inc. Production of heteromultimeric proteins using mammalian cells
SG11201609370QA (en) 2014-05-13 2016-12-29 Chugai Pharmaceutical Co Ltd T cell-redirected antigen-binding molecule for cells having immunosuppression function
US10118969B2 (en) 2014-05-27 2018-11-06 Academia Sinica Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
CA2950440A1 (en) 2014-05-27 2015-12-03 Academia Sinica Anti-her2 glycoantibodies and uses thereof
TWI717319B (en) 2014-05-27 2021-02-01 中央研究院 Fucosidase from bacteroides and methods using the same
AU2015267047A1 (en) 2014-05-27 2017-01-05 Academia Sinica Anti-CD20 glycoantibodies and uses thereof
KR102494193B1 (en) 2014-05-28 2023-01-31 아카데미아 시니카 Anti-tnf-alpha glycoantibodies and uses thereof
JP6899321B2 (en) 2014-09-08 2021-07-07 アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ Activation of human iNKT cells using glycolipids
WO2016044334A1 (en) 2014-09-15 2016-03-24 Genentech, Inc. Antibody formulations
DK3262071T3 (en) 2014-09-23 2020-06-15 Hoffmann La Roche Method of using anti-CD79b immune conjugates
MA40764A (en) 2014-09-26 2017-08-01 Chugai Pharmaceutical Co Ltd THERAPEUTIC AGENT INDUCING CYTOTOXICITY
EP4029508A1 (en) 2014-10-10 2022-07-20 Idera Pharmaceuticals, Inc. Treatment of cancer using tlr9 agonists and checkpoint inhibitors
JP6681396B2 (en) 2014-11-17 2020-04-15 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Method of treating a tumor with a CD3XCD20 bispecific antibody
KR20170088984A (en) 2014-12-04 2017-08-02 브리스톨-마이어스 스큅 컴퍼니 Combination of anti-cs1 and anti-pd1 antibodies to treat cancer (myeloma)
PT3240805T (en) 2014-12-15 2025-01-28 Univ California Bispecific or-gate chimeric antigen receptor responsive to cd19 and cd20
EP3233907B1 (en) 2014-12-19 2021-03-03 Genmab A/S Rodent bispecific heterodimeric proteins
CA2973159A1 (en) * 2015-01-08 2016-07-14 Genmab A/S Bispecific antibodies against cd3 and cd20
US10495645B2 (en) 2015-01-16 2019-12-03 Academia Sinica Cancer markers and methods of use thereof
US9975965B2 (en) 2015-01-16 2018-05-22 Academia Sinica Compositions and methods for treatment and detection of cancers
KR102691114B1 (en) 2015-01-24 2024-08-01 아카데미아 시니카 Novel glycan conjugates and methods of using them
US20180215801A1 (en) 2015-01-29 2018-08-02 Board Of Trustees Of Michigan State University Cryptic polypeptides and uses thereof
KR20240135877A (en) * 2015-03-04 2024-09-12 아이쥐엠 바이오사이언스 인코포레이티드 Cd20 binding molecules and uses thereof
WO2016146143A1 (en) 2015-03-16 2016-09-22 Amal Therapeutics Sa Cell penetrating peptides and complexes comprising the same
EP3273974A4 (en) 2015-03-26 2018-11-07 Women and Infants Hospital of Rhode Island Inc. Therapy for malignant disease
WO2016165762A1 (en) 2015-04-15 2016-10-20 Ganymed Pharmaceuticals Ag Drug conjugates comprising antibodies against claudin 18.2
WO2016165765A1 (en) 2015-04-15 2016-10-20 Ganymed Pharmaceuticals Ag Methods and compositions for prediction of therapeutic efficacy of cancer treatments and cancer prognosis
WO2016175285A1 (en) * 2015-04-30 2016-11-03 株式会社特殊免疫研究所 TRANSGENIC NON-HUMAN ANIMAL EXPRESSING HUMAN-SPECIFIC MOLECULES AND HUMAN FCγ RECEPTOR FAMILY
JP6963508B2 (en) 2015-05-11 2021-11-10 ジェネンテック， インコーポレイテッド Compositions and Methods for Treating Lupus Nephritis
WO2016183183A1 (en) 2015-05-11 2016-11-17 The Johns Hopkins University Autoimmune antibodies for use in inhibiting cancer cell growth
JP6688551B2 (en) 2015-05-21 2020-04-28 ハープーン セラピューティクス，インク． Trispecific binding proteins and methods of use
AU2016267059B2 (en) 2015-05-22 2020-08-13 Translational Drug Development Llc Benzamide and active compound compositions and methods of use
CA2988126A1 (en) 2015-06-03 2016-12-08 Boston Biomedical, Inc. Compositions comprising a cancer stemness inhibitor and an immunotherapeutic agent for use in treating cancer
EP3108897A1 (en) 2015-06-24 2016-12-28 F. Hoffmann-La Roche AG Antibodies against human csf-1r for use in inducing lymphocytosis in lymphomas or leukemias
MY193078A (en) 2015-06-24 2022-09-26 Hoffmann La Roche Anti-transferrin receptor antibodies with tailored affinity
JOP20200312A1 (en) 2015-06-26 2017-06-16 Novartis Ag Factor xi antibodies and methods of use
ES2886657T3 (en) 2015-06-29 2021-12-20 Bristol Myers Squibb Co Immunotherapeutic dosage regimens comprising pomalidomide and an anti-CS1 antibody for the treatment of cancer
US20170029520A1 (en) 2015-06-29 2017-02-02 Genentech, Inc. Compositions and methods for use in organ transplantation
US20180201693A1 (en) 2015-07-09 2018-07-19 Genmab A/S Bispecific and multispecific antibodies and method for isolation of such
IL274572B2 (en) 2015-07-16 2024-01-01 Biolinerx Ltd Preparations and methods for the treatment of cancer
KR20180029079A (en) 2015-07-31 2018-03-19 유니버시티 오브 플로리다 리서치 파운데이션, 아이엔씨. Hematopoietic Stem Cells in Combination Therapy with Immune Checkpoint Inhibitors for Cancer
US20180230431A1 (en) 2015-08-07 2018-08-16 Glaxosmithkline Intellectual Property Development Limited Combination Therapy
WO2017027861A1 (en) 2015-08-13 2017-02-16 Amgen Inc. Charged depth filtration of antigen-binding proteins
JP7002446B2 (en) 2015-09-21 2022-03-04 アプティーボ リサーチ アンド デベロップメント エルエルシー CD3 binding polypeptide
AR106188A1 (en) 2015-10-01 2017-12-20 Hoffmann La Roche ANTI-CD19 HUMANIZED HUMAN ANTIBODIES AND METHODS OF USE
AR106189A1 (en) 2015-10-02 2017-12-20 Hoffmann La Roche BIESPECTIFIC ANTIBODIES AGAINST HUMAN A-b AND THE HUMAN TRANSFERRINE RECEIVER AND METHODS OF USE
IL312251A (en) 2015-10-02 2024-06-01 Hoffmann La Roche Human anti-CD20/human transferrin receptor bispecific antibodies and methods of use
CN114470192A (en) * 2015-10-13 2022-05-13 优瑞科生物技术公司 Antibody agent specific for human CD19 and use thereof
WO2017086367A1 (en) 2015-11-18 2017-05-26 中外製薬株式会社 Combination therapy using t cell redirection antigen binding molecule against cell having immunosuppressing function
US11649293B2 (en) 2015-11-18 2023-05-16 Chugai Seiyaku Kabushiki Kaisha Method for enhancing humoral immune response
UA126897C2 (en) 2015-12-01 2023-02-22 Генмаб Б.В. ANTIBODIES AGAINST DR5 AND METHODS OF THEIR APPLICATION
CN108290954B (en) 2015-12-09 2022-07-26 豪夫迈·罗氏有限公司 Use of type II anti-CD 20 antibodies to reduce anti-drug antibody formation
EP3178848A1 (en) 2015-12-09 2017-06-14 F. Hoffmann-La Roche AG Type ii anti-cd20 antibody for reducing formation of anti-drug antibodies
CN105348388B (en) * 2015-12-11 2018-10-19 安徽大学 The antibody L3H3 of anti-CD20 antigens and its application
SG11201803989WA (en) 2015-12-28 2018-06-28 Chugai Pharmaceutical Co Ltd Method for promoting efficiency of purification of fc region-containing polypeptide
CN115400220A (en) 2015-12-30 2022-11-29 豪夫迈·罗氏有限公司 Formulations to Reduce Polysorbate Degradation
CN108699155B (en) 2016-03-01 2023-03-21 豪夫迈·罗氏有限公司 Orabituzumab variants with altered cell death induction
EP3423593A1 (en) 2016-03-02 2019-01-09 Institut National de la Sante et de la Recherche Medicale (INSERM) Methods and kits for predicting the risk of relapse in patients suffering from idiopathic nephrotic syndrome
AU2017231749A1 (en) 2016-03-08 2018-09-20 Academia Sinica Methods for modular synthesis of N-glycans and arrays thereof
SG11201807936VA (en) 2016-03-14 2018-10-30 Chugai Pharmaceutical Co Ltd Cell injury inducing therapeutic drug for use in cancer therapy
WO2017160599A1 (en) 2016-03-14 2017-09-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Use of cd300b antagonists to treat sepsis and septic shock
BR112018068461A2 (en) 2016-03-15 2019-01-22 Mersana Therapeutics Inc conjugate, pharmaceutical composition, methods for preparing a conjugate and for alleviating a symptom of a cancer.
LT3429618T (en) 2016-03-16 2024-05-10 Amal Therapeutics Sa Combination of an immune checkpoint modulator and a complex comprising a cell penetrating peptide, a cargo and a tlr peptide agonist for use in medicine
EP3445378A1 (en) 2016-04-22 2019-02-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and vaccine compositions for the treatment of b-cell malignancies
WO2017192874A1 (en) 2016-05-04 2017-11-09 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Albumin-binding immunomodulatory compositions and methods of use thereof
US11623958B2 (en) 2016-05-20 2023-04-11 Harpoon Therapeutics, Inc. Single chain variable fragment CD3 binding proteins
TW201802121A (en) 2016-05-25 2018-01-16 諾華公司 Reversal binding agent against factor XI/XIa antibody and use thereof
WO2017210181A1 (en) 2016-05-30 2017-12-07 Geovax Inc. Compositions and methods for generating an immune response to hepatitis b virus
EP3252078A1 (en) 2016-06-02 2017-12-06 F. Hoffmann-La Roche AG Type ii anti-cd20 antibody and anti-cd20/cd3 bispecific antibody for treatment of cancer
IL263481B2 (en) 2016-06-14 2024-06-01 Regeneron Pharma Anti-c5 antibodies and uses thereof
EP3472614A1 (en) * 2016-06-16 2019-04-24 F. Hoffmann-La Roche AG Assay and method for determining cdc eliciting antibodies
EP3478321A4 (en) 2016-06-30 2020-04-22 Oncorus, Inc. Pseudotyped oncolytic viral delivery of therapeutic polypeptides
CN106267406B (en) * 2016-07-01 2019-02-01 翁炳焕 AIDS blood purification
US11649289B2 (en) 2016-08-04 2023-05-16 Glaxosmithkline Intellectual Property Development Limited Anti-ICOS and anti-PD-1 antibody combination therapy
KR102588027B1 (en) 2016-08-22 2023-10-12 초 파마 인크. Antibodies, binding fragments and methods of use
CA3035427A1 (en) * 2016-09-01 2018-03-08 Umc Utrecht Holding B.V. Cd20 antibodies
IL265479B (en) 2016-09-21 2022-09-01 Amal Therapeutics Sa A fusion containing a cell-penetrating peptide, a multiple epitope, and a peptide tlr agonist for cancer therapy
WO2018054484A1 (en) 2016-09-23 2018-03-29 Biontech Ag Bispecific trivalent antibodies binding to claudin 6 or claudin18.2 and cd3 for treatment of claudin expressing cancer diseases
JP7277363B2 (en) 2016-11-01 2023-05-18 ジェンマブ ビー．ブイ． Polypeptide variants and uses thereof
US11135307B2 (en) 2016-11-23 2021-10-05 Mersana Therapeutics, Inc. Peptide-containing linkers for antibody-drug conjugates
CN110234319B (en) 2016-11-23 2022-09-27 转化药物开发有限责任公司 Compositions of benzamide and active compound and methods of use thereof
WO2018099539A1 (en) 2016-11-29 2018-06-07 Horst Lindhofer Combination of t-cell redirecting multifunctional antibodies with immune checkpoint modulators and uses thereof
CA3045306A1 (en) 2016-11-29 2018-06-07 Boston Biomedical, Inc. Naphthofuran derivatives, preparation, and methods of use thereof
US20190343803A1 (en) 2016-12-01 2019-11-14 Glaxosmithkline Intellectual Property Development Limited Combination therapy
AU2017369994A1 (en) 2016-12-01 2019-06-13 Glaxosmithkline Intellectual Property Development Limited Combination therapy
US20200003785A1 (en) 2016-12-01 2020-01-02 Inserm (Institut National De La Sante Et De La Recherche Medicale) Use of anti-uchl1 igg plasma concentration for diagnosing idiopathic steroid sensitive nephrotic syndrome
EP3551047A1 (en) 2016-12-07 2019-10-16 Progenity, Inc. Gastrointestinal tract detection methods, devices and systems
CA3039430A1 (en) 2016-12-19 2018-06-28 F. Hoffmann-La Roche Ag Combination therapy with targeted 4-1bb (cd137) agonists
PL3559034T3 (en) 2016-12-20 2021-04-19 F. Hoffmann-La Roche Ag Combination therapy with anti-CD20 / anti-CD3 bispecific antibodies and 4-1BB (CD137) agonists
KR102616666B1 (en) 2016-12-23 2023-12-27 노파르티스 아게 Factor XI Antibodies and Methods of Use
EP3579885A4 (en) 2017-02-07 2020-12-16 Nantcell, Inc. MAXIMIZATION OF T-CELL MEMORY AND COMPOSITIONS AND METHODS FOR THEREFORE
CN108395482B (en) 2017-02-08 2021-02-05 西比曼生物科技（香港）有限公司 Construction of targeting CD20 antigen chimeric antigen receptor and activity identification of engineered T cell thereof
UA128814C2 (en) 2017-02-10 2024-10-30 Генмаб Б.В. Polypeptide variants and uses thereof
US20180271996A1 (en) 2017-02-28 2018-09-27 Mersana Therapeutics, Inc. Combination therapies of her2-targeted antibody-drug conjugates
US20200150125A1 (en) 2017-03-12 2020-05-14 Yeda Research And Development Co., Ltd. Methods of diagnosing and prognosing cancer
WO2018167780A1 (en) 2017-03-12 2018-09-20 Yeda Research And Development Co. Ltd. Methods of prognosing and treating cancer
US20210138213A1 (en) 2017-03-30 2021-05-13 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with an immune modulatory agent released using an ingestible device
IL269645B1 (en) 2017-03-31 2025-01-01 Genmab Holding B V Bispecific anti-cd37 antibodies, monoclonal anti-cd37 antibodies and methods of use thereof
WO2018209298A1 (en) 2017-05-12 2018-11-15 Harpoon Therapeutics, Inc. Mesothelin binding proteins
US10646464B2 (en) 2017-05-17 2020-05-12 Boston Biomedical, Inc. Methods for treating cancer
MX2019014274A (en) 2017-06-02 2020-01-23 Hoffmann La Roche Type ii anti-cd20 antibody and anti-cd20/cd3 bispecific antibody for treatment of cancer.
EP3634584B1 (en) 2017-06-09 2024-09-18 Providence Health & Services - Oregon Tumor-infiltrating t-cells for use in the treatment of cancer
CN107446046A (en) * 2017-07-05 2017-12-08 无锡傲锐东源生物科技有限公司 Anti- CD20 protein monoclonal antibodies and application thereof
CN110869391A (en) 2017-07-26 2020-03-06 豪夫迈·罗氏有限公司 Combination therapy with BET inhibitors, Bcl-2 inhibitors and anti-CD 20 antibodies
WO2019036855A1 (en) 2017-08-21 2019-02-28 Adagene Inc. Anti-cd137 molecules and use thereof
WO2019048040A1 (en) 2017-09-06 2019-03-14 Ganymed Pharmaceuticals Gmbh Antibodies useful in cancer diagnosis
IL315737A (en) 2017-10-13 2024-11-01 Harpoon Therapeutics Inc B cell maturation antigen binding proteins
WO2019077123A1 (en) 2017-10-20 2019-04-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and kits for determining whether a subject has or is at risk of having of an autoimmune myopathy
WO2019104289A1 (en) 2017-11-27 2019-05-31 Mersana Therapeutics, Inc. Pyrrolobenzodiazepine antibody conjugates
AU2018382966A1 (en) 2017-12-14 2020-04-09 F. Hoffmann-La Roche Ag Use of a CEA CD3 bispecific antibody and a PD-1 axis binding antagonist in a dosage regime to treat cancer
TW201929908A (en) 2017-12-21 2019-08-01 美商梅爾莎納醫療公司 Pyrrolobenzodiazepine antibody conjugates
WO2019133847A1 (en) 2017-12-29 2019-07-04 Oncorus, Inc. Oncolytic viral delivery of therapeutic polypeptides
JP2021510740A (en) 2018-01-24 2021-04-30 ゲンマブ ビー．ブイ． Polypeptide variants and their uses
WO2019148445A1 (en) 2018-02-02 2019-08-08 Adagene Inc. Precision/context-dependent activatable antibodies, and methods of making and using the same
JP2021517589A (en) 2018-03-12 2021-07-26 アンセルム（アンスティチュート・ナシオナル・ドゥ・ラ・サンテ・エ・ドゥ・ラ・ルシェルシュ・メディカル） Use of calorie restriction mimics to enhance chemoimmunotherapy for the treatment of cancer
TWI841551B (en) 2018-03-13 2024-05-11 瑞士商赫孚孟拉羅股份公司 Combination therapy with targeted 4-1bb (cd137) agonists
CA3092002A1 (en) 2018-03-13 2019-09-19 F. Hoffmann-La Roche Ag Therapeutic combination of 4-1 bb agonists with anti-cd20 antibodies
MX2020011552A (en) 2018-05-03 2020-11-24 Genmab Bv Antibody variant combinations and uses thereof.
EP3810109B1 (en) 2018-05-31 2024-08-07 Peloton Therapeutics, Inc. Compounds and compositions for inhibiting cd73
EP3807410A1 (en) 2018-06-15 2021-04-21 MiNA Therapeutics Limited Combination therapies comprising c/ebp alpha sarna
WO2019246317A1 (en) 2018-06-20 2019-12-26 Progenity, Inc. Treatment of a disease or condition in a tissue originating from the endoderm
US20230041197A1 (en) 2018-06-20 2023-02-09 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with an immunomodulator
US12247065B2 (en) 2018-06-22 2025-03-11 Genmab A/S Method for producing a controlled mixture of two or more different antibodies
US20210371539A1 (en) 2018-06-22 2021-12-02 Genmab Holding B.V. Anti-cd37 antibodies and anti-cd20 antibodies, compositions and methods of use thereof
WO2020014139A1 (en) 2018-07-09 2020-01-16 Millennium Pharmaceuticals, Inc. Administration of sumo-activating enzyme inhibitor and anti-cd20 antibodies
GB201811408D0 (en) 2018-07-12 2018-08-29 F Star Beta Ltd CD137 Binding Molecules
EP3833762A4 (en) 2018-08-09 2022-09-28 Verseau Therapeutics, Inc. Oligonucleotide compositions for targeting ccr2 and csf1r and uses thereof
MA53495A (en) 2018-08-31 2021-12-08 Regeneron Pharma DOSING STRATEGY TO MITIGATE CYTOKINE RELEASE SYNDROME FOR CD3/C20 BISPECIFIC ANTIBODIES
WO2020048942A1 (en) 2018-09-04 2020-03-12 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for enhancing cytotoxic t lymphocyte-dependent immune responses
AU2019344795A1 (en) 2018-09-17 2021-03-25 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Bicistronic chimeric antigen receptors targeting CD19 and CD20 and their uses
JP7618950B2 (en) 2018-09-19 2025-01-22 インサーム （インスティテュート ナショナル デ ラ サンテ エ デ ラ ルシェルシェ メディカル） Methods and pharmaceutical compositions for the treatment of cancers resistant to immune checkpoint therapy
WO2020061482A1 (en) 2018-09-21 2020-03-26 Harpoon Therapeutics, Inc. Egfr binding proteins and methods of use
CN113286817B (en) 2018-09-25 2025-01-28 哈普恩治疗公司 DLL3 binding proteins and methods of use
EP3860578A1 (en) 2018-10-01 2021-08-11 Institut National de la Santé et de la Recherche Médicale (INSERM) Use of inhibitors of stress granule formation for targeting the regulation of immune responses
SG11202103100SA (en) 2018-10-04 2021-04-29 Genmab Holding B V Pharmaceutical compositions comprising bispecific anti-cd37 antibodies
EP3868784A4 (en) 2018-10-15 2022-07-27 Industry-Academic Cooperation Foundation, Yonsei University Productivity-enhanced antibody and method for producing same
JP2022505445A (en) * 2018-10-26 2022-01-14 テネオバイオ， インコーポレイテッド Heavy chain antibody that binds to CD38
EA202191175A1 (en) 2018-10-29 2021-09-08 Мерсана Терапьютикс, Инк. CYSTEINE-DESIGNED ANTIBODY-DRUG CONJUGATES CONTAINING PEPTIDE-CONTAINING LINKERS
CA3120619A1 (en) 2018-11-19 2020-05-28 Progenity, Inc. Methods and devices for treating a disease with biotherapeutics
EP3883610A4 (en) 2018-11-20 2022-11-02 Cornell University MACROCYCLIC COMPLEXES OF RADIONUKLIDES AND THEIR USE IN CANCER RADIOTHERAPY
US20220018828A1 (en) 2018-11-28 2022-01-20 Inserm (Institut National De La Santé Et La Recherche Médicale Methods and kit for assaying lytic potential of immune effector cells
CA3119798A1 (en) 2018-12-06 2020-06-11 Genentech, Inc. Combination therapy of diffuse large b-cell lymphoma comprising an anti-cd79b immunoconjugates, an alkylating agent and an anti-cd20 antibody
WO2020115262A1 (en) 2018-12-07 2020-06-11 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of cd26 and cd39 as new phenotypic markers for assessing maturation of foxp3+ t cells and uses thereof for diagnostic purposes
MX2021006831A (en) 2018-12-11 2021-07-02 Theravance Biopharma R&D Ip Llc Alk5 inhibitors.
EP3897624A1 (en) 2018-12-17 2021-10-27 Institut National de la Santé et de la Recherche Médicale (INSERM) Use of sulconazole as a furin inhibitor
WO2020148338A1 (en) 2019-01-15 2020-07-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Mutated interleukin-34 (il-34) polypeptides and uses thereof in therapy
WO2020169472A2 (en) 2019-02-18 2020-08-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of inducing phenotypic changes in macrophages
BR112021019612A2 (en) 2019-04-01 2021-11-30 Genentech Inc Formulations, container, article of manufacture, method for producing the formulation and method for inhibiting aggregation of a protein present in an aqueous solution
WO2020201362A2 (en) 2019-04-02 2020-10-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of predicting and preventing cancer in patients having premalignant lesions
US20220160692A1 (en) 2019-04-09 2022-05-26 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of sk2 inhibitors in combination with immune checkpoint blockade therapy for the treatment of cancer
EP3956446A1 (en) 2019-04-17 2022-02-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions for treatment of nlrp3 inflammasome mediated il-1beta dependent disorders
BR112021022815A2 (en) 2019-05-14 2021-12-28 Genentech Inc Methods to treat follicular lymphoma, kits, immunoconjugates and polatuzumab vedotin
CN110551221B (en) 2019-07-02 2021-03-05 广州爱思迈生物医药科技有限公司 Bispecific antibody and preparation method and application thereof
US20220257796A1 (en) 2019-07-02 2022-08-18 Fred Hutchinson Cancer Research Center Recombinant ad35 vectors and related gene therapy improvements
WO2021024020A1 (en) 2019-08-06 2021-02-11 Astellas Pharma Inc. Combination therapy involving antibodies against claudin 18.2 and immune checkpoint inhibitors for treatment of cancer
AU2020336440A1 (en) * 2019-08-30 2022-03-24 Qilu Puget Sound Biotherapeutics Corporation Anti-CD20 antibodies, anti-CD37 antibodies, and mixtures thereof
CA3152192A1 (en) 2019-09-11 2021-03-18 Novartis Ag Management of conditions other than multiple sclerosis in ofatumumab-treated patients
EP4230655A3 (en) 2019-09-11 2023-11-01 Novartis AG Treatment of rms by switching therapy
JP2022547577A (en) 2019-09-12 2022-11-14 ジェネンテック， インコーポレイテッド Compositions and methods for treating lupus nephritis
WO2021058091A1 (en) 2019-09-24 2021-04-01 Biontech Rna Pharmaceuticals Gmbh Treatment involving therapeutic antibody and interleukin-2 (il2)
EP3800201A1 (en) 2019-10-01 2021-04-07 INSERM (Institut National de la Santé et de la Recherche Médicale) Cd28h stimulation enhances nk cell killing activities
EP4037710A1 (en) 2019-10-04 2022-08-10 Institut National de la Santé et de la Recherche Médicale (INSERM) Methods and pharmaceutical composition for the treatment of ovarian cancer, breast cancer or pancreatic cancer
JP7413519B2 (en) 2019-10-18 2024-01-15 ジェネンテック， インコーポレイテッド Methods of using anti-CD79B immunoconjugates to treat diffuse large B-cell lymphoma
JP2023500701A (en) 2019-11-06 2023-01-10 ジェンマブ ビー．ブイ． Antibody variant combinations and uses thereof
AU2020385400A1 (en) 2019-11-22 2022-06-09 Theravance Biopharma R&D Ip, Llc Substituted 1,5-naphthyridines or quinolines as ALK5 inhibitors
CN111100204B (en) * 2019-11-26 2022-03-11 山东立菲生物产业有限公司 Antibody targeting CD20, preparation method and application thereof
WO2021119482A1 (en) 2019-12-13 2021-06-17 Progenity, Inc. Ingestible device for delivery of therapeutic agent to the gastrointestinal tract
CN115023441A (en) * 2019-12-18 2022-09-06 特诺福尔股份有限公司 Heavy chain antibodies that bind to CD38
JP2023514692A (en) 2020-02-21 2023-04-07 ジェンマブ ビー．ブイ． Methods for the quantification of glycoproteins
EP4126824A1 (en) 2020-03-31 2023-02-08 Theravance Biopharma R&D IP, LLC Substituted pyrimidines and methods of use
IL296701A (en) 2020-04-09 2022-11-01 Novartis Ag Ofatumumab for treating ms while maintaining serum igg
CA3175499A1 (en) 2020-04-21 2021-10-28 University Of Rochester Inhibitors of human epididymus protein 4
MX2022013065A (en) 2020-04-22 2022-12-08 Iovance Biotherapeutics Inc Systems and methods for coordinating manufacturing of cells for patient-specific immunotherapy.
AU2021259861A1 (en) 2020-04-24 2022-11-17 Genentech, Inc. Methods of using anti-CD79b immunoconjugates
IL297986A (en) 2020-05-08 2023-01-01 Genmab As Bispecific antibodies against cd3 and cd20
CA3169518A1 (en) 2020-06-03 2021-12-09 Mv Biotherapeutics Sa Combination of an atp-hydrolyzing enzyme and an immune checkpoint modulator and uses thereof
EP4165041A1 (en) 2020-06-10 2023-04-19 Theravance Biopharma R&D IP, LLC Naphthyridine derivatives useful as alk5 inhibitors
WO2021260675A1 (en) 2020-06-24 2021-12-30 Yeda Research And Development Co. Ltd. Agents for sensitizing solid tumors to treatment
EP4178611A1 (en) 2020-07-07 2023-05-17 BioNTech SE Therapeutic rna for hpv-positive cancer
AU2021305084A1 (en) 2020-07-07 2023-02-02 Cancure, Llc MIC antibodies and binding agents and methods of using the same
US20230295146A1 (en) 2020-07-24 2023-09-21 The University Of Rochester Inhibitors of interleukin-1 receptor-associated kinases 1 and 4
CN112062855B (en) * 2020-08-26 2024-08-30 北京天诺健成医药科技有限公司 Development and application of drug therapeutic agent containing adapter
WO2022043415A1 (en) 2020-08-27 2022-03-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for detecting the presence of pemphigus-specific autoantibodies in a sample
CA3192256A1 (en) 2020-09-10 2022-03-17 Brian Elliott Bispecific antibody against cd3 and cd20 in combination therapy for treating diffuse large b-cell lymphoma
KR20230066581A (en) 2020-09-10 2023-05-16 젠맵 에이/에스 Bispecific antibodies to CD3 and CD20 in combination therapy for the treatment of diffuse large B-cell lymphoma
AU2021340232A1 (en) 2020-09-10 2023-04-13 Genmab A/S Bispecific antibody against CD3 and CD20 in combination therapy for treating diffuse large B-cell lymphoma
WO2022053655A1 (en) 2020-09-10 2022-03-17 Genmab A/S Bispecific antibody against cd3 and cd20 in combination therapy for treating follicular lymphoma
MX2023002546A (en) 2020-09-10 2023-03-14 Genmab As Bispecific antibodies against cd3 and cd20 for treating chronic lymphocytic leukemia.
IL301098A (en) 2020-09-10 2023-05-01 Genmab As A bispecific antibody against CD3 and CD20 in combination therapy for the treatment of follicular lymphoma
AU2021380005A1 (en) 2020-11-11 2023-06-01 BioNTech SE Monoclonal antibodies directed against programmed death-1 protein and their use in medicine
WO2022130206A1 (en) 2020-12-16 2022-06-23 Pfizer Inc. TGFβr1 INHIBITOR COMBINATION THERAPIES
WO2022135666A1 (en) 2020-12-21 2022-06-30 BioNTech SE Treatment schedule for cytokine proteins
TW202245808A (en) 2020-12-21 2022-12-01 德商拜恩迪克公司 Therapeutic rna for treating cancer
WO2022135667A1 (en) 2020-12-21 2022-06-30 BioNTech SE Therapeutic rna for treating cancer
MX2023007846A (en) 2021-01-06 2023-07-07 Hoffmann La Roche Combination therapy employing a pd1-lag3 bispecific antibody and a cd20 t cell bispecific antibody.
TW202300521A (en) 2021-03-15 2023-01-01 美商建南德克公司 Compositions and methods of treating lupus nephritis
WO2022204282A1 (en) 2021-03-24 2022-09-29 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Bicistronic chimeric antigen receptors designed to reduce retroviral recombination and uses thereof
TW202304506A (en) 2021-03-25 2023-02-01 日商安斯泰來製藥公司 Combination therapy involving antibodies against claudin 18.2 for treatment of cancer
AU2022244125A1 (en) 2021-03-26 2023-10-19 BioNTech SE Combination therapy with an anti-ca19-9 antibody and folfirinox in the treatment of cancer
JP2024518709A (en) 2021-04-10 2024-05-02 プロファウンドバイオ ユーエス カンパニー FOLR1-BINDING AGENTS, CONJUGATS THEREOF AND METHODS OF USING SAME
EP4323000A1 (en) 2021-04-14 2024-02-21 Novartis AG Ofatumumab for treating multiple sclerosis in asian patients
WO2022226317A1 (en) 2021-04-23 2022-10-27 Profoundbio Us Co. Anti-cd70 antibodies, conjugates thereof and methods of using the same
WO2022229644A1 (en) 2021-04-28 2022-11-03 Mina Therapeutics Limited Combination therapies comprising c/ebp alpha sarna
TW202243689A (en) 2021-04-30 2022-11-16 瑞士商赫孚孟拉羅股份公司 Dosing for combination treatment with anti-cd20/anti-cd3 bispecific antibody and anti-cd79b antibody drug conjugate
TW202244059A (en) 2021-04-30 2022-11-16 瑞士商赫孚孟拉羅股份公司 Dosing for treatment with anti-cd20/anti-cd3 bispecific antibody
WO2022236047A1 (en) 2021-05-07 2022-11-10 Viela Bio, Inc. Use of an anti-cd19 antibody to treat myasthenia gravis
IL308351A (en) 2021-05-12 2024-01-01 Genentech Inc Methods of using anti-cd79b immunoconjugates to treat diffuse large b-cell lymphoma
WO2022251359A1 (en) 2021-05-26 2022-12-01 Theravance Biopharma R&D Ip, Llc Bicyclic inhibitors of alk5 and methods of use
EP4347647A1 (en) 2021-06-01 2024-04-10 Institut National de la Santé et de la Recherche Médicale (INSERM) Use of b cell depleting agents for the treatment of rheumatic heart disease
WO2022261018A1 (en) 2021-06-07 2022-12-15 Providence Health & Services - Oregon Cxcr5, pd-1, and icos expressing tumor reactive cd4 t cells and their use
WO2022262959A1 (en) 2021-06-15 2022-12-22 Astellas Pharma Europe Bv Bispecific binding agents binding to cldn18.2 and cd3
BR112023024657A2 (en) 2021-06-17 2024-02-20 Glaxosmithkline Intellectual Property Ltd ANTI-BAFF ANTIBODIES FOR USE IN A METHOD OF TREATMENT OF LONG COVID AND/OR ACUTE SEQUELARES POST-SARS-COV2 INFECTION (PASC)
EP4367269A1 (en) 2021-07-05 2024-05-15 Inserm (Institut National De La Sante Et De La Recherche Medicale) Gene signatures for predicting survival time in patients suffering from renal cell carcinoma
MX2024000674A (en) 2021-07-13 2024-02-07 BioNTech SE Multispecific binding agents against cd40 and cd137 in combination therapy for cancer.
US20240336697A1 (en) 2021-08-07 2024-10-10 Genentech, Inc. Methods of using anti-cd79b immunoconjugates to treat diffuse large b-cell lymphoma
WO2023020802A1 (en) 2021-08-16 2023-02-23 Novartis Ag Ofatumumab for treating pediatric ms
TW202333802A (en) 2021-10-11 2023-09-01 德商拜恩迪克公司 Therapeutic rna for lung cancer
JP2024540536A (en) 2021-11-19 2024-10-31 アーディアジェン コーポレーション GPC3 binding agents, conjugates thereof and methods of use thereof
US20230303693A1 (en) 2022-01-28 2023-09-28 Genmab A/S Bispecific antibody against cd3 and cd20 in combination therapy for treating diffuse large b-cell lymphoma
IL314344A (en) 2022-01-28 2024-09-01 Genmab As Bispecific antibody against cd3 and cd20 in combination therapy for treating diffuse large b-cell lymphoma
IL314211A (en) 2022-03-23 2024-09-01 Genentech Inc Combination treatment of an anti-cd20/anti-cd3 bispecific antibody and chemotherapy
WO2023198839A2 (en) 2022-04-13 2023-10-19 Genmab A/S Bispecific antibodies against cd3 and cd20
CN119013300A (en) 2022-04-13 2024-11-22 豪夫迈·罗氏有限公司 Pharmaceutical compositions of anti-CD 20/anti-CD 3 bispecific antibodies and methods of use
WO2023201369A1 (en) 2022-04-15 2023-10-19 Iovance Biotherapeutics, Inc. Til expansion processes using specific cytokine combinations and/or akti treatment
EP4522654A1 (en) 2022-05-12 2025-03-19 BioNTech SE Monoclonal antibodies directed against programmed death-1 protein and their use in medicine
CN116162153B (en) * 2022-09-01 2024-09-10 复旦大学附属中山医院 Monoclonal antibody of hepatitis B virus surface antigen and application thereof
WO2024052356A1 (en) 2022-09-06 2024-03-14 Institut National de la Santé et de la Recherche Médicale Inhibitors of the ceramide metabolic pathway for overcoming immunotherapy resistance in cancer
US20240174761A1 (en) 2022-11-02 2024-05-30 Genmab A/S Bispecific antibodies against cd3 and cd20 for treating richter's syndrome
WO2024094741A1 (en) 2022-11-03 2024-05-10 F. Hoffmann-La Roche Ag Combination therapy with anti-cd19/anti-cd28 bispecific antibody
TW202434286A (en) 2022-11-08 2024-09-01 美商建南德克公司 Compositions and methods of treating childhood onset idiopathic nephrotic syndrome
WO2024112571A2 (en) 2022-11-21 2024-05-30 Iovance Biotherapeutics, Inc. Two-dimensional processes for the expansion of tumor infiltrating lymphocytes and therapies therefrom
WO2024126457A1 (en) 2022-12-14 2024-06-20 Astellas Pharma Europe Bv Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and immune checkpoint inhibitors
WO2024153636A1 (en) 2023-01-17 2024-07-25 Institut National de la Santé et de la Recherche Médicale Vasorin as a biomarker and biotarget in nephrology
WO2024173607A2 (en) 2023-02-14 2024-08-22 Evolveimmune Therapeutics, Inc. Combination of bispecific antibodies and chimeric antigen receptor t cells for treatment
US20240285762A1 (en) 2023-02-28 2024-08-29 Juno Therapeutics, Inc. Cell therapy for treating systemic autoimmune diseases
WO2024213754A1 (en) 2023-04-13 2024-10-17 Genmab A/S Methods of treating lymphoma with bispecific antibodies against cd3 and cd20
WO2024213767A1 (en) 2023-04-14 2024-10-17 Institut National de la Santé et de la Recherche Médicale Engraftment of mesenchymal stromal cells engineered to stimulate immune infiltration in tumors
WO2024261302A1 (en) 2023-06-22 2024-12-26 Institut National de la Santé et de la Recherche Médicale Nlrp3 inhibitors, pak1/2 inhibitors and/or caspase 1 inhibitors for use in the treatment of rac2 monogenic disorders
WO2025003193A1 (en) 2023-06-26 2025-01-02 Institut National de la Santé et de la Recherche Médicale Sertraline and indatraline for disrupting intracellular cholesterol trafficking and subsequently inducing lysosomal damage and anti-tumor immunity
WO2025012417A1 (en) 2023-07-13 2025-01-16 Institut National de la Santé et de la Recherche Médicale Anti-neurotensin long fragment and anti-neuromedin n long fragment antibodies and uses thereof
WO2025021782A1 (en) 2023-07-24 2025-01-30 Institut National de la Santé et de la Recherche Médicale Methods of determining whether a subject suffering from lupus nephritis (ln) will achieve a response with an induction therapy
WO2025045894A1 (en) 2023-08-28 2025-03-06 Institut National de la Santé et de la Recherche Médicale Methods and kits for diagnosing cause of nephrotic syndrome and guiding therapy
WO2025052098A1 (en) 2023-09-08 2025-03-13 Mina Therapeutics Limited Tmem173 sarna compositions and methods of use

Family Cites Families (110)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4475196A (en) 1981-03-06 1984-10-02 Zor Clair G Instrument for locating faults in aircraft passenger reading light and attendant call control system
US4447233A (en) 1981-04-10 1984-05-08 Parker-Hannifin Corporation Medication infusion pump
US4474893A (en) 1981-07-01 1984-10-02 The University of Texas System Cancer Center Recombinant monoclonal antibodies
US4439196A (en) 1982-03-18 1984-03-27 Merck & Co., Inc. Osmotic drug delivery system
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4447224A (en) 1982-09-20 1984-05-08 Infusaid Corporation Variable flow implantable infusion apparatus
US4487603A (en) 1982-11-26 1984-12-11 Cordis Corporation Implantable microinfusion pump system
US4486194A (en) 1983-06-08 1984-12-04 James Ferrara Therapeutic device for administering medicaments through the skin
US4596556A (en) 1985-03-25 1986-06-24 Bioject, Inc. Hypodermic injection apparatus
US5374548A (en) 1986-05-02 1994-12-20 Genentech, Inc. Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor
MX9203291A (en) 1985-06-26 1992-08-01 Liposome Co Inc LIPOSOMAS COUPLING METHOD.
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
US5247069A (en) * 1986-06-13 1993-09-21 Oncogen Ligands and methods for augmenting B-cell proliferation
US5182368A (en) * 1986-06-13 1993-01-26 Ledbetter Jeffrey A Ligands and methods for augmenting B-cell proliferation
US4954617A (en) 1986-07-07 1990-09-04 Trustees Of Dartmouth College Monoclonal antibodies to FC receptors for immunoglobulin G on human mononuclear phagocytes
US4881175A (en) 1986-09-02 1989-11-14 Genex Corporation Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5260203A (en) 1986-09-02 1993-11-09 Enzon, Inc. Single polypeptide chain binding molecules
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
EP0307434B2 (en) 1987-03-18 1998-07-29 Scotgen Biopharmaceuticals, Inc. Altered antibodies
US5013653A (en) 1987-03-20 1991-05-07 Creative Biomolecules, Inc. Product and process for introduction of a hinge region into a fusion protein to facilitate cleavage
US5258498A (en) 1987-05-21 1993-11-02 Creative Biomolecules, Inc. Polypeptide linkers for production of biosynthetic proteins
AU612370B2 (en) 1987-05-21 1991-07-11 Micromet Ag Targeted multifunctional proteins
US5091513A (en) 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
US5132405A (en) 1987-05-21 1992-07-21 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
US4941880A (en) 1987-06-19 1990-07-17 Bioject, Inc. Pre-filled ampule and non-invasive hypodermic injection device assembly
US4790824A (en) 1987-06-19 1988-12-13 Bioject, Inc. Non-invasive hypodermic injection device
GB8717430D0 (en) 1987-07-23 1987-08-26 Celltech Ltd Recombinant dna product
US6218525B1 (en) * 1988-02-25 2001-04-17 The General Hospital Corporation Nucleic acid encoding CD28
US5506126A (en) * 1988-02-25 1996-04-09 The General Hospital Corporation Rapid immunoselection cloning method
GB8809129D0 (en) 1988-04-18 1988-05-18 Celltech Ltd Recombinant dna methods vectors and host cells
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5108921A (en) 1989-04-03 1992-04-28 Purdue Research Foundation Method for enhanced transmembrane transport of exogenous molecules
US5064413A (en) 1989-11-09 1991-11-12 Bioject, Inc. Needleless hypodermic injection device
US5312335A (en) 1989-11-09 1994-05-17 Bioject Inc. Needleless hypodermic injection device
US5877397A (en) 1990-08-29 1999-03-02 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5789650A (en) 1990-08-29 1998-08-04 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5770429A (en) * 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US6255458B1 (en) 1990-08-29 2001-07-03 Genpharm International High affinity human antibodies and human antibodies against digoxin
DE69127627T2 (en) 1990-08-29 1998-02-19 Genpharm Int Production and Use Non-human transgene heterologous antibodies for production
US5874299A (en) 1990-08-29 1999-02-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US6300129B1 (en) 1990-08-29 2001-10-09 Genpharm International Transgenic non-human animals for producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5814318A (en) 1990-08-29 1998-09-29 Genpharm International Inc. Transgenic non-human animals for producing heterologous antibodies
AU2235992A (en) 1991-06-14 1993-01-12 Genpharm International, Inc. Transgenic immunodeficient non-human animals
WO1993001227A1 (en) 1991-07-08 1993-01-21 University Of Massachusetts At Amherst Thermotropic liquid crystal segmented block copolymer
EP1715045A3 (en) 1991-07-25 2006-12-13 Biogen Idec Inc. Recombinant antibodies for human therapy
US5756096A (en) * 1991-07-25 1998-05-26 Idec Pharmaceuticals Corporation Recombinant antibodies for human therapy
US6136310A (en) * 1991-07-25 2000-10-24 Idec Pharmaceuticals Corporation Recombinant anti-CD4 antibodies for human therapy
MX9204374A (en) * 1991-07-25 1993-03-01 Idec Pharma Corp RECOMBINANT ANTIBODY AND METHOD FOR ITS PRODUCTION.
US5383851A (en) 1992-07-24 1995-01-24 Bioject Inc. Needleless hypodermic injection device
US5540926A (en) * 1992-09-04 1996-07-30 Bristol-Myers Squibb Company Soluble and its use in B cell stimulation
GB9223377D0 (en) 1992-11-04 1992-12-23 Medarex Inc Humanized antibodies to fc receptors for immunoglobulin on human mononuclear phagocytes
DE69303494T2 (en) * 1992-11-13 1997-01-16 Idec Pharma Corp THERAPEUTIC USE OF CHIMERIC AND LABELED ANTIBODIES AGAINST HUMAN B LYMPHOCYTIC LIMITED DIFFERENTIATION ANTIQUES FOR THE TREATMENT OF B CELL LYMPHOMA
US5736137A (en) * 1992-11-13 1998-04-07 Idec Pharmaceuticals Corporation Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
CA2161351C (en) 1993-04-26 2010-12-21 Nils Lonberg Transgenic non-human animals capable of producing heterologous antibodies
US6096878A (en) * 1993-05-10 2000-08-01 Japan Tobacco Inc. Human immunoglobulin VH gene segments and DNA fragments containing the same
US5595721A (en) * 1993-09-16 1997-01-21 Coulter Pharmaceutical, Inc. Radioimmunotherapy of lymphoma using anti-CD20
US6121022A (en) 1995-04-14 2000-09-19 Genentech, Inc. Altered polypeptides with increased half-life
EP1978033A3 (en) 1995-04-27 2008-12-24 Amgen Fremont Inc. Human antibodies derived from immunized xenomice
JP2000516594A (en) 1996-07-26 2000-12-12 スミスクライン・ビーチャム・コーポレイション Improved treatment of immune cell-mediated systemic diseases
US20010056066A1 (en) * 1996-07-26 2001-12-27 Smithkline Beecham Corporation Method of treating immune cell mediated systemic diseases
US6277375B1 (en) 1997-03-03 2001-08-21 Board Of Regents, The University Of Texas System Immunoglobulin-like domains with increased half-lives
US6183744B1 (en) 1997-03-24 2001-02-06 Immunomedics, Inc. Immunotherapy of B-cell malignancies using anti-CD22 antibodies
US6306393B1 (en) * 1997-03-24 2001-10-23 Immunomedics, Inc. Immunotherapy of B-cell malignancies using anti-CD22 antibodies
JP2001516766A (en) 1997-09-19 2001-10-02 デイナ−ファーバー キャンサー インスティチュート，インコーポレイテッド Intracellularly expressed antibody-mediated regulation of immune response
ATE395928T1 (en) 1997-12-24 2008-06-15 Ludwig Inst Cancer Res EXPRESSION VECTORS AND CELL LINES FOR EXPRESSING VASCULAR GROWTH FACTOR D, AND METHOD FOR TREATING MELANOMAS
US6194551B1 (en) 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
AU5097099A (en) 1998-07-16 2000-02-07 Vincent Marinkovich Methods and compositions for cancer treatment
CN101695574A (en) * 1998-08-11 2010-04-21 拜奥根Idec公司 Combination therapies for b-cell lymphomas comprising administration of anti-cd20 antibody
US6224866B1 (en) 1998-10-07 2001-05-01 Biocrystal Ltd. Immunotherapy of B cell involvement in progression of solid, nonlymphoid tumors
US20010033839A1 (en) * 1999-10-04 2001-10-25 Emilio Barbera-Guillem Vaccine and immunotherapy for solid nonlymphoid tumor and related immune dysregulation
BR9915164A (en) * 1998-11-09 2003-01-07 Idec Pharma Corp Treatment of hematologic malignancies associated with circulating tumor cells using chimeric anti-cd20 antibody
EP1131096B1 (en) 1998-11-09 2010-01-06 Biogen Idec Inc. Anti-cd20 antibody treatment of patients receiving bmt or pbsc transplants
NZ514914A (en) * 1999-05-07 2004-09-24 Genentech Inc Treatment of autoimmune diseases with antagonists which bind to B cell surface markers
CA2375912C (en) 1999-06-09 2014-03-11 Immunomedics, Inc. Immunotherapy of autoimmune disorders using antibodies which target b-cells
KR20080075044A (en) 1999-07-12 2008-08-13 제넨테크, 인크. Blocking immune response to foreign antigens using antagonists that bind to CD20
IL147765A0 (en) 1999-07-29 2002-08-14 Medarex Inc HUMAN MONOCLONAL ANTIBODIES TO HER2/neu
WO2001010462A1 (en) 1999-08-11 2001-02-15 Idec Pharmaceuticals Corporation Treatment of patients having non-hodgkins lymphoma with bone marrow involvement with anti-cd20 antibodies
US8557244B1 (en) 1999-08-11 2013-10-15 Biogen Idec Inc. Treatment of aggressive non-Hodgkins lymphoma with anti-CD20 antibody
PT1212422E (en) 1999-08-24 2007-04-30 Medarex Inc Human ctla-4 antibodies and their uses
US20020006404A1 (en) * 1999-11-08 2002-01-17 Idec Pharmaceuticals Corporation Treatment of cell malignancies using combination of B cell depleting antibody and immune modulating antibody related applications
EP1229935A1 (en) * 1999-11-08 2002-08-14 Idec Pharmaceuticals Corporation Treatment of b cell malignancies using anti-cd40l antibodies in combination with anti-cd20 antibodies and/or chemotherapeutics and radiotherapy
US20020028178A1 (en) * 2000-07-12 2002-03-07 Nabil Hanna Treatment of B cell malignancies using combination of B cell depleting antibody and immune modulating antibody related applications
DE60130538T2 (en) 2000-02-03 2008-06-12 Millenium Pharmaceuticals, Inc., Cambridge HUMANIZED ANTIBODIES TO CCR2 AND METHOD FOR THEIR USE
EP1125905A1 (en) 2000-02-16 2001-08-22 Pepscan Systems B.V. Segment synthesis
IL151906A0 (en) * 2000-03-24 2003-04-10 Chiron Corp Methods of therapy for non-hodgkin's lymphoma using a combination of an antibody to cd20 and interleukin-2
EP1272518A2 (en) * 2000-03-30 2003-01-08 Amgen, Inc. Cd20/ige-receptor like molecules and uses thereof
JP2004500412A (en) 2000-03-31 2004-01-08 アイデック　ファーマスーティカルズ　コーポレイション Combination of anti-cytokine antibody or antagonist and anti-CD20 for treatment of B-cell lymphoma
WO2001080884A1 (en) 2000-04-25 2001-11-01 Idec Pharmaceuticals Corporation Intrathecal administration of rituximab for treatment of central nervous system lymphomas
AU2001268363B2 (en) * 2000-06-20 2006-08-17 Biogen Idec Inc. Treatment of B cell associated diseases
JP2003535907A (en) 2000-06-22 2003-12-02 ユニバーシティ オブ アイオワ リサーチ ファウンデーション Method for promoting antibody-induced cell lysis and treating cancer
KR20030031957A (en) 2000-07-12 2003-04-23 아이덱 파마슈티칼즈 코포레이션 Treatment of b cell malignancies using combination of b cell depleting antibody and immune modulating antibody related applications
AU2001276018A1 (en) 2000-07-20 2002-02-05 Regents Of The University Of Minnesota Radiolabeled immunotoxins
EA013564B1 (en) * 2000-08-03 2010-06-30 Терапеутик Хьюман Поликлоналз Инк. Humanized immunoglobulin and pharmaceutical composition comprising thereof
US20020058029A1 (en) * 2000-09-18 2002-05-16 Nabil Hanna Combination therapy for treatment of autoimmune diseases using B cell depleting/immunoregulatory antibody combination
AU2002213357A1 (en) * 2000-10-20 2002-05-06 Idec Pharmaceuticals Corporation Variant igg3 rituxan r and therapeutic use thereof
ES2295228T3 (en) 2000-11-30 2008-04-16 Medarex, Inc. TRANSGROMIC TRANSCROMOSOMIC ROLLERS FOR THE PREPARATION OF HUMAN ANTIBODIES.
WO2002062946A2 (en) 2000-12-08 2002-08-15 Duke University Identification of novel ms4a gene family members expressed by hematopoietic cells
US20030133939A1 (en) 2001-01-17 2003-07-17 Genecraft, Inc. Binding domain-immunoglobulin fusion proteins
US7754208B2 (en) 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
US20020159996A1 (en) * 2001-01-31 2002-10-31 Kandasamy Hariharan Use of CD23 antagonists for the treatment of neoplastic disorders
EP2067486A1 (en) 2001-01-31 2009-06-10 Biogen Idec Inc. Use of CD23 antagonists for the treatment of neoplastic disorders
WO2002060485A2 (en) 2001-01-31 2002-08-08 Idec Pharmaceuticals Corporation Use of immunoregulatory antibodies in the treatment of neoplastic disorders
JP2005500018A (en) 2001-04-02 2005-01-06 アイデック ファーマスーティカルズ コーポレイション Recombinant antibody coexpressed with GnTIII
KR20090088973A (en) 2002-10-17 2009-08-20 젠맵 에이/에스 Human monoclonal antibodies against CD20
US20090169550A1 (en) 2007-12-21 2009-07-02 Genentech, Inc. Therapy of rituximab-refractory rheumatoid arthritis patients

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