FI970750A0 - Indoli-2,3-dioni-3-oksimijohdannaisia, niiden valmistus ja käyttö - Google Patents

Indoli-2,3-dioni-3-oksimijohdannaisia, niiden valmistus ja käyttö

Info

Publication number: FI970750A0
Authority: FI; Finland
Prior art keywords: pct; date; indole; preparation; oxime derivatives
Prior art date: 1994-09-14

Application number

FI970750A

Other languages

English (en)

Swedish (sv)

Other versions

FI112482B (fi

FI970750L (fi

Inventor

Peter Moldt

Frank Waetjen

Original Assignee

Neurosearch As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-09-14

Filing date

1997-02-21

Publication date

1997-02-21

1997-02-21 Application filed by Neurosearch As filed Critical Neurosearch As

1997-02-21 Publication of FI970750A0 publication Critical patent/FI970750A0/fi

1997-03-13 Publication of FI970750L publication Critical patent/FI970750L/fi

2003-12-15 Application granted granted Critical

2003-12-15 Publication of FI112482B publication Critical patent/FI112482B/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Psychiatry (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Toxicology (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Psychology (AREA)
Anesthesiology (AREA)
Addiction (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

FI970750A 1994-09-14 1997-02-21 6,7,8,9-tetrahydro-1H-pyrrolo[3,2-h]isokinoliini- ja 1,6,7,8-tetrahydrobentso[2,1-b;3,4-c]-2,3-dioni-3-oksiimijohdannaisia, menetelmä niiden valmistamiseksi ja niiden käyttö FI112482B (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK105394		1994-09-14
PCT/EP1995/003593 WO1996008494A1 (en)	1994-09-14	1995-09-12	Indole-2,3-dione-3-oxime derivatives, their preparation and use

Publications (3)

Publication Number	Publication Date
FI970750A0 true FI970750A0 (fi)	1997-02-21
FI970750L FI970750L (fi)	1997-03-13
FI112482B FI112482B (fi)	2003-12-15

Family

ID=8100455

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI970750A FI112482B (fi)	1994-09-14	1997-02-21	6,7,8,9-tetrahydro-1H-pyrrolo[3,2-h]isokinoliini- ja 1,6,7,8-tetrahydrobentso[2,1-b;3,4-c]-2,3-dioni-3-oksiimijohdannaisia, menetelmä niiden valmistamiseksi ja niiden käyttö

Country Status (12)

Country	Link
US (1)	US5917053A (fi)
EP (1)	EP0781284B1 (fi)
JP (1)	JP3164371B2 (fi)
AT (1)	ATE188700T1 (fi)
AU (1)	AU687255B2 (fi)
CA (1)	CA2199613C (fi)
DE (1)	DE69514532T2 (fi)
EE (1)	EE03355B1 (fi)
FI (1)	FI112482B (fi)
NO (1)	NO308852B1 (fi)
NZ (1)	NZ293265A (fi)
WO (1)	WO1996008494A1 (fi)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UA54403C2 (uk) *	1996-10-01	2003-03-17	Н'Юросерч А/С	Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму
DE69922936T2 (de) *	1998-03-31	2005-12-08	Neurosearch A/S	Verwendung von indol-2,3-dione-3-oximderivate als ampa-antagonisten
CA2369746A1 (en)	1999-05-19	2000-11-30	Neurosearch A/S	Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders
AU781067B2 (en)	2000-01-24	2005-05-05	Neurosearch A/S	Isatine derivatives with neurotrophic activity
WO2002064139A1 (en) *	2001-02-15	2002-08-22	Neurosearch A/S	Treatment of parkinson's disease by the combined action of a compound with neurotrophic activity and a compound enhancing the dopamine activity
BR0211140A (pt)	2001-07-13	2005-10-25	Upjohn Co	Compostos e composições de indóis de hexaidroazepina (4, 5-g) e indolinas como ligantes de receptores 5-ht
US7718641B2 (en)	2005-11-23	2010-05-18	Aros Pharma Aps	Pyrrolo [3,4-H] isoquinoline compounds and methods for modulating gated ion channels
WO2008031831A2 (en) *	2006-09-12	2008-03-20	Neurosearch A/S	Pharmaceutical compositions comprising combinations of an ampa/kainate antagonistic compound and an inhibitor of a multidrug resistance protein
US20150374705A1 (en)	2012-02-14	2015-12-31	Shanghai Institues for Biological Sciences	Substances for treatment or relief of pain

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE69677B1 (en) *	1989-12-11	1996-10-02	Neurosearch As	Isatine derivatives their preparation and use
CA2076948C (en) *	1991-08-28	2002-04-16	Frank Watjen	Isatineoxime derivatives, their preparation and use
AU680632B2 (en) *	1992-10-13	1997-08-07	Neurosearch A/S	Quinoxalinedione derivatives as EAA antagonists

1995
- 1995-09-12 NZ NZ293265A patent/NZ293265A/en unknown
- 1995-09-12 CA CA002199613A patent/CA2199613C/en not_active Expired - Fee Related
- 1995-09-12 EP EP95932729A patent/EP0781284B1/en not_active Expired - Lifetime
- 1995-09-12 JP JP50990796A patent/JP3164371B2/ja not_active Expired - Fee Related
- 1995-09-12 WO PCT/EP1995/003593 patent/WO1996008494A1/en active IP Right Grant
- 1995-09-12 US US08/809,082 patent/US5917053A/en not_active Expired - Lifetime
- 1995-09-12 DE DE69514532T patent/DE69514532T2/de not_active Expired - Lifetime
- 1995-09-12 AU AU35664/95A patent/AU687255B2/en not_active Ceased
- 1995-09-12 AT AT95932729T patent/ATE188700T1/de not_active IP Right Cessation
- 1995-09-12 EE EE9700052A patent/EE03355B1/xx not_active IP Right Cessation
1997
- 1997-02-21 FI FI970750A patent/FI112482B/fi active
- 1997-02-27 NO NO970904A patent/NO308852B1/no unknown

Also Published As

Publication number	Publication date
WO1996008494A1 (en)	1996-03-21
FI112482B (fi)	2003-12-15
NZ293265A (en)	1998-01-26
FI970750L (fi)	1997-03-13
NO970904L (no)	1997-04-24
CA2199613A1 (en)	1996-03-21
AU687255B2 (en)	1998-02-19
EP0781284A1 (en)	1997-07-02
NO970904D0 (no)	1997-02-27
JPH09511524A (ja)	1997-11-18
CA2199613C (en)	2000-02-29
ATE188700T1 (de)	2000-01-15
US5917053A (en)	1999-06-29
NO308852B1 (no)	2000-11-06
AU3566495A (en)	1996-03-29
EP0781284B1 (en)	2000-01-12
DE69514532D1 (de)	2000-02-17
EE03355B1 (et)	2001-02-15
DE69514532T2 (de)	2000-07-06
JP3164371B2 (ja)	2001-05-08

Publication	Publication Date	Title
NO308772B1 (no)	2000-10-30	Sublingual eller buckal farmasoytisk blanding inneholdende trans-5-klor-2-metyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oksepino[4,5-c]pyrrol, samt anvendelse av forbindelsen for fremstilling av farmasoytisk blanding
ES2103479T3 (es)	1997-09-16	Derivados de anilida.
KR960700707A (ko)	1996-02-24	맥관형성 억제제로서 유용한, 생물학적 활성의 3-치환된 옥신돌 유도체(Biologically active 3-substituted oxindole derivatives useful as anti-angiogenic agents)
PT95983A (pt)	1991-09-13	Processo de preparacao de novos derivados de iso-indolona
CA2258548A1 (en)	1997-12-31	Phenylamino-substituted tricyclic derivatives for treatment of hyperproliferative diseases
ES8404990A1 (es)	1984-05-16	Un procedimiento para la preparacion de derivados de prolina.
EA199700098A1 (ru)	1997-12-30	Производные индола, пригодные для лечения остеопороза
FI970750A0 (fi)	1997-02-21	Indoli-2,3-dioni-3-oksimijohdannaisia, niiden valmistus ja käyttö
ATE201671T1 (de)	2001-06-15	Chinolon und acridinon derivate zur behandlung der harninkontinenz
HUP0104469A2 (hu)	2002-04-29	Szubsztituált benzo[de]izokinolin-1,3-dion-származékok, eljárás a vegyületek előállítására és ezeket tartalmazó gyógyszerkészítmények
ATE85334T1 (de)	1993-02-15	Bisphenylalkylpiperazin-derivate, verfahren zur herstellung und arzneimittelzubereitung.
ATE204278T1 (de)	2001-09-15	Serotoninergische ergolin derivate
NO833528L (no)	1984-04-02	Fremgangsmaate for fremstilling av terapeutisk aktive fenyl-cyklobutan-derivater
TR199801069T2 (xx)	1998-08-21	Trisiklik 1,4-dihidro-1,4-diokso-1H-naftalen t�revleri ve bunlar�n terap�tik kullan�m�
FI955386A0 (fi)	1995-11-08	4-p-fluoribentsoyyli-1-piperidinyyli-propoksi-kromen-4-onijohdannaiset, niiden valmistus ja käyttö psykoosin ja skitsofrenian hoidossa
AP9901559A0 (en)	1999-06-30	Tricyclic 3-keto derivatives of 6-0-methylerythromycin.
ATE195072T1 (de)	2000-08-15	Verwendung von 6,7-substituierten-2- aminotetraline zur herstellung von pharmazeutischen zusammensetzungen zur behandlung von septischem schock, und antipyretischer und antientzündlicher zusammensetzungen
ATE212842T1 (de)	2002-02-15	Quinoxalin-derivate zur behandlung von tinnitus
NO912168L (no)	1991-12-09	Fremgangsmaate for fremstilling av terapeutisk aktive piperazinderivater.
ATE186912T1 (de)	1999-12-15	Carbamoylpyrrolidon-derivate zur behandlung von depressionen und cerebrovasculären störungen
DK1264836T3 (da)	2005-03-07	Fremgangsmåde til fremstilling af indolopyrrolocarbaxolderivater