FI923385A0 - Foerfarande foer framstaellning av en oral farmaceutisk sammansaettning som innehaoller cyklosporin. - Google Patents

Foerfarande foer framstaellning av en oral farmaceutisk sammansaettning som innehaoller cyklosporin.

Info

Publication number: FI923385A0
Authority: FI; Finland
Prior art keywords: cyklosporin; sammansaettning; parts; oral pharmaceutical; cyclosporin
Prior art date: 1990-11-27

Application number

FI923385A

Other languages

English (en)

Other versions

FI923385L (fi

Inventor

Erno Orban

Laszlone Tomori

Maria Kurthy

Tibor Balogh

Laszlo Jaszlits

Imre Moravcsik

Istvan Kovacs

Istvanne Jusztin

Sandor Jancso

Erzsebet Takacs

Tamasne Kiss

Antalne Kovacs

Original Assignee

Biogal Gyogyszergyar

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-11-27

Filing date

1992-07-27

Publication date

1992-07-27

1992-07-27 Application filed by Biogal Gyogyszergyar filed Critical Biogal Gyogyszergyar

1992-07-27 Publication of FI923385L publication Critical patent/FI923385L/fi

1992-07-27 Publication of FI923385A0 publication Critical patent/FI923385A0/fi

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 abstract 3
108010036949 Cyclosporine Proteins 0.000 abstract 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 3
229930105110 Cyclosporin A Natural products 0.000 abstract 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
229960001265 ciclosporin Drugs 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
ZMKGDQSIRSGUDJ-VSROPUKISA-N (3s,6s,9s,12r,15s,18s,21s,24s,30s,33s)-33-[(e,1r,2r)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-30-propyl-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,1 Chemical compound CCC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O ZMKGDQSIRSGUDJ-VSROPUKISA-N 0.000 abstract 1
ZMKGDQSIRSGUDJ-UHFFFAOYSA-N NVa2 cyclosporine Natural products CCCC1NC(=O)C(C(O)C(C)CC=CC)N(C)C(=O)C(C(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)N(C)C(=O)C(C(C)C)NC(=O)C(CC(C)C)N(C)C(=O)CN(C)C1=O ZMKGDQSIRSGUDJ-UHFFFAOYSA-N 0.000 abstract 1
229920003171 Poly (ethylene oxide) Polymers 0.000 abstract 1
238000010521 absorption reaction Methods 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
229930182912 cyclosporin Natural products 0.000 abstract 1
108010019249 cyclosporin G Proteins 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
229940100688 oral solution Drugs 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
229920000642 polymer Polymers 0.000 abstract 1
-1 polyoxyethylene Polymers 0.000 abstract 1
229920001451 polypropylene glycol Polymers 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Immunology (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Transplantation (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

FI923385A 1990-11-27 1992-07-27 Foerfarande foer framstaellning av en oral farmaceutisk sammansaettning som innehaoller cyklosporin. FI923385A0 (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HU907653A HU208491B (en)	1990-11-27	1990-11-27	Process for producing oral pharmaceutical composition containing cyclosporin
PCT/HU1991/000050 WO1992009299A1 (en)	1990-11-27	1991-11-27	Oral pharmaceutical composition containing cyclosporin and process for preparing same

Publications (2)

Publication Number	Publication Date
FI923385L FI923385L (fi)	1992-07-27
FI923385A0 true FI923385A0 (fi)	1992-07-27

Family

ID=10972318

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI923385A FI923385A0 (fi)	1990-11-27	1992-07-27	Foerfarande foer framstaellning av en oral farmaceutisk sammansaettning som innehaoller cyklosporin.

Country Status (18)

Country	Link
US (1)	US5430017A (fi)
EP (1)	EP0512109B1 (fi)
JP (1)	JPH082795B2 (fi)
AT (1)	ATE129898T1 (fi)
AU (1)	AU651154B2 (fi)
CA (1)	CA2072983A1 (fi)
CS (1)	CS230492A3 (fi)
DE (1)	DE69114476T2 (fi)
DK (1)	DK0512109T3 (fi)
FI (1)	FI923385A0 (fi)
HU (1)	HU208491B (fi)
IL (1)	IL100162A (fi)
MX (1)	MX9102243A (fi)
NO (1)	NO922961L (fi)
NZ (1)	NZ240762A (fi)
PT (1)	PT99623A (fi)
WO (1)	WO1992009299A1 (fi)
ZA (1)	ZA919352B (fi)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ247516A (en) *	1993-04-28	1995-02-24	Bernard Charles Sherman	Water dispersible pharmaceutical compositions comprising drug dissolved in solvent system comprising at least one alcohol and at least one surfactant
DE4340781C3 (de) *	1993-11-30	2000-01-27	Novartis Ag	Cyclosporin enthaltende flüssige Zubereitungen und Verfahren zu ihrer Herstellung
DK0789580T3 (da)	1994-11-03	2002-09-09	Novartis Ag	Nye præparatformer for cyclosporin til oral administration med simpel sammensætning og høj biotilgængelighed, og fremgangsmåder til deres fremstilling
HU215966B (hu) *	1994-11-21	1999-07-28	BIOGAL Gyógyszergyár Rt.	Orálisan alkalmazható, ciklosporint tartalmazó, összetett emulzió-előkoncentrátum
US6022536A (en) *	1995-08-09	2000-02-08	Schering Corporation	Combined use of interleukin 10 and cyclosporin for immunosuppression therapy
US5766629A (en)	1995-08-25	1998-06-16	Sangstat Medical Corporation	Oral cyclosporin formulations
US5834017A (en) *	1995-08-25	1998-11-10	Sangstat Medical Corporation	Oral cyclopsporin formulations
US5827822A (en) *	1996-03-25	1998-10-27	Sangstat Medical Corporation	Cyclosporin a formulations as nanoparticles
AU764599B2 (en) *	1995-08-25	2003-08-21	Sangstat Medical Corporation	Oral cyclosporin formulations
US5962019A (en) *	1995-08-25	1999-10-05	Sangstat Medical Corporation	Oral cyclosporin formulations
WO1997007787A1 (en) *	1995-08-25	1997-03-06	Sangstat Medical Corporation	Oral cyclosporin formulations
KR20050084502A (ko)	1997-01-30	2005-08-26	노파르티스 아게	오일을 함유하지 않은 사이클로스포린 ａ 함유 제약 조성물
DE69828496T2 (de) *	1997-03-12	2006-03-23	Abbott Laboratories, Abbott Park	Hydrophile binäre systeme zur verabreichung von cyclosporin
US5891845A (en) *	1997-11-21	1999-04-06	Fuisz Technologies Ltd.	Drug delivery systems utilizing liquid crystal structures
GB9826656D0 (en)	1998-12-03	1999-01-27	Novartis Ag	Organic compounds
US7026290B1 (en)	1998-12-30	2006-04-11	Dexcel Ltd.	Dispersible concentrate for the delivery of cyclosprin
US7732404B2 (en)	1999-12-30	2010-06-08	Dexcel Ltd	Pro-nanodispersion for the delivery of cyclosporin

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE290460C (fi) *
DE2907460A1 (de) *	1978-03-07	1979-09-13	Sandoz Ag	Neue resorbierbare galenische kompositionen
CH641356A5 (en) *	1979-02-27	1984-02-29	Sandoz Ag	Pharmaceutical compositions containing cyclosporin
GB8903804D0 (en) *	1989-02-20	1989-04-05	Sandoz Ltd	Improvements in or relating to organic compounds
US4649047A (en) *	1985-03-19	1987-03-10	University Of Georgia Research Foundation, Inc.	Ophthalmic treatment by topical administration of cyclosporin
SE8601624D0 (sv) *	1986-04-11	1986-04-11	Haessle Ab	New pharmaceutical preparations
CA1323306C (en) *	1987-03-05	1993-10-19	Mircea C. Popescu	Pharmacological agent-lipid solution preparation
JP2577049B2 (ja) *	1987-06-04	1997-01-29	三共株式会社	シクロスポリン製剤
KR0148748B1 (ko) *	1988-09-16	1998-08-17	장 크라메르, 한스 루돌프 하우스	사이클로스포린을 함유하는 약학조성물
GB2230440B (en) *	1989-02-09	1993-05-19	Sandoz Ltd	Novel cyclosporin galenic forms
US4996193A (en) *	1989-03-03	1991-02-26	The Regents Of The University Of California	Combined topical and systemic method of administration of cyclosporine

1990
- 1990-11-27 HU HU907653A patent/HU208491B/hu unknown
1991
- 1991-11-27 ZA ZA919352A patent/ZA919352B/xx unknown
- 1991-11-27 IL IL10016291A patent/IL100162A/en not_active IP Right Cessation
- 1991-11-27 EP EP92902040A patent/EP0512109B1/en not_active Expired - Lifetime
- 1991-11-27 MX MX9102243A patent/MX9102243A/es unknown
- 1991-11-27 AU AU89440/91A patent/AU651154B2/en not_active Ceased
- 1991-11-27 DE DE69114476T patent/DE69114476T2/de not_active Expired - Fee Related
- 1991-11-27 NZ NZ240762A patent/NZ240762A/xx unknown
- 1991-11-27 DK DK92902040.2T patent/DK0512109T3/da active
- 1991-11-27 CA CA002072983A patent/CA2072983A1/en not_active Abandoned
- 1991-11-27 PT PT99623A patent/PT99623A/pt not_active Application Discontinuation
- 1991-11-27 JP JP4500525A patent/JPH082795B2/ja not_active Expired - Lifetime
- 1991-11-27 AT AT92902040T patent/ATE129898T1/de not_active IP Right Cessation
- 1991-11-27 WO PCT/HU1991/000050 patent/WO1992009299A1/en not_active Application Discontinuation
1992
- 1992-07-23 CS CS922304A patent/CS230492A3/cs unknown
- 1992-07-27 NO NO92922961A patent/NO922961L/no unknown
- 1992-07-27 FI FI923385A patent/FI923385A0/fi not_active Application Discontinuation
1993
- 1993-05-20 US US07/915,719 patent/US5430017A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JPH082795B2 (ja)	1996-01-17
FI923385L (fi)	1992-07-27
NO922961D0 (no)	1992-07-27
DE69114476D1 (de)	1995-12-14
HU907653D0 (en)	1991-06-28
IL100162A0 (en)	1992-08-18
HU208491B (en)	1993-11-29
MX9102243A (es)	1992-07-08
EP0512109A1 (en)	1992-11-11
EP0512109B1 (en)	1995-11-08
NO922961L (no)	1992-09-23
ZA919352B (en)	1992-09-30
US5430017A (en)	1995-07-04
CA2072983A1 (en)	1992-05-28
PT99623A (pt)	1992-12-31
DE69114476T2 (de)	1996-04-18
AU651154B2 (en)	1994-07-14
NZ240762A (en)	1993-05-26
CS230492A3 (en)	1992-12-16
HUT60929A (en)	1992-11-30
IL100162A (en)	1995-11-27
WO1992009299A1 (en)	1992-06-11
ATE129898T1 (de)	1995-11-15
AU8944091A (en)	1992-06-25
JPH05503306A (ja)	1993-06-03
DK0512109T3 (da)	1995-12-11

Publication	Publication Date	Title
FI923385A0 (fi)	1992-07-27	Foerfarande foer framstaellning av en oral farmaceutisk sammansaettning som innehaoller cyklosporin.
ES2110377T1 (es)	1998-02-16	Formulacion galenica de fenofibrato y aplicacion de la misma.
DE60019693D1 (de)	2005-06-02	Pharmazeutische zusammensetzungen, die wirkstoffabsorptionsfördernde verbindungen enthalten
HUP0300836A2 (hu)	2003-08-28	Taxánokat tartalmazó szájon át beadható gyógyszerkészítmények és ezek alkalmazása
ATE113604T1 (de)	1994-11-15	Mometason-furoate-monohydrat, verfahren zu seiner herstellung und das enthaltende pharmazeutische zusammensetzungen.
CA2183972A1 (en)	1995-09-21	Oxazolidinone derivatives and pharmaceutical compositions containing them
EP0368388A3 (en)	1991-07-17	3-Piperidinyl-1,2-benzisoxazoles
TR200100894T2 (tr)	2001-10-22	Aril ikameli propanolamin türevleri, imalat yöntemleri, ilaç maddeleri, kullanımları.
ES2135743T3 (es)	1999-11-01	Procedimiento para eliminar sales biliares de un paciente y composiciones alquiladas para ello.
ATE84032T1 (de)	1993-01-15	Benzimidazolderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische praeparate.
DE3882679D1 (de)	1993-09-02	Kardiovaskulaer aktive verbindungen.
CA2094806A1 (en)	1992-05-08	Aminosulfonyl urea acat inhibitors
PT77309B (de)	1986-04-18	Isochinolinderivate verfahren zu ihrer herstellung pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung
HUT50787A (en)	1990-03-28	Process for producing pharmaceutical compositions comprising 4-aryl-4-piperidine-, pyrrolidine- or hexahydroazepincarbinol derivatives or heterocyclic analogs thereof as active ingredient and process for producing the new compounds
SE8006550L (sv)	1980-09-18	Farmakologisk komposition, samt sett for dess framstellning
NO905378L (no)	1991-06-24	Fremgangsmaate for fremstilling av terapeutisk aktive diazinderivater
PT75492B (de)	1985-05-31	Sulfonylharnstoffe verfahren zu ihrer herstellung pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung
DK1061938T3 (da)	2002-02-11	Orale sammensætninger med cytotoksiske proteiner i lav dosis
DE69307071D1 (de)	1997-02-13	Kardioaktive 17B-aryl und 17B-heterozyklyl-5-beta,14-beta-Androstan-Derivate,ein Verfahren zu ihrer Herstellung und pharmazeutische Phäparate davon
DE3850044D1 (de)	1994-07-14	Azelastin-Embonat, Verfahren zu seiner Herstellung und pharmazeutische Zubereitungen, die als Wirkstoff Azelastin-Embonat enthalten.
ATE75619T1 (de)	1992-05-15	Bestaendige therapeutische zusammensetzungen, basierend auf hydrophobem pflanzlichem oel und verfahren zu ihrer herstellung.
YU186691A (sh)	1994-05-10	Postupak za dobijanje oralnog farmaceutskog preparata koji sadrži ciklosporin
ATE92037T1 (de)	1993-08-15	Kardiovaskulaer aktive verbindungen.
TH57759A3 (th)	2003-08-20	ยาเม็ดที่มีการปลดปล่อยในทันที
JO1653B1 (en)	1991-11-27	The current benzimidazole is a therapeutically active method for preparing it

Legal Events

Date	Code	Title	Description
1996-06-19	FD	Application lapsed