ATE129898T1 - Cyclosporin enthaltende orale pharmazeutische zusammensetzung sowie verfahren zu deren herstellung. - Google Patents

Cyclosporin enthaltende orale pharmazeutische zusammensetzung sowie verfahren zu deren herstellung.

Info

Publication number: ATE129898T1
Authority: AT; Austria
Prior art keywords: pharmaceutical composition; parts; cyclosporin; production; composition containing
Prior art date: 1990-11-27

Application number

AT92902040T

Other languages

English (en)

Inventor

Ernoe Orban

Laszlone Tomori

Maria Kuerthy

Tibor Balogh

Laszlo Jaszlits

Imre Moravcsik

Istvan Kovacs

Istvanne Jusztin

Sandor Jancso

Erzsebet Takacs

Tamasne Kiss

Antalne Kovacs

Original Assignee

Biogal Gyogyszergyar

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-11-27

Filing date

1991-11-27

Publication date

1995-11-15

1991-11-27 Application filed by Biogal Gyogyszergyar filed Critical Biogal Gyogyszergyar

1995-11-15 Application granted granted Critical

1995-11-15 Publication of ATE129898T1 publication Critical patent/ATE129898T1/de

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 4
108010036949 Cyclosporine Proteins 0.000 title abstract 4
229960001265 ciclosporin Drugs 0.000 title abstract 3
229930182912 cyclosporin Natural products 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title abstract 2
239000008203 oral pharmaceutical composition Substances 0.000 title 1
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 3
229930105110 Cyclosporin A Natural products 0.000 abstract 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
ZMKGDQSIRSGUDJ-VSROPUKISA-N (3s,6s,9s,12r,15s,18s,21s,24s,30s,33s)-33-[(e,1r,2r)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-30-propyl-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,1 Chemical compound CCC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O ZMKGDQSIRSGUDJ-VSROPUKISA-N 0.000 abstract 1
ZMKGDQSIRSGUDJ-UHFFFAOYSA-N NVa2 cyclosporine Natural products CCCC1NC(=O)C(C(O)C(C)CC=CC)N(C)C(=O)C(C(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)N(C)C(=O)C(C(C)C)NC(=O)C(CC(C)C)N(C)C(=O)CN(C)C1=O ZMKGDQSIRSGUDJ-UHFFFAOYSA-N 0.000 abstract 1
229920003171 Poly (ethylene oxide) Polymers 0.000 abstract 1
238000010521 absorption reaction Methods 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
108010019249 cyclosporin G Proteins 0.000 abstract 1
229940100688 oral solution Drugs 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
229920000642 polymer Polymers 0.000 abstract 1
-1 polyoxyethylene Polymers 0.000 abstract 1
229920001451 polypropylene glycol Polymers 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Immunology (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Transplantation (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT92902040T 1990-11-27 1991-11-27 Cyclosporin enthaltende orale pharmazeutische zusammensetzung sowie verfahren zu deren herstellung. ATE129898T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HU907653A HU208491B (en)	1990-11-27	1990-11-27	Process for producing oral pharmaceutical composition containing cyclosporin

Publications (1)

Publication Number	Publication Date
ATE129898T1 true ATE129898T1 (de)	1995-11-15

Family

ID=10972318

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92902040T ATE129898T1 (de)	1990-11-27	1991-11-27	Cyclosporin enthaltende orale pharmazeutische zusammensetzung sowie verfahren zu deren herstellung.

Country Status (18)

Country	Link
US (1)	US5430017A (de)
EP (1)	EP0512109B1 (de)
JP (1)	JPH082795B2 (de)
AT (1)	ATE129898T1 (de)
AU (1)	AU651154B2 (de)
CA (1)	CA2072983A1 (de)
CS (1)	CS230492A3 (de)
DE (1)	DE69114476T2 (de)
DK (1)	DK0512109T3 (de)
FI (1)	FI923385A7 (de)
HU (1)	HU208491B (de)
IL (1)	IL100162A (de)
MX (1)	MX9102243A (de)
NO (1)	NO922961L (de)
NZ (1)	NZ240762A (de)
PT (1)	PT99623A (de)
WO (1)	WO1992009299A1 (de)
ZA (1)	ZA919352B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ247516A (en) *	1993-04-28	1995-02-24	Bernard Charles Sherman	Water dispersible pharmaceutical compositions comprising drug dissolved in solvent system comprising at least one alcohol and at least one surfactant
DE4340781C3 (de) *	1993-11-30	2000-01-27	Novartis Ag	Cyclosporin enthaltende flüssige Zubereitungen und Verfahren zu ihrer Herstellung
EP0789580B1 (de)	1994-11-03	2002-06-05	Novartis AG	Neue zubereitungsformen des cyclosporins zur oralen applikation mit einfacher zusammensetzung und hoher bioverfügbarkeit und verfahren zu deren herstellung
HU215966B (hu) *	1994-11-21	1999-07-28	BIOGAL Gyógyszergyár Rt.	Orálisan alkalmazható, ciklosporint tartalmazó, összetett emulzió-előkoncentrátum
US6022536A (en) *	1995-08-09	2000-02-08	Schering Corporation	Combined use of interleukin 10 and cyclosporin for immunosuppression therapy
US5834017A (en) *	1995-08-25	1998-11-10	Sangstat Medical Corporation	Oral cyclopsporin formulations
US5766629A (en) *	1995-08-25	1998-06-16	Sangstat Medical Corporation	Oral cyclosporin formulations
US5827822A (en) *	1996-03-25	1998-10-27	Sangstat Medical Corporation	Cyclosporin a formulations as nanoparticles
US5962019A (en) *	1995-08-25	1999-10-05	Sangstat Medical Corporation	Oral cyclosporin formulations
AU764599B2 (en) *	1995-08-25	2003-08-21	Sangstat Medical Corporation	Oral cyclosporin formulations
ATE263550T1 (de) *	1995-08-25	2004-04-15	Sangstat Medical Corp	Orale cyclosporinformulierungen
HUP0001013A3 (en)	1997-01-30	2004-10-28	Novartis Ag	Oil-free pharmaceutical compositions containing cyclosporin a
CA2284000C (en) *	1997-03-12	2012-01-03	Abbott Laboratories	Hydrophilic binary systems for the administration of cyclosporine
US5891845A (en) *	1997-11-21	1999-04-06	Fuisz Technologies Ltd.	Drug delivery systems utilizing liquid crystal structures
GB9826656D0 (en)	1998-12-03	1999-01-27	Novartis Ag	Organic compounds
US7026290B1 (en)	1998-12-30	2006-04-11	Dexcel Ltd.	Dispersible concentrate for the delivery of cyclosprin
US7732404B2 (en)	1999-12-30	2010-06-08	Dexcel Ltd	Pro-nanodispersion for the delivery of cyclosporin

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE290460C (de) *
DE2907460A1 (de) *	1978-03-07	1979-09-13	Sandoz Ag	Neue resorbierbare galenische kompositionen
CH641356A5 (en) *	1979-02-27	1984-02-29	Sandoz Ag	Pharmaceutical compositions containing cyclosporin
GB8903804D0 (en) *	1989-02-20	1989-04-05	Sandoz Ltd	Improvements in or relating to organic compounds
US4649047A (en) *	1985-03-19	1987-03-10	University Of Georgia Research Foundation, Inc.	Ophthalmic treatment by topical administration of cyclosporin
SE8601624D0 (sv) *	1986-04-11	1986-04-11	Haessle Ab	New pharmaceutical preparations
CA1323306C (en) *	1987-03-05	1993-10-19	Mircea C. Popescu	Pharmacological agent-lipid solution preparation
JP2577049B2 (ja) *	1987-06-04	1997-01-29	三共株式会社	シクロスポリン製剤
KR0148748B1 (ko) *	1988-09-16	1998-08-17	장 크라메르, 한스 루돌프 하우스	사이클로스포린을 함유하는 약학조성물
GB2230440B (en) *	1989-02-09	1993-05-19	Sandoz Ltd	Novel cyclosporin galenic forms
US4996193A (en) *	1989-03-03	1991-02-26	The Regents Of The University Of California	Combined topical and systemic method of administration of cyclosporine

1990
- 1990-11-27 HU HU907653A patent/HU208491B/hu unknown
1991
- 1991-11-27 NZ NZ240762A patent/NZ240762A/xx unknown
- 1991-11-27 FI FI923385A patent/FI923385A7/fi not_active Application Discontinuation
- 1991-11-27 EP EP92902040A patent/EP0512109B1/de not_active Expired - Lifetime
- 1991-11-27 MX MX9102243A patent/MX9102243A/es unknown
- 1991-11-27 IL IL10016291A patent/IL100162A/en not_active IP Right Cessation
- 1991-11-27 CA CA002072983A patent/CA2072983A1/en not_active Abandoned
- 1991-11-27 DK DK92902040.2T patent/DK0512109T3/da active
- 1991-11-27 JP JP4500525A patent/JPH082795B2/ja not_active Expired - Lifetime
- 1991-11-27 ZA ZA919352A patent/ZA919352B/xx unknown
- 1991-11-27 AU AU89440/91A patent/AU651154B2/en not_active Ceased
- 1991-11-27 WO PCT/HU1991/000050 patent/WO1992009299A1/en not_active Application Discontinuation
- 1991-11-27 PT PT99623A patent/PT99623A/pt not_active Application Discontinuation
- 1991-11-27 AT AT92902040T patent/ATE129898T1/de not_active IP Right Cessation
- 1991-11-27 DE DE69114476T patent/DE69114476T2/de not_active Expired - Fee Related
1992
- 1992-07-23 CS CS922304A patent/CS230492A3/cs unknown
- 1992-07-27 NO NO92922961A patent/NO922961L/no unknown
1993
- 1993-05-20 US US07/915,719 patent/US5430017A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0512109A1 (de)	1992-11-11
NZ240762A (en)	1993-05-26
IL100162A (en)	1995-11-27
ZA919352B (en)	1992-09-30
AU8944091A (en)	1992-06-25
IL100162A0 (en)	1992-08-18
HU208491B (en)	1993-11-29
CA2072983A1 (en)	1992-05-28
NO922961D0 (no)	1992-07-27
FI923385L (fi)	1992-07-27
PT99623A (pt)	1992-12-31
CS230492A3 (en)	1992-12-16
DE69114476D1 (de)	1995-12-14
WO1992009299A1 (en)	1992-06-11
FI923385A0 (fi)	1992-07-27
FI923385A7 (fi)	1992-07-27
NO922961L (no)	1992-09-23
AU651154B2 (en)	1994-07-14
HU907653D0 (en)	1991-06-28
HUT60929A (en)	1992-11-30
US5430017A (en)	1995-07-04
DE69114476T2 (de)	1996-04-18
DK0512109T3 (da)	1995-12-11
JPH082795B2 (ja)	1996-01-17
MX9102243A (es)	1992-07-08
JPH05503306A (ja)	1993-06-03
EP0512109B1 (de)	1995-11-08

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Legal Events

Date	Code	Title	Description
1996-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties