FI84349C - Foerfarande foer framstaellning av en farmakologiskt vaerdefull foerening. - Google Patents

Foerfarande foer framstaellning av en farmakologiskt vaerdefull foerening. Download PDF

Info

Publication number: FI84349C
Authority: FI; Finland
Prior art keywords: methyl; formula; tetrahydro; compound; carbazol
Prior art date: 1984-01-25

Application number

FI850323A

Other languages

English (en)

Finnish (fi)

Swedish (sv)

Other versions

FI850323L (fi

FI850323A0 (fi

FI84349B (fi

Inventor

Ian Harold Coates

David Cedric Humber

James Angus Bell

George Blanch Ewan

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-01-25

Filing date

1985-01-25

Publication date

1991-11-25

1984-01-25 Priority claimed from GB848401888A external-priority patent/GB8401888D0/en

1984-10-15 Priority claimed from GB848425959A external-priority patent/GB8425959D0/en

1985-01-25 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

1985-01-25 Publication of FI850323A0 publication Critical patent/FI850323A0/fi

1985-07-26 Publication of FI850323L publication Critical patent/FI850323L/fi

1991-08-15 Application granted granted Critical

1991-08-15 Publication of FI84349B publication Critical patent/FI84349B/fi

1991-11-25 Publication of FI84349C publication Critical patent/FI84349C/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

FI850323A 1984-01-25 1985-01-25 Foerfarande foer framstaellning av en farmakologiskt vaerdefull foerening. FI84349C (fi)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB848401888A GB8401888D0 (en)	1984-01-25	1984-01-25	Heterocyclic compounds
GB8425959		1984-10-15
GB848425959A GB8425959D0 (en)	1984-10-15	1984-10-15	Heterocyclic compounds
GB8401888		1985-01-25

Publications (4)

Publication Number	Publication Date
FI850323A0 FI850323A0 (fi)	1985-01-25
FI850323L FI850323L (fi)	1985-07-26
FI84349B FI84349B (fi)	1991-08-15
FI84349C true FI84349C (fi)	1991-11-25

Family

ID=26287221

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI850323A FI84349C (fi)	1984-01-25	1985-01-25	Foerfarande foer framstaellning av en farmakologiskt vaerdefull foerening.

Country Status (29)

Country	Link
KR (1)	KR920003064B1 (fr)
AT (1)	AT392276B (fr)
AU (1)	AU579132B2 (fr)
BE (1)	BE901576A (fr)
CA (1)	CA1252793A (fr)
CH (1)	CH664152A5 (fr)
CY (1)	CY1479A (fr)
CZ (1)	CZ404391A3 (fr)
DE (2)	DE3502508A1 (fr)
DK (1)	DK169521B1 (fr)
ES (3)	ES8609309A1 (fr)
FI (1)	FI84349C (fr)
FR (1)	FR2561244B1 (fr)
GB (1)	GB2153821B (fr)
GR (1)	GR850219B (fr)
HK (1)	HK33189A (fr)
HU (1)	HU193592B (fr)
IE (1)	IE57809B1 (fr)
IL (1)	IL74165A (fr)
IT (1)	IT1182150B (fr)
LU (2)	LU88268I2 (fr)
NL (2)	NL190373C (fr)
NO (2)	NO164025C (fr)
NZ (1)	NZ210940A (fr)
PH (1)	PH22672A (fr)
PT (1)	PT79890B (fr)
SE (1)	SE460359B (fr)
SG (1)	SG7089G (fr)
SK (1)	SK277923B6 (fr)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4695578A (en) *	1984-01-25	1987-09-22	Glaxo Group Limited	1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances
DE3680123D1 (en) *	1985-01-23	1991-08-14	Glaxo Group Ltd	Tetrahydrocarbazolonderivate.
DE3689974T2 (de) *	1985-03-14	1994-11-03	Beecham Group Plc	Arzneimittel zur Behandlung von Emesis.
GB8516083D0 (en) *	1985-06-25	1985-07-31	Glaxo Group Ltd	Heterocyclic compounds
US5578628A (en) *	1985-06-25	1996-11-26	Glaxo Group Limited	Medicaments for the treatment of nausea and vomiting
GB8518742D0 (en) *	1985-07-24	1985-08-29	Glaxo Group Ltd	Process
US5204356A (en) *	1985-07-24	1993-04-20	Glaxo Group Limited	Treatment of anxiety
GB8518658D0 (en) *	1985-07-24	1985-08-29	Glaxo Group Ltd	Medicaments
GB8518741D0 (en) *	1985-07-24	1985-08-29	Glaxo Group Ltd	Process
GB8518743D0 (en) *	1985-07-24	1985-08-29	Glaxo Group Ltd	Heterocyclic compounds
GB8518745D0 (en)	1985-07-24	1985-08-29	Glaxo Group Ltd	Heterocyclic compounds
GB8617994D0 (en) *	1986-07-23	1986-08-28	Glaxo Group Ltd	Heterocyclic compounds
NL8701682A (nl) *	1986-07-30	1988-02-16	Sandoz Ag	Werkwijze voor het therapeutisch toepassen van serotonine antagonisten, aktieve verbindingen en farmaceutische preparaten die deze verbindingen bevatten.
AT396870B (de) *	1986-08-07	1993-12-27	Sandoz Ag	Verfahren zur herstellung einer galenischen formulierung zur nasalen verabreichung von serotoninantagonisten
GB8623819D0 (en) *	1986-10-03	1986-11-05	Glaxo Group Ltd	Heterocyclic compounds
DE3777805D1 (de) *	1986-11-21	1992-04-30	Glaxo Group Ltd	Arzneimittel zur behandlung oder vorbeugung des entzugssyndromes.
GB8627909D0 (en) *	1986-11-21	1986-12-31	Glaxo Group Ltd	Medicaments
GR871809B (en) *	1986-11-28	1988-03-07	Glaxo Group Ltd	Process for the preparation of tricyclic ketones
GB8812002D0 (en) *	1988-05-20	1988-06-22	Glaxo Group Ltd	Chemical compounds
US5202343A (en) *	1986-11-28	1993-04-13	Glaxo Group Limited	Tricyclic ketones useful as HT3 -receptor antagonists
GB8628475D0 (en) *	1986-11-28	1987-01-07	Glaxo Group Ltd	Medicaments
US4973594A (en) *	1986-12-17	1990-11-27	Glaxo Group Limited	Medicaments
US5200414A (en) *	1986-12-17	1993-04-06	Glaxo Group Limited	Methods for the treatment of cognitive disorders
ES2052585T3 (es) *	1986-12-17	1994-07-16	Glaxo Group Ltd	Uso de derivados cetonicos en el tratamiento de desordenes cognitivos.
US5190954A (en) *	1986-12-17	1993-03-02	Glaxo Group Limited	Methods for the treatment of cognitive disorders
GB8630071D0 (en) *	1986-12-17	1987-01-28	Glaxo Group Ltd	Medicaments
GB8630079D0 (en) *	1986-12-17	1987-01-28	Glaxo Group Ltd	Medicaments
EP0291172B1 (fr) *	1987-04-14	1992-11-19	Glaxo Group Limited	Dérivés de cétone
DE3874229T2 (de) *	1987-06-16	1993-03-25	British Tech Group	Verwendung von dioxopiperidin-derivaten zur herstellung eines topischen praeparates als analgetika.
DE3822792C2 (de) *	1987-07-11	1997-11-27	Sandoz Ag	Neue Verwendung von 5HT¶3¶-Antagonisten
GB8723157D0 (en) *	1987-10-02	1987-11-04	Beecham Group Plc	Compounds
JPH01258673A (ja) *	1987-10-22	1989-10-16	Glaxo Group Ltd	ケトン誘導体
CA1304082C (fr) *	1987-10-22	1992-06-23	Tetsuya Tahara	Composes de la benzoxazine et leurs utilisations pharmaceutiques
US5225431A (en) *	1987-10-23	1993-07-06	Burroughs Wellcome Co.	Therapeutic substituted indole compounds and compositions thereof
GB8805269D0 (en) *	1988-03-04	1988-04-07	Glaxo Group Ltd	Medicaments
JPH0249772A (ja) *	1988-04-07	1990-02-20	Glaxo Group Ltd	イミダゾール誘導体
DK185489A (da) *	1988-04-22	1989-10-23	Duphar Int Res	Imidazolylmethyl-cycloalkanoebaaindoloner, deres fremstilling og anvendelse
EP0339959A3 (fr) *	1988-04-27	1991-03-20	Glaxo Group Limited	Dérivés de lactame
GB8812636D0 (en) *	1988-05-27	1988-06-29	Glaxo Group Ltd	Chemical compounds
US5290785A (en) *	1988-09-27	1994-03-01	Fujisawa Pharmaceutical Co., Ltd.	Therapeutic agent for ischemic diseases
US5173493A (en) *	1988-09-27	1992-12-22	Fujisawa Pharmaceutical Company, Ltd.	Pyridoindole derivatives and processes for preparation thereof
AU627221B2 (en) *	1988-09-27	1992-08-20	Fujisawa Pharmaceutical Co., Ltd.	Pyridoindole derivatives and processes for preparation thereof
FR2639944B1 (fr) *	1988-12-06	1991-01-18	Adir	Nouveaux derives de l'indole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CA2004911A1 (fr) *	1988-12-22	1990-06-22	Mitsuaki Ohta	Derives de 4,5,6,7-tetrahydrobenzimidazole
EP0377238A1 (fr) *	1988-12-22	1990-07-11	Duphar International Research B.V	Indolo(3,2-c)-lactames annelés
US5223625A (en) *	1988-12-22	1993-06-29	Duphar International Research B.V.	Annelated indolo [3,2,-C]lactams
KR900013959A (ko) *	1989-03-13	1990-10-22	원본미기재	γ-카르블린 또는 그들의 제약학적으로 허용 가능한 산부가염 및/또는 수화물, 및 그들로 구성되는 제약학적 조성물
JPH0669963B2 (ja) *	1989-04-21	1994-09-07	サンド・アクチエンゲゼルシャフト	５ｈｔ▲下３▼受容体拮抗薬の治療的用途
GB8914804D0 (en) *	1989-06-28	1989-08-16	Glaxo Group Ltd	Process
GB8917557D0 (en) *	1989-08-01	1989-09-13	Glaxo Group Ltd	Medicaments
US5276050A (en) *	1989-08-01	1994-01-04	Glaxo Group Limited	Medicaments
US5126343A (en) *	1989-09-11	1992-06-30	G. D. Searle & Co.	N-azabicyclo [3.3.0]octane amides of aromatic acids
GB2236751B (en)	1989-10-14	1993-04-28	Wyeth John & Brother Ltd	Heterocyclic compounds
GB8928837D0 (en) *	1989-12-21	1990-02-28	Beecham Group Plc	Pharmaceuticals
US5187166A (en) *	1990-07-31	1993-02-16	Nisshin Flour Milling Co., Ltd.	Azabicyclo derivatives and their use as antiemetics
EP1022025A3 (fr) *	1991-06-26	2002-06-05	Sepracor, Inc.	Methodes et compositions pour le traitement des vomissements, de la nausee et d'autres troubles faisant appel a l'ondansetron optiquement pur R(+)
JPH05310732A (ja) *	1992-03-12	1993-11-22	Mitsubishi Kasei Corp	シンノリン−３−カルボン酸誘導体
ES2043535B1 (es) *	1992-03-13	1994-08-01	Vita Invest Sa	Procedimiento para la obtencion de la 1,2,3,9-tetrahidro-9-metil-3-(2-metil-1h-imidazol-1-il)metil*-4h-carbazol-4-ona.
HU212934B (en)	1992-10-14	1996-12-30	Richter Gedeon Vegyeszet	Process for producing novel alkoxalylated carbazolone derivatives
CA2106642C (fr) *	1992-10-14	2005-08-16	Peter Bod	Derives de carbazolone et procede d'obtention
HUT68293A (en) *	1993-03-08	1995-06-28	Fujisawa Pharmaceutical Co	5-ht antagonists as acting agent against cerebrovascular deseases
GB9310756D0 (en) *	1993-05-25	1993-07-14	Glaxo Lab Sa	Compositions
GB2327348A (en) *	1994-06-28	1999-01-27	Kenneth Francis Prendergast	Pharmaceutical use of ondansetron
GB9423588D0 (en) *	1994-11-22	1995-01-11	Glaxo Wellcome Inc	Compositions
US6365743B1 (en)	1995-10-13	2002-04-02	Duphar International Research B.V.	Process for the preparation of enantiomerically pure imidazolyl compounds
AU702594B2 (en) *	1995-10-13	1999-02-25	Duphar International Research B.V.	Process for the preparation of enantiomerically pure imidazolyl compounds
US5969137A (en) *	1996-09-19	1999-10-19	Virginia Commonwealth University	Benzylamidine derivatives with serotonin receptor binding activity
EP1181015A2 (fr)	1999-03-01	2002-02-27	Sepracor Inc.	Procedes de traitement de l'apnee et de troubles de l'apnee a l'aide de r(+) ondansetron optiquement pur
EP1207160A1 (fr) *	2000-11-20	2002-05-22	Hanmi Pharm. Co., Ltd.	Procédé de préparation de la 1,2,3,9-tétrahydro-9-méthyl-3-((2-méthyl-1H-imidazol-1-yl)-méthyl)-4H-carbazol-4-one
ATE364611T1 (de)	2002-04-29	2007-07-15	Teva Gyogyszergyar Zartkoeruee	Verfahren zur herstellung von 1,2,3,9-tetrahydro- 9-methyl-3- (2-methyl-1h-imidazol-1-yl)methylö- h-carbazol-4-on
FI6164U1 (fi) *	2003-01-09	2004-03-15	Synthon Bv	Ondansetronmuotoja
GB2398071B (en) *	2003-01-24	2006-06-07	Synthon Bv	Process for making ondansetron and intermediate thereof
ES2238001B1 (es) *	2004-01-21	2006-11-01	Vita Cientifica, S.L.	Nuevas formas polimorficas de ondansetron, procedimientos para su preparacion, composiciones farmaceuticas que los contienen y su uso como aantiemeticos.
CA2565854A1 (fr)	2004-05-07	2005-11-17	Taro Pharmaceutical Industries Ltd.	Procede de preparation de chlorhydrate dihydrate d'ondansetron ayant une granulometrie definie
US20090170872A1 (en) *	2005-07-05	2009-07-02	Orchid Research Laboratories Limited	Compounds and Their Pharmaceutical Use
SI2432467T1 (en)	2009-05-20	2018-06-29	Inserm (Institut National De La Sante Et De La Recherche Medicale)	ANTAGONIST RECEPTOR SEROTONINA 5-HT3 FOR THE USE IN THE TREATMENT OF LEASE VESTIBULAR DISEASES
ES2432618T3 (es)	2009-05-20	2013-12-04	Inserm (Institut National De La Santé Et De La Recherche Medicale)	Antagonistas del receptor 5-HT3 de serotonina para usar en el tratamiento o prevención de una patología del oído interno con déficit vestibular
CN115611864A (zh) *	2022-11-01	2023-01-17	常州兰陵制药有限公司	一种昂丹司琼类化合物及其制备方法与应用
GB202301322D0 (en)	2023-01-30	2023-03-15	Therakind Ltd	Antiemetic pharmaceutical compositions for nasal delivery

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3634420A (en) *	1969-05-09	1972-01-11	American Cyanamid Co	3(morpholinomethyl)-2 3-dihydro-carbazol-4(1h)-ones
US3740404A (en) *	1969-05-09	1973-06-19	American Cyanamid Co	Piperidinomethylenedihydrocarbazolones
DE3680123D1 (en) *	1985-01-23	1991-08-14	Glaxo Group Ltd	Tetrahydrocarbazolonderivate.

1985
- 1985-01-25 NZ NZ210940A patent/NZ210940A/xx unknown
- 1985-01-25 BE BE0/214394A patent/BE901576A/fr not_active IP Right Cessation
- 1985-01-25 FR FR8501056A patent/FR2561244B1/fr not_active Expired
- 1985-01-25 DE DE19853502508 patent/DE3502508A1/de active Granted
- 1985-01-25 GR GR850219A patent/GR850219B/el active IP Right Revival
- 1985-01-25 AT AT204/85A patent/AT392276B/de not_active IP Right Cessation
- 1985-01-25 CH CH346/85A patent/CH664152A5/fr not_active IP Right Cessation
- 1985-01-25 LU LU88268C patent/LU88268I2/xx unknown
- 1985-01-25 DE DE1993175046 patent/DE19375046I2/de active Active
- 1985-01-25 CA CA000472888A patent/CA1252793A/fr not_active Expired
- 1985-01-25 FI FI850323A patent/FI84349C/fi not_active IP Right Cessation
- 1985-01-25 NL NLAANVRAGE8500202,A patent/NL190373C/xx not_active IP Right Cessation
- 1985-01-25 LU LU85743A patent/LU85743A1/fr active Protection Beyond IP Right Term
- 1985-01-25 IT IT47600/85A patent/IT1182150B/it active Protection Beyond IP Right Term
- 1985-01-25 IE IE187/85A patent/IE57809B1/en not_active IP Right Cessation
- 1985-01-25 NO NO850300A patent/NO164025C/no not_active IP Right Cessation
- 1985-01-25 DK DK035785A patent/DK169521B1/da not_active IP Right Cessation
- 1985-01-25 IL IL74165A patent/IL74165A/xx not_active IP Right Cessation
- 1985-01-25 PT PT79890A patent/PT79890B/pt unknown
- 1985-01-25 GB GB08501889A patent/GB2153821B/en not_active Expired
- 1985-01-25 PH PH31770A patent/PH22672A/en unknown
- 1985-01-25 HU HU85296A patent/HU193592B/hu unknown
- 1985-01-25 KR KR1019850000454A patent/KR920003064B1/ko not_active IP Right Cessation
- 1985-01-25 ES ES539852A patent/ES8609309A1/es not_active Expired
- 1985-01-25 AU AU38097/85A patent/AU579132B2/en not_active Expired
- 1985-01-25 SE SE8500368A patent/SE460359B/sv not_active IP Right Cessation
- 1985-10-31 ES ES548430A patent/ES8708224A1/es not_active Expired
1986
- 1986-06-16 ES ES556101A patent/ES8801247A1/es not_active Expired
1989
- 1989-02-09 SG SG70/89A patent/SG7089G/en unknown
- 1989-04-20 HK HK331/89A patent/HK33189A/xx not_active IP Right Cessation
- 1989-07-21 CY CY1479A patent/CY1479A/xx unknown
1991
- 1991-12-23 CZ CS914043A patent/CZ404391A3/cs unknown
- 1991-12-23 SK SK4043-91A patent/SK277923B6/sk unknown
1994
- 1994-05-31 NL NL940009C patent/NL940009I2/nl unknown
- 1994-11-09 NO NO1994022C patent/NO1994022I1/no unknown

Also Published As

Publication number	Publication date
AU3809785A (en)	1985-08-01
CH664152A5 (fr)	1988-02-15
HUT37784A (en)	1986-02-28
IT1182150B (it)	1987-09-30
LU85743A1 (fr)	1986-08-04
PH22672A (en)	1988-11-14
NZ210940A (en)	1989-08-29
ES8801247A1 (es)	1987-12-16
AU579132B2 (en)	1988-11-17
BE901576A (fr)	1985-07-25
NL8500202A (nl)	1985-08-16
ES8708224A1 (es)	1987-10-01
GB8501889D0 (en)	1985-02-27
FR2561244B1 (fr)	1988-03-04
NL940009I2 (nl)	1999-05-03
NL940009I1 (nl)	1994-07-18
SE8500368L (sv)	1985-07-26
KR920003064B1 (ko)	1992-04-13
DE19375046I2 (de)	2002-10-10
SG7089G (en)	1989-06-09
SE8500368D0 (sv)	1985-01-25
ES539852A0 (es)	1986-07-16
GR850219B (fr)	1985-05-23
ES8609309A1 (es)	1986-07-16
FI850323L (fi)	1985-07-26
ATA20485A (de)	1990-08-15
NL190373B (nl)	1993-09-01
HK33189A (en)	1989-04-28
NO164025C (no)	1990-08-22
AT392276B (de)	1991-02-25
SK404391A3 (en)	1995-08-09
PT79890B (en)	1987-02-03
CY1479A (en)	1989-07-21
NO164025B (no)	1990-05-14
ES556101A0 (es)	1987-12-16
DE3502508A1 (de)	1985-08-14
SE460359B (sv)	1989-10-02
CZ404391A3 (en)	1993-04-14
SK277923B6 (en)	1995-08-09
DK169521B1 (da)	1994-11-21
IL74165A (en)	1988-11-15
DK35785A (da)	1985-07-26
ES548430A0 (es)	1987-10-01
DK35785D0 (da)	1985-01-25
FI850323A0 (fi)	1985-01-25
GB2153821A (en)	1985-08-29
NO850300L (no)	1985-07-26
FR2561244A1 (fr)	1985-09-20
CA1252793A (fr)	1989-04-18
GB2153821B (en)	1988-01-20
FI84349B (fi)	1991-08-15
PT79890A (en)	1985-02-01
NL190373C (nl)	1994-02-01
DE3502508C2 (fr)	1990-05-03
IE850187L (en)	1985-07-25
HU193592B (en)	1987-11-30
KR850005439A (ko)	1985-08-26
LU88268I2 (fr)	1994-02-03
IT8547600A0 (it)	1985-01-25
IE57809B1 (en)	1993-04-21
NO1994022I1 (no)	1994-11-09

Publication	Publication Date	Title
FI84349C (fi)	1991-11-25	Foerfarande foer framstaellning av en farmakologiskt vaerdefull foerening.
US4695578A (en)	1987-09-22	1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances
EP0219193B1 (fr)	1992-05-27	Dérivés de tétrahydrocarbazolone, procédés pour leur préparation et compositions pharmaceutiques les contenant
EP0191562B1 (fr)	1991-07-10	Dérivés de tétrahydrocarbazolones
US4997831A (en)	1991-03-05	Lactam derivatives
WO1998056768A1 (fr)	1998-12-17	Derives tricycliques de pyrrole ou de pyrazole
US5563147A (en)	1996-10-08	Serotonerbic tetrahydropyridoindoles
US5849746A (en)	1998-12-15	Substituted 1,4-piperazine-heteroaryl derivatives as 5-HT1D receptor agonists
JPH01258673A (ja)	1989-10-16	ケトン誘導体
RU2098418C1 (ru)	1997-12-10	Конденсированное производное тиазола или его фармацевтически приемлемая соль, фармацевтическая композиция, проявляющая активность агониста 5-нт*003-рецептора на его основе
JP2000503997A (ja)	2000-04-04	縮合した２，３―ベンゾジアゼピン誘導体及びａｍｐａ―レセプター抑制剤としての使用
HU188475B (en)	1986-04-28	Process for producing benzothiopyrano-pyridinones
IE60265B1 (en)	1994-06-29	Condensed diazepinones
US6127388A (en)	2000-10-03	Azetidine, pyrrolidine and piperidine derivatives as 5-HT1D receptor agonists
US4482714A (en)	1984-11-13	Pyrazino[2',3'-3,4]pyrido[1,2-a]indole derivatives
EP0072029B1 (fr)	1986-10-22	Triazolobenzazépines, procédé et intermédiaires pour leur fabrication et médicaments les contenant
US4515949A (en)	1985-05-07	[2-(1H-indol-1-yl)ethyl]-2-piperazine and pyrido[1,2-a]indol-9-one as intermediates for pyrazino(2,3-3,4)pyrido(1,2-a) indoles which are useful for treating hypertension in mammals
US5994374A (en)	1999-11-30	Substituted 1-indolylpropyl-4-benzyl-tetrahydropyridine derivatives
EP0391414A2 (fr)	1990-10-10	Dérivés de benzazépine et benzothiazépine
US4879382A (en)	1989-11-07	Pyrido(3,4-f)pyrrolo(1,2-b)(1,2,5)triazepines
JPH0378862B2 (fr)	1991-12-17
EP0726257B1 (fr)	2001-04-11	Dérivés de 1-(hétéro)arylvinyl-5H-2,3-benzodiazépine utiles dans le traitement des maladies du système nerveux central, et intermédiaires benzopyrylium pour leur préparation
RU2081117C1 (ru)	1997-06-10	Производные лактама или их физиологические приемлемые соли или сольваты
FI89484B (fi)	1993-06-30	Foerfarande foer framstaellning av terapeutiskt aktiva tetrahydro-2-/(imidazol-4-yl)metyl/pyrido(4,3-b)indol- och azepino-/4,3-b/indol-1-oner
PL81337B1 (en)	1975-08-30	Indolazonine and indolazecine derivs. - having pharmacological activity[FR2059489A1]

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1996-01-15	ND	Supplementary protection certificate (spc) granted
1996-01-15	SPCG	Supplementary protection certificate granted	Spc suppl protection certif: L59 Extension date: 20050223
2004-08-31	FG	Patent granted	Owner name: GLAXO GROUP LIMITED
2005-02-09	MA	Patent expired