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FI68236C - Foerfarande foer framstaellning av nya farmakologiskt aktiva morfinderivat - Google Patents

Foerfarande foer framstaellning av nya farmakologiskt aktiva morfinderivat Download PDF

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Publication number
FI68236C
FI68236C FI780882A FI780882A FI68236C FI 68236 C FI68236 C FI 68236C FI 780882 A FI780882 A FI 780882A FI 780882 A FI780882 A FI 780882A FI 68236 C FI68236 C FI 68236C
Authority
FI
Finland
Prior art keywords
alkyl
formula
alkenyl
chloroform
cycloalkyl
Prior art date
Application number
FI780882A
Other languages
English (en)
Finnish (fi)
Other versions
FI68236B (fi
FI780882A (fi
Inventor
Ryszard J Kobylecki
Ian G Guest
John W Lewis
Gordon W Kirby
Original Assignee
Reckitt & Colmann Prod Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reckitt & Colmann Prod Ltd filed Critical Reckitt & Colmann Prod Ltd
Publication of FI780882A publication Critical patent/FI780882A/fi
Publication of FI68236B publication Critical patent/FI68236B/fi
Application granted granted Critical
Publication of FI68236C publication Critical patent/FI68236C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FI780882A 1977-03-23 1978-03-21 Foerfarande foer framstaellning av nya farmakologiskt aktiva morfinderivat FI68236C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1232577 1977-03-23
GB12325/77A GB1593191A (en) 1977-03-23 1977-03-23 Derivatives of morphine

Publications (3)

Publication Number Publication Date
FI780882A FI780882A (fi) 1978-09-24
FI68236B FI68236B (fi) 1985-04-30
FI68236C true FI68236C (fi) 1985-08-12

Family

ID=10002423

Family Applications (1)

Application Number Title Priority Date Filing Date
FI780882A FI68236C (fi) 1977-03-23 1978-03-21 Foerfarande foer framstaellning av nya farmakologiskt aktiva morfinderivat

Country Status (24)

Country Link
US (1) US4241066A (fr)
JP (1) JPS53119899A (fr)
AT (1) AT361139B (fr)
AU (1) AU519643B2 (fr)
BE (1) BE865183A (fr)
CA (1) CA1089456A (fr)
CH (1) CH629809A5 (fr)
CS (1) CS200542B2 (fr)
DD (1) DD133950A5 (fr)
DE (1) DE2812580A1 (fr)
DK (1) DK149858C (fr)
ES (1) ES468173A1 (fr)
FI (1) FI68236C (fr)
FR (1) FR2384774A1 (fr)
GB (1) GB1593191A (fr)
IE (1) IE46443B1 (fr)
IT (1) IT1105176B (fr)
LU (1) LU79294A1 (fr)
NL (1) NL7803083A (fr)
NZ (1) NZ186692A (fr)
PL (1) PL114723B1 (fr)
SE (1) SE436131B (fr)
SU (1) SU921467A3 (fr)
ZA (1) ZA781527B (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4362870A (en) * 1980-01-16 1982-12-07 Regents Of The University Of Minnesota Selective opioid receptor alkylating agents
US4401672A (en) * 1981-10-13 1983-08-30 Regents Of The University Of Minnesota Non-addictive narcotic antitussive preparation
EP0103636B1 (fr) * 1982-03-16 1990-09-12 Rockefeller University Utilisation d'antagonistes d'opium pour la preparation de medicaments pour reduire la dysmotilite gastro-intestinale
GB8711558D0 (en) * 1987-05-15 1987-06-17 Reckitt & Colmann Prod Ltd Derivative of codeine
CA2105072C (fr) * 1992-01-23 1998-07-28 Hiroshi Nagase Derive de la morphinane et ses applications pharmaceutiques
IT1269826B (it) * 1994-05-24 1997-04-15 Paolo Minoia Uso di antagonisti degli oppiacei e di sali di calcio per la preparazione di medicamenti per il trattamento di forme patologiche endorfino-mediate
CN104383542B (zh) 2003-04-08 2017-09-26 普罗热尼奇制药公司 包含甲基纳曲酮的药物配方
US20060063792A1 (en) * 2004-09-17 2006-03-23 Adolor Corporation Substituted morphinans and methods of their use
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
AR057035A1 (es) 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
JP2008546688A (ja) 2005-06-16 2008-12-25 マリンクロッド・インコーポレイテッド １−ハロ−テバインまたは類似体を介する１４−ヒドロキシルオピエート類への合成経路
CA2646313C (fr) * 2006-04-21 2014-05-20 Nektar Therapeutics Al, Corporation Reduction stereoselective d'une morphinone
EP2565195B1 (fr) 2007-03-29 2015-05-06 Wyeth LLC Récepteur opioïde périphérique et son antagoniste ainsi que leurs utilisations
CA2865661C (fr) 2007-03-29 2016-05-17 Progenics Pharmaceuticals, Inc. Antagonistes de recepteurs opioides peripheriques, et leurs utilisations
EP2134718A2 (fr) 2007-03-29 2009-12-23 Progenics Pharmaceuticals, Inc. Formes cristallines, et leurs utilisations
WO2009099411A1 (fr) 2008-02-06 2009-08-13 Progenics Pharmaceuticals, Inc. Préparation et utilisation de (r),(r)-2,2'-bis-méthylnaltrexone
EP2344509B1 (fr) 2008-09-30 2015-11-11 Mallinckrodt LLC Procédés de production de buprénorphine avec formation réduite d'impuretés
US8293906B2 (en) 2008-09-30 2012-10-23 Mallinckrodt Llc Processes for the alkylation of norbuprenorphine with reduced impurity formation
CA2676881C (fr) 2008-09-30 2017-04-25 Wyeth Antagonistes de recepteurs opioides peripheriques, et leurs utilisations
EP3077398B1 (fr) 2013-12-05 2020-03-11 The University of Bath Nouveaux composés opioïdes et leurs utilisations
CN110330500B (zh) * 2019-07-12 2021-11-23 宜昌人福药业有限责任公司 一种6β-羟基-7,8-二氢-吗啡衍生物的立体选择性合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3322771A (en) * 1967-05-30 Intermediates for preparing thebaine derivatives
US3332950A (en) * 1963-03-23 1967-07-25 Endo Lab 14-hydroxydihydronormorphinone derivatives
IL26896A (en) * 1966-01-19 1970-11-30 Endo Lab 14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones
BE788478A (fr) * 1971-09-08 1973-03-06 Bristol Myers Co Procede de preparation de composes analgesiques
US4017497A (en) * 1975-11-18 1977-04-12 Bristol-Myers Company Process for the preparation of 14-hydroxymorphinan derivatives
US4089855A (en) * 1976-04-23 1978-05-16 Cornell Research Foundation, Inc. Process for the stereoselective reduction of 6- and 8-keto morphine and morphinan derivatives with formamidinesulfinic acid and compounds obtained thereby

Also Published As

Publication number Publication date
PL114723B1 (en) 1981-02-28
PL205498A1 (pl) 1979-04-09
IT1105176B (it) 1985-10-28
GB1593191A (en) 1981-07-15
IE46443B1 (en) 1983-06-15
AT361139B (de) 1981-02-25
JPS53119899A (en) 1978-10-19
IE780515L (en) 1978-09-23
FI68236B (fi) 1985-04-30
CA1089456A (fr) 1980-11-11
SE436131B (sv) 1984-11-12
CH629809A5 (fr) 1982-05-14
ES468173A1 (es) 1979-09-16
DD133950A5 (de) 1979-01-31
NZ186692A (en) 1980-02-21
DK149858C (da) 1987-06-29
SE7803328L (sv) 1978-09-24
SU921467A3 (ru) 1982-04-15
FR2384774A1 (fr) 1978-10-20
AU519643B2 (en) 1981-12-17
CS200542B2 (en) 1980-09-15
FR2384774B1 (fr) 1981-10-16
NL7803083A (nl) 1978-09-26
DK149858B (da) 1986-10-13
IT7848544A0 (it) 1978-03-22
DK130078A (da) 1978-09-24
FI780882A (fi) 1978-09-24
ATA204278A (de) 1980-07-15
LU79294A1 (fr) 1979-10-29
BE865183A (fr) 1978-09-22
ZA781527B (en) 1979-04-25
JPH0112755B2 (fr) 1989-03-02
US4241066A (en) 1980-12-23
AU3435778A (en) 1979-09-27
DE2812580A1 (de) 1978-10-05

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MM Patent lapsed

Owner name: RECKITT & COLAMN PRODUKTS LIMITED