FI60719C - Foerfarande foer bestaemning av substrat eller enzymaktiviteter - Google Patents

Foerfarande foer bestaemning av substrat eller enzymaktiviteter Download PDF

Info

Publication number: FI60719C
Authority: FI; Finland
Prior art keywords: ascorbate; oxidase; determination; ascorbate oxidase; glucose
Prior art date: 1976-06-09

Application number

FI771356A

Other languages

English (en)

Finnish (fi)

Swedish (sv)

Other versions

FI771356A (de

FI60719B (fi

Inventor

Josef Danninger

Ulfert Deneke

Gunter Lang

Gerhard Michal

Peter Roeschlau

Original Assignee

Boehringer Mannheim Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-06-09

Filing date

1977-04-28

Publication date

1982-03-10

1977-04-28 Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh

1977-12-10 Publication of FI771356A publication Critical patent/FI771356A/fi

1981-11-30 Application granted granted Critical

1981-11-30 Publication of FI60719B publication Critical patent/FI60719B/fi

1982-03-10 Publication of FI60719C publication Critical patent/FI60719C/fi

Links

102000004190 Enzymes Human genes 0.000 title claims description 18
108090000790 Enzymes Proteins 0.000 title claims description 18
230000000694 effects Effects 0.000 title claims description 9
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 91
108010024957 Ascorbate Oxidase Proteins 0.000 claims description 50
235000010323 ascorbic acid Nutrition 0.000 claims description 46
239000011668 ascorbic acid Substances 0.000 claims description 46
239000003153 chemical reaction reagent Substances 0.000 claims description 26
229960005070 ascorbic acid Drugs 0.000 claims description 25
229940072107 ascorbate Drugs 0.000 claims description 22
238000006243 chemical reaction Methods 0.000 claims description 21
102000003992 Peroxidases Human genes 0.000 claims description 18
108040007629 peroxidase activity proteins Proteins 0.000 claims description 18
229940088598 enzyme Drugs 0.000 claims description 17
238000000034 method Methods 0.000 claims description 17
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 16
239000008103 glucose Substances 0.000 claims description 16
238000003556 assay Methods 0.000 claims description 13
239000000758 substrate Substances 0.000 claims description 13
RLFWWDJHLFCNIJ-UHFFFAOYSA-N 4-aminoantipyrine Chemical compound CN1C(C)=C(N)C(=O)N1C1=CC=CC=C1 RLFWWDJHLFCNIJ-UHFFFAOYSA-N 0.000 claims description 11
ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims description 10
108010015776 Glucose oxidase Proteins 0.000 claims description 9
239000004366 Glucose oxidase Substances 0.000 claims description 9
229940116332 glucose oxidase Drugs 0.000 claims description 9
235000019420 glucose oxidase Nutrition 0.000 claims description 9
239000000872 buffer Substances 0.000 claims description 8
238000006479 redox reaction Methods 0.000 claims description 8
108010092464 Urate Oxidase Proteins 0.000 claims description 7
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 5
LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 claims description 5
TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 claims description 5
229930195712 glutamate Natural products 0.000 claims description 5
239000012085 test solution Substances 0.000 claims description 5
125000003831 tetrazolyl group Chemical group 0.000 claims description 5
229940116269 uric acid Drugs 0.000 claims description 5
HFZWRUODUSTPEG-UHFFFAOYSA-N 2,4-dichlorophenol Chemical compound OC1=CC=C(Cl)C=C1Cl HFZWRUODUSTPEG-UHFFFAOYSA-N 0.000 claims description 4
JRBJSXQPQWSCCF-UHFFFAOYSA-N 3,3'-Dimethoxybenzidine Chemical compound C1=C(N)C(OC)=CC(C=2C=C(OC)C(N)=CC=2)=C1 JRBJSXQPQWSCCF-UHFFFAOYSA-N 0.000 claims description 4
235000009849 Cucumis sativus Nutrition 0.000 claims description 2
240000008067 Cucumis sativus Species 0.000 claims description 2
240000001980 Cucurbita pepo Species 0.000 claims description 2
235000009852 Cucurbita pepo Nutrition 0.000 claims description 2
241000219130 Cucurbita pepo subsp. pepo Species 0.000 claims description 2
235000003954 Cucurbita pepo var melopepo Nutrition 0.000 claims description 2
102000005548 Hexokinase Human genes 0.000 claims description 2
108700040460 Hexokinases Proteins 0.000 claims description 2
102100031126 6-phosphogluconolactonase Human genes 0.000 claims 1
108010029731 6-phosphogluconolactonase Proteins 0.000 claims 1
108010018962 Glucosephosphate Dehydrogenase Proteins 0.000 claims 1
XJLXINKUBYWONI-NNYOXOHSSA-O NADP(+) Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-NNYOXOHSSA-O 0.000 claims 1
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239000000243 solution Substances 0.000 description 29
238000005259 measurement Methods 0.000 description 18
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
210000002700 urine Anatomy 0.000 description 10
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 9
238000001514 detection method Methods 0.000 description 8
239000008363 phosphate buffer Substances 0.000 description 8
OHDRQQURAXLVGJ-HLVWOLMTSA-N azane;(2e)-3-ethyl-2-[(e)-(3-ethyl-6-sulfo-1,3-benzothiazol-2-ylidene)hydrazinylidene]-1,3-benzothiazole-6-sulfonic acid Chemical compound [NH4+].[NH4+].S/1C2=CC(S([O-])(=O)=O)=CC=C2N(CC)C\1=N/N=C1/SC2=CC(S([O-])(=O)=O)=CC=C2N1CC OHDRQQURAXLVGJ-HLVWOLMTSA-N 0.000 description 5
210000004369 blood Anatomy 0.000 description 5
239000008280 blood Substances 0.000 description 5
YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical compound OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 description 5
102000030523 Catechol oxidase Human genes 0.000 description 4
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108010029541 Laccase Proteins 0.000 description 4
102000003425 Tyrosinase Human genes 0.000 description 4
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229910052700 potassium Inorganic materials 0.000 description 4
239000011591 potassium Substances 0.000 description 4
238000002360 preparation method Methods 0.000 description 4
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 4
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
239000007979 citrate buffer Substances 0.000 description 3
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
239000000975 dye Substances 0.000 description 3
238000005470 impregnation Methods 0.000 description 3
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BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 3
IEQAICDLOKRSRL-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO IEQAICDLOKRSRL-UHFFFAOYSA-N 0.000 description 2
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 2
SBJKKFFYIZUCET-JLAZNSOCSA-N Dehydro-L-ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(=O)C1=O SBJKKFFYIZUCET-JLAZNSOCSA-N 0.000 description 2
SBJKKFFYIZUCET-UHFFFAOYSA-N Dehydroascorbic acid Natural products OCC(O)C1OC(=O)C(=O)C1=O SBJKKFFYIZUCET-UHFFFAOYSA-N 0.000 description 2
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
102000004316 Oxidoreductases Human genes 0.000 description 2
108090000854 Oxidoreductases Proteins 0.000 description 2
XJLXINKUBYWONI-DQQFMEOOSA-N [[(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2s,3r,4s,5s)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound NC(=O)C1=CC=C[N+]([C@@H]2[C@H]([C@@H](O)[C@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-DQQFMEOOSA-N 0.000 description 2
239000002250 absorbent Substances 0.000 description 2
230000002745 absorbent Effects 0.000 description 2
POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
239000007864 aqueous solution Substances 0.000 description 2
230000008033 biological extinction Effects 0.000 description 2
239000003638 chemical reducing agent Substances 0.000 description 2
235000020960 dehydroascorbic acid Nutrition 0.000 description 2
239000011615 dehydroascorbic acid Substances 0.000 description 2
239000012153 distilled water Substances 0.000 description 2
238000006911 enzymatic reaction Methods 0.000 description 2
238000002474 experimental method Methods 0.000 description 2
210000003608 fece Anatomy 0.000 description 2
235000013305 food Nutrition 0.000 description 2
150000002432 hydroperoxides Chemical class 0.000 description 2
230000003647 oxidation Effects 0.000 description 2
238000007254 oxidation reaction Methods 0.000 description 2
RDOWQLZANAYVLL-UHFFFAOYSA-N phenanthridine Chemical compound C1=CC=C2C3=CC=CC=C3C=NC2=C1 RDOWQLZANAYVLL-UHFFFAOYSA-N 0.000 description 2
238000005375 photometry Methods 0.000 description 2
239000000047 product Substances 0.000 description 2
OBHRVMZSZIDDEK-UHFFFAOYSA-N urobilinogen Chemical compound CCC1=C(C)C(=O)NC1CC1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(CC3C(=C(CC)C(=O)N3)C)N2)CCC(O)=O)N1 OBHRVMZSZIDDEK-UHFFFAOYSA-N 0.000 description 2
CMCBDXRRFKYBDG-UHFFFAOYSA-N 1-dodecoxydodecane Chemical compound CCCCCCCCCCCCOCCCCCCCCCCCC CMCBDXRRFKYBDG-UHFFFAOYSA-N 0.000 description 1
MNCHAXQEWRVZRB-UHFFFAOYSA-N 1-sulfonyl-1,3-benzothiazole 1-oxide Chemical compound S(=O)(=O)=S1(C=NC2=C1C=CC=C2)=O MNCHAXQEWRVZRB-UHFFFAOYSA-N 0.000 description 1
JGBAASVQPMTVHO-UHFFFAOYSA-N 2,5-dihydroperoxy-2,5-dimethylhexane Chemical compound OOC(C)(C)CCC(C)(C)OO JGBAASVQPMTVHO-UHFFFAOYSA-N 0.000 description 1
JJMQRJKPLUACSO-UHFFFAOYSA-N 3-(4-iodophenyl)-2-(4-nitrophenyl)-5-phenyl-1,3-dihydrotetrazol-3-ium;chloride Chemical compound [Cl-].C1=CC([N+](=O)[O-])=CC=C1N1N(C=2C=CC(I)=CC=2)[NH2+]C(C=2C=CC=CC=2)=N1 JJMQRJKPLUACSO-UHFFFAOYSA-N 0.000 description 1
CDOUZKKFHVEKRI-UHFFFAOYSA-N 3-bromo-n-[(prop-2-enoylamino)methyl]propanamide Chemical compound BrCCC(=O)NCNC(=O)C=C CDOUZKKFHVEKRI-UHFFFAOYSA-N 0.000 description 1
WXMQHPKQCPCDQO-UHFFFAOYSA-N 4-dimorpholin-4-ylphosphorylmorpholine Chemical compound C1COCCN1P(N1CCOCC1)(=O)N1CCOCC1 WXMQHPKQCPCDQO-UHFFFAOYSA-N 0.000 description 1
PPMGNFFGNNRYQC-UHFFFAOYSA-N 9h-carbazole;dihydrochloride Chemical compound Cl.Cl.C1=CC=C2C3=CC=CC=C3NC2=C1 PPMGNFFGNNRYQC-UHFFFAOYSA-N 0.000 description 1
POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 1
101000950981 Bacillus subtilis (strain 168) Catabolic NAD-specific glutamate dehydrogenase RocG Proteins 0.000 description 1
229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
102000016938 Catalase Human genes 0.000 description 1
108010053835 Catalase Proteins 0.000 description 1
108010089254 Cholesterol oxidase Proteins 0.000 description 1
RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
NBSCHQHZLSJFNQ-GASJEMHNSA-N D-Glucose 6-phosphate Chemical compound OC1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@H]1O NBSCHQHZLSJFNQ-GASJEMHNSA-N 0.000 description 1
101710088194 Dehydrogenase Proteins 0.000 description 1
102000028526 Dihydrolipoamide Dehydrogenase Human genes 0.000 description 1
108010028127 Dihydrolipoamide Dehydrogenase Proteins 0.000 description 1
QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 1
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
VFRROHXSMXFLSN-UHFFFAOYSA-N Glc6P Natural products OP(=O)(O)OCC(O)C(O)C(O)C(O)C=O VFRROHXSMXFLSN-UHFFFAOYSA-N 0.000 description 1
102000016901 Glutamate dehydrogenase Human genes 0.000 description 1
102000001554 Hemoglobins Human genes 0.000 description 1
108010054147 Hemoglobins Proteins 0.000 description 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
239000002211 L-ascorbic acid Substances 0.000 description 1
235000000069 L-ascorbic acid Nutrition 0.000 description 1
102000002247 NADPH Dehydrogenase Human genes 0.000 description 1
108010014870 NADPH Dehydrogenase Proteins 0.000 description 1
IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 description 1
239000004677 Nylon Substances 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
239000007983 Tris buffer Substances 0.000 description 1
229920004890 Triton X-100 Polymers 0.000 description 1
239000013504 Triton X-100 Substances 0.000 description 1
229960000583 acetic acid Drugs 0.000 description 1
239000012445 acidic reagent Substances 0.000 description 1
229960000458 allantoin Drugs 0.000 description 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
239000011230 binding agent Substances 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
239000008112 carboxymethyl-cellulose Substances 0.000 description 1
239000000969 carrier Substances 0.000 description 1
239000012876 carrier material Substances 0.000 description 1
239000003054 catalyst Substances 0.000 description 1
239000003086 colorant Substances 0.000 description 1
229910052802 copper Inorganic materials 0.000 description 1
239000010949 copper Substances 0.000 description 1
235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 description 1
239000003814 drug Substances 0.000 description 1
238000001962 electrophoresis Methods 0.000 description 1
230000008030 elimination Effects 0.000 description 1
238000003379 elimination reaction Methods 0.000 description 1
210000003743 erythrocyte Anatomy 0.000 description 1
239000000706 filtrate Substances 0.000 description 1
239000012530 fluid Substances 0.000 description 1
239000011888 foil Substances 0.000 description 1
239000012362 glacial acetic acid Substances 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
239000012535 impurity Substances 0.000 description 1
238000011534 incubation Methods 0.000 description 1
230000002452 interceptive effect Effects 0.000 description 1
229910021645 metal ion Inorganic materials 0.000 description 1
238000006386 neutralization reaction Methods 0.000 description 1
230000000269 nucleophilic effect Effects 0.000 description 1
229920001778 nylon Polymers 0.000 description 1
239000007800 oxidant agent Substances 0.000 description 1
239000001301 oxygen Substances 0.000 description 1
229910052760 oxygen Inorganic materials 0.000 description 1
239000003208 petroleum Substances 0.000 description 1
150000002989 phenols Chemical class 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
229920000728 polyester Polymers 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
239000008057 potassium phosphate buffer Substances 0.000 description 1
239000000376 reactant Substances 0.000 description 1
230000035484 reaction time Effects 0.000 description 1
238000006722 reduction reaction Methods 0.000 description 1
239000011347 resin Substances 0.000 description 1
229920005989 resin Polymers 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
238000007086 side reaction Methods 0.000 description 1
230000006641 stabilisation Effects 0.000 description 1
238000011105 stabilization Methods 0.000 description 1
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
235000015192 vegetable juice Nutrition 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/54—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Analytical Chemistry (AREA)
General Engineering & Computer Science (AREA)
Immunology (AREA)
Microbiology (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Emergency Medicine (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Investigating Or Analysing Biological Materials (AREA)

FI771356A 1976-06-09 1977-04-28 Foerfarande foer bestaemning av substrat eller enzymaktiviteter FI60719C (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE2625834		1976-06-09
DE2625834A DE2625834B2 (de)	1976-06-09	1976-06-09	Verfahren zur Bestimmung von Substraten oder Enzymaktivitäten

Publications (3)

Publication Number	Publication Date
FI771356A FI771356A (de)	1977-12-10
FI60719B FI60719B (fi)	1981-11-30
FI60719C true FI60719C (fi)	1982-03-10

Family

ID=5980154

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI771356A FI60719C (fi)	1976-06-09	1977-04-28	Foerfarande foer bestaemning av substrat eller enzymaktiviteter

Country Status (29)

Country	Link
US (1)	US4168205A (de)
JP (1)	JPS52150692A (de)
AR (1)	AR212763A1 (de)
AT (1)	AT354640B (de)
AU (1)	AU500988B2 (de)
BE (1)	BE854407A (de)
BR (1)	BR7703008A (de)
CA (1)	CA1084393A (de)
CH (1)	CH633887A5 (de)
CS (2)	CS207453B2 (de)
DD (1)	DD130178A5 (de)
DE (1)	DE2625834B2 (de)
DK (1)	DK144949C (de)
ES (1)	ES458544A1 (de)
FI (1)	FI60719C (de)
FR (1)	FR2354561A1 (de)
GB (1)	GB1519134A (de)
HU (1)	HU172931B (de)
IE (1)	IE45546B1 (de)
IL (1)	IL52047A (de)
IT (1)	IT1075527B (de)
LU (1)	LU77290A1 (de)
NL (1)	NL169503C (de)
NO (1)	NO148340C (de)
PL (2)	PL109224B1 (de)
SE (1)	SE426601B (de)
SU (1)	SU797592A3 (de)
YU (1)	YU114477A (de)
ZA (1)	ZA772716B (de)

Families Citing this family (115)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2834705B1 (de) *	1978-08-08	1980-01-24	Boehringer Mannheim Gmbh	Verfahren und Reagenz zur Durchfuehrung enzymatischer Bestimmungen
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1977
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- 1977-04-13 IE IE764/77A patent/IE45546B1/en not_active IP Right Cessation
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- 1977-04-28 FI FI771356A patent/FI60719C/fi not_active IP Right Cessation
- 1977-04-28 US US05/792,073 patent/US4168205A/en not_active Expired - Lifetime
- 1977-04-29 GB GB17993/77A patent/GB1519134A/en not_active Expired
- 1977-05-03 IT IT77@@A patent/IT1075527B/it active
- 1977-05-05 YU YU01144/77A patent/YU114477A/xx unknown
- 1977-05-06 SU SU772481956A patent/SU797592A3/ru active
- 1977-05-06 IL IL52047A patent/IL52047A/xx unknown
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- 1977-05-06 JP JP5195377A patent/JPS52150692A/ja active Granted
- 1977-05-06 CS CS781874A patent/CS235068B2/cs unknown
- 1977-05-06 HU HU77BO00001667A patent/HU172931B/hu unknown
- 1977-05-06 NO NO771599A patent/NO148340C/no unknown
- 1977-05-06 ZA ZA00772716A patent/ZA772716B/xx unknown
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- 1977-05-06 PL PL1977197927A patent/PL109224B1/pl unknown
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- 1977-05-09 AU AU25021/77A patent/AU500988B2/en not_active Expired
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Also Published As

Publication number	Publication date
DE2625834B2 (de)	1978-10-12
DK202677A (da)	1977-12-10
JPS52150692A (en)	1977-12-14
IE45546L (en)	1977-12-09
ATA234077A (de)	1979-06-15
HU172931B (hu)	1979-01-28
IE45546B1 (en)	1982-09-22
PL114343B1 (en)	1981-01-31
PL109224B1 (en)	1980-05-31
FR2354561A1 (fr)	1978-01-06
NL169503B (nl)	1982-02-16
DE2625834A1 (de)	1977-12-15
SE426601B (sv)	1983-01-31
CS207453B2 (en)	1981-07-31
JPS5639198B2 (de)	1981-09-11
CH633887A5 (de)	1982-12-31
LU77290A1 (de)	1977-12-13
DK144949B (da)	1982-07-12
CS235068B2 (en)	1985-04-16
FI771356A (de)	1977-12-10
ZA772716B (en)	1978-05-30
GB1519134A (en)	1978-07-26
SU797592A3 (ru)	1981-01-15
NO148340C (no)	1986-11-06
AU500988B2 (en)	1979-06-07
BE854407A (fr)	1977-11-09
ES458544A1 (es)	1978-04-16
YU114477A (en)	1982-08-31
PL197927A1 (pl)	1978-01-02
DK144949C (da)	1982-11-29
NL169503C (nl)	1982-07-16
SE7705303L (sv)	1977-12-10
IT1075527B (it)	1985-04-22
IL52047A (en)	1981-09-13
US4168205A (en)	1979-09-18
AT354640B (de)	1979-01-25
AU2502177A (en)	1978-11-16
NL7704591A (nl)	1977-12-13
DE2625834C3 (de)	1989-11-23
NO148340B (no)	1983-06-13
BR7703008A (pt)	1978-04-18
IL52047A0 (en)	1977-07-31
NO771599L (no)	1977-12-12
AR212763A1 (es)	1978-09-29
FI60719B (fi)	1981-11-30
CA1084393A (en)	1980-08-26
DD130178A5 (de)	1978-03-08
FR2354561B1 (de)	1981-10-30

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KR920001449B1 (ko)	1992-02-14	효소적산화에 의한 검체의 비색적 측정방법 및 시약
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JPS5819279B2 (ja)	1983-04-16	Ｎａｄ（ｐ）ｈ又はサリチル酸塩を測定する方法及び試薬
JPS6359466B2 (de)	1988-11-18
US5610025A (en)	1997-03-11	Inhibition of interfering endogenous enzyme activity in assays of biological fluids
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AU754237B2 (en)	2002-11-07	Uric acid assay device with stabilized uricase reagent composition
EP0158964B1 (de)	1990-11-14	Testsatz zum Nachweis einer Substanz in einer Körperflüssigkeit
IE61442B1 (en)	1994-11-02	Test composition device and method for the visual determination of hydrogen peroxide
KINOSHITA et al.	1980	A fluorophotometric determination of serum creatinine and creatine using a creatinineamidohydrolase-creatineamidinohydrolase-sarcosine oxidase-peroxidase system and diacetyldichlorofluorescin
EP0141244B1 (de)	1988-12-07	Testmittel zum Nachweis einer Substanz in einer Körperflüssigkeit
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MX2007002224A (es)	2007-05-04	Metodo para determinar la concentracion de analitos en muestras por mediacion directa de enzimas.

Legal Events

Date	Code	Title	Description
1977-04-28	MA	Patent expired
2004-08-31	MA	Patent expired	Owner name: BOEHRINGER MANNHEIM GMBH