FI120768B - Substituoituja tiofeenisulfonyyliureoita ja tioureoita, menetelmä niiden valmistamiseksi, niiden käyttö lääkkeenä tai diagnostisena aineena sekä niitä sisältävä lääke - Google Patents

Substituoituja tiofeenisulfonyyliureoita ja tioureoita, menetelmä niiden valmistamiseksi, niiden käyttö lääkkeenä tai diagnostisena aineena sekä niitä sisältävä lääke Download PDF

Info

Publication number: FI120768B
Authority: FI; Finland
Prior art keywords: formula; substituted; thiophenesulfonylurea; methyl; physiologically acceptable
Prior art date: 1995-02-01

Application number

FI960430A

Other languages

English (en)

Finnish (fi)

Swedish (sv)

Other versions

FI960430L (fi

FI960430A0 (fi

Inventor

Joachim Kaiser

Dieter Mania

Heinrich Englert

Jens Hartung

Heinz Goegelein

Peter Crause

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-02-01

Filing date

1996-01-30

Publication date

2010-02-26

1996-01-30 Application filed by Hoechst Ag filed Critical Hoechst Ag

1996-01-30 Publication of FI960430A0 publication Critical patent/FI960430A0/fi

1996-08-02 Publication of FI960430L publication Critical patent/FI960430L/fi

2010-02-26 Application granted granted Critical

2010-02-26 Publication of FI120768B publication Critical patent/FI120768B/fi

Links

238000002360 preparation method Methods 0.000 title claims description 14
238000000034 method Methods 0.000 title claims description 13
230000008569 process Effects 0.000 title claims description 4
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239000000032 diagnostic agent Substances 0.000 title description 2
229940039227 diagnostic agent Drugs 0.000 title description 2
229940126601 medicinal product Drugs 0.000 title 1
239000008177 pharmaceutical agent Substances 0.000 title 1
-1 aromatic sulfonamide Chemical class 0.000 claims description 66
150000001875 compounds Chemical class 0.000 claims description 36
238000006243 chemical reaction Methods 0.000 claims description 19
150000003839 salts Chemical class 0.000 claims description 19
239000001257 hydrogen Substances 0.000 claims description 15
229910052739 hydrogen Inorganic materials 0.000 claims description 15
239000003814 drug Substances 0.000 claims description 14
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 13
150000001412 amines Chemical class 0.000 claims description 12
238000011282 treatment Methods 0.000 claims description 12
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 11
206010003119 arrhythmia Diseases 0.000 claims description 11
KLPPUPBECAHKEF-UHFFFAOYSA-N thiophen-2-ylsulfonylurea Chemical class NC(=O)NS(=O)(=O)C1=CC=CS1 KLPPUPBECAHKEF-UHFFFAOYSA-N 0.000 claims description 10
239000000460 chlorine Substances 0.000 claims description 9
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ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 7
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239000011737 fluorine Substances 0.000 claims description 7
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GBAVRWCYORZZKO-UHFFFAOYSA-N n-(sulfanylidenemethylidene)thiophene-2-sulfonamide Chemical compound S=C=NS(=O)(=O)C1=CC=CS1 GBAVRWCYORZZKO-UHFFFAOYSA-N 0.000 claims description 2
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UVVUGWBBCDFNSD-UHFFFAOYSA-N tetraisocyanatosilane Chemical compound O=C=N[Si](N=C=O)(N=C=O)N=C=O UVVUGWBBCDFNSD-UHFFFAOYSA-N 0.000 claims description 2
238000004519 manufacturing process Methods 0.000 claims 3
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230000002238 attenuated effect Effects 0.000 claims 1
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JBPHCEHVHVSGEP-UHFFFAOYSA-N n-(oxomethylidene)thiophene-2-sulfonamide Chemical compound O=C=NS(=O)(=O)C1=CC=CS1 JBPHCEHVHVSGEP-UHFFFAOYSA-N 0.000 claims 1
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150000003512 tertiary amines Chemical class 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
NOGBKWXHNPDHFA-UHFFFAOYSA-N tetraisothiocyanatosilane Chemical compound S=C=N[Si](N=C=S)(N=C=S)N=C=S NOGBKWXHNPDHFA-UHFFFAOYSA-N 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
BSXLLFUSNQCWJP-UHFFFAOYSA-N thiophene-2-sulfonic acid Chemical class OS(=O)(=O)C1=CC=CS1 BSXLLFUSNQCWJP-UHFFFAOYSA-N 0.000 description 1
150000003577 thiophenes Chemical class 0.000 description 1
238000011200 topical administration Methods 0.000 description 1
238000002054 transplantation Methods 0.000 description 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
239000012588 trypsin Substances 0.000 description 1
210000004881 tumor cell Anatomy 0.000 description 1
JOYRKODLDBILNP-UHFFFAOYSA-N urethane group Chemical group NC(=O)OCC JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
208000003663 ventricular fibrillation Diseases 0.000 description 1
206010047302 ventricular tachycardia Diseases 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Cardiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

FI960430A 1995-02-01 1996-01-30 Substituoituja tiofeenisulfonyyliureoita ja tioureoita, menetelmä niiden valmistamiseksi, niiden käyttö lääkkeenä tai diagnostisena aineena sekä niitä sisältävä lääke FI120768B (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19503136		1995-02-01
DE19503136A DE19503136A1 (de)	1995-02-01	1995-02-01	Substituierte Thiophenylsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Publications (3)

Publication Number	Publication Date
FI960430A0 FI960430A0 (fi)	1996-01-30
FI960430L FI960430L (fi)	1996-08-02
FI120768B true FI120768B (fi)	2010-02-26

Family

ID=7752837

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI960430A FI120768B (fi)	1995-02-01	1996-01-30	Substituoituja tiofeenisulfonyyliureoita ja tioureoita, menetelmä niiden valmistamiseksi, niiden käyttö lääkkeenä tai diagnostisena aineena sekä niitä sisältävä lääke

Country Status (29)

Country	Link
US (1)	US5792788A (xx)
EP (1)	EP0729954B1 (xx)
JP (1)	JP4021949B2 (xx)
KR (1)	KR100449192B1 (xx)
CN (1)	CN1071752C (xx)
AR (1)	AR002026A1 (xx)
AT (1)	ATE248829T1 (xx)
AU (1)	AU700884B2 (xx)
BR (1)	BR9600290A (xx)
CA (1)	CA2168517C (xx)
CZ (1)	CZ290738B6 (xx)
DE (2)	DE19503136A1 (xx)
DK (1)	DK0729954T3 (xx)
ES (1)	ES2206525T3 (xx)
FI (1)	FI120768B (xx)
HR (1)	HRP960042B1 (xx)
HU (1)	HU226121B1 (xx)
IL (1)	IL116980A (xx)
MY (1)	MY113423A (xx)
NO (1)	NO315160B1 (xx)
NZ (1)	NZ280890A (xx)
PL (1)	PL183561B1 (xx)
PT (1)	PT729954E (xx)
RU (1)	RU2164916C2 (xx)
SI (1)	SI9600033B (xx)
SK (1)	SK284325B6 (xx)
TR (1)	TR199600079A2 (xx)
TW (1)	TW355184B (xx)
ZA (1)	ZA96720B (xx)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE102004061017A1 (de) *	2004-12-18	2006-06-22	Sanofi-Aventis Deutschland Gmbh	Piperidinsulfonylharnstoffe und -thioharnstoffe, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
US20250145564A1 (en) *	2021-08-16	2025-05-08	Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences	Sulfonylurea compound, preparation method therefor, and application thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3124597A (en) *		1964-03-10
DE1493672C3 (de) *	1964-08-01	1974-05-02	Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt	Verfahren zur Herstellung von Benzolsulfonylharnstoffen
DE1518874C3 (de) *	1964-10-07	1975-03-13	Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt	Benzolsulfonylharnstoffe und Verfahren zu ihrer Herstellung
BE754588A (fr) *	1969-08-07	1971-02-08	Hoechst Ag	Thiophene-sulfonyl-urees et les medicaments qui contiennent cessubstances
DE2413514C3 (de) *	1974-03-21	1982-03-04	Hoechst Ag, 6000 Frankfurt	N-Acylaminoathylbenzolsulfonyl-N'-methylharnstoffe, Verfahren zu ihrer Herstellung und deren Verwendung
ZA813332B (en) *	1980-06-21	1982-05-26	Pfizer	Larvicides and isecticides
ZA871109B (en) *	1986-02-19	1987-10-28	Duphar Int Res	New thio compounds having fungicidal activity
GB9012252D0 (en) *	1990-06-01	1990-07-18	Lilly Industries Ltd	Pharmaceutical compounds
DE59401361D1 (de) *	1993-02-23	1997-02-06	Hoechst Ag	Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe- Verfahren zu ihrer Herstellung und ihre Verwendung als Pharmazeutika
DE4341655A1 (de) *	1993-12-07	1995-06-08	Hoechst Ag	Aminosubstituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung als Pharmazeutika
DE4344957A1 (de) *	1993-12-30	1995-07-06	Hoechst Ag	Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Herstellungsverfahren und Verwendungsmöglichkeiten pharmazeutischer Präparate auf Basis dieser Verbindungen

1995
- 1995-02-01 DE DE19503136A patent/DE19503136A1/de not_active Withdrawn
1996
- 1996-01-26 AT AT96101096T patent/ATE248829T1/de active
- 1996-01-26 DK DK96101096T patent/DK0729954T3/da active
- 1996-01-26 DE DE59610691T patent/DE59610691D1/de not_active Expired - Lifetime
- 1996-01-26 NZ NZ280890A patent/NZ280890A/en not_active IP Right Cessation
- 1996-01-26 PT PT96101096T patent/PT729954E/pt unknown
- 1996-01-26 ES ES96101096T patent/ES2206525T3/es not_active Expired - Lifetime
- 1996-01-26 EP EP96101096A patent/EP0729954B1/de not_active Expired - Lifetime
- 1996-01-29 HR HR960042A patent/HRP960042B1/xx not_active IP Right Cessation
- 1996-01-29 PL PL96312532A patent/PL183561B1/pl not_active IP Right Cessation
- 1996-01-29 TW TW085101042A patent/TW355184B/zh not_active IP Right Cessation
- 1996-01-30 US US08/593,621 patent/US5792788A/en not_active Expired - Lifetime
- 1996-01-30 MY MYPI96000343A patent/MY113423A/en unknown
- 1996-01-30 TR TR96/00079A patent/TR199600079A2/xx unknown
- 1996-01-30 SK SK134-96A patent/SK284325B6/sk not_active IP Right Cessation
- 1996-01-30 FI FI960430A patent/FI120768B/fi not_active IP Right Cessation
- 1996-01-30 AU AU42246/96A patent/AU700884B2/en not_active Ceased
- 1996-01-30 AR ARP960101212A patent/AR002026A1/es active IP Right Grant
- 1996-01-30 CZ CZ1996280A patent/CZ290738B6/cs not_active IP Right Cessation
- 1996-01-30 CN CN96101109A patent/CN1071752C/zh not_active Expired - Fee Related
- 1996-01-31 HU HU9600218A patent/HU226121B1/hu not_active IP Right Cessation
- 1996-01-31 NO NO19960411A patent/NO315160B1/no not_active IP Right Cessation
- 1996-01-31 RU RU96101797/04A patent/RU2164916C2/ru not_active IP Right Cessation
- 1996-01-31 BR BR9600290A patent/BR9600290A/pt not_active IP Right Cessation
- 1996-01-31 IL IL11698096A patent/IL116980A/en not_active IP Right Cessation
- 1996-01-31 JP JP01575996A patent/JP4021949B2/ja not_active Expired - Lifetime
- 1996-01-31 CA CA002168517A patent/CA2168517C/en not_active Expired - Fee Related
- 1996-01-31 ZA ZA96720A patent/ZA96720B/xx unknown
- 1996-02-01 KR KR1019960002405A patent/KR100449192B1/ko not_active Expired - Fee Related
- 1996-02-01 SI SI9600033A patent/SI9600033B/sl not_active IP Right Cessation

Also Published As

Publication number	Publication date
ZA96720B (en)	1997-07-31
AU4224696A (en)	1996-08-08
NZ280890A (en)	1996-10-28
SI9600033A (en)	1996-10-31
IL116980A0 (en)	1996-05-14
TW355184B (en)	1999-04-01
DE19503136A1 (de)	1996-08-08
HRP960042A2 (en)	1997-10-31
AU700884B2 (en)	1999-01-14
TR199600079A2 (tr)	1996-08-21
EP0729954B1 (de)	2003-09-03
HUP9600218A2 (en)	1997-05-28
NO960411L (no)	1996-08-02
BR9600290A (pt)	1997-12-23
SI9600033B (en)	2001-12-31
CZ28096A3 (cs)	1998-04-15
HUP9600218A3 (en)	2000-03-28
FI960430L (fi)	1996-08-02
HU226121B1 (en)	2008-04-28
CA2168517A1 (en)	1996-08-02
AR002026A1 (es)	1998-01-07
KR100449192B1 (ko)	2005-09-06
KR960031453A (ko)	1996-09-17
CN1071752C (zh)	2001-09-26
ATE248829T1 (de)	2003-09-15
PT729954E (pt)	2004-01-30
DE59610691D1 (de)	2003-10-09
SK284325B6 (sk)	2005-01-03
MY113423A (en)	2002-02-28
HRP960042B1 (en)	2004-10-31
US5792788A (en)	1998-08-11
ES2206525T3 (es)	2004-05-16
FI960430A0 (fi)	1996-01-30
CA2168517C (en)	2007-02-27
SK13496A3 (en)	1996-10-02
CZ290738B6 (cs)	2002-10-16
CN1134421A (zh)	1996-10-30
JP4021949B2 (ja)	2007-12-12
PL183561B1 (pl)	2002-06-28
DK0729954T3 (da)	2003-12-01
NO960411D0 (no)	1996-01-31
IL116980A (en)	2001-06-14
EP0729954A1 (de)	1996-09-04
PL312532A1 (en)	1996-08-05
JPH08253471A (ja)	1996-10-01
NO315160B1 (no)	2003-07-21
RU2164916C2 (ru)	2001-04-10

Publication	Publication Date	Title
FI114152B (fi)	2004-08-31	Menetelmä terapeuttisesti käyttökelpoisten substituoitujen bentseenisulfonyylivirtsa-aineiden ja -tiovirtsa-aineiden valmistamiseksi
JP4242936B2 (ja)	2009-03-25	３−アミドクロマニルスルホニル（チオ）尿素、それらの製法、それらの使用およびそれらを含有する医薬製剤
RU2198163C2 (ru)	2003-02-10	Замещенные бензолсульфонилмочевины и -тиомочевины, способ их получения, содержащая их фармацевтическая композиция и способ ее получения
FI107152B (fi)	2001-06-15	Menetelmä uusien terapeuttisesti käyttökelpoisten aminosubstituoitujen bentseenisulfonyylitioureajohdannaisten valmistamiseksi
FI120768B (fi)	2010-02-26	Substituoituja tiofeenisulfonyyliureoita ja tioureoita, menetelmä niiden valmistamiseksi, niiden käyttö lääkkeenä tai diagnostisena aineena sekä niitä sisältävä lääke
KR100446565B1 (ko)	2004-12-03	치환된벤젠설포닐티오우레아,이의제조방법및이를포함하는약제학적조성물
KR100432259B1 (ko)	2004-09-18	치환된벤젠설포닐우레아및벤젠설포닐티오우레아,이들의제조방법및이들을포함하는약제학적조성물
JP3718248B2 (ja)	2005-11-24	置換ベンゼンスルホニル尿素および−チオ尿素、その製造方法および該化合物をベースとする医薬製剤の使用
PL194299B1 (pl)	2007-05-31	2,5-Podstawione benzenosulfonylo(tio)moczniki, sposób ich wytwarzania, środek farmaceutyczny i zastosowanie 2,5-podstawionych benzenosulfonylo(tio)moczników do wytwarzania leku
MXPA97008783A (en)	1998-10-23	3-amido-cromanilsulfonil (tio) ureas, procedure for its preparation, its employment and pharmaceutical preparations that contain it

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